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Q09708 (YAGG_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Uncharacterized protein C12G12.16c
Gene names
ORF Names:SPAC12G12.16c, SPAC18B11.01c
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces ›

Protein attributes

Sequence length496 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Cofactor

Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding By similarity.

Sequence similarities

Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.

Ontologies

Keywords
   LigandMagnesium
Metal-binding
   Molecular functionEndonuclease
Hydrolase
Nuclease
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processDNA repair

Inferred from sequence model. Source: PomBase

   Cellular_componentcytoplasm

Inferred from direct assay PubMed 16823372. Source: PomBase

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: InterPro

endonuclease activity

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

nuclease activity

Inferred from sequence model. Source: PomBase

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 496496Uncharacterized protein C12G12.16c
PRO_0000154047

Sites

Metal binding361Magnesium 1 By similarity
Metal binding811Magnesium 1 By similarity
Metal binding3001Magnesium 1 By similarity
Metal binding3021Magnesium 1 By similarity
Metal binding3211Magnesium 2 By similarity
Metal binding3231Magnesium 2 By similarity
Metal binding3751Magnesium 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q09708 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: F2A16D26846F24C3

FASTA49657,764
        10         20         30         40         50         60 
MGVHGLLPII RKVASEGIRW LQPEFFSKYY PVLAVDGNLL LYRFFRSPNT PLHTNYQHVL 

        70         80         90        100        110        120 
WALKLSRYCR KLKTSPIVVF DNLKPNDFKA EEHEKRSLIS SQIVNQRQVV QEQMYFLCNL 

       130        140        150        160        170        180 
KNCLIDNNFP TGNFYYEIGP LLSQIGKLLF DLRSLNERDN PFHAQNNAEN LENATFVRLI 

       190        200        210        220        230        240 
VDKLNDREKT LMIQEKKNHL IHSLRQLLAF SEINDFPSEI RSYLEFILSN LDLECLTLCL 

       250        260        270        280        290        300 
KIIKGILTLD ELQKAIKLKQ TELDKLERRL YRPSPQNIFE IFEILKILGI PASFSPIGVE 

       310        320        330        340        350        360 
AEAFASAISQ NNLAYAVATQ DTDVLLLGSS MISNFLDLND NFHLPLQIMD PRKIAQELNL 

       370        380        390        400        410        420 
TFDGFQDYCL MCGTDFTSRI PKIGPVRALK LIRYYGNAFD VLKALNVEEK YIIPTDYIKK 

       430        440        450        460        470        480 
FLTAKKLFTD LPSNNELFSF IHNIPKEFLH LSDSTYLDLE KQVLRIFNVQ IEELDAKTPW 

       490 
YYHYELEKDV KSTYEY

« Hide

References

[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CU329670 Genomic DNA. Translation: CAA90586.1.
PIRS58300. T37913.
RefSeqNP_592882.1. NM_001018282.2.

3D structure databases

ProteinModelPortalQ09708.
ModBaseSearch...

Protein-protein interaction databases

STRING4896.SPAC12G12.16c-1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPAC12G12.16c.1; SPAC12G12.16c.1:pep; SPAC12G12.16c.
GeneID2543216.
KEGGspo:SPAC12G12.16c.

Organism-specific databases

PomBaseSPAC12G12.16c.

Phylogenomic databases

eggNOGCOG0258.
OrthoDBEOG4VT96S.

Family and domain databases

InterProIPR020045. 5-3_exonuclease_C.
IPR008918. HhH2.
IPR006086. XPG-I_dom.
IPR006084. XPG/Rad2.
IPR006085. XPG_DNA_repair_N.
[Graphical view]
PANTHERPTHR11081. PTHR11081. 1 hit.
PfamPF00867. XPG_I. 1 hit.
PF00752. XPG_N. 1 hit.
[Graphical view]
PRINTSPR00853. XPGRADSUPER.
SMARTSM00279. HhH2. 1 hit.
SM00484. XPGI. 1 hit.
SM00485. XPGN. 1 hit.
[Graphical view]
SUPFAMSSF47807. 5_3_exo_C. 1 hit.
ProtoNetSearch...

Other

NextBio20804238.

Entry information

Entry nameYAGG_SCHPO
AccessionPrimary (citable) accession number: Q09708
Secondary accession number(s): Q9UTN5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 3, 2013
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

SIMILARITY comments

Index of protein domains and families

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