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Protein

Negative regulator of differentiation 1

Gene

nrd1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Negative regulator of sexual differentiation. Acts by repressing the transcription of meiosis-inducing, ste11-regulated genes until cells reach a critical level of starvation. RNA-binding protein that preferentially binds poly(U).1 Publication

GO - Molecular functioni

  • nucleotide binding Source: InterPro
  • poly(U) RNA binding Source: PomBase
  • RNA binding Source: PomBase

GO - Biological processi

  • negative regulation of conjugation with cellular fusion Source: PomBase
  • negative regulation of induction of conjugation with cellular fusion by negative regulation of transcription from RNA polymerase II promoter Source: PomBase
  • regulation of conjugation with cellular fusion by regulation of transcription from RNA polymerase II promoter Source: PomBase
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Negative regulator of differentiation 1
Alternative name(s):
Multicopy suppressor of sporulation protein msa2
Gene namesi
Name:nrd1
Synonyms:msa2
ORF Names:SPAC2F7.11
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC2F7.11.
PomBaseiSPAC2F7.11. nrd1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 529529Negative regulator of differentiation 1PRO_0000081687Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei93 – 931Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ09702.

PTM databases

iPTMnetiQ09702.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
rkp1Q102814EBI-696291,EBI-696304

Protein-protein interaction databases

BioGridi278249. 10 interactions.
IntActiQ09702. 1 interaction.
MINTiMINT-1203513.

Structurei

Secondary structure

1
529
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi196 – 1994Combined sources
Beta strandi208 – 2114Combined sources
Helixi219 – 2268Combined sources
Turni227 – 2293Combined sources
Beta strandi233 – 2386Combined sources
Turni239 – 2424Combined sources
Beta strandi243 – 2475Combined sources
Helixi251 – 26010Combined sources
Helixi261 – 2633Combined sources
Helixi267 – 2693Combined sources
Beta strandi272 – 2743Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2RT3NMR-A188-284[»]
ProteinModelPortaliQ09702.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini115 – 18874RRM 1PROSITE-ProRule annotationAdd
BLAST
Domaini206 – 27772RRM 2PROSITE-ProRule annotationAdd
BLAST
Domaini323 – 39674RRM 3PROSITE-ProRule annotationAdd
BLAST
Domaini414 – 48572RRM 4PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi2 – 109Poly-Ser

Sequence similaritiesi

Contains 4 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000113850.
InParanoidiQ09702.
OMAiRFGHIEH.
OrthoDBiEOG7PS1R0.
PhylomeDBiQ09702.

Family and domain databases

Gene3Di3.30.70.330. 4 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
[Graphical view]
SMARTiSM00360. RRM. 4 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 3 hits.
PROSITEiPS50102. RRM. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q09702-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSSPSSQS RLSVPGRTPH LPPLTIPHTV SAEGLATPNT PHALLPTGLL
60 70 80 90 100
MGSPFVQSPT SYTSMHGLPF STTQMAAAPA HPTTGYNVSR VTSPNVANFA
110 120 130 140 150
PGYFPLPNNT TQPVKTVYVG NLPPNTPIDE ILSCVRTGPI ESAWILPEKN
160 170 180 190 200
CAFISFLDPS HATAFFQDAA LKRLTIRGTE VKVGWGKNSA SNSSVLLAVQ
210 220 230 240 250
QSGACRNVFL GNLPNGITED EIREDLEPFG PIDQIKIVTE RNIAFVHFLN
260 270 280 290 300
IAAAIKAVQE LPLNPKWSKR RIYYGRDRCA VGLKQPAYFS KGQVGVVGGY
310 320 330 340 350
PVMGYPPPSP VLQKPDLIMT GNRTVYIGNI HADTTIEEIC NAVRGGLLHN
360 370 380 390 400
IRYLQEKHIC FVTFVDPVSA FRFFEMSNIH GLVIRNRRLK IGWGKHSGPL
410 420 430 440 450
PSNIALAVAG GASRNIYIGN ADDSLTIERL KEDFEEFGEI EYVNFFREKN
460 470 480 490 500
CAFVNFTSLA SAINAIDRIK QKKGYENYRI SYGKDRCGNP PRTNSKSDVL
510 520
SVSSDMSMPV DLVVPQQGIS GFMPTNSNI
Length:529
Mass (Da):57,761
Last modified:November 1, 1995 - v1
Checksum:i958D8416D07599DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF079876 Genomic DNA. Translation: AAC28857.1.
CU329670 Genomic DNA. Translation: CAA90498.1.
PIRiT38559. S58155.
RefSeqiNP_592982.1. NM_001018382.2.

Genome annotation databases

EnsemblFungiiSPAC2F7.11.1; SPAC2F7.11.1:pep; SPAC2F7.11.
GeneIDi2541755.
KEGGispo:SPAC2F7.11.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF079876 Genomic DNA. Translation: AAC28857.1.
CU329670 Genomic DNA. Translation: CAA90498.1.
PIRiT38559. S58155.
RefSeqiNP_592982.1. NM_001018382.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2RT3NMR-A188-284[»]
ProteinModelPortaliQ09702.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278249. 10 interactions.
IntActiQ09702. 1 interaction.
MINTiMINT-1203513.

PTM databases

iPTMnetiQ09702.

Proteomic databases

MaxQBiQ09702.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC2F7.11.1; SPAC2F7.11.1:pep; SPAC2F7.11.
GeneIDi2541755.
KEGGispo:SPAC2F7.11.

Organism-specific databases

EuPathDBiFungiDB:SPAC2F7.11.
PomBaseiSPAC2F7.11. nrd1.

Phylogenomic databases

HOGENOMiHOG000113850.
InParanoidiQ09702.
OMAiRFGHIEH.
OrthoDBiEOG7PS1R0.
PhylomeDBiQ09702.

Miscellaneous databases

PROiQ09702.

Family and domain databases

Gene3Di3.30.70.330. 4 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
[Graphical view]
SMARTiSM00360. RRM. 4 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 3 hits.
PROSITEiPS50102. RRM. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "An RNA binding protein negatively controlling differentiation in fission yeast."
    Tsukahara K., Yamamoto H., Okayama H.
    Mol. Cell. Biol. 18:4488-4498(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  3. "A novel gene, msa1, inhibits sexual differentiation in Schizosaccharomyces pombe."
    Jeong H.T., Ozoe F., Tanaka K., Nakagawa T., Matsuda H., Kawamukai M.
    Genetics 167:77-91(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-93, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiNRD1_SCHPO
AccessioniPrimary (citable) accession number: Q09702
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 8, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.