Skip Header

 
Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot Q09701 (AKR1_SCHPO)

Last modified November 24, 2009. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein namesRecommended name:
    Palmitoyltransferase akr1
    EC=2.3.1.-
Alternative name(s):
    Ankyrin repeat-containing protein akr1
Gene names
Name: akr1
ORF Names: SPAC2F7.10
OrganismSchizosaccharomyces pombe (Fission yeast) [Complete proteome]
Taxonomic identifier4896 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Hide | Top

Protein attributes

Sequence length642 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

Hide | Top

General annotation (Comments)

Function

Palmitoyltransferase specific for casein kinase 1 By similarity.

Catalytic activity

Palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA.

Subcellular location

Early endosome membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein By similarity.

Domain

The DHHC domain is required for palmitoyltransferase activity By similarity.

Sequence similarities

Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.

Contains 6 ANK repeats.

Contains 1 DHHC-type zinc finger.

Hide | Top

Ontologies

Keywords
   Cellular componentEndosome
Golgi apparatus
Membrane
   DomainANK repeat
Repeat
Transmembrane
Zinc-finger
   LigandMetal-binding
Zinc
   Molecular functionAcyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular componentGolgi apparatus

Inferred from direct assay. Source: GeneDB_SPombe

endosome

Inferred from electronic annotation. Source: UniProtKB-KW

fungal-type vacuole membrane

Inferred from direct assay. Source: GeneDB_SPombe

integral to membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionacyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-KW

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Hide | Top

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 642642Palmitoyltransferase akr1
PRO_0000212931

Regions

Topological domain1 – 256256Cytoplasmic Potential
Transmembrane257 – 27721 Potential
Transmembrane278 – 29821 Potential
Topological domain299 – 31618Cytoplasmic Potential
Transmembrane317 – 33721 Potential
Topological domain338 – 3436Lumenal Potential
Transmembrane344 – 36421 Potential
Topological domain365 – 44480Cytoplasmic Potential
Transmembrane445 – 46521 Potential
Topological domain466 – 49631Lumenal Potential
Transmembrane497 – 51721 Potential
Topological domain518 – 642125Cytoplasmic Potential
Repeat1 – 2929ANK 1
Repeat33 – 6230ANK 2
Repeat67 – 9630ANK 3
Repeat100 – 12930ANK 4
Repeat133 – 16230ANK 5
Repeat166 – 19631ANK 6
Zinc finger400 – 45051DHHC-type

Sites

Active site4301S-palmitoyl cysteine intermediate By similarity

Hide | Top

Sequences

Sequence LengthMass (Da)Tools
Q09701-1 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: C83584A3300BDDA0

FASTA64272,522
        10         20         30         40         50         60 
MGSLFLAASQ GELDTVKNLI SSEKIDVNAT DEGGATALHW AALNQQIPIC KFLLEHGADV 

        70         80         90        100        110        120 
NAIGGDLQAA PIHWAAKRGS VKTVHYLVQH GADPLLKDKQ GFNCLHLAVH AASPLLVVYL 

       130        140        150        160        170        180 
LHLDISVDLR DDQQHTPLMW ASYHGNEPIT NCLLRWGADV LATDEDKMTP LHWSIVGGNL 

       190        200        210        220        230        240 
KCMKLILKEG GIPCTAVTAN LSGQLKTPWA LASELRVSHL FKQALISNGL KVKETSEEPE 

       250        260        270        280        290        300 
KWVVVPSKFQ FSQKTFIIFC FLSSFIITGV FFFIMSICPM VISLIIAPLW IYFTFKYITT 

       310        320        330        340        350        360 
CIHANIDIVH FYLETPFLAG IFSSIFFWVW CHSLLYIVPK TLPIKPLSSL LFVLISFTCI 

       370        380        390        400        410        420 
GLYVRTAFQN PGYVDKIGAV VQRREEISKL LDKDLFNQSH YCLKCFQVKP PRSYHCGACK 

       430        440        450        460        470        480 
RCINRYDHHC PWTGNCVGAR NHRTFLLFVF TLSTLIPIYF YVAFYYLQNI PIQKKYESYR 

       490        500        510        520        530        540 
CLFISGTICQ WSLKDMFVLV ASLTLFVNWC WVVVLAFTQI CQVAHNVTTA EFRLFKRYGT 

       550        560        570        580        590        600 
LVPPTKQNSS PKNGHGIHGS FLRTVCGILG LDQCILLIRE SNCFVRCFPS RAELGSQNST 

       610        620        630        640 
SLSRNLSTVN PYDEGSIIKN CKTFWKQNFL NDGRQDEATR HV

« Hide

Hide | Top

References

[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed: 11859360] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 38366 / 972.

Hide | Top

Cross-references

Sequence databases

CU329670 Genomic DNA. Translation: CAA90497.1.
PIRS58154.
RefSeqNP_592981.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID2541757.
GenomeReviewsGene locus akr1 in contig CU329670_GR.
KEGGspo:SPAC2F7.10.
NMPDRfig|4896.1.peg.2951.

Organism-specific databases

GeneDB_SpombeSPAC2F7.10.

Phylogenomic databases

OMACIGARNH.
OrthoDBEOG9QRJM8.

Gene expression databases

ArrayExpressQ09701.

Family and domain databases

InterProIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001594. Znf_DHHC.
[Graphical view]
Gene3DG3DSA:1.25.40.20. ANK. 1 hit.
PfamPF00023. Ank. 6 hits.
PF01529. zf-DHHC. 1 hit.
[Graphical view]
SMARTSM00248. ANK. 6 hits.
[Graphical view]
PROSITEPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
PS50216. ZF_DHHC. 1 hit.
[Graphical view]
ProtoNetSearch...

Hide | Top

Entry information

Entry nameAKR1_SCHPO
AccessionPrimary (citable) accession number: Q09701
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 24, 2009
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

Hide | Top

Relevant documents

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents