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Protein

Palmitoyltransferase akr1

Gene

akr1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Palmitoyltransferase specific for casein kinase 1.By similarity

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei430S-palmitoyl cysteine intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyltransferase akr1 (EC:2.3.1.225)
Alternative name(s):
Ankyrin repeat-containing protein akr1
Gene namesi
Name:akr1
ORF Names:SPAC2F7.10
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC2F7.10.
PomBaseiSPAC2F7.10. akr1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 256CytoplasmicSequence analysisAdd BLAST256
Transmembranei257 – 277HelicalSequence analysisAdd BLAST21
Transmembranei278 – 298HelicalSequence analysisAdd BLAST21
Topological domaini299 – 316CytoplasmicSequence analysisAdd BLAST18
Transmembranei317 – 337HelicalSequence analysisAdd BLAST21
Topological domaini338 – 343LumenalSequence analysis6
Transmembranei344 – 364HelicalSequence analysisAdd BLAST21
Topological domaini365 – 444CytoplasmicSequence analysisAdd BLAST80
Transmembranei445 – 465HelicalSequence analysisAdd BLAST21
Topological domaini466 – 496LumenalSequence analysisAdd BLAST31
Transmembranei497 – 517HelicalSequence analysisAdd BLAST21
Topological domaini518 – 642CytoplasmicSequence analysisAdd BLAST125

GO - Cellular componenti

  • early endosome membrane Source: UniProtKB-SubCell
  • fungal-type vacuole membrane Source: PomBase
  • Golgi apparatus Source: PomBase
  • Golgi membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • protein complex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002129311 – 642Palmitoyltransferase akr1Add BLAST642

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

MaxQBiQ09701.
PRIDEiQ09701.

Interactioni

Protein-protein interaction databases

BioGridi278251. 25 interactors.
MINTiMINT-4694228.

Structurei

3D structure databases

ProteinModelPortaliQ09701.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati1 – 29ANK 1Add BLAST29
Repeati33 – 62ANK 2Add BLAST30
Repeati67 – 96ANK 3Add BLAST30
Repeati100 – 129ANK 4Add BLAST30
Repeati133 – 162ANK 5Add BLAST30
Repeati166 – 196ANK 6Add BLAST31
Domaini400 – 450DHHCPROSITE-ProRule annotationAdd BLAST51

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Contains 6 ANK repeats.PROSITE-ProRule annotation
Contains 1 DHHC domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiQ09701.
KOiK20032.
OMAiFQSSAFW.
OrthoDBiEOG092C216R.
PhylomeDBiQ09701.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
PF01529. zf-DHHC. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 6 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
PS50216. DHHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q09701-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSLFLAASQ GELDTVKNLI SSEKIDVNAT DEGGATALHW AALNQQIPIC
60 70 80 90 100
KFLLEHGADV NAIGGDLQAA PIHWAAKRGS VKTVHYLVQH GADPLLKDKQ
110 120 130 140 150
GFNCLHLAVH AASPLLVVYL LHLDISVDLR DDQQHTPLMW ASYHGNEPIT
160 170 180 190 200
NCLLRWGADV LATDEDKMTP LHWSIVGGNL KCMKLILKEG GIPCTAVTAN
210 220 230 240 250
LSGQLKTPWA LASELRVSHL FKQALISNGL KVKETSEEPE KWVVVPSKFQ
260 270 280 290 300
FSQKTFIIFC FLSSFIITGV FFFIMSICPM VISLIIAPLW IYFTFKYITT
310 320 330 340 350
CIHANIDIVH FYLETPFLAG IFSSIFFWVW CHSLLYIVPK TLPIKPLSSL
360 370 380 390 400
LFVLISFTCI GLYVRTAFQN PGYVDKIGAV VQRREEISKL LDKDLFNQSH
410 420 430 440 450
YCLKCFQVKP PRSYHCGACK RCINRYDHHC PWTGNCVGAR NHRTFLLFVF
460 470 480 490 500
TLSTLIPIYF YVAFYYLQNI PIQKKYESYR CLFISGTICQ WSLKDMFVLV
510 520 530 540 550
ASLTLFVNWC WVVVLAFTQI CQVAHNVTTA EFRLFKRYGT LVPPTKQNSS
560 570 580 590 600
PKNGHGIHGS FLRTVCGILG LDQCILLIRE SNCFVRCFPS RAELGSQNST
610 620 630 640
SLSRNLSTVN PYDEGSIIKN CKTFWKQNFL NDGRQDEATR HV
Length:642
Mass (Da):72,522
Last modified:November 1, 1995 - v1
Checksum:iC83584A3300BDDA0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA90497.1.
PIRiS58154.
RefSeqiNP_592981.1. NM_001018381.2.

Genome annotation databases

EnsemblFungiiSPAC2F7.10.1; SPAC2F7.10.1:pep; SPAC2F7.10.
GeneIDi2541757.
KEGGispo:SPAC2F7.10.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA90497.1.
PIRiS58154.
RefSeqiNP_592981.1. NM_001018381.2.

3D structure databases

ProteinModelPortaliQ09701.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278251. 25 interactors.
MINTiMINT-4694228.

Proteomic databases

MaxQBiQ09701.
PRIDEiQ09701.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC2F7.10.1; SPAC2F7.10.1:pep; SPAC2F7.10.
GeneIDi2541757.
KEGGispo:SPAC2F7.10.

Organism-specific databases

EuPathDBiFungiDB:SPAC2F7.10.
PomBaseiSPAC2F7.10. akr1.

Phylogenomic databases

InParanoidiQ09701.
KOiK20032.
OMAiFQSSAFW.
OrthoDBiEOG092C216R.
PhylomeDBiQ09701.

Miscellaneous databases

PROiQ09701.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
PF01529. zf-DHHC. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 6 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
PS50216. DHHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAKR1_SCHPO
AccessioniPrimary (citable) accession number: Q09701
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 30, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.