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Protein

DNA polymerase type-X family protein pol4

Gene

pol4

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Repair polymerase. Involved in gap-filling in DNA non-homologous end joining (NHEJ) required for double-strand break repair. Can incorporate a ribonucleotide (rNTP) into a primer DNA.1 Publication

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi355MagnesiumBy similarity1
Metal bindingi357MagnesiumBy similarity1
Metal bindingi419MagnesiumBy similarity1

GO - Molecular functioni

  • 5'-deoxyribose-5-phosphate lyase activity Source: PomBase
  • DNA binding Source: InterPro
  • DNA-directed DNA polymerase activity Source: PomBase
  • DNA primase activity Source: PomBase
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • base-excision repair, gap-filling Source: PomBase
  • double-strand break repair via nonhomologous end joining Source: PomBase
  • error-prone translesion synthesis Source: PomBase
  • gap filling involved in double-strand break repair via nonhomologous end joining Source: PomBase
  • mitotic DNA-dependent DNA replication Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase

Keywords - Biological processi

DNA damage, DNA repair

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase type-X family protein pol4 (EC:2.7.7.7)
Gene namesi
Name:pol4
ORF Names:SPAC2F7.06c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC2F7.06c.
PomBaseiSPAC2F7.06c. pol4.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002188001 – 506DNA polymerase type-X family protein pol4Add BLAST506

Proteomic databases

MaxQBiQ09693.
PRIDEiQ09693.

Interactioni

Protein-protein interaction databases

BioGridi278134. 3 interactors.
MINTiMINT-4694137.

Structurei

3D structure databases

ProteinModelPortaliQ09693.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 98BRCTPROSITE-ProRule annotationAdd BLAST98

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni348 – 357Involved in ssDNA bindingBy similarity10

Sequence similaritiesi

Belongs to the DNA polymerase type-X family.Curated
Contains 1 BRCT domain.PROSITE-ProRule annotation

Phylogenomic databases

InParanoidiQ09693.
KOiK10981.
OMAiPRICINE.
OrthoDBiEOG092C2OBE.
PhylomeDBiQ09693.

Family and domain databases

CDDicd00141. NT_POLXc. 1 hit.
Gene3Di1.10.150.110. 1 hit.
3.30.210.10. 1 hit.
InterProiIPR001357. BRCT_dom.
IPR002054. DNA-dir_DNA_pol_X.
IPR019843. DNA_pol-X_BS.
IPR010996. DNA_pol_b-like_N.
IPR028207. DNA_pol_B_palm_palm.
IPR018944. DNA_pol_lambd_fingers_domain.
IPR022312. DNA_pol_X.
IPR002008. DNA_pol_X_beta-like.
IPR027421. DNA_pol_X_lyase_dom.
IPR029398. PolB_thumb.
[Graphical view]
PfamiPF14792. DNA_pol_B_palm. 1 hit.
PF14791. DNA_pol_B_thumb. 1 hit.
PF10391. DNA_pol_lambd_f. 1 hit.
PF14716. HHH_8. 1 hit.
[Graphical view]
PRINTSiPR00869. DNAPOLX.
PR00870. DNAPOLXBETA.
SMARTiSM00483. POLXc. 1 hit.
[Graphical view]
SUPFAMiSSF47802. SSF47802. 1 hit.
PROSITEiPS50172. BRCT. 1 hit.
PS00522. DNA_POLYMERASE_X. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q09693-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKILASSTNY VLHNRLSNSQ YEDARSKIVN FGGEFTNDAA KADYIFVNYS
60 70 80 90 100
QINRVRRELR TIGTPLETCV SCKLIVKIDW LNEPKESLTP GNPYVIWHRK
110 120 130 140 150
PEMKVGSPYT PSTRPASHTE APNDFENHET PNTENNNEVK SIDNVDQEGS
160 170 180 190 200
VYPTTKEYPY VLEIPRYACQ RKTPLKCVNQ AFVNALSVLK TCREVNGESV
210 220 230 240 250
RTRAYGMAIA TIKAFPLPID SAEQLEKMPG CGPKIVHLWK EFASTGTLKE
260 270 280 290 300
AEEFQKDPAS KILLLFYNIF GVGASHAAEW YQKGWRTIEQ VRKHKDSFTK
310 320 330 340 350
QIKVGLEFYE DFCKTVTIEE ATEIYETIVS RMPDGIKIQS CLVGGFRRGK
360 370 380 390 400
PVGADVDMVL SPSHTHSTKH LVDVLLRILD EEFQFRLISV QEHSCGGKKG
410 420 430 440 450
YVMLAVILSN SSKINRRVDI IVVPPAYIGS AVLGWSGGIF FLRDLKLYAN
460 470 480 490 500
SHLGLSYDSF EIINLKTGKD ICPDEFNEWK DPVEAEKDIF RYFSLEYIEP

KFRNTG
Length:506
Mass (Da):57,396
Last modified:November 1, 1995 - v1
Checksum:iF9A51ED54D428134
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA90493.1.
PIRiT38554. S58150.
RefSeqiNP_592977.1. NM_001018377.2.

Genome annotation databases

EnsemblFungiiSPAC2F7.06c.1; SPAC2F7.06c.1:pep; SPAC2F7.06c.
GeneIDi2541638.
KEGGispo:SPAC2F7.06c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA90493.1.
PIRiT38554. S58150.
RefSeqiNP_592977.1. NM_001018377.2.

3D structure databases

ProteinModelPortaliQ09693.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278134. 3 interactors.
MINTiMINT-4694137.

Proteomic databases

MaxQBiQ09693.
PRIDEiQ09693.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC2F7.06c.1; SPAC2F7.06c.1:pep; SPAC2F7.06c.
GeneIDi2541638.
KEGGispo:SPAC2F7.06c.

Organism-specific databases

EuPathDBiFungiDB:SPAC2F7.06c.
PomBaseiSPAC2F7.06c. pol4.

Phylogenomic databases

InParanoidiQ09693.
KOiK10981.
OMAiPRICINE.
OrthoDBiEOG092C2OBE.
PhylomeDBiQ09693.

Miscellaneous databases

PROiQ09693.

Family and domain databases

CDDicd00141. NT_POLXc. 1 hit.
Gene3Di1.10.150.110. 1 hit.
3.30.210.10. 1 hit.
InterProiIPR001357. BRCT_dom.
IPR002054. DNA-dir_DNA_pol_X.
IPR019843. DNA_pol-X_BS.
IPR010996. DNA_pol_b-like_N.
IPR028207. DNA_pol_B_palm_palm.
IPR018944. DNA_pol_lambd_fingers_domain.
IPR022312. DNA_pol_X.
IPR002008. DNA_pol_X_beta-like.
IPR027421. DNA_pol_X_lyase_dom.
IPR029398. PolB_thumb.
[Graphical view]
PfamiPF14792. DNA_pol_B_palm. 1 hit.
PF14791. DNA_pol_B_thumb. 1 hit.
PF10391. DNA_pol_lambd_f. 1 hit.
PF14716. HHH_8. 1 hit.
[Graphical view]
PRINTSiPR00869. DNAPOLX.
PR00870. DNAPOLXBETA.
SMARTiSM00483. POLXc. 1 hit.
[Graphical view]
SUPFAMiSSF47802. SSF47802. 1 hit.
PROSITEiPS50172. BRCT. 1 hit.
PS00522. DNA_POLYMERASE_X. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDPO4_SCHPO
AccessioniPrimary (citable) accession number: Q09693
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 5, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.