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Protein

Tryptophan--tRNA ligase, cytoplasmic

Gene

wrs1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligase, cytoplasmic (EC:6.1.1.2)
Alternative name(s):
Tryptophanyl-tRNA synthetase
Short name:
TrpRS
Gene namesi
Name:wrs1
ORF Names:SPAC2F7.13c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC2F7.13c
PomBaseiSPAC2F7.13c wrs1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001367431 – 395Tryptophan--tRNA ligase, cytoplasmicAdd BLAST395

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei288Phosphothreonine1 Publication1
Modified residuei290Phosphothreonine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ09692
PaxDbiQ09692
PRIDEiQ09692

PTM databases

iPTMnetiQ09692

Interactioni

Protein-protein interaction databases

STRINGi4896.SPAC2F7.13c.1

Structurei

3D structure databases

ProteinModelPortaliQ09692
SMRiQ09692
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi91 – 100"HIGH" region10
Motifi275 – 279"KMSKS" region5

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000224742
InParanoidiQ09692
KOiK01867
OMAiADILHPQ
OrthoDBiEOG092C2ZCA
PhylomeDBiQ09692

Family and domain databases

CDDicd00806 TrpRS_core, 1 hit
Gene3Di3.40.50.620, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002305 aa-tRNA-synth_Ic
IPR014729 Rossmann-like_a/b/a_fold
IPR002306 Trp-tRNA-ligase
PfamiView protein in Pfam
PF00579 tRNA-synt_1b, 1 hit
PRINTSiPR01039 TRNASYNTHTRP
TIGRFAMsiTIGR00233 trpS, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q09692-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVEEQIVTP WDVKGSIVDG EEKGIDYERL IVQFGTRKIT PEQLERFEKL
60 70 80 90 100
TGKKPHLLLR RGAFFSHRDF DMILDRYEQK KPFYLYTGRG PSSDSMHLGH
110 120 130 140 150
MIPFMFCKWL QDVFQVPLVI QLTDDEKFLF KQGVSLEDCQ RFARENAKDI
160 170 180 190 200
IAVGFDPKKT FIFMNSTYVG GAFYQNVVRI AKCITANQSK ACFGFTDSDS
210 220 230 240 250
IGKIHFASIQ AAPSFSSSFP HIFNGAKDIP CLIPCAIDQD PYFRLTRDVS
260 270 280 290 300
GRLKFKKPAL LHSRFFPALQ GPQSKMSASK DSSAIFMTDT PNKIKNKINR
310 320 330 340 350
HAFSGGGATI EIHREKGGNP DVDVAYQYLS FFLDDDEKLK QLYNTYKAGT
360 370 380 390
LSTGEMKGEC IKLLQQFVSD FQAARSKVDE ATLDMFMDGS RKLEW
Length:395
Mass (Da):44,910
Last modified:November 1, 1995 - v1
Checksum:iE656AE8B76C5FDF9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAA90500.1
PIRiS58157
RefSeqiNP_592983.1, NM_001018383.2

Genome annotation databases

EnsemblFungiiSPAC2F7.13c.1; SPAC2F7.13c.1:pep; SPAC2F7.13c
GeneIDi2541841
KEGGispo:SPAC2F7.13c

Similar proteinsi

Entry informationi

Entry nameiSYWC_SCHPO
AccessioniPrimary (citable) accession number: Q09692
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: March 28, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health