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Q09690

- POM1_SCHPO

UniProt

Q09690 - POM1_SCHPO

Protein

Dual specificity protein kinase pom1

Gene

pom1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Involved in localization of polarized growth and cytokinesis. May interact with both the actin and microtubule cytoskeleton. Requires tea1 for localization to the cell ends but not to the cell center.2 Publications

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei728 – 7281ATPPROSITE-ProRule annotation
    Active sitei825 – 8251Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi705 – 7139ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein binding Source: IntAct
    3. protein serine/threonine/tyrosine kinase activity Source: UniProtKB-EC
    4. protein serine/threonine kinase activity Source: PomBase

    GO - Biological processi

    1. actin filament bundle distribution Source: PomBase
    2. activation of bipolar cell growth Source: PomBase
    3. cell morphogenesis involved in conjugation with cellular fusion Source: PomBase
    4. cellular protein localization Source: PomBase
    5. establishment of actomyosin contractile ring localization Source: PomBase
    6. negative regulation of establishment of actomyosin contractile ring localization Source: PomBase
    7. negative regulation of G2/M transition of mitotic cell cycle Source: PomBase
    8. protein localization to medial cortex Source: PomBase
    9. regulation of cell size Source: PomBase
    10. regulation of establishment or maintenance of cell polarity regulating cell shape Source: PomBase
    11. signal transduction Source: PomBase

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dual specificity protein kinase pom1 (EC:2.7.12.1)
    Gene namesi
    Name:pom1
    ORF Names:SPAC2F7.03c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC2F7.03c.

    Subcellular locationi

    Cell tip 1 Publication. Cell septum 1 Publication
    Note: Present at both poles of the cell throughout the cell cycle irrespective of whether the tips are growing or not. Localized to the septum at the time of cytokinesis.

    GO - Cellular componenti

    1. cell cortex of cell tip Source: PomBase
    2. cell division site Source: PomBase
    3. cell septum Source: UniProtKB-SubCell
    4. cell tip Source: PomBase
    5. non-growing cell tip Source: PomBase
    6. site of polarized growth Source: PomBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10871087Dual specificity protein kinase pom1PRO_0000086579Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei513 – 5131Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ09690.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    tea4O601325EBI-4319163,EBI-1099982

    Protein-protein interaction databases

    BioGridi278379. 193 interactions.
    DIPiDIP-59764N.
    IntActiQ09690. 3 interactions.
    MINTiMINT-4694097.
    STRINGi4896.SPAC2F7.03c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ09690.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini699 – 995297Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi62 – 654Poly-Ser

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    KOiK08825.
    OMAiWIRDISS.
    OrthoDBiEOG7WDNBB.
    PhylomeDBiQ09690.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q09690-1 [UniParc]FASTAAdd to Basket

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    MGYLQSQKAV SLGDENTDAL FKLHTSNRKS ANMFGIKSEL LNPSELSAVG     50
    SYSNDICPNR QSSSSTAADT SPSTNASNTN ISFPEQEHKD ELFMNVEPKG 100
    VGSSMDNHAI TIHHSTGNGL LRSSFDHDYR QKNSPRNSIH RLSNISIGNN 150
    PIDFESSQQN NPSSLNTSSH HRTSSISNSK SFGTSLSYYN RSSKPSDWNQ 200
    QNNGGHLSGV ISITQDVSSV PLQSSVFSSG NHAYHASMAP KRSGSWRHTN 250
    FHSTSHPRAA SIGNKSGIPP VPTIPPNIGH STDHQHPKAN ISGSLTKSSS 300
    ESKNLSTIQS PLKTSNSFFK ELSPHSQITL SNVKNNHSHV GSQTKSHSFA 350
    TPSVFDNNKP VSSDNHNNTT TSSQVHPDSR NPDPKAAPKA VSQKTNVDGH 400
    RNHEAKHGNT VQNESKSQKS SNKEGRSSRG GFFSRLSFSR SSSRMKKGSK 450
    AKHEDAPDVP AIPHAYIADS STKSSYRNGK KTPTRTKSRM QQFINWFKPS 500
    KERSSNGNSD SASPPPVPRL SITRSQVSRE PEKPEEIPSV PPLPSNFKDK 550
    GHVPQQRSVS YTPKRSSDTS ESLQPSLSFA SSNVLSEPFD RKVADLAMKA 600
    INSKRINKLL DDAKVMQSLL DRACIITPVR NTEVQLINTA PLTEYEQDEI 650
    NNYDNIYFTG LRNVDKRRSA DENTSSNFGF DDERGDYKVV LGDHIAYRYE 700
    VVDFLGKGSF GQVLRCIDYE TGKLVALKII RNKKRFHMQA LVETKILQKI 750
    REWDPLDEYC MVQYTDHFYF RDHLCVATEL LGKNLYELIK SNGFKGLPIV 800
    VIKSITRQLI QCLTLLNEKH VIHCDLKPEN ILLCHPFKSQ VKVIDFGSSC 850
    FEGECVYTYI QSRFYRSPEV ILGMGYGTPI DVWSLGCIIA EMYTGFPLFP 900
    GENEQEQLAC IMEIFGPPDH SLIDKCSRKK VFFDSSGKPR PFVSSKGVSR 950
    RPFSKSLHQV LQCKDVSFLS FISDCLKWDP DERMTPQQAA QHDFLTGKQD 1000
    VRRPNTAPAR QKFARPPNIE TAPIPRPLPN LPMEYNDHTL PSPKEPSNQA 1050
    SNLVRSSDKF PNLLTNLDYS IISDNGFLRK PVEKSRP 1087
    Length:1,087
    Mass (Da):121,146
    Last modified:November 1, 1995 - v1
    Checksum:i3277E7CA840F8BE2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAA90490.1.
    PIRiS58147.
    RefSeqiNP_592974.1. NM_001018374.2.

    Genome annotation databases

    EnsemblFungiiSPAC2F7.03c.1; SPAC2F7.03c.1:pep; SPAC2F7.03c.
    GeneIDi2541889.
    KEGGispo:SPAC2F7.03c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAA90490.1 .
    PIRi S58147.
    RefSeqi NP_592974.1. NM_001018374.2.

    3D structure databases

    ProteinModelPortali Q09690.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 278379. 193 interactions.
    DIPi DIP-59764N.
    IntActi Q09690. 3 interactions.
    MINTi MINT-4694097.
    STRINGi 4896.SPAC2F7.03c-1.

    Proteomic databases

    MaxQBi Q09690.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC2F7.03c.1 ; SPAC2F7.03c.1:pep ; SPAC2F7.03c .
    GeneIDi 2541889.
    KEGGi spo:SPAC2F7.03c.

    Organism-specific databases

    PomBasei SPAC2F7.03c.

    Phylogenomic databases

    eggNOGi COG0515.
    KOi K08825.
    OMAi WIRDISS.
    OrthoDBi EOG7WDNBB.
    PhylomeDBi Q09690.

    Miscellaneous databases

    NextBioi 20802976.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "Pom1p, a fission yeast protein kinase that provides positional information for both polarized growth and cytokinesis."
      Baehler J., Pringle J.R.
      Genes Dev. 12:1356-1370(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
      Strain: 972 / ATCC 24843.
    3. "Role of Tea1p, Tea3p and Pom1p in the determination of cell ends in Schizosaccharomyces pombe."
      Niccoli T., Arellano M., Nurse P.
      Yeast 20:1349-1358(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-513, IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiPOM1_SCHPO
    AccessioniPrimary (citable) accession number: Q09690
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 119 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3