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Protein

Dual specificity protein kinase pom1

Gene

pom1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in localization of polarized growth and cytokinesis. May interact with both the actin and microtubule cytoskeleton. Requires tea1 for localization to the cell ends but not to the cell center.2 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei728ATPPROSITE-ProRule annotation1
Active sitei825Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi705 – 713ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

  • actin filament bundle distribution Source: PomBase
  • activation of bipolar cell growth Source: PomBase
  • cell morphogenesis involved in conjugation with cellular fusion Source: PomBase
  • cellular protein localization Source: PomBase
  • establishment of mitotic actomyosin contractile ring localization Source: PomBase
  • negative regulation of G2/M transition of mitotic cell cycle Source: PomBase
  • peptidyl-serine phosphorylation Source: PomBase
  • protein localization to medial cortex Source: PomBase
  • protein trans-autophosphorylation Source: PomBase
  • regulation of cell size Source: PomBase
  • regulation of establishment or maintenance of cell polarity regulating cell shape Source: PomBase
  • regulation of protein localization to cell cortex Source: PomBase
  • signal transduction Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-6804756. Regulation of TP53 Activity through Phosphorylation.

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein kinase pom1 (EC:2.7.12.1)
Gene namesi
Name:pom1
ORF Names:SPAC2F7.03c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC2F7.03c.
PomBaseiSPAC2F7.03c. pom1.

Subcellular locationi

  • Cell tip 1 Publication
  • Cell septum 1 Publication

  • Note: Present at both poles of the cell throughout the cell cycle irrespective of whether the tips are growing or not. Localized to the septum at the time of cytokinesis.

GO - Cellular componenti

  • cell cortex of cell tip Source: PomBase
  • cell division site Source: PomBase
  • cell septum Source: UniProtKB-SubCell
  • cell tip Source: PomBase
  • non-growing cell tip Source: PomBase
  • site of polarized growth Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000865791 – 1087Dual specificity protein kinase pom1Add BLAST1087

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei513Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ09690.
PRIDEiQ09690.

PTM databases

iPTMnetiQ09690.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
tea4O601325EBI-4319163,EBI-1099982

Protein-protein interaction databases

BioGridi278379. 197 interactors.
DIPiDIP-59764N.
IntActiQ09690. 3 interactors.
MINTiMINT-4694097.

Structurei

3D structure databases

ProteinModelPortaliQ09690.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini699 – 995Protein kinasePROSITE-ProRule annotationAdd BLAST297

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi62 – 65Poly-Ser4

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

InParanoidiQ09690.
KOiK18669.
OMAiSSERCEK.
OrthoDBiEOG092C2DKP.
PhylomeDBiQ09690.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q09690-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGYLQSQKAV SLGDENTDAL FKLHTSNRKS ANMFGIKSEL LNPSELSAVG
60 70 80 90 100
SYSNDICPNR QSSSSTAADT SPSTNASNTN ISFPEQEHKD ELFMNVEPKG
110 120 130 140 150
VGSSMDNHAI TIHHSTGNGL LRSSFDHDYR QKNSPRNSIH RLSNISIGNN
160 170 180 190 200
PIDFESSQQN NPSSLNTSSH HRTSSISNSK SFGTSLSYYN RSSKPSDWNQ
210 220 230 240 250
QNNGGHLSGV ISITQDVSSV PLQSSVFSSG NHAYHASMAP KRSGSWRHTN
260 270 280 290 300
FHSTSHPRAA SIGNKSGIPP VPTIPPNIGH STDHQHPKAN ISGSLTKSSS
310 320 330 340 350
ESKNLSTIQS PLKTSNSFFK ELSPHSQITL SNVKNNHSHV GSQTKSHSFA
360 370 380 390 400
TPSVFDNNKP VSSDNHNNTT TSSQVHPDSR NPDPKAAPKA VSQKTNVDGH
410 420 430 440 450
RNHEAKHGNT VQNESKSQKS SNKEGRSSRG GFFSRLSFSR SSSRMKKGSK
460 470 480 490 500
AKHEDAPDVP AIPHAYIADS STKSSYRNGK KTPTRTKSRM QQFINWFKPS
510 520 530 540 550
KERSSNGNSD SASPPPVPRL SITRSQVSRE PEKPEEIPSV PPLPSNFKDK
560 570 580 590 600
GHVPQQRSVS YTPKRSSDTS ESLQPSLSFA SSNVLSEPFD RKVADLAMKA
610 620 630 640 650
INSKRINKLL DDAKVMQSLL DRACIITPVR NTEVQLINTA PLTEYEQDEI
660 670 680 690 700
NNYDNIYFTG LRNVDKRRSA DENTSSNFGF DDERGDYKVV LGDHIAYRYE
710 720 730 740 750
VVDFLGKGSF GQVLRCIDYE TGKLVALKII RNKKRFHMQA LVETKILQKI
760 770 780 790 800
REWDPLDEYC MVQYTDHFYF RDHLCVATEL LGKNLYELIK SNGFKGLPIV
810 820 830 840 850
VIKSITRQLI QCLTLLNEKH VIHCDLKPEN ILLCHPFKSQ VKVIDFGSSC
860 870 880 890 900
FEGECVYTYI QSRFYRSPEV ILGMGYGTPI DVWSLGCIIA EMYTGFPLFP
910 920 930 940 950
GENEQEQLAC IMEIFGPPDH SLIDKCSRKK VFFDSSGKPR PFVSSKGVSR
960 970 980 990 1000
RPFSKSLHQV LQCKDVSFLS FISDCLKWDP DERMTPQQAA QHDFLTGKQD
1010 1020 1030 1040 1050
VRRPNTAPAR QKFARPPNIE TAPIPRPLPN LPMEYNDHTL PSPKEPSNQA
1060 1070 1080
SNLVRSSDKF PNLLTNLDYS IISDNGFLRK PVEKSRP
Length:1,087
Mass (Da):121,146
Last modified:November 1, 1995 - v1
Checksum:i3277E7CA840F8BE2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA90490.1.
PIRiS58147.
RefSeqiNP_592974.1. NM_001018374.2.

Genome annotation databases

EnsemblFungiiSPAC2F7.03c.1; SPAC2F7.03c.1:pep; SPAC2F7.03c.
GeneIDi2541889.
KEGGispo:SPAC2F7.03c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA90490.1.
PIRiS58147.
RefSeqiNP_592974.1. NM_001018374.2.

3D structure databases

ProteinModelPortaliQ09690.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278379. 197 interactors.
DIPiDIP-59764N.
IntActiQ09690. 3 interactors.
MINTiMINT-4694097.

PTM databases

iPTMnetiQ09690.

Proteomic databases

MaxQBiQ09690.
PRIDEiQ09690.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC2F7.03c.1; SPAC2F7.03c.1:pep; SPAC2F7.03c.
GeneIDi2541889.
KEGGispo:SPAC2F7.03c.

Organism-specific databases

EuPathDBiFungiDB:SPAC2F7.03c.
PomBaseiSPAC2F7.03c. pom1.

Phylogenomic databases

InParanoidiQ09690.
KOiK18669.
OMAiSSERCEK.
OrthoDBiEOG092C2DKP.
PhylomeDBiQ09690.

Enzyme and pathway databases

ReactomeiR-SPO-6804756. Regulation of TP53 Activity through Phosphorylation.

Miscellaneous databases

PROiQ09690.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPOM1_SCHPO
AccessioniPrimary (citable) accession number: Q09690
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.