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Q09687

- AGM1_SCHPO

UniProt

Q09687 - AGM1_SCHPO

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Protein

Phosphoacetylglucosamine mutase 1

Gene

SPAC13C5.05c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, which is a biosynthetic precursor of chitin and also supplies the amino sugars for N-linked oligosaccharides of glycoproteins.By similarity

Catalytic activityi

N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate.By similarity

Cofactori

Mg2+By similarityNote: Binds 1 Mg(2+) ion per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei51 – 511Phosphoserine intermediateBy similarity
Metal bindingi51 – 511Magnesium; via phosphate groupBy similarity
Metal bindingi267 – 2671MagnesiumBy similarity
Metal bindingi269 – 2691MagnesiumBy similarity
Metal bindingi271 – 2711MagnesiumBy similarity
Binding sitei495 – 4951SubstrateBy similarity

GO - Molecular functioni

  1. magnesium ion binding Source: InterPro
  2. phosphoacetylglucosamine mutase activity Source: PomBase

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. N-acetylglucosamine biosynthetic process Source: PomBase
  3. UDP-N-acetylglucosamine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism, Cell wall biogenesis/degradation

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00113; UER00530.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoacetylglucosamine mutase 1By similarity (EC:5.4.2.3By similarity)
Short name:
PAGM
Alternative name(s):
Acetylglucosamine phosphomutaseBy similarity
N-acetylglucosamine-phosphate mutaseBy similarity
Gene namesi
ORF Names:SPAC13C5.05cImported
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC13C5.05c.

Subcellular locationi

Cytoplasm 1 Publication. Nucleus 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: PomBase
  2. cytosol Source: PomBase
  3. nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 518518Phosphoacetylglucosamine mutase 1PRO_0000148017Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei49 – 491Phosphothreonine1 Publication
Modified residuei51 – 511Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ09687.

Interactioni

Protein-protein interaction databases

MINTiMINT-4694067.
STRINGi4896.SPAC13C5.05c-1.

Structurei

3D structure databases

ProteinModelPortaliQ09687.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni360 – 3623Substrate bindingBy similarity
Regioni486 – 4905Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the phosphohexose mutase family.Curated

Phylogenomic databases

eggNOGiCOG1109.
HOGENOMiHOG000210027.
InParanoidiQ09687.
KOiK01836.
OMAiDWETHAT.
OrthoDBiEOG7V1G0D.
PhylomeDBiQ09687.

Family and domain databases

Gene3Di3.30.310.50. 1 hit.
3.40.120.10. 3 hits.
InterProiIPR005844. A-D-PHexomutase_a/b/a-I.
IPR016055. A-D-PHexomutase_a/b/a-I/II/III.
IPR005845. A-D-PHexomutase_a/b/a-II.
IPR005846. A-D-PHexomutase_a/b/a-III.
IPR005843. A-D-PHexomutase_C.
IPR016066. A-D-PHexomutase_CS.
IPR016657. PAGM.
[Graphical view]
PfamiPF02878. PGM_PMM_I. 2 hits.
PF02879. PGM_PMM_II. 1 hit.
PF02880. PGM_PMM_III. 1 hit.
PF00408. PGM_PMM_IV. 1 hit.
[Graphical view]
PIRSFiPIRSF016408. PAGM. 1 hit.
SUPFAMiSSF53738. SSF53738. 4 hits.
SSF55957. SSF55957. 1 hit.
PROSITEiPS00710. PGM_PMM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q09687-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTKNKKYSYG TAGFRTKASD LEAAVYSSGV AAALRSMELK GKTIGVMITA
60 70 80 90 100
SHNPVEDNGV KIIDADGGML AMEWEDKCTQ LANAPSKAEF DFLIKQFLTP
110 120 130 140 150
TTCQPKVIIG YDTRPSSPRL AELLKVCLDE MSASYIDYGY ITTPQLHWLV
160 170 180 190 200
RLINKSTAAS FLEEGPPITE YYDTLTSAFS KIDPSMQDSP TVSRVVVDCA
210 220 230 240 250
NGVGSQPLKT VAGLVKDSLS IELVNTDVRA SELLNNGCGA DFVKTKQSPP
260 270 280 290 300
LALEGKIKPN QLYASIDGDA DRLIFYYINQ NRKFHLLDGD KISTALVGYL
310 320 330 340 350
NILVKKSGMP FSLGVVQTAY ANGASTEYLQ DLGITTVFTP TGVKHLHKAA
360 370 380 390 400
KEFDIGVYFE ANGHGTVLFS DKALANLAHP FFTPSPVQAA AIEQLQSYSV
410 420 430 440 450
LINQAIGDAI SDLLATISVL NALHWDASAW SNTYKDLPNK LAKVKVSDRT
460 470 480 490 500
IYKSTDAERR LVSPDGLQEK IDALVAKYEK GRSFVRASGT EDVVRVYAEA
510
STKQAADELC EKVCQLVL
Length:518
Mass (Da):56,347
Last modified:November 1, 1995 - v1
Checksum:iDA8ACB0008C29594
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA90456.1.
PIRiS59642.
RefSeqiNP_592933.1. NM_001018334.2.

Genome annotation databases

EnsemblFungiiSPAC13C5.05c.1; SPAC13C5.05c.1:pep; SPAC13C5.05c.
GeneIDi2542320.
KEGGispo:SPAC13C5.05c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA90456.1 .
PIRi S59642.
RefSeqi NP_592933.1. NM_001018334.2.

3D structure databases

ProteinModelPortali Q09687.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4694067.
STRINGi 4896.SPAC13C5.05c-1.

Proteomic databases

MaxQBi Q09687.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC13C5.05c.1 ; SPAC13C5.05c.1:pep ; SPAC13C5.05c .
GeneIDi 2542320.
KEGGi spo:SPAC13C5.05c.

Organism-specific databases

PomBasei SPAC13C5.05c.

Phylogenomic databases

eggNOGi COG1109.
HOGENOMi HOG000210027.
InParanoidi Q09687.
KOi K01836.
OMAi DWETHAT.
OrthoDBi EOG7V1G0D.
PhylomeDBi Q09687.

Enzyme and pathway databases

UniPathwayi UPA00113 ; UER00530 .

Miscellaneous databases

NextBioi 20803381.

Family and domain databases

Gene3Di 3.30.310.50. 1 hit.
3.40.120.10. 3 hits.
InterProi IPR005844. A-D-PHexomutase_a/b/a-I.
IPR016055. A-D-PHexomutase_a/b/a-I/II/III.
IPR005845. A-D-PHexomutase_a/b/a-II.
IPR005846. A-D-PHexomutase_a/b/a-III.
IPR005843. A-D-PHexomutase_C.
IPR016066. A-D-PHexomutase_CS.
IPR016657. PAGM.
[Graphical view ]
Pfami PF02878. PGM_PMM_I. 2 hits.
PF02879. PGM_PMM_II. 1 hit.
PF02880. PGM_PMM_III. 1 hit.
PF00408. PGM_PMM_IV. 1 hit.
[Graphical view ]
PIRSFi PIRSF016408. PAGM. 1 hit.
SUPFAMi SSF53738. SSF53738. 4 hits.
SSF55957. SSF55957. 1 hit.
PROSITEi PS00710. PGM_PMM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-49 AND SER-51, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiAGM1_SCHPO
AccessioniPrimary (citable) accession number: Q09687
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 26, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3