Q09673 (PANC_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pantoate--beta-alanine ligase
EC=6.3.2.1

Alternative name(s):
Pantoate-activating enzyme
Pantothenate synthetase

Gene names

Name:	pan6
ORF Names:	SPAC5H10.08c

Organism

Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

Taxonomic identifier

284812 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length	283 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.
Pathway	Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.
Sequence similarities	Belongs to the pantothenate synthetase family.

Ontologies

Keywords
Biological process	Pantothenate biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	pantothenate biosynthetic process Inferred from genetic interaction. Source: GeneDB_Spombe
Cellular component	cytosol Inferred from direct assay. Source: GeneDB_Spombe nucleus Inferred from sequence or structural similarity. Source: GeneDB_Spombe
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW pantoate-beta-alanine ligase activity Inferred from genetic interaction. Source: GeneDB_Spombe
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 283	283	Pantoate--beta-alanine ligase		PRO_0000128297

Sequences

	Sequence		Length	Mass (Da)
	Q09673 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 97EE26E911FF4AD7	FASTA	283	31,877
	10 20 30 40 50 60 MQVLKEKLLI HQQVDNWRKD GNRIAFVPTM GNLHEGHFSL VREAKRHAEK VVVSIFVNPM 70 80 90 100 110 120 QFNNPQDLLL YPRTMDQDCS QLQNLGVDLV YAPTVEELYP EGSQDITFVD VPKLSTMLEG 130 140 150 160 170 180 ASRPGHFRGV TTVVSKLFHI VNPDVACFGE KDFQQVAIIK KMVRDLNFFI EIIQVPIVRA 190 200 210 220 230 240 DDGLALSSRN GYLTSEERKI APNLYKILKK LAQELSNGNG DLEKLIAETN TELSRCRFIP 250 260 270 280 DQLEICDSTT LEPFTAGTKN VVILAAAWLG KARLIDNIQT TIN

References

[1]

"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 972 / ATCC 24843.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CU329670 Genomic DNA. Translation: CAA89958.1.
PIR	S55486.
RefSeq	NP_592821.1. NM_001018221.1.
3D structure databases
ProteinModelPortal	Q09673.
SMR	Q09673. Positions 1-281.
ModBase	Search...
Protein-protein interaction databases
STRING	Q09673.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	SPAC5H10.08c.1; SPAC5H10.08c.1:pep; SPAC5H10.08c.
GeneID	2541618.
GenomeReviews	Gene locus pan6 in contig CU329670_GR.
KEGG	spo:SPAC5H10.08c.
NMPDR	fig|4896.1.peg.2791.
Organism-specific databases
GeneDB_Spombe	SPAC5H10.08c.
Phylogenomic databases
eggNOG	fuNOG04348.
GeneTree	EFGT00050000005239.
HOGENOM	HBG428839.
OMA	EMDGLAM.
OrthoDB	EOG43JGDR.
Enzyme and pathway databases
BioCyc	SPOM-XXX-01:SPOM-XXX-01-000566-MONOMER.
Gene expression databases
ArrayExpress	Q09673.
Family and domain databases
InterPro	IPR004821. Cyt_trans-rel. IPR003721. Pantoate_ligase. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
Gene3D	G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
KO	K01918.
PANTHER	PTHR21299:SF1. Pantoate_ligase. 1 hit.
Pfam	PF02569. Pantoate_ligase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00125. Cyt_tran_rel. 1 hit. TIGR00018. PanC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PANC_SCHPO

Accession

Primary (citable) accession number: Q09673

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	December 14, 2011
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program