Q09670 (OYEA_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative NADPH dehydrogenase C5H10.04
EC=1.6.99.1

Alternative name(s):
Old yellow enzyme homolog 1

Gene names

ORF Names:

SPAC5H10.04

Organism

Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

Taxonomic identifier

284812 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length	382 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	NADPH + acceptor = NADP+ + reduced acceptor.
Cofactor	FMN.
Subunit structure	Homodimer or heterodimer By similarity.
Sequence similarities	Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.

Ontologies

Keywords
Ligand	FMN Flavoprotein NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytosol Inferred from direct assay. Source: GeneDB_Spombe nucleus Inferred from direct assay. Source: GeneDB_Spombe
Molecular function	FMN binding Inferred from electronic annotation. Source: InterPro NADPH dehydrogenase activity Inferred from electronic annotation. Source: EC pentaerythritol trinitrate reductase activity Inferred from electronic annotation. Source: EC trichloro-p-hydroquinone reductive dehalogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 382	382	Putative NADPH dehydrogenase C5H10.04		PRO_0000194477
Sites
	Binding site	28	1	FMN By similarity
	Binding site	189	1	FMN By similarity
	Binding site	189	1	Substrate By similarity
	Binding site	192	1	Substrate By similarity
	Binding site	242	1	FMN By similarity
	Binding site	334	1	FMN By similarity
	Binding site	361	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q09670 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 3F7939599CA167D1	FASTA	382	43,813
	10 20 30 40 50 60 MNDRGELFKP IKVGNMLLQH RIVHAPMTRL RATDYGKITG LMVEYYSQRS MIPGTLLIAD 70 80 90 100 110 120 ATFVGEKSGG FPNNPRCFTK EQAESWIPLV EAVHKNKSFL FIQFWPLPGD LKDEYRNDLE 130 140 150 160 170 180 KMQKITYSDC PQDPGGLPAG IHSFDAVQGV EVYKKKYMSK RDIQEHIQDF VNAADLAVNI 190 200 210 220 230 240 AKADGVEIHQ VNGFLLDRFV LGGFGDQCDP EYRGSIENRC RFPLEVLEAV TRKIGQERVG 250 260 270 280 290 300 YRISPFSGWM QKIDFMEVNI YLMSEIAKRF PKLAYIHAIE PRKYWSGHKL VSSEQNTSFL 310 320 330 340 350 360 QKYWKGPFIT AGGYDPETAV QAANERGVLV AFGRNFIANP DLVFRIKHHI PLNKWDRSSF 370 380 YLPKTEKGYT DYPFSKEFLQ SK

References

[1]

"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 972 / ATCC 24843.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CU329670 Genomic DNA. Translation: CAA89954.1.
PIR	S55482.
RefSeq	NP_592817.1. NM_001018217.1.
3D structure databases
ProteinModelPortal	Q09670.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	SPAC5H10.04.1; SPAC5H10.04.1:pep; SPAC5H10.04.
GeneID	2541543.
KEGG	spo:SPAC5H10.04.
NMPDR	fig|4896.1.peg.2787.
Organism-specific databases
GeneDB_Spombe	SPAC5H10.04.
Phylogenomic databases
eggNOG	fuNOG09074.
GeneTree	EFGT00050000000722.
HOGENOM	HBG583461.
OMA	NIYLMSE.
OrthoDB	EOG4HMNK3.
Enzyme and pathway databases
BioCyc	SPOM-XXX-01:SPOM-XXX-01-000562-MONOMER.
Gene expression databases
ArrayExpress	Q09670.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR001155. OxRdtase_FMN_N. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K00354.
Pfam	PF00724. Oxidored_FMN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OYEA_SCHPO

Accession

Primary (citable) accession number: Q09670

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	December 14, 2011
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program