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Protein

Alcohol dehydrogenase 4

Gene

adh4

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in ethanol oxidation in mitochondria.1 Publication

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.
A secondary alcohol + NAD+ = a ketone + NADH.

Cofactori

Zn2+By similarity

GO - Molecular functioni

  • alcohol dehydrogenase (NAD) activity Source: PomBase
  • alcohol dehydrogenase activity, zinc-dependent Source: PomBase
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • ethanol biosynthetic process involved in glucose fermentation to ethanol Source: PomBase

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

BRENDAi1.1.1.1 5613

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 4 (EC:1.1.1.1)
Alternative name(s):
Alcohol dehydrogenase IV
Gene namesi
Name:adh4
ORF Names:SPAC5H10.06c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC5H10.06c
PomBaseiSPAC5H10.06c adh4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 29MitochondrionSequence analysisAdd BLAST29
ChainiPRO_000008781830 – 422Alcohol dehydrogenase 4Add BLAST393

Proteomic databases

MaxQBiQ09669
PaxDbiQ09669
PRIDEiQ09669

Expressioni

Inductioni

Induced in response to zinc deficiency.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi279167, 22 interactors
STRINGi4896.SPAC5H10.06c.1

Structurei

3D structure databases

ProteinModelPortaliQ09669
SMRiQ09669
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000243333
InParanoidiQ09669
KOiK13954
OMAiMNGFDKG
OrthoDBiEOG092C28AS
PhylomeDBiQ09669

Family and domain databases

InterProiView protein in InterPro
IPR001670 ADH_Fe/gldA
IPR018211 ADH_Fe_CS
PfamiView protein in Pfam
PF00465 Fe-ADH, 1 hit
PROSITEiView protein in PROSITE
PS00913 ADH_IRON_1, 1 hit
PS00060 ADH_IRON_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q09669-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSILRSPFRL IRSPARFFPS LFHSSCNQSF TNGLKHQSTS SKAMPVSAFY
60 70 80 90 100
IPSFNLFGKG CLAEAAKQIK MSGFKNTLIV TDPGIIKVGL YDKVKALLEE
110 120 130 140 150
QSITVHLYDG VQPNPTVGNV NQGLEIVKKE NCDSMVSIGG GSAHDCAKGI
160 170 180 190 200
ALLATNGGKI ADYEGVDKSS KPQLPLIAIN TTAGTASEMT RFAIITEETR
210 220 230 240 250
HIKMAIIDKH TMPILSVNDP ETMYGLPPSL TAATGMDALT HAVEAYVSTA
260 270 280 290 300
ANPITDACAV KCIELVNKYL KRAVDNGKDE EARDNMAYAE FLGGMAFNNA
310 320 330 340 350
SLGYVHAMAH QLGGFYGIPH GVCNAVLLAH VQKFNSRDPR ANARLGDIAF
360 370 380 390 400
HLGCEEHTAE AALDRISQLV LEVKIRPHLV DLGVKEKDFD VLVDHAMKDA
410 420
CGATNPIQPT HDEVKAIFKS AM
Length:422
Mass (Da):45,527
Last modified:November 1, 1995 - v1
Checksum:iC70B56632DBC658E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAA89956.1
PIRiS55484
RefSeqiNP_592819.1, NM_001018219.2

Genome annotation databases

GeneIDi2542714
KEGGispo:SPAC5H10.06c

Similar proteinsi

Entry informationi

Entry nameiADH4_SCHPO
AccessioniPrimary (citable) accession number: Q09669
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: March 28, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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