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Q09669 (ADH4_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alcohol dehydrogenase 4
EC=1.1.1.1
Alternative name(s):
Alcohol dehydrogenase IV
Gene names
Name:adh4
ORF Names:SPAC5H10.06c
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length422 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in ethanol oxidation in mitochondria. Ref.4

Catalytic activity

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactor

Zinc By similarity.

Subcellular location

Mitochondrion matrix Ref.3 Ref.4.

Induction

Induced in response to zinc deficiency. Ref.5

Sequence similarities

Belongs to the iron-containing alcohol dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 2929Mitochondrion Potential
Chain30 – 422393Alcohol dehydrogenase 4
PRO_0000087818

Sequences

Sequence LengthMass (Da)Tools
Q09669 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: C70B56632DBC658E

FASTA42245,527
        10         20         30         40         50         60 
MSILRSPFRL IRSPARFFPS LFHSSCNQSF TNGLKHQSTS SKAMPVSAFY IPSFNLFGKG 

        70         80         90        100        110        120 
CLAEAAKQIK MSGFKNTLIV TDPGIIKVGL YDKVKALLEE QSITVHLYDG VQPNPTVGNV 

       130        140        150        160        170        180 
NQGLEIVKKE NCDSMVSIGG GSAHDCAKGI ALLATNGGKI ADYEGVDKSS KPQLPLIAIN 

       190        200        210        220        230        240 
TTAGTASEMT RFAIITEETR HIKMAIIDKH TMPILSVNDP ETMYGLPPSL TAATGMDALT 

       250        260        270        280        290        300 
HAVEAYVSTA ANPITDACAV KCIELVNKYL KRAVDNGKDE EARDNMAYAE FLGGMAFNNA 

       310        320        330        340        350        360 
SLGYVHAMAH QLGGFYGIPH GVCNAVLLAH VQKFNSRDPR ANARLGDIAF HLGCEEHTAE 

       370        380        390        400        410        420 
AALDRISQLV LEVKIRPHLV DLGVKEKDFD VLVDHAMKDA CGATNPIQPT HDEVKAIFKS 


AM

« Hide

References

« Hide 'large scale' references
[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed: 11859360] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[2]"A distinct type of alcohol dehydrogenase, adh4+, complements ethanol fermentation in an adh1-deficient strain of Schizosaccharomyces pombe."
Sakurai M., Tohda H., Kumagai H., Giga-Hama Y.
FEMS Yeast Res. 4:649-654(2004) [PubMed: 15040954] [Abstract]
Cited for: IDENTIFICATION.
[3]"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
Nat. Biotechnol. 24:841-847(2006) [PubMed: 16823372] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[4]"Identification of a mitochondrial alcohol dehydrogenase in Schizosaccharomyces pombe: new insights into energy metabolism."
Crichton P.G., Affourtit C., Moore A.L.
Biochem. J. 401:459-464(2007) [PubMed: 16999687] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[5]"Response of Schizosaccharomyces pombe to zinc deficiency."
Dainty S.J., Kennedy C.A., Watt S., Baehler J., Whitehall S.K.
Eukaryot. Cell 7:454-464(2008) [PubMed: 18203864] [Abstract]
Cited for: INDUCTION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CU329670 Genomic DNA. Translation: CAA89956.1.
PIRS55484.
RefSeqNP_592819.1. NM_001018219.1.

3D structure databases

ProteinModelPortalQ09669.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ09669.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPAC5H10.06c.1; SPAC5H10.06c.1:pep; SPAC5H10.06c.
GeneID2542714.
GenomeReviewsGene locus adh4 in contig CU329670_GR.
KEGGspo:SPAC5H10.06c.
NMPDRfig|4896.1.peg.2789.

Organism-specific databases

GeneDB_SpombeSPAC5H10.06c.

Phylogenomic databases

eggNOGfuNOG07707.
GeneTreeEFGT00050000001042.
HOGENOMHBG742415.
OMATARKVKM.
OrthoDBEOG4SXRN9.

Enzyme and pathway databases

BioCycSPOM-XXX-01:SPOM-XXX-01-000564-MONOMER.

Gene expression databases

ArrayExpressQ09669.

Family and domain databases

InterProIPR001670. ADH_Fe.
IPR018211. ADH_Fe_CS.
[Graphical view]
KOK13954.
PfamPF00465. Fe-ADH. 1 hit.
[Graphical view]
PROSITEPS00913. ADH_IRON_1. 1 hit.
PS00060. ADH_IRON_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameADH4_SCHPO
AccessionPrimary (citable) accession number: Q09669
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: December 14, 2011
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents