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Protein

Alcohol dehydrogenase 4

Gene

adh4

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in ethanol oxidation in mitochondria.1 Publication

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactori

Zn2+By similarity

GO - Molecular functioni

  • alcohol dehydrogenase (NAD) activity Source: PomBase
  • alcohol dehydrogenase activity, zinc-dependent Source: PomBase
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • ethanol biosynthetic process involved in glucose fermentation to ethanol Source: PomBase

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

BRENDAi1.1.1.1. 5613.

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 4 (EC:1.1.1.1)
Alternative name(s):
Alcohol dehydrogenase IV
Gene namesi
Name:adh4
ORF Names:SPAC5H10.06c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC5H10.06c.
PomBaseiSPAC5H10.06c. adh4.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial matrix Source: UniProtKB-SubCell
  • mitochondrion Source: PomBase

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 29MitochondrionSequence analysisAdd BLAST29
ChainiPRO_000008781830 – 422Alcohol dehydrogenase 4Add BLAST393

Proteomic databases

MaxQBiQ09669.
PRIDEiQ09669.

Expressioni

Inductioni

Induced in response to zinc deficiency.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi279167. 21 interactors.
MINTiMINT-4693918.
STRINGi4896.SPAC5H10.06c.1.

Structurei

3D structure databases

ProteinModelPortaliQ09669.
SMRiQ09669.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000243333.
InParanoidiQ09669.
KOiK13954.
OMAiPRVWAFN.
OrthoDBiEOG092C28AS.
PhylomeDBiQ09669.

Family and domain databases

InterProiView protein in InterPro
IPR001670. ADH_Fe.
IPR018211. ADH_Fe_CS.
PfamiView protein in Pfam
PF00465. Fe-ADH. 1 hit.
PROSITEiView protein in PROSITE
PS00913. ADH_IRON_1. 1 hit.
PS00060. ADH_IRON_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q09669-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSILRSPFRL IRSPARFFPS LFHSSCNQSF TNGLKHQSTS SKAMPVSAFY
60 70 80 90 100
IPSFNLFGKG CLAEAAKQIK MSGFKNTLIV TDPGIIKVGL YDKVKALLEE
110 120 130 140 150
QSITVHLYDG VQPNPTVGNV NQGLEIVKKE NCDSMVSIGG GSAHDCAKGI
160 170 180 190 200
ALLATNGGKI ADYEGVDKSS KPQLPLIAIN TTAGTASEMT RFAIITEETR
210 220 230 240 250
HIKMAIIDKH TMPILSVNDP ETMYGLPPSL TAATGMDALT HAVEAYVSTA
260 270 280 290 300
ANPITDACAV KCIELVNKYL KRAVDNGKDE EARDNMAYAE FLGGMAFNNA
310 320 330 340 350
SLGYVHAMAH QLGGFYGIPH GVCNAVLLAH VQKFNSRDPR ANARLGDIAF
360 370 380 390 400
HLGCEEHTAE AALDRISQLV LEVKIRPHLV DLGVKEKDFD VLVDHAMKDA
410 420
CGATNPIQPT HDEVKAIFKS AM
Length:422
Mass (Da):45,527
Last modified:November 1, 1995 - v1
Checksum:iC70B56632DBC658E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA89956.1.
PIRiS55484.
RefSeqiNP_592819.1. NM_001018219.2.

Genome annotation databases

GeneIDi2542714.
KEGGispo:SPAC5H10.06c.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiADH4_SCHPO
AccessioniPrimary (citable) accession number: Q09669
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 5, 2017
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families