Q09666 (AHNK_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Neuroblast differentiation-associated protein AHNAK

Alternative name(s):
Desmoyokin

Gene names

Name:	AHNAK
Synonyms:	PM227

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	5890 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be required for neuronal cell differentiation.
Subunit structure	Interacts with DYSF; the interaction is direct and Ca2+-independent. Ref.8
Subcellular location	Nucleus.
Sequence similarities	Contains 1 PDZ (DHR) domain.
Sequence caution	The sequence AAA69899.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	nervous system development Non-traceable author statement. Source: UniProtKB
Cellular_component	nucleus Non-traceable author statement Ref.4. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q09666-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q09666-2)

The sequence of this isoform differs from the canonical sequence as follows:
     115-149: SGDDEEYQRIYTTKIKPRLKSEDGVEGDLGETQSR → NTPQPSALECKDQNKQKEASSQAGAVSVSTPNAGL
     150-5890: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 5890	5890	Neuroblast differentiation-associated protein AHNAK		PRO_0000064504
Regions
	Domain	9 – 90	82	PDZ
	Motif	4971 – 4979	9	Nuclear localization signal Potential
	Motif	5019 – 5027	9	Nuclear localization signal Potential
	Motif	5034 – 5039	6	Nuclear localization signal Potential
	Motif	5706 – 5716	11	Nuclear localization signal Potential
	Motif	5772 – 5779	8	Nuclear localization signal Potential
	Compositional bias	5458 – 5654	197	Gly-rich
Amino acid modifications
	Modified residue	41	1	Phosphoserine Ref.6 Ref.7 Ref.11 Ref.12 Ref.17
	Modified residue	93	1	Phosphoserine Ref.6 Ref.12 Ref.17 Ref.19
	Modified residue	101	1	Phosphothreonine Ref.17
	Modified residue	135	1	Phosphoserine Ref.17 Ref.19
	Modified residue	177	1	Phosphoserine Ref.17 Ref.19
	Modified residue	210	1	Phosphoserine Ref.17
	Modified residue	212	1	Phosphoserine Ref.17
	Modified residue	216	1	Phosphoserine Ref.17
	Modified residue	490	1	Phosphothreonine Ref.6 Ref.9 Ref.17 Ref.19
	Modified residue	511	1	Phosphoserine Ref.6 Ref.7 Ref.9 Ref.11 Ref.12 Ref.15 Ref.16 Ref.17 Ref.19
	Modified residue	559	1	Phosphoserine Ref.17 Ref.19
	Modified residue	570	1	Phosphoserine Ref.12 Ref.16 Ref.17
	Modified residue	793	1	Phosphoserine Ref.12 Ref.17
	Modified residue	1068	1	Phosphoserine Ref.17
	Modified residue	1192	1	Phosphothreonine Ref.17
	Modified residue	1286	1	Phosphoserine Ref.17
	Modified residue	1986	1	Phosphothreonine Ref.17
	Modified residue	2181	1	Phosphothreonine Ref.17
	Modified residue	2309	1	Phosphothreonine Ref.17
	Modified residue	2397	1	Phosphoserine Ref.16 Ref.17
	Modified residue	2670	1	Phosphoserine Ref.17
	Modified residue	2798	1	Phosphoserine Ref.17
	Modified residue	2832	1	Phosphothreonine Ref.17
	Modified residue	2845	1	Phosphothreonine Ref.17
	Modified residue	3054	1	Phosphoserine Ref.17
	Modified residue	3409	1	Phosphoserine Ref.17
	Modified residue	3412	1	Phosphoserine Ref.17
	Modified residue	3426	1	Phosphoserine Ref.17
	Modified residue	3716	1	Phosphothreonine Ref.17
	Modified residue	3836	1	Phosphoserine Ref.17
	Modified residue	4092	1	Phosphoserine Ref.17
	Modified residue	4100	1	Phosphothreonine Ref.6 Ref.17
	Modified residue	4220	1	Phosphoserine Ref.17
	Modified residue	4430	1	Phosphothreonine Ref.17
	Modified residue	4516	1	Phosphoserine Ref.17
	Modified residue	4684	1	Phosphoserine Ref.17
	Modified residue	4766	1	Phosphothreonine Ref.6
	Modified residue	4812	1	Phosphoserine Ref.17
	Modified residue	4903	1	Phosphoserine Ref.12
	Modified residue	4960	1	Phosphoserine Ref.12 Ref.17
	Modified residue	4986	1	Phosphoserine Ref.9 Ref.17
	Modified residue	4993	1	Phosphoserine Ref.12
	Modified residue	5009	1	Phosphothreonine Ref.12
	Modified residue	5077	1	Phosphoserine Ref.6 Ref.17
	Modified residue	5099	1	Phosphoserine Ref.9 Ref.12 Ref.17
	Modified residue	5110	1	Phosphoserine Ref.6 Ref.9 Ref.17
	Modified residue	5125	1	Phosphoserine Ref.17
	Modified residue	5332	1	Phosphoserine Ref.17
	Modified residue	5386	1	Phosphoserine Ref.17
	Modified residue	5400	1	Phosphoserine Ref.17
	Modified residue	5415	1	Phosphothreonine Ref.12
	Modified residue	5448	1	Phosphoserine Ref.6 Ref.16 Ref.17
	Modified residue	5552	1	Phosphoserine Ref.6 Ref.9 Ref.17
	Modified residue	5620	1	Phosphoserine Ref.17
	Modified residue	5731	1	Phosphoserine Ref.7 Ref.12 Ref.16 Ref.17 Ref.19
	Modified residue	5739	1	Phosphoserine Ref.17
	Modified residue	5749	1	Phosphoserine Ref.10 Ref.12 Ref.14 Ref.16
	Modified residue	5752	1	Phosphoserine Ref.6 Ref.10 Ref.12 Ref.15 Ref.16 Ref.17
	Modified residue	5763	1	Phosphoserine Ref.7 Ref.12 Ref.16 Ref.17
	Modified residue	5780	1	Phosphoserine Ref.12 Ref.17
	Modified residue	5782	1	Phosphoserine Ref.12 Ref.17
	Modified residue	5790	1	Phosphoserine Ref.17
	Modified residue	5793	1	Phosphoserine Ref.12
	Modified residue	5794	1	Phosphothreonine Ref.12
	Modified residue	5824	1	Phosphothreonine Ref.17
	Modified residue	5830	1	Phosphoserine Ref.12 Ref.17
	Modified residue	5841	1	Phosphoserine Ref.12 Ref.17 Ref.19
	Modified residue	5857	1	Phosphoserine Ref.17
Natural variations
	Alternative sequence	115 – 149	35	SGDDE…ETQSR → NTPQPSALECKDQNKQKEAS SQAGAVSVSTPNAGL in isoform 2.		VSP_044233
	Alternative sequence	150 – 5890	5741	Missing in isoform 2.		VSP_044234
	Natural variant	962	1	G → V. Corresponds to variant rs664761 [ dbSNP | Ensembl ].		VAR_039058
	Natural variant	2114	1	A → T. Corresponds to variant rs1298288 [ dbSNP | Ensembl ].		VAR_039059
	Natural variant	2247	1	K → T. Corresponds to variant rs61524789 [ dbSNP | Ensembl ].		VAR_061551
	Natural variant	2439	1	P → L. Corresponds to variant rs11824660 [ dbSNP | Ensembl ].		VAR_039060
	Natural variant	3003	1	Q → K. Corresponds to variant rs566144 [ dbSNP | Ensembl ].		VAR_039061
	Natural variant	3190	1	V → I. Corresponds to variant rs11231129 [ dbSNP | Ensembl ].		VAR_039062
	Natural variant	3724	1	S → P. Corresponds to variant rs11231128 [ dbSNP | Ensembl ].		VAR_039063
	Natural variant	4304	1	D → G. Corresponds to variant rs11828907 [ dbSNP | Ensembl ].		VAR_061552
	Natural variant	4561	1	G → D. Corresponds to variant rs12795508 [ dbSNP | Ensembl ].		VAR_039064
	Natural variant	4611	1	M → V. Corresponds to variant rs12801302 [ dbSNP | Ensembl ].		VAR_039065
	Natural variant	4613	1	I → V. Corresponds to variant rs12801153 [ dbSNP | Ensembl ].		VAR_039066
	Natural variant	4631	1	D → G. Corresponds to variant rs12801123 [ dbSNP | Ensembl ].		VAR_039067
	Natural variant	5415	1	T → A. Corresponds to variant rs11231126 [ dbSNP | Ensembl ].		VAR_039068
Experimental info
	Sequence conflict	288	1	A → P in AAA69899. Ref.4
	Sequence conflict	302	1	G → A in AAA69899. Ref.4
	Sequence conflict	1156	1	V → D in AAA69899. Ref.4
	Sequence conflict	1737	1	P → R in AAA69899. Ref.4
	Sequence conflict	1821	1	F → L in AAA69899. Ref.4
	Sequence conflict	4614	1	S → T in AAA69898. Ref.4
	Sequence conflict	4627	1	V → A in AAA69898. Ref.4
	Sequence conflict	4630 – 4631	2	RD → KG in AAA69898. Ref.4
	Sequence conflict	4637 – 4638	2	DV → NT in AAA69898. Ref.4
	Sequence conflict	4644	1	Q → H in AAA69898. Ref.4
	Sequence conflict	4830	1	A → P in AAA69898. Ref.4
	Sequence conflict	4834	1	G → V in AAA69898. Ref.4
	Sequence conflict	4837	1	F → V in AAA69898. Ref.4
	Sequence conflict	4984	1	A → P in AAA69898. Ref.4
	Sequence conflict	5445	1	P → S in AAA69898. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 13, 2007. Version 2. Checksum: A82FC9645FDCA8DC	FASTA	5,890	629,101
	10 20 30 40 50 60 MEKEETTREL LLPNWQGSGS HGLTIAQRDD GVFVQEVTQN SPAARTGVVK EGDQIVGATI 70 80 90 100 110 120 YFDNLQSGEV TQLLNTMGHH TVGLKLHRKG DRSPEPGQTW TREVFSSCSS EVVLSGDDEE 130 140 150 160 170 180 YQRIYTTKIK PRLKSEDGVE GDLGETQSRT ITVTRRVTAY TVDVTGREGA KDIDISSPEF 190 200 210 220 230 240 KIKIPRHELT EISNVDVETQ SGKTVIRLPS GSGAASPTGS AVDIRAGAIS ASGPELQGAG 250 260 270 280 290 300 HSKLQVTMPG IKVGGSGVNV NAKGLDLGGR GGVQVPAVDI SSSLGGRAVE VQGPSLESGD 310 320 330 340 350 360 HGKIKFPTMK VPKFGVSTGR EGQTPKAGLR VSAPEVSVGH KGGKPGLTIQ APQLEVSVPS 370 380 390 400 410 420 ANIEGLEGKL KGPQITGPSL EGDLGLKGAK PQGHIGVDAS APQIGGSITG PSVEVQAPDI 430 440 450 460 470 480 DVQGPGSKLN VPKMKVPKFS VSGAKGEETG IDVTLPTGEV TVPGVSGDVS LPEIATGGLE 490 500 510 520 530 540 GKMKGTKVKT PEMIIQKPKI SMQDVDLSLG SPKLKGDIKV SAPGVQGDVK GPQVALKGSR 550 560 570 580 590 600 VDIETPNLEG TLTGPRLGSP SGKTGTCRIS MSEVDLNVAA PKVKGGVDVT LPRVEGKVKV 610 620 630 640 650 660 PEVDVRGPKV DVSAPDVEAH GPEWNLKMPK MKMPTFSTPG AKGEGPDVHM TLPKGDISIS 670 680 690 700 710 720 GPKVNVEAPD VNLEGLGGKL KGPDVKLPDM SVKTPKISMP DVDLHVKGTK VKGEYDVTVP 730 740 750 760 770 780 KLEGELKGPK VDIDAPDVDV HGPDWHLKMP KMKMPKFSVP GFKAEGPEVD VNLPKADVDI 790 800 810 820 830 840 SGPKIDVTAP DVSIEEPEGK LKGPKFKMPE MNIKVPKISM PDVDLHLKGP NVKGEYDVTM 850 860 870 880 890 900 PKVESEIKVP DVELKSAKMD IDVPDVEVQG PDWHLKMPKM KMPKFSMPGF KAEGPEVDVN 910 920 930 940 950 960 LPKADVDISG PKVGVEVPDV NIEGPEGKLK GPKFKMPEMN IKAPKISMPD VDLHMKGPKV 970 980 990 1000 1010 1020 KGEYDMTVPK LEGDLKGPKV DVSAPDVEMQ GPDWNLKMPK IKMPKFSMPS LKGEGPEFDV 1030 1040 1050 1060 1070 1080 NLSKANVDIS APKVDTNAPD LSLEGPEGKL KGPKFKMPEM HFRAPKMSLP DVDLDLKGPK 1090 1100 1110 1120 1130 1140 MKGNVDISAP KIEGEMQVPD VDIRGPKVDI KAPDVEGQGL DWSLKIPKMK MPKFSMPSLK 1150 1160 1170 1180 1190 1200 GEGPEVDVNL PKADVVVSGP KVDIEAPDVS LEGPEGKLKG PKFKMPEMHF KTPKISMPDV 1210 1220 1230 1240 1250 1260 DLHLKGPKVK GDVDVSVPKV EGEMKVPDVE IKGPKMDIDA PDVEVQGPDW HLKMPKMKMP 1270 1280 1290 1300 1310 1320 KFSMPGFKGE GREVDVNLPK ADIDVSGPKV DVEVPDVSLE GPEGKLKGPK FKMPEMHFKA 1330 1340 1350 1360 1370 1380 PKISMPDVDL NLKGPKLKGD VDVSLPEVEG EMKVPDVDIK GPKVDISAPD VDVHGPDWHL 1390 1400 1410 1420 1430 1440 KMPKVKMPKF SMPGFKGEGP EVDVKLPKAD VDVSGPKMDA EVPDVNIEGP DAKLKGPKFK 1450 1460 1470 1480 1490 1500 MPEMSIKPQK ISIPDVGLHL KGPKMKGDYD VTVPKVEGEI KAPDVDIKGP KVDINAPDVE 1510 1520 1530 1540 1550 1560 VHGPDWHLKM PKVKMPKFSM PGFKGEGPEV DMNLPKADLG VSGPKVDIDV PDVNLEAPEG 1570 1580 1590 1600 1610 1620 KLKGPKFKMP SMNIQTHKIS MPDVGLNLKA PKLKTDVDVS LPKVEGDLKG PEIDVKAPKM 1630 1640 1650 1660 1670 1680 DVNVGDIDIE GPEGKLKGPK FKMPEMHFKA PKISMPDVDL HLKGPKVKGD MDVSVPKVEG 1690 1700 1710 1720 1730 1740 EMKVPDVDIK GPKVDIDAPD VEVHDPDWHL KMPKMKMPKF SMPGFKAEGP EVDVNLPKAD 1750 1760 1770 1780 1790 1800 IDVSGPSVDT DAPDLDIEGP EGKLKGSKFK MPKLNIKAPK VSMPDVDLNL KGPKLKGEID 1810 1820 1830 1840 1850 1860 ASVPELEGDL RGPQVDVKGP FVEAEVPDVD LECPDAKLKG PKFKMPEMHF KAPKISMPDV 1870 1880 1890 1900 1910 1920 DLHLKGPKVK GDADVSVPKL EGDLTGPSVG VEVPDVELEC PDAKLKGPKF KMPDMHFKAP 1930 1940 1950 1960 1970 1980 KISMPDVDLH LKGPKVKGDV DVSVPKLEGD LTGPSVGVEV PDVELECPDA KLKGPKFKMP 1990 2000 2010 2020 2030 2040 EMHFKTPKIS MPDVDLHLKG PKVKGDMDVS VPKVEGEMKV PDVDIKGPKM DIDAPDVDVH 2050 2060 2070 2080 2090 2100 GPDWHLKMPK MKMPKFSMPG FKAEGPEVDV NLPKADVVVS GPKVDVEVPD VSLEGPEGKL 2110 2120 2130 2140 2150 2160 KGPKLKMPEM HFKAPKISMP DVDLHLKGPK VKGDVDVSLP KLEGDLTGPS VDVEVPDVEL 2170 2180 2190 2200 2210 2220 ECPDAKLKGP KFKMPEMHFK TPKISMPDVN LNLKGPKVKG DMDVSVPKVE GEMKVPDVDI 2230 2240 2250 2260 2270 2280 RGPKVDIDAP DVDVHGPDWH LKMPKMKMPK FSMPGFKGEG PEVDVNLPKA DVDVSGPKVD 2290 2300 2310 2320 2330 2340 VEVPDVSLEG PEGKLKGPKF KMPEMHFKTP KISMPDVDFN LKGPKIKGDV DVSAPKLEGE 2350 2360 2370 2380 2390 2400 LKGPELDVKG PKLDADMPEV AVEGPNGKWK TPKFKMPDMH FKAPKISMPD LDLHLKSPKA 2410 2420 2430 2440 2450 2460 KGEVDVDVPK LEGDLKGPHV DVSGPDIDIE GPEGKLKGPK FKMPDMHFKA PNISMPDVDL 2470 2480 2490 2500 2510 2520 NLKGPKIKGD VDVSVPEVEG KLEVPDMNIR GPKVDVNAPD VQAPDWHLKM PKMKMPKFSM 2530 2540 2550 2560 2570 2580 PGFKAEGPEV DVNLPKADVD ISGPKVDIEG PDVNIEGPEG KLKGPKLKMP EMNIKAPKIS 2590 2600 2610 2620 2630 2640 MPDFDLHLKG PKVKGDVDVS LPKVEGDLKG PEVDIKGPKV DINAPDVGVQ GPDWHLKMPK 2650 2660 2670 2680 2690 2700 VKMPKFSMPG FKGEGPDGDV KLPKADIDVS GPKVDIEGPD VNIEGPEGKL KGPKFKMPEM 2710 2720 2730 2740 2750 2760 NIKAPKISMP DIDLNLKGPK VKGDVDVSLP KVEGDLKGPE VDIKGPKVDI DAPDVDVHGP 2770 2780 2790 2800 2810 2820 DWHLKMPKIK MPKISMPGFK GEGPDVDVNL PKADIDVSGP KVDVECPDVN IEGPEGKWKS 2830 2840 2850 2860 2870 2880 PKFKMPEMHF KTPKISMPDI DLNLTGPKIK GDVDVTGPKV EGDLKGPEVD LKGPKVDIDV 2890 2900 2910 2920 2930 2940 PDVNVQGPDW HLKMPKMKMP KFSMPGFKAE GPEVDVNLPK ADVDVSGPKV DVEGPDVNIE 2950 2960 2970 2980 2990 3000 GPEGKLKGPK FKMPEMNIKA PKIPMPDFDL HLKGPKVKGD VDISLPKVEG DLKGPEVDIR 3010 3020 3030 3040 3050 3060 GPQVDIDVPD VGVQGPDWHL KMPKVKMPKF SMPGFKGEGP DVDVNLPKAD LDVSGPKVDI 3070 3080 3090 3100 3110 3120 DVPDVNIEGP EGKLKGPKFK MPEMNIKAPK ISMPDIDLNL KGPKVKGDMD VSLPKVEGDM 3130 3140 3150 3160 3170 3180 KVPDVDIKGP KVDINAPDVD VQGPDWHLKM PKIKMPKISM PGFKGEGPEV DVNLPKADLD 3190 3200 3210 3220 3230 3240 VSGPKVDVDV PDVNIEGPDA KLKGPKFKMP EMNIKAPKIS MPDLDLNLKG PKMKGEVDVS 3250 3260 3270 3280 3290 3300 LANVEGDLKG PALDIKGPKI DVDAPDIDIH GPDAKLKGPK LKMPDMHVNM PKISMPEIDL 3310 3320 3330 3340 3350 3360 NLKGSKLKGD VDVSGPKLEG DIKAPSLDIK GPEVDVSGPK LNIEGKSKKS RFKLPKFNFS 3370 3380 3390 3400 3410 3420 GSKVQTPEVD VKGKKPDIDI TGPKVDINAP DVEVQGKVKG SKFKMPFLSI SSPKVSMPDV 3430 3440 3450 3460 3470 3480 ELNLKSPKVK GDLDIAGPNL EGDFKGPKVD IKAPEVNLNA PDVDVHGPDW NLKMPKMKMP 3490 3500 3510 3520 3530 3540 KFSVSGLKAE GPDVAVDLPK GDINIEGPSM NIEGPDLNVE GPEGGLKGPK FKMPDMNIKA 3550 3560 3570 3580 3590 3600 PKISMPDIDL NLKGPKVKGD VDISLPKLEG DLKGPEVDIK GPKVDINAPD VDVHGPDWHL 3610 3620 3630 3640 3650 3660 KMPKVKMPKF SMPGFKGEGP EVDVTLPKAD IDISGPNVDV DVPDVNIEGP DAKLKGPKFK 3670 3680 3690 3700 3710 3720 MPEMNIKAPK ISMPDFDLNL KGPKMKGDVV VSLPKVEGDL KGPEVDIKGP KVDIDTPDIN 3730 3740 3750 3760 3770 3780 IEGSEGKFKG PKFKIPEMHL KAPKISMPDI DLNLKGPKVK GDVDVSLPKM EGDLKGPEVD 3790 3800 3810 3820 3830 3840 IKGPKVDINA PDVDVQGPDW HLKMPKVKMP KFSMPGFKGE GPDVDVNLPK ADLDVSGPKV 3850 3860 3870 3880 3890 3900 DIDVPDVNIE GPEGKLKGPK FKMPEMNIKA PKISMPDIDL NLKGPKVKGD MDVSLPKVEG 3910 3920 3930 3940 3950 3960 DMQVPDLDIK GPKVDINAPD VDVRGPDWHL KMPKIKMPKI SMPGFKGEGP EVDVNLPKAD 3970 3980 3990 4000 4010 4020 LDVSGPKVDV DVPDVNIEGP DAKLKGPKFK MPEMNIKAPK ISMPDFDLHL KGPKVKGDVD 4030 4040 4050 4060 4070 4080 VSLPKMEGDL KAPEVDIKGP KVDIDAPDVD VHGPDWHLKM PKVKMPKFSM PGFKGEGPEV 4090 4100 4110 4120 4130 4140 DVNLPKADID VSGPKVDIDT PDIDIHGPEG KLKGPKFKMP DLHLKAPKIS MPEVDLNLKG 4150 4160 4170 4180 4190 4200 PKMKGDVDVS LPKVEGDLKG PEVDIKGPKV DIDVPDVDVQ GPDWHLKMPK VKMPKFSMPG 4210 4220 4230 4240 4250 4260 FKGEGPDVDV NLPKADLDVS GPKVDIDVPD VNIEGPDAKL KGPKFKMPEM NIKAPKISMP 4270 4280 4290 4300 4310 4320 DFDLHLKGPK VKGDVDVSLP KVEGDLKGPE VDIKGPKVDI DAPDVDVHGP DWHLKMPKVK 4330 4340 4350 4360 4370 4380 MPKFSMPGFK GEGPDVDVTL PKADIEISGP KVDIDAPDVS IEGPDAKLKG PKFKMPEMNI 4390 4400 4410 4420 4430 4440 KAPKISMPDI DFNLKGPKVK GDVDVSLPKV EGDLKGPEID IKGPSLDIDT PDVNIEGPEG 4450 4460 4470 4480 4490 4500 KLKGPKFKMP EMNIKAPKIS MPDFDLHLKG PKVKGDVDVS LPKVESDLKG PEVDIEGPEG 4510 4520 4530 4540 4550 4560 KLKGPKFKMP DVHFKSPQIS MSDIDLNLKG PKIKGDMDIS VPKLEGDLKG PKVDVKGPKV 4570 4580 4590 4600 4610 4620 GIDTPDIDIH GPEGKLKGPK FKMPDLHLKA PKISMPEVDL NLKGPKVKGD MDISLPKVEG 4630 4640 4650 4660 4670 4680 DLKGPEVDIR DPKVDIDVPD VDVQGPDWHL KMPKVKMPKF SMPGFKGEGP DVDVNLPKAD 4690 4700 4710 4720 4730 4740 IDVSGPKVDV DVPDVNIEGP DAKLKGPKFK MPEMSIKAPK ISMPDIDLNL KGPKVKGDVD 4750 4760 4770 4780 4790 4800 VTLPKVEGDL KGPEADIKGP KVDINTPDVD VHGPDWHLKM PKVKMPKFSM PGFKGEGPDV 4810 4820 4830 4840 4850 4860 DVSLPKADID VSGPKVDVDI PDVNIEGPDA KLKGPKFKMP EINIKAPKIS IPDVDLDLKG 4870 4880 4890 4900 4910 4920 PKVKGDFDVS VPKVEGTLKG PEVDLKGPRL DFEGPDAKLS GPSLKMPSLE ISAPKVTAPD 4930 4940 4950 4960 4970 4980 VDLHLKAPKI GFSGPKLEGG EVDLKGPKVE APSLDVHMDS PDINIEGPDV KIPKFKKPKF 4990 5000 5010 5020 5030 5040 GFGAKSPKAD IKSPSLDVTV PEAELNLETP EISVGGKGKK SKFKMPKIHM SGPKIKAKKQ 5050 5060 5070 5080 5090 5100 GFDLNVPGGE IDASLKAPDV DVNIAGPDAA LKVDVKSPKT KKTMFGKMYF PDVEFDIKSP 5110 5120 5130 5140 5150 5160 KFKAEAPLPS PKLEGELQAP DLELSLPAIH VEGLDIKAKA PKVKMPDVDI SVPKIEGDLK 5170 5180 5190 5200 5210 5220 GPKVQANLGA PDINIEGLDA KVKTPSFGIS APQVSIPDVN VNLKGPKIKG DVPSVGLEGP 5230 5240 5250 5260 5270 5280 DVDLQGPEAK IKFPKFSMPK IGIPGVKMEG GGAEVHAQLP SLEGDLRGPD VKLEGPDVSL 5290 5300 5310 5320 5330 5340 KGPGVDLPSV NLSMPKVSGP DLDLNLKGPS LKGDLDASVP SMKVHAPGLN LSGVGGKMQV 5350 5360 5370 5380 5390 5400 GGDGVKVPGI DATTKLNVGA PDVTLRGPSL QGDLAVSGDI KCPKVSVGAP DLSLEASEGS 5410 5420 5430 5440 5450 5460 IKLPKMKLPQ FGISTPGSDL HVNAKGPQVS GELKGPGVDV NLKGPRISAP NVDFNLEGPK 5470 5480 5490 5500 5510 5520 VKGSLGATGE IKGPTVGGGL PGIGVQGLEG NLQMPGIKSS GCDVNLPGVN VKLPTGQISG 5530 5540 5550 5560 5570 5580 PEIKGGLKGS EVGFHGAAPD ISVKGPAFNM ASPESDFGIN LKGPKIKGGA DVSGGVSAPD 5590 5600 5610 5620 5630 5640 ISLGEGHLSV KGSGGEWKGP QVSSALNLDT SKFAGGLHFS GPKVEGGVKG GQIGLQAPGL 5650 5660 5670 5680 5690 5700 SVSGPQGHLE SGSGKVTFPK MKIPKFTFSG RELVGREMGV DVHFPKAEAS IQAGAGDGEW 5710 5720 5730 5740 5750 5760 EESEVKLKKS KIKMPKFNFS KPKGKGGVTG SPEASISGSK GDLKSSKASL GSLEGEAEAE 5770 5780 5790 5800 5810 5820 ASSPKGKFSL FKSKKPRHRS NSFSDEREFS GPSTPTGTLE FEGGEVSLEG GKVKGKHGKL 5830 5840 5850 5860 5870 5880 KFGTFGGLGS KSKGHYEVTG SDDETGKLQG SGVSLASKKS RLSSSSSNDS GNKVGIQLPE 5890 VELSVSTKKE
	Isoform 2 [UniParc]. Checksum: 4CB0471C1B60F60D	FASTA	149	16,061
	10 20 30 40 50 60 MEKEETTREL LLPNWQGSGS HGLTIAQRDD GVFVQEVTQN SPAARTGVVK EGDQIVGATI 70 80 90 100 110 120 YFDNLQSGEV TQLLNTMGHH TVGLKLHRKG DRSPEPGQTW TREVFSSCSS EVVLNTPQPS 130 140 ALECKDQNKQ KEASSQAGAV SVSTPNAGL

References

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[1]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[4]	"A human gene (AHNAK) encoding an unusually large protein with a 1.2-microns polyionic rod structure." Shtivelman E., Cohen F.E., Bishop J.M. Proc. Natl. Acad. Sci. U.S.A. 89:5472-5476(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 114-1930 (ISOFORM 1), NUCLEOTIDE SEQUENCE [MRNA] OF 4614-5890 (ISOFORM 1). Tissue: Placenta.
[5]	Erratum Shtivelman E., Cohen F.E., Bishop J.M. Proc. Natl. Acad. Sci. U.S.A. 90:4328-4328(1993)
[6]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-41; SER-93; THR-490; SER-511; THR-4100; THR-4766; SER-5077; SER-5110; SER-5448; SER-5552 AND SER-5752, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[7]	"A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-41; SER-511; SER-5731 AND SER-5763, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[8]	"AHNAK, a novel component of the dysferlin protein complex, redistributes to the cytoplasm with dysferlin during skeletal muscle regeneration." Huang Y., Laval S.H., van Remoortere A., Baudier J., Benaud C., Anderson L.V., Straub V., Deelder A., Frants R.R., den Dunnen J.T., Bushby K., van der Maarel S.M. FASEB J. 21:732-742(2007) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH DYSF.
[9]	"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra." Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D. J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-490; SER-511; SER-4986; SER-5099; SER-5110 AND SER-5552, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment." Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J. J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-5749 AND SER-5752, MASS SPECTROMETRY. Tissue: T-cell.
[11]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-41 AND SER-511, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[12]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-41; SER-93; SER-511; SER-570; SER-793; SER-4903; SER-4960; SER-4993; THR-5009; SER-5099; THR-5415; SER-5731; SER-5749; SER-5752; SER-5763; SER-5780; SER-5782; SER-5793; THR-5794; SER-5830 AND SER-5841, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[13]	"Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography." Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J. Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Liver.
[14]	Carrascal M., Abian J. Submitted (JAN-2008) to UniProtKB Cited for: PHOSPHORYLATION AT SER-5749, MASS SPECTROMETRY.
[15]	"Large-scale proteomics analysis of the human kinome." Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H. Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-511 AND SER-5752, MASS SPECTROMETRY.
[16]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-511; SER-570; SER-2397; SER-5448; SER-5731; SER-5749; SER-5752 AND SER-5763, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[17]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-41; SER-93; THR-101; SER-135; SER-177; SER-210; SER-212; SER-216; THR-490; SER-511; SER-559; SER-570; SER-793; SER-1068; THR-1192; SER-1286; THR-1986; THR-2181; THR-2309; SER-2397; SER-2670; SER-2798; THR-2832; THR-2845; SER-3054; SER-3409; SER-3412; SER-3426; THR-3716; SER-3836; SER-4092; THR-4100; SER-4220; THR-4430; SER-4516; SER-4684; SER-4812; SER-4960; SER-4986; SER-5077; SER-5099; SER-5110; SER-5125; SER-5332; SER-5386; SER-5400; SER-5448; SER-5552; SER-5620; SER-5731; SER-5739; SER-5752; SER-5763; SER-5780; SER-5782; SER-5790; THR-5824; SER-5830; SER-5841 AND SER-5857, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[18]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[19]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-93; SER-135; SER-177; THR-490; SER-511; SER-559; SER-5731 AND SER-5841, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AP001363 Genomic DNA. No translation available.
AP003064 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW74019.1.
BC128460 mRNA. Translation: AAI28461.1.
M80899 mRNA. Translation: AAA69898.1.
M80902 mRNA. Translation: AAA69899.1. Different initiation.

IPI

IPI00021812.

PIR

A45259.

RefSeq

NP_001611.1. NM_001620.2.
NP_076965.2. NM_024060.3.

UniGene

Hs.502756.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
4DRW	X-ray	3.50	E/F	5654-5673	[»]
4FTG	X-ray	2.51	E	5654-5673	[»]
4HRG	X-ray	2.00	C/D	5655-5668	[»]

ProteinModelPortal

Q09666.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q09666. 14 interactions.

MINT

MINT-4998803.

STRING

9606.ENSP00000367263.

Protein family/group databases

TCDB

1.A.31.1.4. annexin family.

PTM databases

PhosphoSite

Q09666.

Polymorphism databases

DMDM

160332335.

Proteomic databases

PaxDb

Q09666.

PeptideAtlas

Q09666.

PRIDE

Q09666.

Protocols and materials databases

DNASU

79026.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000257247; ENSP00000257247; ENSG00000124942.
ENST00000378024; ENSP00000367263; ENSG00000124942.

GeneID

79026.

KEGG

hsa:79026.

UCSC

uc001ntl.3. human.

Organism-specific databases

CTD

79026.

GeneCards

GC11M062202.

H-InvDB

HIX0171266.
HIX0171345.

HGNC

HGNC:347. AHNAK.

HPA

HPA019010.
HPA019070.
HPA026643.

MIM

103390. gene.

neXtProt

NX_Q09666.

PharmGKB

PA24640.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG12793.

HOGENOM

HOG000033865.

HOVERGEN

HBG104864.

InParanoid

Q09666.

OMA

WKGPKFK.

OrthoDB

EOG4RFKTT.

Gene expression databases

ArrayExpress

Q09666.

Bgee

Q09666.

CleanEx

HS_AHNAK.

Genevestigator

Q09666.

GermOnline

ENSG00000124942. Homo sapiens.

Family and domain databases

InterPro

IPR001478. PDZ.
[Graphical view]

SMART

SM00228. PDZ. 1 hit.
[Graphical view]

SUPFAM

SSF50156. PDZ. 1 hit.

PROSITE

PS50106. PDZ. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

AHNAK. human.

GenomeRNAi

79026.

NextBio

67715.

SOURCE

Search...

Entry information

Entry name

AHNK_HUMAN

Accession

Primary (citable) accession number: Q09666
Secondary accession number(s): A1A586

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	November 13, 2007
Last modified:	May 1, 2013
This is version 107 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.