Reviewed, UniProtKB/Swiss-Prot Q09666 (AHNK_HUMAN)

Names and origin

Protein names

Recommended name:
    Neuroblast differentiation-associated protein AHNAK
Alternative name(s):
    Desmoyokin

Gene names

Name:	AHNAK
Synonyms:	PM227

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	5890 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May be required for neuronal cell differentiation.
Subunit structure	Interacts with DYSF; the interaction is direct and Ca2+-independent. Ref.4
Subcellular location	Nucleus.
Sequence similarities	Contains 1 PDZ (DHR) domain.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Domain	Repeat
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	nervous system development Non-traceable author statement. Source: UniProtKB
Cellular component	nucleus Ref.2 Non-traceable author statement. Source: UniProtKB
Molecular function	protein binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 5890	5890	Neuroblast differentiation-associated protein AHNAK		PRO_0000064504
Regions
	Domain	9 – 90	82	PDZ
	Motif	4971 – 4979	9	Nuclear localization signal Potential
	Motif	5019 – 5027	9	Nuclear localization signal Potential
	Motif	5034 – 5039	6	Nuclear localization signal Potential
	Motif	5706 – 5716	11	Nuclear localization signal Potential
	Motif	5772 – 5779	8	Nuclear localization signal Potential
	Compositional bias	5458 – 5654	197	Gly-rich
Amino acid modifications
	Modified residue	41	1	Phosphoserine Ref.7 Ref.8 Ref.13
	Modified residue	93	1	Phosphoserine Ref.7 Ref.8
	Modified residue	177	1	Phosphoserine
	Modified residue	210	1	Phosphoserine
	Modified residue	216	1	Phosphoserine
	Modified residue	490	1	Phosphothreonine Ref.8 Ref.12 Ref.14
	Modified residue	511	1	Phosphoserine Ref.7 Ref.8 Ref.13 Ref.12 Ref.14 Ref.11
	Modified residue	559	1	Phosphoserine Ref.11
	Modified residue	570	1	Phosphoserine Ref.8
	Modified residue	715	1	Phosphotyrosine Ref.17
	Modified residue	793	1	Phosphoserine Ref.8
	Modified residue	836	1	Phosphotyrosine Ref.17
	Modified residue	964	1	Phosphotyrosine Ref.17
	Modified residue	1068	1	Phosphoserine Ref.8
	Modified residue	1469	1	Phosphotyrosine Ref.17
	Modified residue	2397	1	Phosphoserine
	Modified residue	3716	1	Phosphothreonine
	Modified residue	4684	1	Phosphoserine Ref.8
	Modified residue	4766	1	Phosphothreonine Ref.8 Ref.12
	Modified residue	4787	1	N6-acetyllysine Ref.19
	Modified residue	4812	1	Phosphoserine Ref.8
	Modified residue	4903	1	Phosphoserine Ref.8
	Modified residue	4960	1	Phosphoserine Ref.8
	Modified residue	4986	1	Phosphoserine Ref.8 Ref.14
	Modified residue	4993	1	Phosphoserine Ref.8
	Modified residue	5009	1	Phosphothreonine Ref.8
	Modified residue	5077	1	Phosphoserine Ref.8 Ref.12
	Modified residue	5089	1	Phosphotyrosine Ref.17
	Modified residue	5099	1	Phosphoserine Ref.8 Ref.14
	Modified residue	5110	1	Phosphoserine Ref.8 Ref.12 Ref.14
	Modified residue	5332	1	Phosphoserine Ref.8
	Modified residue	5397	1	Phosphoserine Ref.12
	Modified residue	5415	1	Phosphothreonine Ref.8
	Modified residue	5448	1	Phosphoserine Ref.8 Ref.12 Ref.11
	Modified residue	5552	1	Phosphoserine Ref.7 Ref.8 Ref.12 Ref.14
	Modified residue	5555	1	Phosphoserine Ref.8
	Modified residue	5620	1	Phosphoserine Ref.12
	Modified residue	5731	1	Phosphoserine Ref.7 Ref.8 Ref.13 Ref.12 Ref.14 Ref.11 Ref.5
	Modified residue	5739	1	Phosphoserine Ref.12
	Modified residue	5749	1	Phosphoserine Ref.8 Ref.10
	Modified residue	5752	1	Phosphoserine Ref.8 Ref.12 Ref.11 Ref.6
	Modified residue	5763	1	Phosphoserine Ref.8 Ref.13
	Modified residue	5769	1	Phosphoserine Ref.8
	Modified residue	5780	1	Phosphoserine Ref.8 Ref.12
	Modified residue	5782	1	Phosphoserine Ref.8 Ref.12 Ref.11
	Modified residue	5784	1	Phosphoserine Ref.8
	Modified residue	5793	1	Phosphoserine Ref.8
	Modified residue	5794	1	Phosphothreonine Ref.8
	Modified residue	5830	1	Phosphoserine Ref.8
	Modified residue	5836	1	Phosphotyrosine Ref.17
	Modified residue	5841	1	Phosphoserine Ref.8 Ref.12 Ref.9
	Modified residue	5851	1	Phosphoserine Ref.12
	Modified residue	5854	1	Phosphoserine Ref.12
	Modified residue	5857	1	Phosphoserine Ref.12
Natural variations
	Natural variant	962	1	G → V: dbSNP rs664761.		VAR_039058
	Natural variant	2114	1	A → T: dbSNP rs1298288.		VAR_039059
	Natural variant	2439	1	P → L: dbSNP rs11824660.		VAR_039060
	Natural variant	3003	1	Q → K: dbSNP rs566144.		VAR_039061
	Natural variant	3190	1	V → I: dbSNP rs11231129.		VAR_039062
	Natural variant	3724	1	S → P: dbSNP rs11231128.		VAR_039063
	Natural variant	4561	1	G → D: dbSNP rs12795508.		VAR_039064
	Natural variant	4611	1	M → V: dbSNP rs12801302.		VAR_039065
	Natural variant	4613	1	I → V: dbSNP rs12801153.		VAR_039066
	Natural variant	4631	1	D → G: dbSNP rs12801123.		VAR_039067
	Natural variant	5415	1	T → A: dbSNP rs11231126.		VAR_039068
Experimental info
	Sequence conflict	288	1	A → P in AAA69899. Ref.2
	Sequence conflict	302	1	G → A in AAA69899. Ref.2
	Sequence conflict	1156	1	V → D in AAA69899. Ref.2
	Sequence conflict	1737	1	P → R in AAA69899. Ref.2
	Sequence conflict	1821	1	F → L in AAA69899. Ref.2
	Sequence conflict	4614	1	S → T in AAA69898. Ref.2
	Sequence conflict	4627	1	V → A in AAA69898. Ref.2
	Sequence conflict	4630 – 4631	2	RD → KG in AAA69898. Ref.2
	Sequence conflict	4637 – 4638	2	DV → NT in AAA69898. Ref.2
	Sequence conflict	4644	1	Q → H in AAA69898. Ref.2
	Sequence conflict	4830	1	A → P in AAA69898. Ref.2
	Sequence conflict	4834	1	G → V in AAA69898. Ref.2
	Sequence conflict	4837	1	F → V in AAA69898. Ref.2
	Sequence conflict	4984	1	A → P in AAA69898. Ref.2
	Sequence conflict	5445	1	P → S in AAA69898. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q09666-1 [UniParc]. Last modified November 13, 2007. Version 2. Checksum: A82FC9645FDCA8DC	FASTA	5,890	629,101
	10 20 30 40 50 60 MEKEETTREL LLPNWQGSGS HGLTIAQRDD GVFVQEVTQN SPAARTGVVK EGDQIVGATI 70 80 90 100 110 120 YFDNLQSGEV TQLLNTMGHH TVGLKLHRKG DRSPEPGQTW TREVFSSCSS EVVLSGDDEE 130 140 150 160 170 180 YQRIYTTKIK PRLKSEDGVE GDLGETQSRT ITVTRRVTAY TVDVTGREGA KDIDISSPEF 190 200 210 220 230 240 KIKIPRHELT EISNVDVETQ SGKTVIRLPS GSGAASPTGS AVDIRAGAIS ASGPELQGAG 250 260 270 280 290 300 HSKLQVTMPG IKVGGSGVNV NAKGLDLGGR GGVQVPAVDI SSSLGGRAVE VQGPSLESGD 310 320 330 340 350 360 HGKIKFPTMK VPKFGVSTGR EGQTPKAGLR VSAPEVSVGH KGGKPGLTIQ APQLEVSVPS 370 380 390 400 410 420 ANIEGLEGKL KGPQITGPSL EGDLGLKGAK PQGHIGVDAS APQIGGSITG PSVEVQAPDI 430 440 450 460 470 480 DVQGPGSKLN VPKMKVPKFS VSGAKGEETG IDVTLPTGEV TVPGVSGDVS LPEIATGGLE 490 500 510 520 530 540 GKMKGTKVKT PEMIIQKPKI SMQDVDLSLG SPKLKGDIKV SAPGVQGDVK GPQVALKGSR 550 560 570 580 590 600 VDIETPNLEG TLTGPRLGSP SGKTGTCRIS MSEVDLNVAA PKVKGGVDVT LPRVEGKVKV 610 620 630 640 650 660 PEVDVRGPKV DVSAPDVEAH GPEWNLKMPK MKMPTFSTPG AKGEGPDVHM TLPKGDISIS 670 680 690 700 710 720 GPKVNVEAPD VNLEGLGGKL KGPDVKLPDM SVKTPKISMP DVDLHVKGTK VKGEYDVTVP 730 740 750 760 770 780 KLEGELKGPK VDIDAPDVDV HGPDWHLKMP KMKMPKFSVP GFKAEGPEVD VNLPKADVDI 790 800 810 820 830 840 SGPKIDVTAP DVSIEEPEGK LKGPKFKMPE MNIKVPKISM PDVDLHLKGP NVKGEYDVTM 850 860 870 880 890 900 PKVESEIKVP DVELKSAKMD IDVPDVEVQG PDWHLKMPKM KMPKFSMPGF KAEGPEVDVN 910 920 930 940 950 960 LPKADVDISG PKVGVEVPDV NIEGPEGKLK GPKFKMPEMN IKAPKISMPD VDLHMKGPKV 970 980 990 1000 1010 1020 KGEYDMTVPK LEGDLKGPKV DVSAPDVEMQ GPDWNLKMPK IKMPKFSMPS LKGEGPEFDV 1030 1040 1050 1060 1070 1080 NLSKANVDIS APKVDTNAPD LSLEGPEGKL KGPKFKMPEM HFRAPKMSLP DVDLDLKGPK 1090 1100 1110 1120 1130 1140 MKGNVDISAP KIEGEMQVPD VDIRGPKVDI KAPDVEGQGL DWSLKIPKMK MPKFSMPSLK 1150 1160 1170 1180 1190 1200 GEGPEVDVNL PKADVVVSGP KVDIEAPDVS LEGPEGKLKG PKFKMPEMHF KTPKISMPDV 1210 1220 1230 1240 1250 1260 DLHLKGPKVK GDVDVSVPKV EGEMKVPDVE IKGPKMDIDA PDVEVQGPDW HLKMPKMKMP 1270 1280 1290 1300 1310 1320 KFSMPGFKGE GREVDVNLPK ADIDVSGPKV DVEVPDVSLE GPEGKLKGPK FKMPEMHFKA 1330 1340 1350 1360 1370 1380 PKISMPDVDL NLKGPKLKGD VDVSLPEVEG EMKVPDVDIK GPKVDISAPD VDVHGPDWHL 1390 1400 1410 1420 1430 1440 KMPKVKMPKF SMPGFKGEGP EVDVKLPKAD VDVSGPKMDA EVPDVNIEGP DAKLKGPKFK 1450 1460 1470 1480 1490 1500 MPEMSIKPQK ISIPDVGLHL KGPKMKGDYD VTVPKVEGEI KAPDVDIKGP KVDINAPDVE 1510 1520 1530 1540 1550 1560 VHGPDWHLKM PKVKMPKFSM PGFKGEGPEV DMNLPKADLG VSGPKVDIDV PDVNLEAPEG 1570 1580 1590 1600 1610 1620 KLKGPKFKMP SMNIQTHKIS MPDVGLNLKA PKLKTDVDVS LPKVEGDLKG PEIDVKAPKM 1630 1640 1650 1660 1670 1680 DVNVGDIDIE GPEGKLKGPK FKMPEMHFKA PKISMPDVDL HLKGPKVKGD MDVSVPKVEG 1690 1700 1710 1720 1730 1740 EMKVPDVDIK GPKVDIDAPD VEVHDPDWHL KMPKMKMPKF SMPGFKAEGP EVDVNLPKAD 1750 1760 1770 1780 1790 1800 IDVSGPSVDT DAPDLDIEGP EGKLKGSKFK MPKLNIKAPK VSMPDVDLNL KGPKLKGEID 1810 1820 1830 1840 1850 1860 ASVPELEGDL RGPQVDVKGP FVEAEVPDVD LECPDAKLKG PKFKMPEMHF KAPKISMPDV 1870 1880 1890 1900 1910 1920 DLHLKGPKVK GDADVSVPKL EGDLTGPSVG VEVPDVELEC PDAKLKGPKF KMPDMHFKAP 1930 1940 1950 1960 1970 1980 KISMPDVDLH LKGPKVKGDV DVSVPKLEGD LTGPSVGVEV PDVELECPDA KLKGPKFKMP 1990 2000 2010 2020 2030 2040 EMHFKTPKIS MPDVDLHLKG PKVKGDMDVS VPKVEGEMKV PDVDIKGPKM DIDAPDVDVH 2050 2060 2070 2080 2090 2100 GPDWHLKMPK MKMPKFSMPG FKAEGPEVDV NLPKADVVVS GPKVDVEVPD VSLEGPEGKL 2110 2120 2130 2140 2150 2160 KGPKLKMPEM HFKAPKISMP DVDLHLKGPK VKGDVDVSLP KLEGDLTGPS VDVEVPDVEL 2170 2180 2190 2200 2210 2220 ECPDAKLKGP KFKMPEMHFK TPKISMPDVN LNLKGPKVKG DMDVSVPKVE GEMKVPDVDI 2230 2240 2250 2260 2270 2280 RGPKVDIDAP DVDVHGPDWH LKMPKMKMPK FSMPGFKGEG PEVDVNLPKA DVDVSGPKVD 2290 2300 2310 2320 2330 2340 VEVPDVSLEG PEGKLKGPKF KMPEMHFKTP KISMPDVDFN LKGPKIKGDV DVSAPKLEGE 2350 2360 2370 2380 2390 2400 LKGPELDVKG PKLDADMPEV AVEGPNGKWK TPKFKMPDMH FKAPKISMPD LDLHLKSPKA 2410 2420 2430 2440 2450 2460 KGEVDVDVPK LEGDLKGPHV DVSGPDIDIE GPEGKLKGPK FKMPDMHFKA PNISMPDVDL 2470 2480 2490 2500 2510 2520 NLKGPKIKGD VDVSVPEVEG KLEVPDMNIR GPKVDVNAPD VQAPDWHLKM PKMKMPKFSM 2530 2540 2550 2560 2570 2580 PGFKAEGPEV DVNLPKADVD ISGPKVDIEG PDVNIEGPEG KLKGPKLKMP EMNIKAPKIS 2590 2600 2610 2620 2630 2640 MPDFDLHLKG PKVKGDVDVS LPKVEGDLKG PEVDIKGPKV DINAPDVGVQ GPDWHLKMPK 2650 2660 2670 2680 2690 2700 VKMPKFSMPG FKGEGPDGDV KLPKADIDVS GPKVDIEGPD VNIEGPEGKL KGPKFKMPEM 2710 2720 2730 2740 2750 2760 NIKAPKISMP DIDLNLKGPK VKGDVDVSLP KVEGDLKGPE VDIKGPKVDI DAPDVDVHGP 2770 2780 2790 2800 2810 2820 DWHLKMPKIK MPKISMPGFK GEGPDVDVNL PKADIDVSGP KVDVECPDVN IEGPEGKWKS 2830 2840 2850 2860 2870 2880 PKFKMPEMHF KTPKISMPDI DLNLTGPKIK GDVDVTGPKV EGDLKGPEVD LKGPKVDIDV 2890 2900 2910 2920 2930 2940 PDVNVQGPDW HLKMPKMKMP KFSMPGFKAE GPEVDVNLPK ADVDVSGPKV DVEGPDVNIE 2950 2960 2970 2980 2990 3000 GPEGKLKGPK FKMPEMNIKA PKIPMPDFDL HLKGPKVKGD VDISLPKVEG DLKGPEVDIR 3010 3020 3030 3040 3050 3060 GPQVDIDVPD VGVQGPDWHL KMPKVKMPKF SMPGFKGEGP DVDVNLPKAD LDVSGPKVDI 3070 3080 3090 3100 3110 3120 DVPDVNIEGP EGKLKGPKFK MPEMNIKAPK ISMPDIDLNL KGPKVKGDMD VSLPKVEGDM 3130 3140 3150 3160 3170 3180 KVPDVDIKGP KVDINAPDVD VQGPDWHLKM PKIKMPKISM PGFKGEGPEV DVNLPKADLD 3190 3200 3210 3220 3230 3240 VSGPKVDVDV PDVNIEGPDA KLKGPKFKMP EMNIKAPKIS MPDLDLNLKG PKMKGEVDVS 3250 3260 3270 3280 3290 3300 LANVEGDLKG PALDIKGPKI DVDAPDIDIH GPDAKLKGPK LKMPDMHVNM PKISMPEIDL 3310 3320 3330 3340 3350 3360 NLKGSKLKGD VDVSGPKLEG DIKAPSLDIK GPEVDVSGPK LNIEGKSKKS RFKLPKFNFS 3370 3380 3390 3400 3410 3420 GSKVQTPEVD VKGKKPDIDI TGPKVDINAP DVEVQGKVKG SKFKMPFLSI SSPKVSMPDV 3430 3440 3450 3460 3470 3480 ELNLKSPKVK GDLDIAGPNL EGDFKGPKVD IKAPEVNLNA PDVDVHGPDW NLKMPKMKMP 3490 3500 3510 3520 3530 3540 KFSVSGLKAE GPDVAVDLPK GDINIEGPSM NIEGPDLNVE GPEGGLKGPK FKMPDMNIKA 3550 3560 3570 3580 3590 3600 PKISMPDIDL NLKGPKVKGD VDISLPKLEG DLKGPEVDIK GPKVDINAPD VDVHGPDWHL 3610 3620 3630 3640 3650 3660 KMPKVKMPKF SMPGFKGEGP EVDVTLPKAD IDISGPNVDV DVPDVNIEGP DAKLKGPKFK 3670 3680 3690 3700 3710 3720 MPEMNIKAPK ISMPDFDLNL KGPKMKGDVV VSLPKVEGDL KGPEVDIKGP KVDIDTPDIN 3730 3740 3750 3760 3770 3780 IEGSEGKFKG PKFKIPEMHL KAPKISMPDI DLNLKGPKVK GDVDVSLPKM EGDLKGPEVD 3790 3800 3810 3820 3830 3840 IKGPKVDINA PDVDVQGPDW HLKMPKVKMP KFSMPGFKGE GPDVDVNLPK ADLDVSGPKV 3850 3860 3870 3880 3890 3900 DIDVPDVNIE GPEGKLKGPK FKMPEMNIKA PKISMPDIDL NLKGPKVKGD MDVSLPKVEG 3910 3920 3930 3940 3950 3960 DMQVPDLDIK GPKVDINAPD VDVRGPDWHL KMPKIKMPKI SMPGFKGEGP EVDVNLPKAD 3970 3980 3990 4000 4010 4020 LDVSGPKVDV DVPDVNIEGP DAKLKGPKFK MPEMNIKAPK ISMPDFDLHL KGPKVKGDVD 4030 4040 4050 4060 4070 4080 VSLPKMEGDL KAPEVDIKGP KVDIDAPDVD VHGPDWHLKM PKVKMPKFSM PGFKGEGPEV 4090 4100 4110 4120 4130 4140 DVNLPKADID VSGPKVDIDT PDIDIHGPEG KLKGPKFKMP DLHLKAPKIS MPEVDLNLKG 4150 4160 4170 4180 4190 4200 PKMKGDVDVS LPKVEGDLKG PEVDIKGPKV DIDVPDVDVQ GPDWHLKMPK VKMPKFSMPG 4210 4220 4230 4240 4250 4260 FKGEGPDVDV NLPKADLDVS GPKVDIDVPD VNIEGPDAKL KGPKFKMPEM NIKAPKISMP 4270 4280 4290 4300 4310 4320 DFDLHLKGPK VKGDVDVSLP KVEGDLKGPE VDIKGPKVDI DAPDVDVHGP DWHLKMPKVK 4330 4340 4350 4360 4370 4380 MPKFSMPGFK GEGPDVDVTL PKADIEISGP KVDIDAPDVS IEGPDAKLKG PKFKMPEMNI 4390 4400 4410 4420 4430 4440 KAPKISMPDI DFNLKGPKVK GDVDVSLPKV EGDLKGPEID IKGPSLDIDT PDVNIEGPEG 4450 4460 4470 4480 4490 4500 KLKGPKFKMP EMNIKAPKIS MPDFDLHLKG PKVKGDVDVS LPKVESDLKG PEVDIEGPEG 4510 4520 4530 4540 4550 4560 KLKGPKFKMP DVHFKSPQIS MSDIDLNLKG PKIKGDMDIS VPKLEGDLKG PKVDVKGPKV 4570 4580 4590 4600 4610 4620 GIDTPDIDIH GPEGKLKGPK FKMPDLHLKA PKISMPEVDL NLKGPKVKGD MDISLPKVEG 4630 4640 4650 4660 4670 4680 DLKGPEVDIR DPKVDIDVPD VDVQGPDWHL KMPKVKMPKF SMPGFKGEGP DVDVNLPKAD 4690 4700 4710 4720 4730 4740 IDVSGPKVDV DVPDVNIEGP DAKLKGPKFK MPEMSIKAPK ISMPDIDLNL KGPKVKGDVD 4750 4760 4770 4780 4790 4800 VTLPKVEGDL KGPEADIKGP KVDINTPDVD VHGPDWHLKM PKVKMPKFSM PGFKGEGPDV 4810 4820 4830 4840 4850 4860 DVSLPKADID VSGPKVDVDI PDVNIEGPDA KLKGPKFKMP EINIKAPKIS IPDVDLDLKG 4870 4880 4890 4900 4910 4920 PKVKGDFDVS VPKVEGTLKG PEVDLKGPRL DFEGPDAKLS GPSLKMPSLE ISAPKVTAPD 4930 4940 4950 4960 4970 4980 VDLHLKAPKI GFSGPKLEGG EVDLKGPKVE APSLDVHMDS PDINIEGPDV KIPKFKKPKF 4990 5000 5010 5020 5030 5040 GFGAKSPKAD IKSPSLDVTV PEAELNLETP EISVGGKGKK SKFKMPKIHM SGPKIKAKKQ 5050 5060 5070 5080 5090 5100 GFDLNVPGGE IDASLKAPDV DVNIAGPDAA LKVDVKSPKT KKTMFGKMYF PDVEFDIKSP 5110 5120 5130 5140 5150 5160 KFKAEAPLPS PKLEGELQAP DLELSLPAIH VEGLDIKAKA PKVKMPDVDI SVPKIEGDLK 5170 5180 5190 5200 5210 5220 GPKVQANLGA PDINIEGLDA KVKTPSFGIS APQVSIPDVN VNLKGPKIKG DVPSVGLEGP 5230 5240 5250 5260 5270 5280 DVDLQGPEAK IKFPKFSMPK IGIPGVKMEG GGAEVHAQLP SLEGDLRGPD VKLEGPDVSL 5290 5300 5310 5320 5330 5340 KGPGVDLPSV NLSMPKVSGP DLDLNLKGPS LKGDLDASVP SMKVHAPGLN LSGVGGKMQV 5350 5360 5370 5380 5390 5400 GGDGVKVPGI DATTKLNVGA PDVTLRGPSL QGDLAVSGDI KCPKVSVGAP DLSLEASEGS 5410 5420 5430 5440 5450 5460 IKLPKMKLPQ FGISTPGSDL HVNAKGPQVS GELKGPGVDV NLKGPRISAP NVDFNLEGPK 5470 5480 5490 5500 5510 5520 VKGSLGATGE IKGPTVGGGL PGIGVQGLEG NLQMPGIKSS GCDVNLPGVN VKLPTGQISG 5530 5540 5550 5560 5570 5580 PEIKGGLKGS EVGFHGAAPD ISVKGPAFNM ASPESDFGIN LKGPKIKGGA DVSGGVSAPD 5590 5600 5610 5620 5630 5640 ISLGEGHLSV KGSGGEWKGP QVSSALNLDT SKFAGGLHFS GPKVEGGVKG GQIGLQAPGL 5650 5660 5670 5680 5690 5700 SVSGPQGHLE SGSGKVTFPK MKIPKFTFSG RELVGREMGV DVHFPKAEAS IQAGAGDGEW 5710 5720 5730 5740 5750 5760 EESEVKLKKS KIKMPKFNFS KPKGKGGVTG SPEASISGSK GDLKSSKASL GSLEGEAEAE 5770 5780 5790 5800 5810 5820 ASSPKGKFSL FKSKKPRHRS NSFSDEREFS GPSTPTGTLE FEGGEVSLEG GKVKGKHGKL 5830 5840 5850 5860 5870 5880 KFGTFGGLGS KSKGHYEVTG SDDETGKLQG SGVSLASKKS RLSSSSSNDS GNKVGIQLPE 5890 VELSVSTKKE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed: 16554811] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"A human gene (AHNAK) encoding an unusually large protein with a 1.2-microns polyionic rod structure." Shtivelman E., Cohen F.E., Bishop J.M. Proc. Natl. Acad. Sci. U.S.A. 89:5472-5476(1992) [PubMed: 1608957] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 114-1930, NUCLEOTIDE SEQUENCE [MRNA] OF 4614-5890. Tissue: Placenta.
[3]	Erratum Shtivelman E., Cohen F.E., Bishop J.M. Proc. Natl. Acad. Sci. U.S.A. 90:4328-4328(1993)
[4]	"AHNAK, a novel component of the dysferlin protein complex, redistributes to the cytoplasm with dysferlin during skeletal muscle regeneration." Huang Y., Laval S.H., van Remoortere A., Baudier J., Benaud C., Anderson L.V., Straub V., Deelder A., Frants R.R., den Dunnen J.T., Bushby K., van der Maarel S.M. FASEB J. 21:732-742(2007) [PubMed: 17185750] [Abstract] Cited for: INTERACTION WITH DYSF.
[5]	"Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis." Wang B., Malik R., Nigg E.A., Korner R. Anal. Chem. 80:9526-9533(2008) [PubMed: 19007248] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-5731, MASS SPECTROMETRY.
[6]	"Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment." Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J. J. Proteome Res. 7:5167-5176(2008) [PubMed: 19367720] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-5752, MASS SPECTROMETRY. Tissue: T-cell.
[7]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-41; SER-93; SER-511; SER-5552 AND SER-5731, MASS SPECTROMETRY.
[8]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-41; SER-93; THR-490; SER-511; SER-570; SER-793; SER-1068; SER-4684; THR-4766; SER-4812; SER-4903; SER-4960; SER-4986; SER-4993; THR-5009; SER-5077; SER-5099; SER-5110; SER-5332; THR-5415; SER-5448; SER-5552; SER-5555; SER-5731; SER-5749; SER-5752; SER-5763; SER-5769; SER-5780; SER-5782; SER-5784; SER-5793; THR-5794; SER-5830 AND SER-5841, MASS SPECTROMETRY.
[9]	"Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography." Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J. Proteomics 8:1346-1361(2008) [PubMed: 18318008] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-5841, MASS SPECTROMETRY. Tissue: Liver.
[10]	Carrascal M., Abian J. Submitted (JAN-2008) to UniProtKB Cited for: PHOSPHORYLATION AT SER-5749, MASS SPECTROMETRY.
[11]	"Large-scale characterization of HeLa cell nuclear phosphoproteins." Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-511; SER-559; SER-5448; SER-5731; SER-5752 AND SER-5782, MASS SPECTROMETRY. Tissue: Epithelium.
[12]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-490; SER-511; THR-4766; SER-5077; SER-5110; SER-5397; SER-5448; SER-5552; SER-5620; SER-5731; SER-5739; SER-5752; SER-5780; SER-5782; SER-5841; SER-5851; SER-5854 AND SER-5857, MASS SPECTROMETRY. Tissue: Epithelium.
[13]	"A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed: 16964243] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-41; SER-511; SER-5731 AND SER-5763, MASS SPECTROMETRY. Tissue: Epithelium.
[14]	"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra." Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D. J. Proteome Res. 6:4150-4162(2007) [PubMed: 17924679] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-490; SER-511; SER-4986; SER-5099; SER-5110; SER-5552 AND SER-5731, MASS SPECTROMETRY. Tissue: Epithelium.
[15]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[16]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-177; SER-210; SER-216; THR-3716; SER-5731; SER-5749; SER-5752 AND SER-5763, MASS SPECTROMETRY.
[17]	"An extensive survey of tyrosine phosphorylation revealing new sites in human mammary epithelial cells." Heibeck T.H., Ding S.-J., Opresko L.K., Zhao R., Schepmoes A.A., Yang F., Tolmachev A.V., Monroe M.E., Camp D.G. II, Smith R.D., Wiley H.S., Qian W.-J. J. Proteome Res. 8:3852-3861(2009) [PubMed: 19534553] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-715; TYR-836; TYR-964; TYR-1469; TYR-5089 AND TYR-5836, MASS SPECTROMETRY. Tissue: Mammary epithelium.
[18]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-511; SER-570; SER-2397; SER-5448; SER-5731; SER-5749; SER-5752 AND SER-5763, MASS SPECTROMETRY. Tissue: T-cell.
[19]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-4787, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP001363 Genomic DNA. No translation available. M80899 mRNA. Translation: AAA69898.1. M80902 mRNA. Translation: AAA69899.1. Different initiation.
IPI	IPI00021812.
PIR	A45259.
RefSeq	NP_001611.1.
UniGene	Hs.502756
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q09666.
Protein family/group databases
TCDB	1.A.31.1.4. annexin family.
PTM databases
PhosphoSite	Q09666.
Proteomic databases
PeptideAtlas	Q09666.
PRIDE	Q09666.
Genome annotation databases
Ensembl	ENST00000378024; ENSP00000367263; ENSG00000124942; Homo sapiens. [Genome view]
GeneID	79026.
KEGG	hsa:79026.
UCSC	uc001ntl.1. human.
Organism-specific databases
CTD	79026.
GeneCards	GC11M062040.
HGNC	HGNC:347. AHNAK.
HPA	HPA019010. HPA019070.
MIM	103390. gene.
PharmGKB	PA24640.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q09666.
OrthoDB	EOG95QKZB
Gene expression databases
ArrayExpress	Q09666.
Bgee	Q09666.
CleanEx	HS_AHNAK.
Genevestigator	Q09666.
GermOnline	ENSG00000124942. Homo sapiens.
Family and domain databases
InterPro	IPR007597. CheC. IPR001478. PDZ/DHR/GLGF. [Graphical view]
Pfam	PF04509. CheC. 33 hits. PF00595. PDZ. 1 hit. [Graphical view]
SMART	SM00228. PDZ. 1 hit. [Graphical view]
PROSITE	PS50106. PDZ. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	67715.
SOURCE	Search...

Entry information

Entry name

AHNK_HUMAN

Accession

Primary (citable) accession number: Q09666

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	November 13, 2007
Last modified:	November 24, 2009
This is version 73 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.