Q09654 (TRI23_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
E3 ubiquitin-protein ligase arc-1
EC=6.3.2.-

Alternative name(s):
Putative GTP-binding protein trim-23 homolog

Gene names

Name:	arc-1
Synonyms:	arl-4
ORF Names:	ZK1320.6

Organism

Caenorhabditis elegans [Reference proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	539 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Acts as an E3 ubiquitin-protein ligase By similarity.
Pathway	Protein modification; protein ubiquitination.
Sequence similarities	In the C-terminal section; belongs to the small GTPase superfamily. Arf family. Contains 1 B box-type zinc finger. Contains 1 RING-type zinc finger.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Domain	Zinc-finger
Ligand	GTP-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Ligase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein ubiquitination Inferred from electronic annotation. Source: UniProtKB-UniPathway small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular_function	GTP binding Non-traceable author statement. Source: UniProtKB ligase activity Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Non-traceable author statement. Source: UniProtKB zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 539	539	E3 ubiquitin-protein ligase arc-1		PRO_0000207486
Regions
	Zinc finger	6 – 53	48	RING-type
	Zinc finger	103 – 149	47	B box-type
	Nucleotide binding	376 – 383	8	GTP By similarity
	Nucleotide binding	422 – 426	5	GTP By similarity
	Nucleotide binding	481 – 484	4	GTP By similarity
	Region	369 – 539	171	ARF-like

Sequences

	Sequence		Length	Mass (Da)
	Q09654 [UniParc]. Last modified May 24, 2005. Version 3. Checksum: 79F959556BB0755A	FASTA	539	60,682
	10 20 30 40 50 60 MNEYGCNVCN EEYSARDPLK CPRVLTGCGH TICHNCAISI AGRNSSIFCP FDRTATQIPG 70 80 90 100 110 120 GDLQNLKKNF ALLELLEKIA DGGGLLEKSG EVVKFDRYSK ERLLNLECDE DSEHVAVIYC 130 140 150 160 170 180 TVCDSNLCER CSESTHSTNV LSKHRRIPLT EKPPPLVHCR LHSSYVVEFV CKELSCDTES 190 200 210 220 230 240 PLMCMMCRDY GRHKGHSHVL IEKEVEDLRE KVREHLGELS KQSETIGNAL HSIDSVIHEL 250 260 270 280 290 300 TPGQEDGSLE ETRQEVRNHF RRLRTALDRD EEDAVETVDR YARNRVESLQ TQKERLEAIS 310 320 330 340 350 360 SKIGNTCTTL QKALIMERGK ILDRKDDLLA LAESTAAEPT AVLDQSQLST RIAFSFLNDR 370 380 390 400 410 420 KLHIGDFIES RVVLLGLDGA GKTSIVRRLK KVQMDTVMAP HPTIGFNIET IHYKNYRLNF 430 440 450 460 470 480 WDVGGLPKLR HLWKHYYSNA QAIFYVIDGY AVERFSEAIK ELNRVMSDPL VGTCPVIVAV 490 500 510 520 530 NRKDGYALNG HMDALLSQLE ALPFQHHFHC CDAATGSGID QIIDQITVCL SRLNGTCPV

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z46934 Genomic DNA. Translation: CAA87044.3.
PIR	T27752.
RefSeq	NP_496089.3. NM_063688.5.
3D structure databases
ProteinModelPortal	Q09654.
SMR	Q09654. Positions 368-527.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-3386265.
Proteomic databases
PaxDb	Q09654.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	ZK1320.6.1; ZK1320.6.1; ZK1320.6. ZK1320.6.2; ZK1320.6.2; ZK1320.6.
GeneID	174525.
KEGG	cel:CELE_ZK1320.6.
UCSC	ZK1320.6. c. elegans.
Organism-specific databases
CTD	174525.
WormBase	ZK1320.6; CE37598; WBGene00000180; arc-1.
Phylogenomic databases
eggNOG	COG1100.
GeneTree	ENSGT00700000104039.
InParanoid	Q09654.
KO	K07963.
OMA	RAVRCPF.
Enzyme and pathway databases
UniPathway	UPA00143.
Family and domain databases
Gene3D	3.30.40.10. 2 hits.
InterPro	IPR003649. Bbox_C. IPR005225. Small_GTP-bd_dom. IPR024156. Small_GTPase_ARF. IPR006689. Small_GTPase_ARF/SAR. IPR000315. Znf_B-box. IPR007087. Znf_C2H2. IPR001841. Znf_RING. IPR013083. Znf_RING/FYVE/PHD. IPR017907. Znf_RING_CS. [Graphical view]
Pfam	PF00025. Arf. 1 hit. PF00643. zf-B_box. 1 hit. [Graphical view]
PRINTS	PR00328. SAR1GTPBP.
SMART	SM00502. BBC. 1 hit. SM00336. BBOX. 2 hits. SM00184. RING. 1 hit. [Graphical view]
TIGRFAMs	TIGR00231. small_GTP. 1 hit.
PROSITE	PS51417. ARF. 1 hit. PS50119. ZF_BBOX. 1 hit. PS00518. ZF_RING_1. 1 hit. PS50089. ZF_RING_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	884400.

Entry information

Entry name

TRI23_CAEEL

Accession

Primary (citable) accession number: Q09654

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2003
Last sequence update:	May 24, 2005
Last modified:	May 1, 2013
This is version 100 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project