Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

E3 ubiquitin-protein ligase arc-1

Gene

arc-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Acts as an E3 ubiquitin-protein ligase.By similarity

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri6 – 53RING-typePROSITE-ProRule annotationAdd BLAST48
Zinc fingeri103 – 149B box-typePROSITE-ProRule annotationAdd BLAST47
Nucleotide bindingi376 – 383GTPBy similarity8
Nucleotide bindingi422 – 426GTPBy similarity5
Nucleotide bindingi481 – 484GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandGTP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase arc-1 (EC:2.3.2.27)
Alternative name(s):
Putative GTP-binding protein trim-23 homolog
RING-type E3 ubiquitin transferase arc-1Curated
Gene namesi
Name:arc-1
Synonyms:arl-4
ORF Names:ZK1320.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiZK1320.6; CE37598; WBGene00000180; arc-1.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002074861 – 539E3 ubiquitin-protein ligase arc-1Add BLAST539

Proteomic databases

PaxDbiQ09654.

Expressioni

Gene expression databases

BgeeiWBGene00000180.

Interactioni

Protein-protein interaction databases

IntActiQ09654. 1 interactor.
MINTiMINT-3386265.
STRINGi6239.ZK1320.6.2.

Structurei

3D structure databases

ProteinModelPortaliQ09654.
SMRiQ09654.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni369 – 539ARF-likeAdd BLAST171

Sequence similaritiesi

In the C-terminal section; belongs to the small GTPase superfamily. Arf family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri6 – 53RING-typePROSITE-ProRule annotationAdd BLAST48
Zinc fingeri103 – 149B box-typePROSITE-ProRule annotationAdd BLAST47

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG0070. Eukaryota.
KOG4185. Eukaryota.
ENOG410ZGPK. LUCA.
GeneTreeiENSGT00780000121855.
InParanoidiQ09654.
KOiK07963.
OMAiRAVRCPF.
OrthoDBiEOG091G05L6.
PhylomeDBiQ09654.

Family and domain databases

Gene3Di3.30.40.10. 2 hits.
3.40.50.300. 1 hit.
InterProiView protein in InterPro
IPR003649. Bbox_C.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
IPR027370. Znf-RING_LisH.
IPR000315. Znf_B-box.
IPR007087. Znf_C2H2.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
PfamiView protein in Pfam
PF00025. Arf. 1 hit.
PF00643. zf-B_box. 1 hit.
PF13445. zf-RING_UBOX. 1 hit.
PRINTSiPR00328. SAR1GTPBP.
SMARTiView protein in SMART
SM00502. BBC. 1 hit.
SM00336. BBOX. 2 hits.
SM00184. RING. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiView protein in PROSITE
PS51417. ARF. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q09654-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNEYGCNVCN EEYSARDPLK CPRVLTGCGH TICHNCAISI AGRNSSIFCP
60 70 80 90 100
FDRTATQIPG GDLQNLKKNF ALLELLEKIA DGGGLLEKSG EVVKFDRYSK
110 120 130 140 150
ERLLNLECDE DSEHVAVIYC TVCDSNLCER CSESTHSTNV LSKHRRIPLT
160 170 180 190 200
EKPPPLVHCR LHSSYVVEFV CKELSCDTES PLMCMMCRDY GRHKGHSHVL
210 220 230 240 250
IEKEVEDLRE KVREHLGELS KQSETIGNAL HSIDSVIHEL TPGQEDGSLE
260 270 280 290 300
ETRQEVRNHF RRLRTALDRD EEDAVETVDR YARNRVESLQ TQKERLEAIS
310 320 330 340 350
SKIGNTCTTL QKALIMERGK ILDRKDDLLA LAESTAAEPT AVLDQSQLST
360 370 380 390 400
RIAFSFLNDR KLHIGDFIES RVVLLGLDGA GKTSIVRRLK KVQMDTVMAP
410 420 430 440 450
HPTIGFNIET IHYKNYRLNF WDVGGLPKLR HLWKHYYSNA QAIFYVIDGY
460 470 480 490 500
AVERFSEAIK ELNRVMSDPL VGTCPVIVAV NRKDGYALNG HMDALLSQLE
510 520 530
ALPFQHHFHC CDAATGSGID QIIDQITVCL SRLNGTCPV
Length:539
Mass (Da):60,682
Last modified:May 24, 2005 - v3
Checksum:i79F959556BB0755A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46934 Genomic DNA. Translation: CAA87044.3.
PIRiT27752.
RefSeqiNP_496089.3. NM_063688.5.
UniGeneiCel.8296.

Genome annotation databases

EnsemblMetazoaiZK1320.6; ZK1320.6; WBGene00000180.
GeneIDi174525.
KEGGicel:CELE_ZK1320.6.
UCSCiZK1320.6. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46934 Genomic DNA. Translation: CAA87044.3.
PIRiT27752.
RefSeqiNP_496089.3. NM_063688.5.
UniGeneiCel.8296.

3D structure databases

ProteinModelPortaliQ09654.
SMRiQ09654.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ09654. 1 interactor.
MINTiMINT-3386265.
STRINGi6239.ZK1320.6.2.

Proteomic databases

PaxDbiQ09654.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiZK1320.6; ZK1320.6; WBGene00000180.
GeneIDi174525.
KEGGicel:CELE_ZK1320.6.
UCSCiZK1320.6. c. elegans.

Organism-specific databases

CTDi174525.
WormBaseiZK1320.6; CE37598; WBGene00000180; arc-1.

Phylogenomic databases

eggNOGiKOG0070. Eukaryota.
KOG4185. Eukaryota.
ENOG410ZGPK. LUCA.
GeneTreeiENSGT00780000121855.
InParanoidiQ09654.
KOiK07963.
OMAiRAVRCPF.
OrthoDBiEOG091G05L6.
PhylomeDBiQ09654.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

PROiQ09654.

Gene expression databases

BgeeiWBGene00000180.

Family and domain databases

Gene3Di3.30.40.10. 2 hits.
3.40.50.300. 1 hit.
InterProiView protein in InterPro
IPR003649. Bbox_C.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
IPR027370. Znf-RING_LisH.
IPR000315. Znf_B-box.
IPR007087. Znf_C2H2.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
PfamiView protein in Pfam
PF00025. Arf. 1 hit.
PF00643. zf-B_box. 1 hit.
PF13445. zf-RING_UBOX. 1 hit.
PRINTSiPR00328. SAR1GTPBP.
SMARTiView protein in SMART
SM00502. BBC. 1 hit.
SM00336. BBOX. 2 hits.
SM00184. RING. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiView protein in PROSITE
PS51417. ARF. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTRI23_CAEEL
AccessioniPrimary (citable) accession number: Q09654
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: May 24, 2005
Last modified: March 15, 2017
This is version 124 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.