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Protein

Putative cytochrome P450 CYP13A10

Gene

cyp-13A10

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi465 – 4651Iron (heme axial ligand)By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-CEL-211979. Eicosanoids.
R-CEL-2162123. Synthesis of Prostaglandins (PG) and Thromboxanes (TX).

Names & Taxonomyi

Protein namesi
Recommended name:
Putative cytochrome P450 CYP13A10 (EC:1.14.-.-)
Gene namesi
Name:cyp-13A10
Synonyms:cyp13a10
ORF Names:ZK1320.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiZK1320.4; CE37736; WBGene00014254; cyp-13A10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei3 – 2321HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 519519Putative cytochrome P450 CYP13A10PRO_0000052269Add
BLAST

Proteomic databases

PaxDbiQ09653.

Interactioni

Protein-protein interaction databases

STRINGi6239.ZK1320.4.

Structurei

3D structure databases

ProteinModelPortaliQ09653.
SMRiQ09653. Positions 26-509.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0158. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118816.
HOGENOMiHOG000016177.
InParanoidiQ09653.
KOiK17861.
OMAiEVGTMVQ.
OrthoDBiEOG7W6WKQ.
PhylomeDBiQ09653.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q09653-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVILLAIPT LFIGFISYYL WIWTYWRRRG IPGPLGYPLV GSFPKTLKSE
60 70 80 90 100
YPQYLQIRDW TKLYGPIYGY TEGTIKTLIV SDIDIVRQIF VEQYDNFYGR
110 120 130 140 150
KLNPIQGDPE KDERTNLFSA QGFRWKRLRA ISSPTFSNNS LRKINVTVED
160 170 180 190 200
SAMELLRHIE EQTSEGQQID MLQFYQEFTM DTIGRIAMGQ TDSQMFKNPL
210 220 230 240 250
LKFVRAIFGD NRKHIPLIGG VFPTLAQVFR FFMLKFPLLG AANFIHVNKT
260 270 280 290 300
VVTAVQNRID QRENDRKNGI EIGEPQDFID LFLEARADDV EHFQENNGDF
310 320 330 340 350
SKTSSYGNRQ LTTQEIVGQC LVFLIAGFDT TALSLSYTTF LLATHPEVQK
360 370 380 390 400
KLQEEIEREC IEPSISFDHL SKLKYMDCII KETLRLYPLG TMANSRRCMR
410 420 430 440 450
ATKLGNVEVE VGTMVQVDTW SLHTDTKIWG DDAKEFKPER WLDPNCDQVF
460 470 480 490 500
QKGGYISFGL GPRQCVGMRL AYMEEKMLLA HILRKYTFEV GTKTEIPLKL
510
VGRATTQPET VWMHLKQRI
Length:519
Mass (Da):60,017
Last modified:May 10, 2005 - v3
Checksum:iAFC961B7E214B12A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46934 Genomic DNA. Translation: CAA87042.3.
PIRiT27750.
RefSeqiNP_496085.3. NM_063684.4.
UniGeneiCel.7908.

Genome annotation databases

EnsemblMetazoaiZK1320.4; ZK1320.4; WBGene00014254.
GeneIDi174522.
KEGGicel:CELE_ZK1320.4.
UCSCiZK1320.4. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46934 Genomic DNA. Translation: CAA87042.3.
PIRiT27750.
RefSeqiNP_496085.3. NM_063684.4.
UniGeneiCel.7908.

3D structure databases

ProteinModelPortaliQ09653.
SMRiQ09653. Positions 26-509.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.ZK1320.4.

Proteomic databases

PaxDbiQ09653.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiZK1320.4; ZK1320.4; WBGene00014254.
GeneIDi174522.
KEGGicel:CELE_ZK1320.4.
UCSCiZK1320.4. c. elegans.

Organism-specific databases

CTDi174522.
WormBaseiZK1320.4; CE37736; WBGene00014254; cyp-13A10.

Phylogenomic databases

eggNOGiKOG0158. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118816.
HOGENOMiHOG000016177.
InParanoidiQ09653.
KOiK17861.
OMAiEVGTMVQ.
OrthoDBiEOG7W6WKQ.
PhylomeDBiQ09653.

Enzyme and pathway databases

ReactomeiR-CEL-211979. Eicosanoids.
R-CEL-2162123. Synthesis of Prostaglandins (PG) and Thromboxanes (TX).

Miscellaneous databases

NextBioi884386.
PROiQ09653.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiC13AA_CAEEL
AccessioniPrimary (citable) accession number: Q09653
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 10, 2005
Last modified: May 11, 2016
This is version 109 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.