Q09653 (C13AA_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative cytochrome P450 CYP13A10
EC=1.14.-.-

Gene names

Name:	cyp-13A10
Synonyms:	cyp13a10
ORF Names:	ZK1320.4

Organism

Caenorhabditis elegans

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	519 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Cofactor	Heme group By similarity.
Subcellular location	Membrane; Single-pass membrane protein Potential.
Sequence similarities	Belongs to the cytochrome P450 family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	epoxygenase P450 pathway Non-traceable author statement. Source: UniProtKB
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro monooxygenase activity Inferred from electronic annotation. Source: UniProtKB-KW oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 519	519	Putative cytochrome P450 CYP13A10		PRO_0000052269
Regions
	Transmembrane	3 – 23	21	Helical; Potential
Sites
	Metal binding	465	1	Iron (heme axial ligand) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q09653 [UniParc]. Last modified May 10, 2005. Version 3. Checksum: AFC961B7E214B12A	FASTA	519	60,017
	10 20 30 40 50 60 MSVILLAIPT LFIGFISYYL WIWTYWRRRG IPGPLGYPLV GSFPKTLKSE YPQYLQIRDW 70 80 90 100 110 120 TKLYGPIYGY TEGTIKTLIV SDIDIVRQIF VEQYDNFYGR KLNPIQGDPE KDERTNLFSA 130 140 150 160 170 180 QGFRWKRLRA ISSPTFSNNS LRKINVTVED SAMELLRHIE EQTSEGQQID MLQFYQEFTM 190 200 210 220 230 240 DTIGRIAMGQ TDSQMFKNPL LKFVRAIFGD NRKHIPLIGG VFPTLAQVFR FFMLKFPLLG 250 260 270 280 290 300 AANFIHVNKT VVTAVQNRID QRENDRKNGI EIGEPQDFID LFLEARADDV EHFQENNGDF 310 320 330 340 350 360 SKTSSYGNRQ LTTQEIVGQC LVFLIAGFDT TALSLSYTTF LLATHPEVQK KLQEEIEREC 370 380 390 400 410 420 IEPSISFDHL SKLKYMDCII KETLRLYPLG TMANSRRCMR ATKLGNVEVE VGTMVQVDTW 430 440 450 460 470 480 SLHTDTKIWG DDAKEFKPER WLDPNCDQVF QKGGYISFGL GPRQCVGMRL AYMEEKMLLA 490 500 510 HILRKYTFEV GTKTEIPLKL VGRATTQPET VWMHLKQRI

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z46934 Genomic DNA. Translation: CAA87042.3.
PIR	T27750.
RefSeq	NP_496085.3. NM_063684.3.
UniGene	Cel.7908.
3D structure databases
ProteinModelPortal	Q09653.
SMR	Q09653. Positions 28-518.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	ZK1320.4; ZK1320.4; ZK1320.4.
GeneID	174522.
KEGG	cel:ZK1320.4.
UCSC	ZK1320.4. c. elegans.
Organism-specific databases
CTD	174522.
WormBase	ZK1320.4; CE37736; WBGene00014254; cyp-13A10.
Phylogenomic databases
eggNOG	meNOG09107.
GeneTree	EMGT00050000001178.
HOGENOM	HBG389200.
InParanoid	Q09653.
OMA	DDAKEFK.
PhylomeDB	Q09653.
Gene expression databases
ArrayExpress	Q09653.
Family and domain databases
InterPro	IPR001128. Cyt_P450. IPR017972. Cyt_P450_CS. IPR002401. Cyt_P450_E_grp-I. [Graphical view]
Gene3D	G3DSA:1.10.630.10. Cyt_P450. 1 hit.
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00463. EP450I. PR00385. P450.
SUPFAM	SSF48264. Cytochrome_P450. 1 hit.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	884386.

Entry information

Entry name

C13AA_CAEEL

Accession

Primary (citable) accession number: Q09653

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	May 10, 2005
Last modified:	September 21, 2011
This is version 76 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project