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Protein

Glutathione S-transferase kappa 1

Gene

gstk-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei53 – 531GlutathioneBy similarity

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB-EC
  2. protein disulfide oxidoreductase activity Source: InterPro

GO - Biological processi

  1. innate immune response Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase kappa 1 (EC:2.5.1.18)
Alternative name(s):
GST class-kappa
Gene namesi
Name:gstk-1
ORF Names:ZK1320.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome II

Organism-specific databases

WormBaseiZK1320.1; CE01698; WBGene00014251; gstk-1.

Subcellular locationi

GO - Cellular componenti

  1. peroxisome Source: WormBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 226226Glutathione S-transferase kappa 1PRO_0000185895Add
BLAST

Proteomic databases

PaxDbiQ09652.
PRIDEiQ09652.

Interactioni

Protein-protein interaction databases

IntActiQ09652. 1 interaction.
STRINGi6239.ZK1320.1.

Structurei

3D structure databases

ProteinModelPortaliQ09652.
SMRiQ09652. Positions 4-216.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni15 – 173Glutathione bindingBy similarity
Regioni199 – 2002Glutathione bindingBy similarity

Sequence similaritiesi

Belongs to the GST superfamily. Kappa family.Curated

Phylogenomic databases

eggNOGiCOG3917.
GeneTreeiENSGT00440000033697.
HOGENOMiHOG000019211.
InParanoidiQ09652.
KOiK13299.
OMAiQMFWGQD.
OrthoDBiEOG793B9B.
PhylomeDBiQ09652.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR001853. DSBA-like_thioredoxin_dom.
IPR014440. HCCAis_GSTk.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF01323. DSBA. 1 hit.
[Graphical view]
PIRSFiPIRSF006386. HCCAis_GSTk. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.

Sequencei

Sequence statusi: Complete.

Q09652-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPKLPRIDFY FDVISPYSYI AFEVFQKLET QWKGVTIRYI PFFLGAVMKE
60 70 80 90 100
SGNRPPAMLP ARSIMMMTDL KRTAKFWDIP LTPPPLFMEW IKKYRTTGAM
110 120 130 140 150
KVLLVLQEQD KELMLRAARE MWVRLWSRSE KIFEDQDFVE VLKAVGVKNP
160 170 180 190 200
EQIVEKSKDE KYIKILMENT NKGVDLMAYG APWINVHTED GSEHSFFGSD
210 220
RFHLIADLLQ QPQPLPDRLF GQKSKL
Length:226
Mass (Da):26,482
Last modified:November 1, 1996 - v1
Checksum:iDBA39A5994300164
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46934 Genomic DNA. Translation: CAA87039.1.
PIRiT27747.
RefSeqiNP_496082.1. NM_063681.1.
UniGeneiCel.35643.

Genome annotation databases

EnsemblMetazoaiZK1320.1; ZK1320.1; WBGene00014251.
GeneIDi191563.
KEGGicel:CELE_ZK1320.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46934 Genomic DNA. Translation: CAA87039.1.
PIRiT27747.
RefSeqiNP_496082.1. NM_063681.1.
UniGeneiCel.35643.

3D structure databases

ProteinModelPortaliQ09652.
SMRiQ09652. Positions 4-216.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ09652. 1 interaction.
STRINGi6239.ZK1320.1.

Proteomic databases

PaxDbiQ09652.
PRIDEiQ09652.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiZK1320.1; ZK1320.1; WBGene00014251.
GeneIDi191563.
KEGGicel:CELE_ZK1320.1.

Organism-specific databases

CTDi191563.
WormBaseiZK1320.1; CE01698; WBGene00014251; gstk-1.

Phylogenomic databases

eggNOGiCOG3917.
GeneTreeiENSGT00440000033697.
HOGENOMiHOG000019211.
InParanoidiQ09652.
KOiK13299.
OMAiQMFWGQD.
OrthoDBiEOG793B9B.
PhylomeDBiQ09652.

Miscellaneous databases

NextBioi949596.
PROiQ09652.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR001853. DSBA-like_thioredoxin_dom.
IPR014440. HCCAis_GSTk.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF01323. DSBA. 1 hit.
[Graphical view]
PIRSFiPIRSF006386. HCCAis_GSTk. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiGSTK1_CAEEL
AccessioniPrimary (citable) accession number: Q09652
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: January 7, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.