Q09652 (GSTK1_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutathione S-transferase kappa 1
EC=2.5.1.18

Alternative name(s):
GST class-kappa

Gene names

Name:	gstk-1
ORF Names:	ZK1320.1

Organism

Caenorhabditis elegans [Reference proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	226 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	RX + glutathione = HX + R-S-glutathione.
Sequence similarities	Belongs to the GST superfamily. Kappa family.

Ontologies

Keywords
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	peroxisome Inferred from direct assay PubMed 19663909. Source: WormBase
Molecular_function	glutathione transferase activity Inferred from electronic annotation. Source: EC protein disulfide oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 226	226	Glutathione S-transferase kappa 1		PRO_0000185895
Regions
	Region	15 – 17	3	Glutathione binding By similarity
	Region	199 – 200	2	Glutathione binding By similarity
Sites
	Binding site	53	1	Glutathione By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q09652 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: DBA39A5994300164	FASTA	226	26,482
	10 20 30 40 50 60 MPKLPRIDFY FDVISPYSYI AFEVFQKLET QWKGVTIRYI PFFLGAVMKE SGNRPPAMLP 70 80 90 100 110 120 ARSIMMMTDL KRTAKFWDIP LTPPPLFMEW IKKYRTTGAM KVLLVLQEQD KELMLRAARE 130 140 150 160 170 180 MWVRLWSRSE KIFEDQDFVE VLKAVGVKNP EQIVEKSKDE KYIKILMENT NKGVDLMAYG 190 200 210 220 APWINVHTED GSEHSFFGSD RFHLIADLLQ QPQPLPDRLF GQKSKL

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z46934 Genomic DNA. Translation: CAA87039.1.
PIR	T27747.
RefSeq	NP_496082.1. NM_063681.1.
UniGene	Cel.35643.
3D structure databases
ProteinModelPortal	Q09652.
SMR	Q09652. Positions 4-216.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q09652. 1 interaction.
STRING	6239.ZK1320.1.
Proteomic databases
PaxDb	Q09652.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	ZK1320.1; ZK1320.1; ZK1320.1.
GeneID	191563.
KEGG	cel:CELE_ZK1320.1.
Organism-specific databases
CTD	191563.
WormBase	ZK1320.1; CE01698; WBGene00014251; gstk-1.
Phylogenomic databases
eggNOG	COG3917.
GeneTree	ENSGT00440000033697.
HOGENOM	HOG000019211.
InParanoid	Q09652.
KO	K13299.
OMA	MLPARSI.
Family and domain databases
Gene3D	3.40.30.10. 1 hit.
InterPro	IPR001853. DSBA-like_thioredoxin_dom. IPR014440. HCCAis_GSTk. IPR012336. Thioredoxin-like_fold. [Graphical view]
Pfam	PF01323. DSBA. 1 hit. [Graphical view]
PIRSF	PIRSF006386. HCCAis_GSTk. 1 hit.
SUPFAM	SSF52833. Thiordxn-like_fd. 1 hit.
ProtoNet	Search...
Other
NextBio	949596.

Entry information

Entry name

GSTK1_CAEEL

Accession

Primary (citable) accession number: Q09652

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project