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Protein

Glutathione S-transferase kappa 1

Gene

gstk-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei53GlutathioneBy similarity1

GO - Molecular functioni

GO - Biological processi

  • innate immune response Source: WormBase

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

ReactomeiR-CEL-156590. Glutathione conjugation.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase kappa 1 (EC:2.5.1.18)
Alternative name(s):
GST class-kappa
Gene namesi
Name:gstk-1
ORF Names:ZK1320.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiZK1320.1; CE01698; WBGene00014251; gstk-1.

Subcellular locationi

GO - Cellular componenti

  • peroxisome Source: WormBase

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001858951 – 226Glutathione S-transferase kappa 1Add BLAST226

Proteomic databases

EPDiQ09652.
PaxDbiQ09652.
PeptideAtlasiQ09652.
PRIDEiQ09652.

Expressioni

Gene expression databases

BgeeiWBGene00014251.

Interactioni

Protein-protein interaction databases

IntActiQ09652. 1 interactor.
STRINGi6239.ZK1320.1.

Structurei

3D structure databases

ProteinModelPortaliQ09652.
SMRiQ09652.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni15 – 17Glutathione bindingBy similarity3
Regioni199 – 200Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Kappa family.Curated

Phylogenomic databases

eggNOGiENOG410IJK9. Eukaryota.
COG3917. LUCA.
GeneTreeiENSGT00440000033697.
HOGENOMiHOG000019211.
InParanoidiQ09652.
KOiK13299.
OMAiGGINHLS.
OrthoDBiEOG091G0LCM.
PhylomeDBiQ09652.

Family and domain databases

InterProiView protein in InterPro
IPR001853. DSBA-like_thioredoxin_dom.
IPR014440. HCCAis_GSTk.
IPR012336. Thioredoxin-like_fold.
PfamiView protein in Pfam
PF01323. DSBA. 1 hit.
PIRSFiPIRSF006386. HCCAis_GSTk. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.

Sequencei

Sequence statusi: Complete.

Q09652-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKLPRIDFY FDVISPYSYI AFEVFQKLET QWKGVTIRYI PFFLGAVMKE
60 70 80 90 100
SGNRPPAMLP ARSIMMMTDL KRTAKFWDIP LTPPPLFMEW IKKYRTTGAM
110 120 130 140 150
KVLLVLQEQD KELMLRAARE MWVRLWSRSE KIFEDQDFVE VLKAVGVKNP
160 170 180 190 200
EQIVEKSKDE KYIKILMENT NKGVDLMAYG APWINVHTED GSEHSFFGSD
210 220
RFHLIADLLQ QPQPLPDRLF GQKSKL
Length:226
Mass (Da):26,482
Last modified:November 1, 1996 - v1
Checksum:iDBA39A5994300164
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46934 Genomic DNA. Translation: CAA87039.1.
PIRiT27747.
RefSeqiNP_496082.1. NM_063681.1.
UniGeneiCel.35643.

Genome annotation databases

EnsemblMetazoaiZK1320.1; ZK1320.1; WBGene00014251.
GeneIDi191563.
KEGGicel:CELE_ZK1320.1.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiGSTK1_CAEEL
AccessioniPrimary (citable) accession number: Q09652
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: June 7, 2017
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families