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Protein
Submitted name:

FiZzy Related family

Gene

fzr-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-CEL-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-CEL-176407. Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase.
R-CEL-176408. Regulation of APC/C activators between G1/S and early anaphase.
SignaLinkiQ09649.

Names & Taxonomyi

Protein namesi
Submitted name:
FiZzy Related familyImported
Gene namesi
Name:fzr-1Imported
ORF Names:CELE_ZK1307.6Imported, ZK1307.6Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiZK1307.6; CE01695; WBGene00001510; fzr-1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: WormBase
  • nucleus Source: WormBase
Complete GO annotation...

PTM / Processingi

Proteomic databases

EPDiQ09649.
PaxDbiQ09649.
PRIDEiQ09649.

Interactioni

Protein-protein interaction databases

STRINGi6239.ZK1307.6.

Structurei

3D structure databases

ProteinModelPortaliQ09649.
SMRiQ09649. Positions 376-682.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini434 – 689256WD_REPEATS_REGIONInterPro annotationAdd
BLAST

Keywords - Domaini

RepeatUniRule annotationSAAS annotation, WD repeatSAAS annotation

Phylogenomic databases

eggNOGiKOG0305. Eukaryota.
ENOG410XQ8I. LUCA.
GeneTreeiENSGT00840000129804.
InParanoidiQ09649.
KOiK03364.
OMAiWDVTTQK.
OrthoDBiEOG76X602.
PhylomeDBiQ09649.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR024977. Apc4_WD40_dom.
IPR033010. Cdc20/Fizzy.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR19918. PTHR19918. 3 hits.
PfamiPF12894. ANAPC4_WD40. 1 hit.
PF00400. WD40. 3 hits.
[Graphical view]
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q09649-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEQQPPANS PAIFHSPQAM PVRRTLGPHN SPVKSMSTNS SAHTSPRVTP
60 70 80 90 100
TKGANPYGDR FMPLRQSNIE WNARYHSINS DDDSGFKKPM GTSSCNRHLG
110 120 130 140 150
GGQNSAFMSD SSTHPSSSSL AGLGALATAP SSSQSSLSSH PHQHHNHHSS
160 170 180 190 200
SSSSYHDYYQ GTSSGSGNTS PTAQAACMDD TRSSEAVLRA LLRNEMLKDR
210 220 230 240 250
IDDVKTQVQT SEEVIATFSL GPVVSAFPQP TQESGTRGII PQLERNAYGG
260 270 280 290 300
SVDTVFPVVA NEGIIDVTRI SGAESPTMAQ MMEPRLRCGA DSVADIPLSP
310 320 330 340 350
AASINGDTPT KAPPPALPLS PIVQKQSPAR SLFTYSAKTT PVKYGGQATT
360 370 380 390 400
TATSPFGGPF GVDSQRLLRT PRKPIRKVPK NPYKVLDAPE LQDDFYLNLV
410 420 430 440 450
DWSSQNQLSV GLAACVYLWS ATTSQVIKLC DLGQTNEQDQ VTSVQWCDKG
460 470 480 490 500
DLLAVGTSRG VTQIWDVTTQ KKTRELTGHS SRVGCLAWNA DTICSGSRDR
510 520 530 540 550
TIMHRDIRCD DNDMGRKLTN HRQEVCGLKW SPDKQLLASG GNDNQLLVWN
560 570 580 590 600
LRRNEPIQTY TQHNAAVKAL AWSPHHHGLL VSGGGTADRC LRFWNTLTAQ
610 620 630 640 650
PMQCVDTGSQ VCNVAWSKHS SELVSTHGYS FNHVIIWKYP SLQPVTKLVG
660 670 680 690 700
HQYRVLYLAM SPDGESIVTG AGDETLRFWH VFNKGNPPTI TRSKLNLHST

IR
Length:702
Mass (Da):76,403
Last modified:November 1, 1996 - v1
Checksum:iB4B78432467FB558
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284602 Genomic DNA. Translation: CAA87433.1.
PIRiT27730.
RefSeqiNP_496075.1. NM_063674.4.
UniGeneiCel.13686.

Genome annotation databases

EnsemblMetazoaiZK1307.6; ZK1307.6; WBGene00001510.
GeneIDi174516.
KEGGicel:CELE_ZK1307.6.
UCSCiZK1307.6. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284602 Genomic DNA. Translation: CAA87433.1.
PIRiT27730.
RefSeqiNP_496075.1. NM_063674.4.
UniGeneiCel.13686.

3D structure databases

ProteinModelPortaliQ09649.
SMRiQ09649. Positions 376-682.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.ZK1307.6.

Proteomic databases

EPDiQ09649.
PaxDbiQ09649.
PRIDEiQ09649.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiZK1307.6; ZK1307.6; WBGene00001510.
GeneIDi174516.
KEGGicel:CELE_ZK1307.6.
UCSCiZK1307.6. c. elegans.

Organism-specific databases

CTDi174516.
WormBaseiZK1307.6; CE01695; WBGene00001510; fzr-1.

Phylogenomic databases

eggNOGiKOG0305. Eukaryota.
ENOG410XQ8I. LUCA.
GeneTreeiENSGT00840000129804.
InParanoidiQ09649.
KOiK03364.
OMAiWDVTTQK.
OrthoDBiEOG76X602.
PhylomeDBiQ09649.

Enzyme and pathway databases

ReactomeiR-CEL-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-CEL-176407. Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase.
R-CEL-176408. Regulation of APC/C activators between G1/S and early anaphase.
SignaLinkiQ09649.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR024977. Apc4_WD40_dom.
IPR033010. Cdc20/Fizzy.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR19918. PTHR19918. 3 hits.
PfamiPF12894. ANAPC4_WD40. 1 hit.
PF00400. WD40. 3 hits.
[Graphical view]
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Sulson J.E., Waterston R.
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiQ09649_CAEEL
AccessioniPrimary (citable) accession number: Q09649
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.