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Protein

Tubulin polyglutamylase ttll-4

Gene

ttll-4

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Polyglutamylase involved in side-chain polyglutamylation of tubulin in sensory cilia.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei295 – 2951ATPBy similarity
Binding sitei297 – 2971ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi282 – 2854ATP bindingBy similarity

GO - Molecular functioni

GO - Biological processi

  • protein polyglutamylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin polyglutamylase ttll-4 (EC:6.-.-.-)
Alternative name(s):
Tubulin--tyrosine ligase-like protein 4
Gene namesi
Name:ttll-4
ORF Names:ZK1128.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiZK1128.6a; CE29940; WBGene00014232; ttll-4.
ZK1128.6b; CE38015; WBGene00014232; ttll-4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 601601Tubulin polyglutamylase ttll-4PRO_0000403767Add
BLAST

Proteomic databases

EPDiQ09647.
PaxDbiQ09647.
PRIDEiQ09647.

Expressioni

Tissue specificityi

Expressed in many sensory neurons in amphid.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ09647.
SMRiQ09647. Positions 187-466.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini138 – 476339TTLPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the tubulin--tyrosine ligase family.Curated
Contains 1 TTL domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2156. Eukaryota.
ENOG410XTI2. LUCA.
GeneTreeiENSGT00760000118951.
HOGENOMiHOG000019081.
InParanoidiQ09647.
KOiK16601.
OMAiLRIYLYN.
PhylomeDBiQ09647.

Family and domain databases

InterProiIPR004344. TTL/TTLL_fam.
IPR027748. TTLL-4.
[Graphical view]
PANTHERiPTHR12241:SF9. PTHR12241:SF9. 1 hit.
PfamiPF03133. TTL. 1 hit.
[Graphical view]
PROSITEiPS51221. TTL. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform a (identifier: Q09647-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSGYSSAPS VSHTSSDTDL NRIDSYDDGA EETTDEQRMC GLSELVTSCL
60 70 80 90 100
TSSRLKAIDE EDEEENCNDI EIVGLSKTTT KVKRSKKVLS CPIVSSSTKK
110 120 130 140 150
ENGNAAPFLK SSQFTDVPPT IRFYTKGTKV TKPARKIQAR LTWCHNSLLP
160 170 180 190 200
IVMRQTLAAS HFTVVDESLF YVGYWGRHLK SAQYRALQPH QKVNHFPGAF
210 220 230 240 250
HIGRKDRLWM HIRKQQERFE GEFDIMPFTY ILPTDRQELL KYLETDASRH
260 270 280 290 300
VIVKPPASAR GTGISVTRKP KDFPTTATLV AQHYIERPLT INRAKFDLRL
310 320 330 340 350
YAYVPTFEPL RVYIYDQGLV RFASVPYSHS VSTISNKYMH LTNYSINKLA
360 370 380 390 400
EADGVANKPV PKWTLHHLWE HFDEMGVDRE KIQREIEEVI IKAFISTEKP
410 420 430 440 450
IREHMSRFLE QEFICYELFG IDIILDEDYK PWLLEVNISP SLHSGTPLDV
460 470 480 490 500
SVKAPLAKDV LNLAGVYVPP SFDKLSDADY STRPRNGRKN REQLIKEASW
510 520 530 540 550
VAAYKDQLGV IDNRIFKRLT PEDTRALVEF EDELERIGDF KLVFPTAHTS
560 570 580 590 600
HYQKYFAETI YMNILLQQWQ IAQEDDRSIG INRLEQLCRQ KHMQSDQETS

F
Length:601
Mass (Da):69,188
Last modified:March 1, 2002 - v3
Checksum:i8EF1E33096CD5756
GO
Isoform b (identifier: Q09647-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-38: Missing.

Note: No experimental confirmation available.
Show »
Length:563
Mass (Da):65,093
Checksum:i65F219330BE5274E
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3838Missing in isoform b. CuratedVSP_040444Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z47357 Genomic DNA. Translation: CAA87425.3.
Z47357 Genomic DNA. Translation: CAI46580.1.
PIRiE88575.
T27699.
RefSeqiNP_001022985.1. NM_001027814.2. [Q09647-1]
NP_001022986.1. NM_001027815.3. [Q09647-2]
UniGeneiCel.5668.

Genome annotation databases

EnsemblMetazoaiZK1128.6a; ZK1128.6a; WBGene00014232. [Q09647-1]
GeneIDi176427.
KEGGicel:CELE_ZK1128.6.
UCSCiZK1128.6a. c. elegans. [Q09647-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z47357 Genomic DNA. Translation: CAA87425.3.
Z47357 Genomic DNA. Translation: CAI46580.1.
PIRiE88575.
T27699.
RefSeqiNP_001022985.1. NM_001027814.2. [Q09647-1]
NP_001022986.1. NM_001027815.3. [Q09647-2]
UniGeneiCel.5668.

3D structure databases

ProteinModelPortaliQ09647.
SMRiQ09647. Positions 187-466.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

EPDiQ09647.
PaxDbiQ09647.
PRIDEiQ09647.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiZK1128.6a; ZK1128.6a; WBGene00014232. [Q09647-1]
GeneIDi176427.
KEGGicel:CELE_ZK1128.6.
UCSCiZK1128.6a. c. elegans. [Q09647-1]

Organism-specific databases

CTDi176427.
WormBaseiZK1128.6a; CE29940; WBGene00014232; ttll-4.
ZK1128.6b; CE38015; WBGene00014232; ttll-4.

Phylogenomic databases

eggNOGiKOG2156. Eukaryota.
ENOG410XTI2. LUCA.
GeneTreeiENSGT00760000118951.
HOGENOMiHOG000019081.
InParanoidiQ09647.
KOiK16601.
OMAiLRIYLYN.
PhylomeDBiQ09647.

Miscellaneous databases

PROiQ09647.

Family and domain databases

InterProiIPR004344. TTL/TTLL_fam.
IPR027748. TTLL-4.
[Graphical view]
PANTHERiPTHR12241:SF9. PTHR12241:SF9. 1 hit.
PfamiPF03133. TTL. 1 hit.
[Graphical view]
PROSITEiPS51221. TTL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "Identification of tubulin deglutamylase among Caenorhabditis elegans and mammalian cytosolic carboxypeptidases (CCPs)."
    Kimura Y., Kurabe N., Ikegami K., Tsutsumi K., Konishi Y., Kaplan O.I., Kunitomo H., Iino Y., Blacque O.E., Setou M.
    J. Biol. Chem. 285:22936-22941(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiTTLL4_CAEEL
AccessioniPrimary (citable) accession number: Q09647
Secondary accession number(s): Q5FC81
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: March 1, 2002
Last modified: June 8, 2016
This is version 102 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.