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Protein

Tubulin polyglutamylase ttll-4

Gene

ttll-4

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Polyglutamylase involved in side-chain polyglutamylation of tubulin in sensory cilia.1 Publication

Caution

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei295ATPBy similarity1
Binding sitei297ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi282 – 285ATP bindingBy similarity4

GO - Molecular functioni

GO - Biological processi

  • protein polyglutamylation Source: UniProtKB

Keywordsi

Molecular functionLigase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin polyglutamylase ttll-4 (EC:6.-.-.-)
Alternative name(s):
Tubulin--tyrosine ligase-like protein 4
Gene namesi
Name:ttll-4
ORF Names:ZK1128.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiZK1128.6a ; CE29940 ; WBGene00014232 ; ttll-4
ZK1128.6b ; CE38015 ; WBGene00014232 ; ttll-4

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004037671 – 601Tubulin polyglutamylase ttll-4Add BLAST601

Proteomic databases

EPDiQ09647
PaxDbiQ09647
PeptideAtlasiQ09647

Expressioni

Tissue specificityi

Expressed in many sensory neurons in amphid.1 Publication

Gene expression databases

BgeeiWBGene00014232

Interactioni

Protein-protein interaction databases

STRINGi6239.ZK1128.6a

Structurei

3D structure databases

ProteinModelPortaliQ09647
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini138 – 476TTLPROSITE-ProRule annotationAdd BLAST339

Sequence similaritiesi

Belongs to the tubulin--tyrosine ligase family.Curated

Phylogenomic databases

eggNOGiKOG2156 Eukaryota
ENOG410XTI2 LUCA
GeneTreeiENSGT00760000118951
HOGENOMiHOG000019081
InParanoidiQ09647
KOiK16601
OMAiVPRTYVL
OrthoDBiEOG091G03UM
PhylomeDBiQ09647

Family and domain databases

Gene3Di3.30.1490.201 hit
InterProiView protein in InterPro
IPR013815 ATP_grasp_subdomain_1
IPR004344 TTL/TTLL_fam
IPR027748 TTLL-4
PANTHERiPTHR12241:SF145 PTHR12241:SF145, 1 hit
PfamiView protein in Pfam
PF03133 TTL, 1 hit
PROSITEiView protein in PROSITE
PS51221 TTL, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform a (identifier: Q09647-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSGYSSAPS VSHTSSDTDL NRIDSYDDGA EETTDEQRMC GLSELVTSCL
60 70 80 90 100
TSSRLKAIDE EDEEENCNDI EIVGLSKTTT KVKRSKKVLS CPIVSSSTKK
110 120 130 140 150
ENGNAAPFLK SSQFTDVPPT IRFYTKGTKV TKPARKIQAR LTWCHNSLLP
160 170 180 190 200
IVMRQTLAAS HFTVVDESLF YVGYWGRHLK SAQYRALQPH QKVNHFPGAF
210 220 230 240 250
HIGRKDRLWM HIRKQQERFE GEFDIMPFTY ILPTDRQELL KYLETDASRH
260 270 280 290 300
VIVKPPASAR GTGISVTRKP KDFPTTATLV AQHYIERPLT INRAKFDLRL
310 320 330 340 350
YAYVPTFEPL RVYIYDQGLV RFASVPYSHS VSTISNKYMH LTNYSINKLA
360 370 380 390 400
EADGVANKPV PKWTLHHLWE HFDEMGVDRE KIQREIEEVI IKAFISTEKP
410 420 430 440 450
IREHMSRFLE QEFICYELFG IDIILDEDYK PWLLEVNISP SLHSGTPLDV
460 470 480 490 500
SVKAPLAKDV LNLAGVYVPP SFDKLSDADY STRPRNGRKN REQLIKEASW
510 520 530 540 550
VAAYKDQLGV IDNRIFKRLT PEDTRALVEF EDELERIGDF KLVFPTAHTS
560 570 580 590 600
HYQKYFAETI YMNILLQQWQ IAQEDDRSIG INRLEQLCRQ KHMQSDQETS

F
Length:601
Mass (Da):69,188
Last modified:March 1, 2002 - v3
Checksum:i8EF1E33096CD5756
GO
Isoform b (identifier: Q09647-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-38: Missing.

Note: No experimental confirmation available.
Show »
Length:563
Mass (Da):65,093
Checksum:i65F219330BE5274E
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0404441 – 38Missing in isoform b. CuratedAdd BLAST38

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z47357 Genomic DNA Translation: CAA87425.3
Z47357 Genomic DNA Translation: CAI46580.1
PIRiE88575
T27699
RefSeqiNP_001022985.1, NM_001027814.2 [Q09647-1]
NP_001022986.1, NM_001027815.3 [Q09647-2]
UniGeneiCel.5668

Genome annotation databases

EnsemblMetazoaiZK1128.6a; ZK1128.6a; WBGene00014232 [Q09647-1]
GeneIDi176427
KEGGicel:CELE_ZK1128.6
UCSCiZK1128.6a c. elegans

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTTLL4_CAEEL
AccessioniPrimary (citable) accession number: Q09647
Secondary accession number(s): Q5FC81
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: March 1, 2002
Last modified: February 28, 2018
This is version 115 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome