Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

G protein-coupled receptor kinase 2

Gene

grk-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Specifically phosphorylates the activated forms of G protein-coupled receptors.By similarity

Catalytic activityi

ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei220 – 2201ATPPROSITE-ProRule annotation
Active sitei318 – 3181Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi197 – 2059ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

  • chemotaxis Source: WormBase
  • hyperosmotic response Source: WormBase
  • multicellular organismal process Source: WormBase
  • olfactory behavior Source: WormBase
  • positive regulation of growth rate Source: WormBase
  • signal transduction Source: InterPro
  • termination of G-protein coupled receptor signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_322035. Calmodulin induced events.
REACT_352961. G alpha (q) signalling events.
SignaLinkiQ09639.

Names & Taxonomyi

Protein namesi
Recommended name:
G protein-coupled receptor kinase 2 (EC:2.7.11.16)
Gene namesi
Name:grk-2
ORF Names:W02B3.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiW02B3.2; CE32946; WBGene00001709; grk-2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 707707G protein-coupled receptor kinase 2PRO_0000086841Add
BLAST

Proteomic databases

PaxDbiQ09639.
PRIDEiQ09639.

Interactioni

Protein-protein interaction databases

IntActiQ09639. 1 interaction.
MINTiMINT-1795241.
STRINGi6239.W02B3.2.

Structurei

3D structure databases

ProteinModelPortaliQ09639.
SMRiQ09639. Positions 30-667.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini54 – 175122RGSPROSITE-ProRule annotationAdd
BLAST
Domaini191 – 455265Protein kinasePROSITE-ProRule annotationAdd
BLAST
Domaini456 – 52368AGC-kinase C-terminalAdd
BLAST
Domaini558 – 658101PHPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 190190N-terminalAdd
BLAST

Sequence similaritiesi

Contains 1 AGC-kinase C-terminal domain.Curated
Contains 1 PH domain.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 RGS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00770000120493.
HOGENOMiHOG000006742.
InParanoidiQ09639.
KOiK00910.
OMAiDHVQTHL.
OrthoDBiEOG7FV3PP.
PhylomeDBiQ09639.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
InterProiIPR000961. AGC-kinase_C.
IPR000239. GPCR_kinase.
IPR011009. Kinase-like_dom.
IPR011993. PH-like_dom.
IPR001849. PH_domain.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR016137. RGS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR00717. GPCRKINASE.
SMARTiSM00233. PH. 1 hit.
SM00315. RGS. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q09639-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADLEAVLAD VSYLMAMEKS RSQPAARASK RIVLPDPSVR SIMQKFLEKS
60 70 80 90 100
GDMKFDKIFN QKLGFLLLKD YAENVSESPC PQIKFYEAIK EYEKMETPDE
110 120 130 140 150
RLTKAREIYD HHIMVEMLAH AHNYSKESLQ HVQYHLLKQN VPPDLFHRYV
160 170 180 190 200
LEICDQLRGD IFQRFLESDK FTRFCQWKNL ELNMQLTMND FSVHRIIGRG
210 220 230 240 250
GFGEVYGCRK ADTGKMYAMK CLDKKRIKMK QGETLALNER IMLSLVSTGQ
260 270 280 290 300
DCPFIVCMTY AFQSPDKLCF ILDLMNGGDL HYHLSQHGVF TEQEMIFYAS
310 320 330 340 350
EVILGLEHMH NRFVVYRDLK PANILLDENG HVRVSDLGLA CDYSKKKPHA
360 370 380 390 400
SVGTHGYMAP EVLAKGVAYD SSADWFSLGC MLYKLLKGHS PFRQHKSKDK
410 420 430 440 450
NEIDKMTLTQ DIELPNEGLS KDCRDLLEGL LKRDVPDRLG CRGKGPTEVK
460 470 480 490 500
EHPFFKDVDW QTVYLRRMTP PLIPPRGEVN AADAFDIGNF DDDEVKGVKL
510 520 530 540 550
QDGDSDLYKN FNIVISERWQ NEIAETIFEV VNQDADKAES KKRSKQKIKV
560 570 580 590 600
AVEEKDSDVI VHGYIKKLGG PFTSAWQTKY GKLYPSRLEL YPESLTAKPE
610 620 630 640 650
LVFMDQIEDV CAEMQTIKGE TAIIVKLRDG FKEPKICLTN SDEISLKEWH
660 670 680 690 700
TSLRTAHKVS QELLQRMGRK AIKIYGVNHD PMLSESERPG SVTRAFLNRA

SSVDSGV
Length:707
Mass (Da):80,978
Last modified:April 23, 2003 - v2
Checksum:iD37F03260F324939
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080476 Genomic DNA. Translation: CCD63981.1.
PIRiT26096.
RefSeqiNP_497235.2. NM_064834.4.
UniGeneiCel.9949.

Genome annotation databases

EnsemblMetazoaiW02B3.2; W02B3.2; WBGene00001709.
GeneIDi175223.
KEGGicel:CELE_W02B3.2.
UCSCiW02B3.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080476 Genomic DNA. Translation: CCD63981.1.
PIRiT26096.
RefSeqiNP_497235.2. NM_064834.4.
UniGeneiCel.9949.

3D structure databases

ProteinModelPortaliQ09639.
SMRiQ09639. Positions 30-667.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ09639. 1 interaction.
MINTiMINT-1795241.
STRINGi6239.W02B3.2.

Proteomic databases

PaxDbiQ09639.
PRIDEiQ09639.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiW02B3.2; W02B3.2; WBGene00001709.
GeneIDi175223.
KEGGicel:CELE_W02B3.2.
UCSCiW02B3.2. c. elegans.

Organism-specific databases

CTDi175223.
WormBaseiW02B3.2; CE32946; WBGene00001709; grk-2.

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00770000120493.
HOGENOMiHOG000006742.
InParanoidiQ09639.
KOiK00910.
OMAiDHVQTHL.
OrthoDBiEOG7FV3PP.
PhylomeDBiQ09639.

Enzyme and pathway databases

ReactomeiREACT_322035. Calmodulin induced events.
REACT_352961. G alpha (q) signalling events.
SignaLinkiQ09639.

Miscellaneous databases

NextBioi887266.
PROiQ09639.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
InterProiIPR000961. AGC-kinase_C.
IPR000239. GPCR_kinase.
IPR011009. Kinase-like_dom.
IPR011993. PH-like_dom.
IPR001849. PH_domain.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR016137. RGS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR00717. GPCRKINASE.
SMARTiSM00233. PH. 1 hit.
SM00315. RGS. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiGRK2_CAEEL
AccessioniPrimary (citable) accession number: Q09639
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: April 23, 2003
Last modified: July 22, 2015
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.