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Q09639

- GRK2_CAEEL

UniProt

Q09639 - GRK2_CAEEL

Protein

G protein-coupled receptor kinase 2

Gene

grk-2

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 2 (23 Apr 2003)
      Previous versions | rss
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    Functioni

    Specifically phosphorylates the activated forms of G protein-coupled receptors.By similarity

    Catalytic activityi

    ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei220 – 2201ATPPROSITE-ProRule annotation
    Active sitei318 – 3181Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi197 – 2059ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. G-protein coupled receptor kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. chemotaxis Source: WormBase
    2. hyperosmotic response Source: WormBase
    3. multicellular organismal process Source: WormBase
    4. olfactory behavior Source: WormBase
    5. positive regulation of growth rate Source: WormBase
    6. signal transduction Source: InterPro
    7. termination of G-protein coupled receptor signaling pathway Source: InterPro

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    SignaLinkiQ09639.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    G protein-coupled receptor kinase 2 (EC:2.7.11.16)
    Gene namesi
    Name:grk-2
    ORF Names:W02B3.2
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome III

    Organism-specific databases

    WormBaseiW02B3.2; CE32946; WBGene00001709; grk-2.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 707707G protein-coupled receptor kinase 2PRO_0000086841Add
    BLAST

    Proteomic databases

    PaxDbiQ09639.
    PRIDEiQ09639.

    Interactioni

    Protein-protein interaction databases

    IntActiQ09639. 1 interaction.
    MINTiMINT-1795241.
    STRINGi6239.W02B3.2.

    Structurei

    3D structure databases

    ProteinModelPortaliQ09639.
    SMRiQ09639. Positions 30-667.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini54 – 175122RGSPROSITE-ProRule annotationAdd
    BLAST
    Domaini191 – 455265Protein kinasePROSITE-ProRule annotationAdd
    BLAST
    Domaini456 – 52368AGC-kinase C-terminalAdd
    BLAST
    Domaini558 – 658101PHPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 190190N-terminalAdd
    BLAST

    Sequence similaritiesi

    Contains 1 AGC-kinase C-terminal domain.Curated
    Contains 1 PH domain.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation
    Contains 1 RGS domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00730000110751.
    HOGENOMiHOG000006742.
    InParanoidiQ09639.
    KOiK00910.
    OMAiQTHLAKK.
    OrthoDBiEOG7FV3PP.
    PhylomeDBiQ09639.

    Family and domain databases

    Gene3Di2.30.29.30. 2 hits.
    InterProiIPR000961. AGC-kinase_C.
    IPR000239. GPCR_kinase.
    IPR011009. Kinase-like_dom.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    PF00615. RGS. 1 hit.
    [Graphical view]
    PRINTSiPR00717. GPCRKINASE.
    SMARTiSM00233. PH. 1 hit.
    SM00315. RGS. 1 hit.
    SM00133. S_TK_X. 1 hit.
    SM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF48097. SSF48097. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    PS50132. RGS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q09639-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADLEAVLAD VSYLMAMEKS RSQPAARASK RIVLPDPSVR SIMQKFLEKS    50
    GDMKFDKIFN QKLGFLLLKD YAENVSESPC PQIKFYEAIK EYEKMETPDE 100
    RLTKAREIYD HHIMVEMLAH AHNYSKESLQ HVQYHLLKQN VPPDLFHRYV 150
    LEICDQLRGD IFQRFLESDK FTRFCQWKNL ELNMQLTMND FSVHRIIGRG 200
    GFGEVYGCRK ADTGKMYAMK CLDKKRIKMK QGETLALNER IMLSLVSTGQ 250
    DCPFIVCMTY AFQSPDKLCF ILDLMNGGDL HYHLSQHGVF TEQEMIFYAS 300
    EVILGLEHMH NRFVVYRDLK PANILLDENG HVRVSDLGLA CDYSKKKPHA 350
    SVGTHGYMAP EVLAKGVAYD SSADWFSLGC MLYKLLKGHS PFRQHKSKDK 400
    NEIDKMTLTQ DIELPNEGLS KDCRDLLEGL LKRDVPDRLG CRGKGPTEVK 450
    EHPFFKDVDW QTVYLRRMTP PLIPPRGEVN AADAFDIGNF DDDEVKGVKL 500
    QDGDSDLYKN FNIVISERWQ NEIAETIFEV VNQDADKAES KKRSKQKIKV 550
    AVEEKDSDVI VHGYIKKLGG PFTSAWQTKY GKLYPSRLEL YPESLTAKPE 600
    LVFMDQIEDV CAEMQTIKGE TAIIVKLRDG FKEPKICLTN SDEISLKEWH 650
    TSLRTAHKVS QELLQRMGRK AIKIYGVNHD PMLSESERPG SVTRAFLNRA 700
    SSVDSGV 707
    Length:707
    Mass (Da):80,978
    Last modified:April 23, 2003 - v2
    Checksum:iD37F03260F324939
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080476 Genomic DNA. Translation: CCD63981.1.
    PIRiT26096.
    RefSeqiNP_497235.2. NM_064834.4.
    UniGeneiCel.9949.

    Genome annotation databases

    EnsemblMetazoaiW02B3.2; W02B3.2; WBGene00001709.
    GeneIDi175223.
    KEGGicel:CELE_W02B3.2.
    UCSCiW02B3.2. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080476 Genomic DNA. Translation: CCD63981.1 .
    PIRi T26096.
    RefSeqi NP_497235.2. NM_064834.4.
    UniGenei Cel.9949.

    3D structure databases

    ProteinModelPortali Q09639.
    SMRi Q09639. Positions 30-667.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q09639. 1 interaction.
    MINTi MINT-1795241.
    STRINGi 6239.W02B3.2.

    Proteomic databases

    PaxDbi Q09639.
    PRIDEi Q09639.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai W02B3.2 ; W02B3.2 ; WBGene00001709 .
    GeneIDi 175223.
    KEGGi cel:CELE_W02B3.2.
    UCSCi W02B3.2. c. elegans.

    Organism-specific databases

    CTDi 175223.
    WormBasei W02B3.2 ; CE32946 ; WBGene00001709 ; grk-2.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00730000110751.
    HOGENOMi HOG000006742.
    InParanoidi Q09639.
    KOi K00910.
    OMAi QTHLAKK.
    OrthoDBi EOG7FV3PP.
    PhylomeDBi Q09639.

    Enzyme and pathway databases

    SignaLinki Q09639.

    Miscellaneous databases

    NextBioi 887266.

    Family and domain databases

    Gene3Di 2.30.29.30. 2 hits.
    InterProi IPR000961. AGC-kinase_C.
    IPR000239. GPCR_kinase.
    IPR011009. Kinase-like_dom.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    PF00615. RGS. 1 hit.
    [Graphical view ]
    PRINTSi PR00717. GPCRKINASE.
    SMARTi SM00233. PH. 1 hit.
    SM00315. RGS. 1 hit.
    SM00133. S_TK_X. 1 hit.
    SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48097. SSF48097. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS51285. AGC_KINASE_CTER. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    PS50132. RGS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiGRK2_CAEEL
    AccessioniPrimary (citable) accession number: Q09639
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: April 23, 2003
    Last modified: October 1, 2014
    This is version 118 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3