Reviewed,
UniProtKB/Swiss-Prot Q09639 (GRK2_CAEEL)
Last modified
November 3, 2009.
Version 78.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: G protein-coupled receptor kinase 2 EC=2.7.11.16 | ||||
| Gene names |
| ||||
| Organism | Caenorhabditis elegans [Complete proteome] | ||||
| Taxonomic identifier | 6239 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Protein attributes
| Sequence length | 707 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Specifically phosphorylates the activated forms of G protein-coupled receptors By similarity. |
| Catalytic activity | ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate. |
| Sequence similarities | Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. Contains 1 AGC-kinase C-terminal domain. Contains 1 PH domain. Contains 1 protein kinase domain. Contains 1 RGS domain. |
Ontologies
| Keywords | |
|---|---|
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Kinase Serine/threonine-protein kinase Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro signal transductionInferred from electronic annotation. Source: InterPro |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW G-protein coupled receptor kinase activityInferred from electronic annotation. Source: EC signal transducer activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 707 | 707 | G protein-coupled receptor kinase 2 | PRO_0000086841 | |||||
Regions | |||||||||
| Domain | 54 – 175 | 122 | RGS | ||||||
| Domain | 191 – 455 | 265 | Protein kinase | ||||||
| Domain | 456 – 523 | 68 | AGC-kinase C-terminal | ||||||
| Domain | 558 – 658 | 101 | PH | ||||||
| Nucleotide binding | 197 – 205 | 9 | ATP By similarity | ||||||
| Region | 1 – 190 | 190 | N-terminal | ||||||
Sites | |||||||||
| Active site | 318 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 220 | 1 | ATP By similarity | ||||||
Sequences
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References
| [1] | "Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| U22833 Genomic DNA. Translation: AAA64322.2. | |
| PIR | T26096. |
| RefSeq | NP_497235.2. |
| UniGene | Cel.9949 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1OMW based on UniProtKB P21146. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q09639. |
Genome annotation databases | |
| Ensembl | W02B3.2; W02B3.2; W02B3.2; Caenorhabditis elegans. [Genome view] |
| GeneID | 175223. |
| KEGG | cel:W02B3.2. |
| NMPDR | fig|6239.3.peg.8512. |
| UCSC | W02B3.2. c. elegans. |
Organism-specific databases | |
| CTD | 175223. |
| WormBase | WBGene00001709. grk-2. |
| WormPep | W02B3.2. CE32946. [WorfDB] |
Phylogenomic databases | |
| OMA | KFLNKPR. |
Enzyme and pathway databases | |
| BRENDA | 2.7.11.16. 672. |
Gene expression databases | |
| ArrayExpress | Q09639. |
Family and domain databases | |
| InterPro | IPR000961. AGC-kinase_C. IPR015743. B-adrenergic_rcpt_kinase. IPR000239. GPCR_kinase. IPR001849. Pleckstrin_homology. IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_BS. IPR000342. Regulat_G_prot_signal. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. IPR002290. Ser_thr_pkinase. [Graphical view] |
| PANTHER | PTHR22985:SF5. BARK. 1 hit. |
| Pfam | PF00169. PH. 1 hit. PF00069. Pkinase. 1 hit. PF00615. RGS. 1 hit. [Graphical view] |
| PRINTS | PR00717. GPCRKINASE. |
| ProDom | PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| SMART | SM00233. PH. 1 hit. SM00315. RGS. 1 hit. SM00133. S_TK_X. 1 hit. SM00220. S_TKc. 1 hit. [Graphical view] |
| PROSITE | PS51285. AGC_KINASE_CTER. 1 hit. PS50003. PH_DOMAIN. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. PS50132. RGS. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 887266. |
Entry information
| Entry name | GRK2_CAEEL | ||||||||
| Accession | Primary (citable) accession number: Q09639 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Caenorhabditis annotation project | ||||||||
Relevant documents
| Caenorhabditis elegans Caenorhabditis elegans: entries, gene names and cross-references to WormPep |
| SIMILARITY comments Index of protein domains and families |

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