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Q09639 (GRK2_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
G protein-coupled receptor kinase 2

EC=2.7.11.16
Gene names
Name:grk-2
ORF Names:W02B3.2
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length707 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Specifically phosphorylates the activated forms of G protein-coupled receptors By similarity.

Catalytic activity

ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate.

Sequence similarities

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

Contains 1 AGC-kinase C-terminal domain.

Contains 1 PH domain.

Contains 1 protein kinase domain.

Contains 1 RGS domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 707707G protein-coupled receptor kinase 2
PRO_0000086841

Regions

Domain54 – 175122RGS
Domain191 – 455265Protein kinase
Domain456 – 52368AGC-kinase C-terminal
Domain558 – 658101PH
Nucleotide binding197 – 2059ATP By similarity
Region1 – 190190N-terminal

Sites

Active site3181Proton acceptor By similarity
Binding site2201ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q09639 [UniParc].

Last modified April 23, 2003. Version 2.
Checksum: D37F03260F324939

FASTA70780,978
        10         20         30         40         50         60 
MADLEAVLAD VSYLMAMEKS RSQPAARASK RIVLPDPSVR SIMQKFLEKS GDMKFDKIFN 

        70         80         90        100        110        120 
QKLGFLLLKD YAENVSESPC PQIKFYEAIK EYEKMETPDE RLTKAREIYD HHIMVEMLAH 

       130        140        150        160        170        180 
AHNYSKESLQ HVQYHLLKQN VPPDLFHRYV LEICDQLRGD IFQRFLESDK FTRFCQWKNL 

       190        200        210        220        230        240 
ELNMQLTMND FSVHRIIGRG GFGEVYGCRK ADTGKMYAMK CLDKKRIKMK QGETLALNER 

       250        260        270        280        290        300 
IMLSLVSTGQ DCPFIVCMTY AFQSPDKLCF ILDLMNGGDL HYHLSQHGVF TEQEMIFYAS 

       310        320        330        340        350        360 
EVILGLEHMH NRFVVYRDLK PANILLDENG HVRVSDLGLA CDYSKKKPHA SVGTHGYMAP 

       370        380        390        400        410        420 
EVLAKGVAYD SSADWFSLGC MLYKLLKGHS PFRQHKSKDK NEIDKMTLTQ DIELPNEGLS 

       430        440        450        460        470        480 
KDCRDLLEGL LKRDVPDRLG CRGKGPTEVK EHPFFKDVDW QTVYLRRMTP PLIPPRGEVN 

       490        500        510        520        530        540 
AADAFDIGNF DDDEVKGVKL QDGDSDLYKN FNIVISERWQ NEIAETIFEV VNQDADKAES 

       550        560        570        580        590        600 
KKRSKQKIKV AVEEKDSDVI VHGYIKKLGG PFTSAWQTKY GKLYPSRLEL YPESLTAKPE 

       610        620        630        640        650        660 
LVFMDQIEDV CAEMQTIKGE TAIIVKLRDG FKEPKICLTN SDEISLKEWH TSLRTAHKVS 

       670        680        690        700 
QELLQRMGRK AIKIYGVNHD PMLSESERPG SVTRAFLNRA SSVDSGV 

« Hide

References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FO080476 Genomic DNA. Translation: CCD63981.1.
PIRT26096.
RefSeqNP_497235.2. NM_064834.4.
UniGeneCel.9949.

3D structure databases

ProteinModelPortalQ09639.
SMRQ09639. Positions 30-667.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ09639. 1 interaction.
MINTMINT-1795241.
STRING6239.W02B3.2.

Proteomic databases

PaxDbQ09639.
PRIDEQ09639.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaW02B3.2; W02B3.2; W02B3.2.
GeneID175223.
KEGGcel:CELE_W02B3.2.
UCSCW02B3.2. c. elegans.

Organism-specific databases

CTD175223.
WormBaseW02B3.2; CE32946; WBGene00001709; grk-2.

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000006742.
InParanoidQ09639.
KOK00910.
OMADIFQKFM.
OrthoDBEOG7FV3PP.
PhylomeDBQ09639.

Enzyme and pathway databases

SignaLinkQ09639.

Family and domain databases

Gene3D2.30.29.30. 2 hits.
InterProIPR000961. AGC-kinase_C.
IPR000239. GPCR_kinase.
IPR011009. Kinase-like_dom.
IPR011993. PH_like_dom.
IPR001849. Pleckstrin_homology.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSPR00717. GPCRKINASE.
SMARTSM00233. PH. 1 hit.
SM00315. RGS. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF48097. SSF48097. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEPS51285. AGC_KINASE_CTER. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio887266.

Entry information

Entry nameGRK2_CAEEL
AccessionPrimary (citable) accession number: Q09639
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: April 23, 2003
Last modified: April 16, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase