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Q09614 (PTC1_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein patched homolog 1
Gene names
Name:ptc-1
ORF Names:ZK675.1
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length1408 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required but not essential for cytokinesis of mitotically proliferating germ cells. Ref.1

Subcellular location

Membrane; Multi-pass membrane protein. Note: Highly concentrated in a punctate pattern at the apices and internal membranes adjacent to the rachis. Expression is more intense in the distal proliferative region and in oocytes of the gonad arm. Ref.1

Tissue specificity

Germ line and its progenitors. Ref.1

Developmental stage

Expressed both maternally and zygotically. Ref.1

Miscellaneous

Membrane proteins Patch and Smoothened form a receptor complex that binds Hedgehog morphogens. Despite the lack of Hh and Smo homologs, ptc-1 is still found to be functional. Absence of ptc-1 leads to the formation of multinucleate germ cells and sterility. Ref.1

Sequence similarities

Belongs to the patched family.

Contains 1 SSD (sterol-sensing) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 14081408Protein patched homolog 1
PRO_0000205969

Regions

Topological domain1 – 136136Cytoplasmic Potential
Transmembrane137 – 15721Helical; Potential
Topological domain158 – 649492Extracellular Potential
Transmembrane650 – 67021Helical; Potential
Topological domain671 – 68616Cytoplasmic Potential
Transmembrane687 – 70721Helical; Potential
Topological domain708 – 7092Extracellular Potential
Transmembrane710 – 73021Helical; Potential
Topological domain731 – 76535Cytoplasmic Potential
Transmembrane766 – 78621Helical; Potential
Topological domain787 – 7959Extracellular Potential
Transmembrane796 – 81621Helical; Potential
Topological domain817 – 90185Cytoplasmic Potential
Transmembrane902 – 92221Helical; Potential
Topological domain923 – 1175253Extracellular Potential
Transmembrane1176 – 119621Helical; Potential
Topological domain1197 – 121721Cytoplasmic Potential
Transmembrane1218 – 123821Helical; Potential
Transmembrane1239 – 125921Helical; Potential
Topological domain1260 – 127617Extracellular Potential
Transmembrane1277 – 129721Helical; Potential
Topological domain1298 – 13058Cytoplasmic Potential
Transmembrane1306 – 132621Helical; Potential
Topological domain1327 – 140882Extracellular Potential
Domain654 – 816163SSD

Amino acid modifications

Glycosylation5991N-linked (GlcNAc...) Ref.3
Glycosylation10261N-linked (GlcNAc...) Ref.3
Glycosylation10361N-linked (GlcNAc...) Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q09614 [UniParc].

Last modified September 2, 2008. Version 2.
Checksum: E7C2EBF4BFC5C389

FASTA1,408155,818
        10         20         30         40         50         60 
MLTLLEPPGA KRSPTVGNYN NRSAQHLLNL APEEDDLYET YEETEDYAEN EPTGNILTRS 

        70         80         90        100        110        120 
FQFLDQYLVG QSSSADYNDR WKREFRARPS WCDADLCLQQ MNRGKATGNR YALYSRSLIQ 

       130        140        150        160        170        180 
KLLFALGNTV HRNAWSIILA VSMIFAVCCY GLQYVHIETD IVKLWVAQGG RLDEELNFLP 

       190        200        210        220        230        240 
NIKEAMRNVT GDSGPELPRE NGLGGGYQVL IQTPEYEGQD ALAAGPLLKH VEIMKHIASF 

       250        260        270        280        290        300 
NVSVHGVDWS LSDICFKPAP PSVAADSAAS SLGDVIDKIV PCIWITPIDC FWEGSKALGP 

       310        320        330        340        350        360 
HPSLPKSSLG PLGMLLSSLS DGDMIRWSDF DPIAVIDEIH RSFNLGSHYT FFERAGVSHG 

       370        380        390        400        410        420 
YMDRPCIDPL DPECPPMAKN YFDVCPHIDR VREIAKKYGT ELEEEKKKDS GYSFFDFLGR 

       430        440        450        460        470        480 
KKREAGDQPK MIHPAQPADS IPTIEDAVPA QVPVSTAPIP TTTTLSPEEA RAAEEKEKKQ 

       490        500        510        520        530        540 
KARELKDYCK SYRKSAFEWL KKNKDKWPEV MSENMYPQNV DYAAEMTGGC SGFASNVLNW 

       550        560        570        580        590        600 
PEDMILGNPR RAKKGGKLSG ADALQSVFLV ASPADVFLRF KQKPGRNSMK TGLDMDAWNE 

       610        620        630        640        650        660 
TAAEQVLQAW QRNFTKSLYN HKANVDEDGN ERRTLHPLAS TSIADMLEEF CQFNYTIILA 

       670        680        690        700        710        720 
GYALMLAYAI VTQARFDNCL PATESSMGLA LAGVLVVTFA SVAGLGLATW FGIEFNAATT 

       730        740        750        760        770        780 
QIVPFLTLGI GVDNMFMLLH NYRDVVKLAG GHAEMAILMR ETGMSILCTS INNILSFLTG 

       790        800        810        820        830        840 
TLLPIPALRS FCAQSSILLT FNFIAILTIY PAIISIDLRR KKAQRRDLVC CLYGDTREES 

       850        860        870        880        890        900 
YSMISKPKIQ SKRIIGAPSE ASIMQQFDGI TQAQMASSDD PAPWSLHSFI RYYYIPFISK 

       910        920        930        940        950        960 
PASKVAIIVG CCALLGASFI GMRQSTLGLE LGDVLPEHTA PAQFLRARDK YFSFYPMFAV 

       970        980        990       1000       1010       1020 
IKGPNIDYAH QQRQIDNYRQ SIGSSKYVIK NKNEEPSEKY WLGLMRDWLI SIQRGFDEEV 

      1030       1040       1050       1060       1070       1080 
AKGSFNLTSG TVIGSNVSED ARLAHALMCS HGSLFGCAGR VGKIRLVDAS GIINSDGFYN 

      1090       1100       1110       1120       1130       1140 
YLTAWFNVDH MMYYVSQASF FPTPPKWELS KNHTENFIPA AEPLAYSQIP FYLTGLTDTA 

      1150       1160       1170       1180       1190       1200 
VIVDAIKDIR SVCERFTDQG LPNFPQGIAF TFWEQYLFLT GNLMQAISII TISVFCVISV 

      1210       1220       1230       1240       1250       1260 
LLFNPWAALM VVCILGIMTC ELAGFMGLVG IKLNPVSAVT LITAVGIGVE FTVHVVVSFL 

      1270       1280       1290       1300       1310       1320 
TALGTRSQRT SSAVDRVFVP VIHGSFSTLL GILMLGFSEF EFVVKYFFIV MTALICIGII 

      1330       1340       1350       1360       1370       1380 
NGLILLPVLL SWFGPRREIS PTGGKTTLTL PPPLPKNANS SRSGGDDSDE DDEPSGLVMY 

      1390       1400 
SRQAPPTTRT SGGNRGTVGN NTRRLPAV

« Hide

References

« Hide 'large scale' references
[1]"A C. elegans patched gene, ptc-1, functions in germ-line cytokinesis."
Kuwabara P.E., Lee M.-H., Schedl T., Jefferis G.S.X.E.
Genes Dev. 14:1933-1944(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
[2]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
[3]"Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins."
Kaji H., Kamiie J., Kawakami H., Kido K., Yamauchi Y., Shinkawa T., Taoka M., Takahashi N., Isobe T.
Mol. Cell. Proteomics 6:2100-2109(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-599; ASN-1026 AND ASN-1036, MASS SPECTROMETRY.
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		Z46812 Genomic DNA. Translation: CAA86843.2.
PIRT27969.
RefSeqNP_495662.2. NM_063261.4.

3D structure databases

ProteinModelPortalQ09614.
ModBaseSearch...

Protein-protein interaction databases

STRING6239.ZK675.1.2.

Proteomic databases

PaxDbQ09614.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaZK675.1.1; ZK675.1.1; ZK675.1.
ZK675.1.2; ZK675.1.2; ZK675.1.
GeneID174274.
KEGGcel:CELE_ZK675.1.
UCSCZK675.1.1. c. elegans.

Organism-specific databases

CTD174274.
WormBaseZK675.1; CE42497; WBGene00004208; ptc-1.

Phylogenomic databases

eggNOGNOG313603.
GeneTreeENSGT00680000099777.
HOGENOMHOG000016673.
InParanoidQ09614.
KOK06225.
OMACQFNYTI.

Gene expression databases

GermOnlineZK675.1. Caenorhabditis elegans.

Family and domain databases

InterProIPR003392. Patched.
IPR000731. SSD.
[Graphical view]
PfamPF02460. Patched. 1 hit.
[Graphical view]
PROSITEPS50156. SSD. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio883327.

Entry information

Entry namePTC1_CAEEL
AccessionPrimary (citable) accession number: Q09614
Entry history
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: September 2, 2008
Last modified: May 1, 2013
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents