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Q09607

- GST36_CAEEL

UniProt

Q09607 - GST36_CAEEL

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Protein

Probable glutathione S-transferase gst-36

Gene

gst-36

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei8 – 81GlutathioneBy similarity
Binding sitei39 – 391GlutathioneBy similarity
Binding sitei43 – 431GlutathioneBy similarity

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB

GO - Biological processi

  1. metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Enzyme and pathway databases

ReactomeiREACT_184548. Detoxification of Reactive Oxygen Species.
REACT_263468. Glutathione conjugation.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glutathione S-transferase gst-36 (EC:2.5.1.18)
Alternative name(s):
GST class-sigma
Gene namesi
Name:gst-36
ORF Names:R07B1.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome X

Organism-specific databases

WormBaseiR07B1.4; CE30562; WBGene00001784; gst-36.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 210210Probable glutathione S-transferase gst-36PRO_0000185933Add
BLAST

Proteomic databases

PaxDbiQ09607.
PRIDEiQ09607.

Interactioni

Protein-protein interaction databases

BioGridi52332. 2 interactions.
IntActiQ09607. 1 interaction.
MINTiMINT-1068164.
STRINGi6239.R07B1.4.

Structurei

3D structure databases

ProteinModelPortaliQ09607.
SMRiQ09607. Positions 1-208.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 7978GST N-terminalAdd
BLAST
Domaini81 – 210130GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni50 – 512Glutathione bindingBy similarity
Regioni63 – 642Glutathione bindingBy similarity

Sequence similaritiesi

Belongs to the GST superfamily. Sigma family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiNOG293691.
GeneTreeiENSGT00670000097856.
HOGENOMiHOG000115733.
InParanoidiQ09607.
KOiK00799.
OMAiDCARLDM.
OrthoDBiEOG7MH138.
PhylomeDBiQ09607.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q09607-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPHFKFYYFD VRGRGEAIRL LFHLADEKFD DERFGMEQWG VLKSEMPLGQ
60 70 80 90 100
VPVLEIDGVK ISQTTAIARY LGHQFHRAGT NAVDCARLDM IAEVIQEFMS
110 120 130 140 150
SSGMGKFSRV LLGMIQANKE QFFKENVLPD VEKYAPIVEK FLLENGNNGL
160 170 180 190 200
LLGDRETWVD VFAAESFSKL IDYGSPDALD AYPHILALIN RVFNHPNIKK
210
YVSQRKATPA
Length:210
Mass (Da):23,876
Last modified:June 20, 2002 - v2
Checksum:i0E6010336B385D9B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48621 Genomic DNA. Translation: CAA88541.2.
PIRiT23994.
RefSeqiNP_509652.2. NM_077251.4.
UniGeneiCel.19822.

Genome annotation databases

EnsemblMetazoaiR07B1.4; R07B1.4; WBGene00001784.
GeneIDi187645.
KEGGicel:CELE_R07B1.4.
UCSCiR07B1.4. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48621 Genomic DNA. Translation: CAA88541.2 .
PIRi T23994.
RefSeqi NP_509652.2. NM_077251.4.
UniGenei Cel.19822.

3D structure databases

ProteinModelPortali Q09607.
SMRi Q09607. Positions 1-208.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 52332. 2 interactions.
IntActi Q09607. 1 interaction.
MINTi MINT-1068164.
STRINGi 6239.R07B1.4.

Proteomic databases

PaxDbi Q09607.
PRIDEi Q09607.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai R07B1.4 ; R07B1.4 ; WBGene00001784 .
GeneIDi 187645.
KEGGi cel:CELE_R07B1.4.
UCSCi R07B1.4. c. elegans.

Organism-specific databases

CTDi 187645.
WormBasei R07B1.4 ; CE30562 ; WBGene00001784 ; gst-36.

Phylogenomic databases

eggNOGi NOG293691.
GeneTreei ENSGT00670000097856.
HOGENOMi HOG000115733.
InParanoidi Q09607.
KOi K00799.
OMAi DCARLDM.
OrthoDBi EOG7MH138.
PhylomeDBi Q09607.

Enzyme and pathway databases

Reactomei REACT_184548. Detoxification of Reactive Oxygen Species.
REACT_263468. Glutathione conjugation.

Miscellaneous databases

NextBioi 935986.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view ]
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiGST36_CAEEL
AccessioniPrimary (citable) accession number: Q09607
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: June 20, 2002
Last modified: November 26, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3