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Protein

Probable glutathione S-transferase gst-36

Gene

gst-36

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei8GlutathioneBy similarity1
Binding sitei39GlutathioneBy similarity1
Binding sitei43GlutathioneBy similarity1

GO - Molecular functioni

  • glutathione peroxidase activity Source: WormBase
  • glutathione transferase activity Source: WormBase

GO - Biological processi

  • oxidation-reduction process Source: WormBase

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

ReactomeiR-CEL-156590 Glutathione conjugation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glutathione S-transferase gst-36 (EC:2.5.1.18)
Alternative name(s):
GST class-sigma
Gene namesi
Name:gst-36
ORF Names:R07B1.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiR07B1.4 ; CE30562 ; WBGene00001784 ; gst-36

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001859331 – 210Probable glutathione S-transferase gst-36Add BLAST210

Proteomic databases

EPDiQ09607
PaxDbiQ09607
PeptideAtlasiQ09607
PRIDEiQ09607

Expressioni

Gene expression databases

BgeeiWBGene00001784

Interactioni

Protein-protein interaction databases

BioGridi52332, 2 interactors
IntActiQ09607, 2 interactors
STRINGi6239.R07B1.4

Structurei

3D structure databases

ProteinModelPortaliQ09607
SMRiQ09607
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 79GST N-terminalAdd BLAST78
Domaini81 – 210GST C-terminalAdd BLAST130

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni49 – 51Glutathione bindingBy similarity3
Regioni63 – 64Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Sigma family.Curated

Phylogenomic databases

eggNOGiKOG1695 Eukaryota
ENOG4111VAU LUCA
GeneTreeiENSGT00670000097856
HOGENOMiHOG000115733
InParanoidiQ09607
KOiK00799
OMAiDCARLDM
OrthoDBiEOG091G0O3D
PhylomeDBiQ09607

Family and domain databases

InterProiView protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR004045 Glutathione_S-Trfase_N
IPR004046 GST_C
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF14497 GST_C_3, 1 hit
PF02798 GST_N, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit

Sequencei

Sequence statusi: Complete.

Q09607-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPHFKFYYFD VRGRGEAIRL LFHLADEKFD DERFGMEQWG VLKSEMPLGQ
60 70 80 90 100
VPVLEIDGVK ISQTTAIARY LGHQFHRAGT NAVDCARLDM IAEVIQEFMS
110 120 130 140 150
SSGMGKFSRV LLGMIQANKE QFFKENVLPD VEKYAPIVEK FLLENGNNGL
160 170 180 190 200
LLGDRETWVD VFAAESFSKL IDYGSPDALD AYPHILALIN RVFNHPNIKK
210
YVSQRKATPA
Length:210
Mass (Da):23,876
Last modified:June 20, 2002 - v2
Checksum:i0E6010336B385D9B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48621 Genomic DNA Translation: CAA88541.2
PIRiT23994
RefSeqiNP_509652.2, NM_077251.4
UniGeneiCel.19822

Genome annotation databases

EnsemblMetazoaiR07B1.4; R07B1.4; WBGene00001784
GeneIDi187645
KEGGicel:CELE_R07B1.4
UCSCiR07B1.4 c. elegans

Similar proteinsi

Entry informationi

Entry nameiGST36_CAEEL
AccessioniPrimary (citable) accession number: Q09607
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: June 20, 2002
Last modified: March 28, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health