Q09607 (GST36_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable glutathione S-transferase gst-36
EC=2.5.1.18

Alternative name(s):
GST class-sigma

Gene names

Name:	gst-36
ORF Names:	R07B1.4

Organism

Caenorhabditis elegans

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	210 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles By similarity.
Catalytic activity	RX + glutathione = HX + R-S-glutathione.
Sequence similarities	Belongs to the GST superfamily. Sigma family. Contains 1 GST C-terminal domain. Contains 1 GST N-terminal domain.

Ontologies

Keywords
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	glutathione transferase activity Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 210	210	Probable glutathione S-transferase gst-36		PRO_0000185933
Regions
	Domain	2 – 79	78	GST N-terminal
	Domain	81 – 210	130	GST C-terminal
	Region	50 – 51	2	Glutathione binding By similarity
	Region	63 – 64	2	Glutathione binding By similarity
Sites
	Binding site	8	1	Glutathione By similarity
	Binding site	39	1	Glutathione By similarity
	Binding site	43	1	Glutathione By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q09607 [UniParc]. Last modified June 20, 2002. Version 2. Checksum: 0E6010336B385D9B	FASTA	210	23,876
	10 20 30 40 50 60 MPHFKFYYFD VRGRGEAIRL LFHLADEKFD DERFGMEQWG VLKSEMPLGQ VPVLEIDGVK 70 80 90 100 110 120 ISQTTAIARY LGHQFHRAGT NAVDCARLDM IAEVIQEFMS SSGMGKFSRV LLGMIQANKE 130 140 150 160 170 180 QFFKENVLPD VEKYAPIVEK FLLENGNNGL LLGDRETWVD VFAAESFSKL IDYGSPDALD 190 200 210 AYPHILALIN RVFNHPNIKK YVSQRKATPA

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z48621 Genomic DNA. Translation: CAA88541.2.
PIR	T23994.
RefSeq	NP_509652.2. NM_077251.3.
UniGene	Cel.19822.
3D structure databases
ProteinModelPortal	Q09607.
SMR	Q09607. Positions 1-209.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q09607. 1 interaction.
MINT	MINT-1068164.
STRING	Q09607.
Proteomic databases
PRIDE	Q09607.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	R07B1.4; R07B1.4; R07B1.4.
GeneID	187645.
KEGG	cel:R07B1.4.
NMPDR	fig|6239.3.peg.24312.
UCSC	R07B1.4. c. elegans.
Organism-specific databases
CTD	187645.
WormBase	R07B1.4; CE30562; WBGene00001784; gst-36.
Phylogenomic databases
eggNOG	KOG1695.
GeneTree	EMGT00050000007317.
HOGENOM	HBG563238.
InParanoid	Q09607.
OMA	PHILALI.
PhylomeDB	Q09607.
Gene expression databases
ArrayExpress	Q09607.
Family and domain databases
InterPro	IPR010987. Glutathione-S-Trfase_C-like. IPR004045. Glutathione_S-Trfase_N. IPR017933. Glutathione_S_Trfase/Cl_chnl_C. IPR004046. GST_C. IPR012336. Thioredoxin-like_fold. [Graphical view]
Gene3D	G3DSA:1.20.1050.10. GST_C_like. 1 hit. G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
KO	K00799.
Pfam	PF00043. GST_C. 1 hit. PF02798. GST_N. 1 hit. [Graphical view]
SUPFAM	SSF47616. GST_C_like. 1 hit. SSF52833. Thiordxn-like_fd. 1 hit.
PROSITE	PS50405. GST_CTER. 1 hit. PS50404. GST_NTER. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	935986.

Entry information

Entry name

GST36_CAEEL

Accession

Primary (citable) accession number: Q09607

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	June 20, 2002
Last modified:	November 16, 2011
This is version 80 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project