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Q09601 (NUP53_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nucleoporin NUP53
Alternative name(s):
35 kDa nucleoporin
Nuclear pore complex protein Nup53
Nucleoporin npp-19
Gene names
Name:npp-19
ORF Names:R06F6.5
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length381 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors By similarity.

Subcellular location

Nucleusnuclear pore complex By similarity.

Sequence similarities

Belongs to the Nup53 family.

Contains 1 RRM Nup35-type domain.

Ontologies

Keywords
   Biological processmRNA transport
Protein transport
Translocation
Transport
   Cellular componentNuclear pore complex
Nucleus
   Coding sequence diversityAlternative splicing
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmRNA transport

Inferred from electronic annotation. Source: UniProtKB-KW

protein transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnuclear envelope

Inferred from direct assay PubMed 19146848. Source: WormBase

nuclear pore

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform b (identifier: Q09601-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: No experimental confirmation available.
Isoform a (identifier: Q09601-2)

The sequence of this isoform differs from the canonical sequence as follows:
     356-358: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 381381Nucleoporin NUP53
PRO_0000065418

Regions

Domain195 – 27581RRM Nup35-type

Natural variations

Alternative sequence356 – 3583Missing in isoform a.
VSP_020780

Sequences

Sequence LengthMass (Da)Tools
Isoform b [UniParc].

Last modified October 3, 2006. Version 2.
Checksum: 209A625812D6A823

FASTA38140,786
        10         20         30         40         50         60 
MFSHLNQNTS GRHNSMDLNN SSISNFGTPV EQSTPALLFG KRKATVPSSY TASPLNTASA 

        70         80         90        100        110        120 
PCSDIFAVSA PAVPQHLKDT PGSKSVHWSP SLVQSGEKSA AQTQNTPANL SFGGNSSFSA 

       130        140        150        160        170        180 
PTKPAPQSIQ TSSFGGQAMH APPLRSLRDK VEPAKKISRR NTFTARSTPL STPITQRVTS 

       190        200        210        220        230        240 
RLAEAEEQPM EEEADAADTW VTVFGFQPSQ VSILLNLFSR HGEVVSHQTP SKGNFIHMRY 

       250        260        270        280        290        300 
SCVTHAQQAI SRNGTLLDQD TFIGVVQCTN KDVINGSASG IVARSSNIAA AANRSASMYN 

       310        320        330        340        350        360 
SFVENDMADQ SVNHNENSVL NSSNVFDANN SLNSSRISVR SGVGMRPLAA DQRTNILQGT 

       370        380 
PSVRKAPDGL LNKFWNTIGL N 

« Hide

Isoform a [UniParc].

Checksum: 02FB08F44B8BDDEC
Show »

FASTA37840,432

References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z46794 Genomic DNA. Translation: CAA86775.1.
Z46794 Genomic DNA. Translation: CAA86784.1.
PIRT23976.
T23985.
RefSeqNP_496324.1. NM_063923.5.
NP_496325.1. NM_063924.5.
UniGeneCel.6495.

3D structure databases

ProteinModelPortalQ09601.
SMRQ09601. Positions 198-274.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid39976. 19 interactions.
IntActQ09601. 19 interactions.

Proteomic databases

PaxDbQ09601.
PRIDEQ09601.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaR06F6.5b.1; R06F6.5b.1; R06F6.5. [Q09601-1]
R06F6.5b.2; R06F6.5b.2; R06F6.5. [Q09601-1]
GeneID174663.
KEGGcel:CELE_R06F6.5.
UCSCR06F6.5b. c. elegans. [Q09601-1]

Organism-specific databases

CTD174663.
WormBaseR06F6.5a; CE01621; WBGene00003805; npp-19.
R06F6.5b; CE18121; WBGene00003805; npp-19.

Phylogenomic databases

eggNOGNOG253574.
HOGENOMHOG000016785.
InParanoidQ09601.
KOK14313.
OMAHGEVVSH.
PhylomeDBQ09601.

Family and domain databases

InterProIPR007846. RRM_NUP35_dom.
[Graphical view]
PfamPF05172. Nup35_RRM. 1 hit.
[Graphical view]
PROSITEPS51472. RRM_NUP35. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio884968.

Entry information

Entry nameNUP53_CAEEL
AccessionPrimary (citable) accession number: Q09601
Secondary accession number(s): O62340
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: October 3, 2006
Last modified: April 16, 2014
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase