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Q09601

- NUP53_CAEEL

UniProt

Q09601 - NUP53_CAEEL

Protein

Nucleoporin NUP53

Gene

npp-19

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 2 (03 Oct 2006)
      Previous versions | rss
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    Functioni

    Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors By similarity.By similarity

    GO - Biological processi

    1. mRNA transport Source: UniProtKB-KW
    2. protein transport Source: UniProtKB-KW

    Keywords - Biological processi

    mRNA transport, Protein transport, Translocation, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nucleoporin NUP53
    Alternative name(s):
    35 kDa nucleoporin
    Nuclear pore complex protein Nup53
    Nucleoporin npp-19
    Gene namesi
    Name:npp-19
    ORF Names:R06F6.5
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome II

    Organism-specific databases

    WormBaseiR06F6.5a; CE01621; WBGene00003805; npp-19.
    R06F6.5b; CE18121; WBGene00003805; npp-19.

    Subcellular locationi

    Nucleusnuclear pore complex By similarity

    GO - Cellular componenti

    1. nuclear envelope Source: WormBase
    2. nuclear pore Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nuclear pore complex, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 381381Nucleoporin NUP53PRO_0000065418Add
    BLAST

    Proteomic databases

    PaxDbiQ09601.
    PRIDEiQ09601.

    Interactioni

    Protein-protein interaction databases

    BioGridi39976. 19 interactions.
    IntActiQ09601. 18 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ09601.
    SMRiQ09601. Positions 198-274.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini195 – 27581RRM Nup35-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the Nup53 family.Curated
    Contains 1 RRM Nup35-type domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG253574.
    GeneTreeiENSGT00390000005923.
    HOGENOMiHOG000016785.
    InParanoidiQ09601.
    KOiK14313.
    OMAiHGEVVSH.
    PhylomeDBiQ09601.

    Family and domain databases

    InterProiIPR007846. RRM_NUP35_dom.
    [Graphical view]
    PfamiPF05172. Nup35_RRM. 1 hit.
    [Graphical view]
    PROSITEiPS51472. RRM_NUP35. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform b (identifier: Q09601-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MFSHLNQNTS GRHNSMDLNN SSISNFGTPV EQSTPALLFG KRKATVPSSY    50
    TASPLNTASA PCSDIFAVSA PAVPQHLKDT PGSKSVHWSP SLVQSGEKSA 100
    AQTQNTPANL SFGGNSSFSA PTKPAPQSIQ TSSFGGQAMH APPLRSLRDK 150
    VEPAKKISRR NTFTARSTPL STPITQRVTS RLAEAEEQPM EEEADAADTW 200
    VTVFGFQPSQ VSILLNLFSR HGEVVSHQTP SKGNFIHMRY SCVTHAQQAI 250
    SRNGTLLDQD TFIGVVQCTN KDVINGSASG IVARSSNIAA AANRSASMYN 300
    SFVENDMADQ SVNHNENSVL NSSNVFDANN SLNSSRISVR SGVGMRPLAA 350
    DQRTNILQGT PSVRKAPDGL LNKFWNTIGL N 381

    Note: No experimental confirmation available.

    Length:381
    Mass (Da):40,786
    Last modified:October 3, 2006 - v2
    Checksum:i209A625812D6A823
    GO
    Isoform a (identifier: Q09601-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         356-358: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:378
    Mass (Da):40,432
    Checksum:i02FB08F44B8BDDEC
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei356 – 3583Missing in isoform a. CuratedVSP_020780

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46794 Genomic DNA. Translation: CAA86775.1.
    Z46794 Genomic DNA. Translation: CAA86784.1.
    PIRiT23976.
    T23985.
    RefSeqiNP_496324.1. NM_063923.5. [Q09601-1]
    NP_496325.1. NM_063924.5. [Q09601-2]
    UniGeneiCel.6495.

    Genome annotation databases

    EnsemblMetazoaiR06F6.5b; R06F6.5b; WBGene00003805. [Q09601-1]
    GeneIDi174663.
    KEGGicel:CELE_R06F6.5.
    UCSCiR06F6.5b. c. elegans. [Q09601-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46794 Genomic DNA. Translation: CAA86775.1 .
    Z46794 Genomic DNA. Translation: CAA86784.1 .
    PIRi T23976.
    T23985.
    RefSeqi NP_496324.1. NM_063923.5. [Q09601-1 ]
    NP_496325.1. NM_063924.5. [Q09601-2 ]
    UniGenei Cel.6495.

    3D structure databases

    ProteinModelPortali Q09601.
    SMRi Q09601. Positions 198-274.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 39976. 19 interactions.
    IntActi Q09601. 18 interactions.

    Proteomic databases

    PaxDbi Q09601.
    PRIDEi Q09601.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai R06F6.5b ; R06F6.5b ; WBGene00003805 . [Q09601-1 ]
    GeneIDi 174663.
    KEGGi cel:CELE_R06F6.5.
    UCSCi R06F6.5b. c. elegans. [Q09601-1 ]

    Organism-specific databases

    CTDi 174663.
    WormBasei R06F6.5a ; CE01621 ; WBGene00003805 ; npp-19.
    R06F6.5b ; CE18121 ; WBGene00003805 ; npp-19.

    Phylogenomic databases

    eggNOGi NOG253574.
    GeneTreei ENSGT00390000005923.
    HOGENOMi HOG000016785.
    InParanoidi Q09601.
    KOi K14313.
    OMAi HGEVVSH.
    PhylomeDBi Q09601.

    Miscellaneous databases

    NextBioi 884968.

    Family and domain databases

    InterProi IPR007846. RRM_NUP35_dom.
    [Graphical view ]
    Pfami PF05172. Nup35_RRM. 1 hit.
    [Graphical view ]
    PROSITEi PS51472. RRM_NUP35. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiNUP53_CAEEL
    AccessioniPrimary (citable) accession number: Q09601
    Secondary accession number(s): O62340
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: October 3, 2006
    Last modified: October 1, 2014
    This is version 86 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3