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Q09601

- NUP53_CAEEL

UniProt

Q09601 - NUP53_CAEEL

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Protein

Nucleoporin NUP53

Gene
npp-19, R06F6.5
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors By similarity.

GO - Biological processi

  1. mRNA transport Source: UniProtKB-KW
  2. protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

mRNA transport, Protein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoporin NUP53
Alternative name(s):
35 kDa nucleoporin
Nuclear pore complex protein Nup53
Nucleoporin npp-19
Gene namesi
Name:npp-19
ORF Names:R06F6.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome II

Organism-specific databases

WormBaseiR06F6.5a; CE01621; WBGene00003805; npp-19.
R06F6.5b; CE18121; WBGene00003805; npp-19.

Subcellular locationi

Nucleusnuclear pore complex By similarity

GO - Cellular componenti

  1. nuclear envelope Source: WormBase
  2. nuclear pore Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nuclear pore complex, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 381381Nucleoporin NUP53PRO_0000065418Add
BLAST

Proteomic databases

PaxDbiQ09601.
PRIDEiQ09601.

Interactioni

Protein-protein interaction databases

BioGridi39976. 19 interactions.
IntActiQ09601. 19 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ09601.
SMRiQ09601. Positions 198-274.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini195 – 27581RRM Nup35-typeAdd
BLAST

Sequence similaritiesi

Belongs to the Nup53 family.

Phylogenomic databases

eggNOGiNOG253574.
GeneTreeiENSGT00390000005923.
HOGENOMiHOG000016785.
InParanoidiQ09601.
KOiK14313.
OMAiHGEVVSH.
PhylomeDBiQ09601.

Family and domain databases

InterProiIPR007846. RRM_NUP35_dom.
[Graphical view]
PfamiPF05172. Nup35_RRM. 1 hit.
[Graphical view]
PROSITEiPS51472. RRM_NUP35. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform b (identifier: Q09601-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MFSHLNQNTS GRHNSMDLNN SSISNFGTPV EQSTPALLFG KRKATVPSSY    50
TASPLNTASA PCSDIFAVSA PAVPQHLKDT PGSKSVHWSP SLVQSGEKSA 100
AQTQNTPANL SFGGNSSFSA PTKPAPQSIQ TSSFGGQAMH APPLRSLRDK 150
VEPAKKISRR NTFTARSTPL STPITQRVTS RLAEAEEQPM EEEADAADTW 200
VTVFGFQPSQ VSILLNLFSR HGEVVSHQTP SKGNFIHMRY SCVTHAQQAI 250
SRNGTLLDQD TFIGVVQCTN KDVINGSASG IVARSSNIAA AANRSASMYN 300
SFVENDMADQ SVNHNENSVL NSSNVFDANN SLNSSRISVR SGVGMRPLAA 350
DQRTNILQGT PSVRKAPDGL LNKFWNTIGL N 381

Note: No experimental confirmation available.

Length:381
Mass (Da):40,786
Last modified:October 3, 2006 - v2
Checksum:i209A625812D6A823
GO
Isoform a (identifier: Q09601-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     356-358: Missing.

Note: No experimental confirmation available.

Show »
Length:378
Mass (Da):40,432
Checksum:i02FB08F44B8BDDEC
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei356 – 3583Missing in isoform a. VSP_020780

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z46794 Genomic DNA. Translation: CAA86775.1.
Z46794 Genomic DNA. Translation: CAA86784.1.
PIRiT23976.
T23985.
RefSeqiNP_496324.1. NM_063923.5. [Q09601-1]
NP_496325.1. NM_063924.5. [Q09601-2]
UniGeneiCel.6495.

Genome annotation databases

EnsemblMetazoaiR06F6.5b; R06F6.5b; WBGene00003805. [Q09601-1]
GeneIDi174663.
KEGGicel:CELE_R06F6.5.
UCSCiR06F6.5b. c. elegans. [Q09601-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z46794 Genomic DNA. Translation: CAA86775.1 .
Z46794 Genomic DNA. Translation: CAA86784.1 .
PIRi T23976.
T23985.
RefSeqi NP_496324.1. NM_063923.5. [Q09601-1 ]
NP_496325.1. NM_063924.5. [Q09601-2 ]
UniGenei Cel.6495.

3D structure databases

ProteinModelPortali Q09601.
SMRi Q09601. Positions 198-274.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 39976. 19 interactions.
IntActi Q09601. 19 interactions.

Proteomic databases

PaxDbi Q09601.
PRIDEi Q09601.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai R06F6.5b ; R06F6.5b ; WBGene00003805 . [Q09601-1 ]
GeneIDi 174663.
KEGGi cel:CELE_R06F6.5.
UCSCi R06F6.5b. c. elegans. [Q09601-1 ]

Organism-specific databases

CTDi 174663.
WormBasei R06F6.5a ; CE01621 ; WBGene00003805 ; npp-19.
R06F6.5b ; CE18121 ; WBGene00003805 ; npp-19.

Phylogenomic databases

eggNOGi NOG253574.
GeneTreei ENSGT00390000005923.
HOGENOMi HOG000016785.
InParanoidi Q09601.
KOi K14313.
OMAi HGEVVSH.
PhylomeDBi Q09601.

Miscellaneous databases

NextBioi 884968.

Family and domain databases

InterProi IPR007846. RRM_NUP35_dom.
[Graphical view ]
Pfami PF05172. Nup35_RRM. 1 hit.
[Graphical view ]
PROSITEi PS51472. RRM_NUP35. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiNUP53_CAEEL
AccessioniPrimary (citable) accession number: Q09601
Secondary accession number(s): O62340
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: October 3, 2006
Last modified: June 11, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi