Q09601 (NUP53_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nucleoporin NUP53

Alternative name(s):
35 kDa nucleoporin
Nuclear pore complex protein Nup53
Nucleoporin npp-19

Gene names

Name:	npp-19
ORF Names:	R06F6.5

Organism

Caenorhabditis elegans [Reference proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	381 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors By similarity.
Subcellular location	Nucleus › nuclear pore complex By similarity.
Sequence similarities	Belongs to the Nup53 family. Contains 1 RRM Nup35-type domain.

Ontologies

Keywords
Biological process	Protein transport Translocation Transport mRNA transport
Cellular component	Nuclear pore complex Nucleus
Coding sequence diversity	Alternative splicing
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	mRNA transport Inferred from electronic annotation. Source: UniProtKB-KW protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nuclear envelope Inferred from direct assay PubMed 19146848. Source: WormBase nuclear pore Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform b (identifier: Q09601-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available.

Isoform a (identifier: Q09601-2)

The sequence of this isoform differs from the canonical sequence as follows:
     356-358: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 381	381	Nucleoporin NUP53		PRO_0000065418
Regions
	Domain	195 – 275	81	RRM Nup35-type
Natural variations
	Alternative sequence	356 – 358	3	Missing in isoform a.		VSP_020780

Sequences

	Sequence		Length	Mass (Da)
	Isoform b [UniParc]. Last modified October 3, 2006. Version 2. Checksum: 209A625812D6A823	FASTA	381	40,786
	10 20 30 40 50 60 MFSHLNQNTS GRHNSMDLNN SSISNFGTPV EQSTPALLFG KRKATVPSSY TASPLNTASA 70 80 90 100 110 120 PCSDIFAVSA PAVPQHLKDT PGSKSVHWSP SLVQSGEKSA AQTQNTPANL SFGGNSSFSA 130 140 150 160 170 180 PTKPAPQSIQ TSSFGGQAMH APPLRSLRDK VEPAKKISRR NTFTARSTPL STPITQRVTS 190 200 210 220 230 240 RLAEAEEQPM EEEADAADTW VTVFGFQPSQ VSILLNLFSR HGEVVSHQTP SKGNFIHMRY 250 260 270 280 290 300 SCVTHAQQAI SRNGTLLDQD TFIGVVQCTN KDVINGSASG IVARSSNIAA AANRSASMYN 310 320 330 340 350 360 SFVENDMADQ SVNHNENSVL NSSNVFDANN SLNSSRISVR SGVGMRPLAA DQRTNILQGT 370 380 PSVRKAPDGL LNKFWNTIGL N
	Isoform a [UniParc]. Checksum: 02FB08F44B8BDDEC	FASTA	378	40,432
	10 20 30 40 50 60 MFSHLNQNTS GRHNSMDLNN SSISNFGTPV EQSTPALLFG KRKATVPSSY TASPLNTASA 70 80 90 100 110 120 PCSDIFAVSA PAVPQHLKDT PGSKSVHWSP SLVQSGEKSA AQTQNTPANL SFGGNSSFSA 130 140 150 160 170 180 PTKPAPQSIQ TSSFGGQAMH APPLRSLRDK VEPAKKISRR NTFTARSTPL STPITQRVTS 190 200 210 220 230 240 RLAEAEEQPM EEEADAADTW VTVFGFQPSQ VSILLNLFSR HGEVVSHQTP SKGNFIHMRY 250 260 270 280 290 300 SCVTHAQQAI SRNGTLLDQD TFIGVVQCTN KDVINGSASG IVARSSNIAA AANRSASMYN 310 320 330 340 350 360 SFVENDMADQ SVNHNENSVL NSSNVFDANN SLNSSRISVR SGVGMRPLAA DQRTNGTPSV 370 RKAPDGLLNK FWNTIGLN

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z46794 Genomic DNA. Translation: CAA86775.1. Z46794 Genomic DNA. Translation: CAA86784.1.
PIR	T23976. T23985.
RefSeq	NP_496324.1. NM_063923.5. NP_496325.1. NM_063924.5.
3D structure databases
ProteinModelPortal	Q09601.
SMR	Q09601. Positions 198-274.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q09601. 19 interactions.
MINT	MINT-6669916.
Proteomic databases
PaxDb	Q09601.
PRIDE	Q09601.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	R06F6.5b.1; R06F6.5b.1; R06F6.5. R06F6.5b.2; R06F6.5b.2; R06F6.5.
GeneID	174663.
KEGG	cel:CELE_R06F6.5.
UCSC	R06F6.5b. c. elegans.
Organism-specific databases
CTD	174663.
WormBase	R06F6.5a; CE01621; WBGene00003805; npp-19. R06F6.5b; CE18121; WBGene00003805; npp-19.
Phylogenomic databases
eggNOG	NOG253574.
GeneTree	ENSGT00390000005923.
HOGENOM	HOG000016785.
InParanoid	Q09601.
KO	K14313.
OMA	HGEVVSH.
Family and domain databases
InterPro	IPR007846. RRM_NUP35_dom. [Graphical view]
Pfam	PF05172. Nup35_RRM. 1 hit. [Graphical view]
PROSITE	PS51472. RRM_NUP35. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	884968.

Entry information

Entry name

NUP53_CAEEL

Accession

Primary (citable) accession number: Q09601
Secondary accession number(s): O62340

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	October 3, 2006
Last modified:	May 1, 2013
This is version 79 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project