ID   GST5_CAEEL              Reviewed;         207 AA.
AC   Q09596;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   05-MAY-2009, entry version 70.
DE   RecName: Full=Probable glutathione S-transferase 5;
DE            EC=2.5.1.18;
DE   AltName: Full=GST class-sigma;
GN   Name=gst-5; ORFNames=R03D7.6;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea;
OC   Rhabditidae; Peloderinae; Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   MEDLINE=99069613; PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for
RT   investigating biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Conjugation of reduced glutathione to a wide number of
CC       exogenous and endogenous hydrophobic electrophiles (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: RX + glutathione = HX + R-S-glutathione.
CC   -!- SIMILARITY: Belongs to the GST superfamily. Sigma family.
CC   -!- SIMILARITY: Contains 1 GST C-terminal domain.
CC   -!- SIMILARITY: Contains 1 GST N-terminal domain.
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DR   EMBL; Z46828; CAA86859.1; -; Genomic_DNA.
DR   PIR; T23872; T23872.
DR   RefSeq; NP_496357.1; -.
DR   UniGene; Cel.14876; -.
DR   PDB; 1ZL9; X-ray; 2.01 A; A/B=1-207.
DR   PDBsum; 1ZL9; -.
DR   DIP; DIP:26899N; -.
DR   IntAct; Q09596; 30.
DR   Ensembl; R03D7.6; Caenorhabditis elegans.
DR   GeneID; 187537; -.
DR   KEGG; cel:R03D7.6; -.
DR   NMPDR; fig|6239.3.peg.7351; -.
DR   WormBase; WBGene00001753; gst-5.
DR   WormPep; R03D7.6; CE01613.
DR   OMA; Q09596; KDYSSEA.
DR   BRENDA; 2.5.1.18; 672.
DR   NextBio; 935622; -.
DR   ArrayExpress; Q09596; -.
DR   GO; GO:0004364; F:glutathione transferase activity; IEA:EC.
DR   InterPro; IPR010987; Glutathione-S-Trfase_C-like.
DR   InterPro; IPR004045; Glutathione_S-Trfase_N.
DR   InterPro; IPR017933; Glutathione_S_Trfase/Cl_chnl_C.
DR   InterPro; IPR004046; GST_C.
DR   InterPro; IPR012335; Thioredoxin_fold.
DR   Gene3D; G3DSA:1.20.1050.10; GST_C_like; 1.
DR   Gene3D; G3DSA:3.40.30.10; Thioredoxin_fold; 1.
DR   Pfam; PF00043; GST_C; 1.
DR   Pfam; PF02798; GST_N; 1.
DR   PROSITE; PS50405; GST_CTER; 1.
DR   PROSITE; PS50404; GST_NTER; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Complete proteome; Transferase.
FT   CHAIN         1    207       Probable glutathione S-transferase 5.
FT                                /FTId=PRO_0000185928.
FT   DOMAIN        2     81       GST N-terminal.
FT   DOMAIN       83    207       GST C-terminal.
FT   STRAND        4     12
FT   HELIX        13     15
FT   HELIX        16     25
FT   STRAND       30     34
FT   TURN         36     38
FT   HELIX        39     44
FT   STRAND       55     58
FT   STRAND       61     64
FT   HELIX        66     76
FT   HELIX        84    111
FT   HELIX       119    125
FT   HELIX       127    145
FT   STRAND      147    151
FT   HELIX       157    171
FT   HELIX       180    191
FT   HELIX       193    201
SQ   SEQUENCE   207 AA;  23252 MW;  7FDE101B24F7468B CRC64;
     MVSYKLTYFN GRGAGEVSRQ IFAYAGQQYE DNRVTQEQWP ALKETCAAPF GQLPFLEVDG
     KKLAQSHAIA RFLAREFKLN GKTAWEEAQV NSLADQYKDY SSEARPYFYA VMGFGPGDVE
     TLKKDIFLPA FEKFYGFLVN FLKASGSGFL VGDSLTWIDL AIAQHSADLI AKGGDFSKFP
     ELKAHAEKIQ AIPQIKKWIE TRPVTPF
//