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Q09596

- GST5_CAEEL

UniProt

Q09596 - GST5_CAEEL

Protein

Probable glutathione S-transferase 5

Gene

gst-5

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.By similarity

    Catalytic activityi

    RX + glutathione = HX + R-S-glutathione.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei8 – 81GlutathioneBy similarity
    Binding sitei39 – 391GlutathioneBy similarity
    Binding sitei43 – 431GlutathioneBy similarity

    GO - Molecular functioni

    1. glutathione transferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. innate immune response Source: WormBase

    Keywords - Molecular functioni

    Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glutathione S-transferase 5 (EC:2.5.1.18)
    Alternative name(s):
    GST class-sigma
    Gene namesi
    Name:gst-5
    ORF Names:R03D7.6
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome II

    Organism-specific databases

    WormBaseiR03D7.6a; CE01613; WBGene00001753; gst-5.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 207207Probable glutathione S-transferase 5PRO_0000185928Add
    BLAST

    Proteomic databases

    PaxDbiQ09596.

    Expressioni

    Gene expression databases

    ArrayExpressiQ09596.

    Interactioni

    Protein-protein interaction databases

    BioGridi52227. 1 interaction.
    DIPiDIP-26899N.
    IntActiQ09596. 27 interactions.
    MINTiMINT-1122168.
    STRINGi6239.R03D7.6.

    Structurei

    Secondary structure

    1
    207
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi4 – 129
    Helixi13 – 153
    Helixi16 – 2510
    Beta strandi30 – 345
    Turni36 – 383
    Helixi39 – 446
    Beta strandi55 – 584
    Beta strandi61 – 644
    Helixi66 – 7611
    Helixi84 – 11128
    Helixi119 – 1257
    Helixi127 – 14519
    Beta strandi147 – 1515
    Helixi157 – 17115
    Helixi180 – 19112
    Helixi193 – 2019

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1ZL9X-ray2.01A/B1-207[»]
    ProteinModelPortaliQ09596.
    SMRiQ09596. Positions 1-207.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ09596.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 8180GST N-terminalAdd
    BLAST
    Domaini83 – 207125GST C-terminalAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni52 – 532Glutathione bindingBy similarity
    Regioni65 – 662Glutathione bindingBy similarity

    Sequence similaritiesi

    Belongs to the GST superfamily. Sigma family.Curated
    Contains 1 GST C-terminal domain.Curated
    Contains 1 GST N-terminal domain.Curated

    Phylogenomic databases

    eggNOGiNOG271723.
    GeneTreeiENSGT00670000097856.
    HOGENOMiHOG000115733.
    InParanoidiQ09596.
    KOiK00799.
    OMAiDIFLPAF.
    PhylomeDBiQ09596.

    Family and domain databases

    Gene3Di1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProiIPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF00043. GST_C. 1 hit.
    PF02798. GST_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEiPS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q09596-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVSYKLTYFN GRGAGEVSRQ IFAYAGQQYE DNRVTQEQWP ALKETCAAPF    50
    GQLPFLEVDG KKLAQSHAIA RFLAREFKLN GKTAWEEAQV NSLADQYKDY 100
    SSEARPYFYA VMGFGPGDVE TLKKDIFLPA FEKFYGFLVN FLKASGSGFL 150
    VGDSLTWIDL AIAQHSADLI AKGGDFSKFP ELKAHAEKIQ AIPQIKKWIE 200
    TRPVTPF 207
    Length:207
    Mass (Da):23,252
    Last modified:November 1, 1995 - v1
    Checksum:i7FDE101B24F7468B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46828 Genomic DNA. Translation: CAA86859.1.
    PIRiT23872.
    RefSeqiNP_001254267.1. NM_001267338.1.
    UniGeneiCel.14876.

    Genome annotation databases

    EnsemblMetazoaiR03D7.6a; R03D7.6a; WBGene00001753.
    GeneIDi187537.
    KEGGicel:CELE_R03D7.6.
    UCSCiR03D7.6. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46828 Genomic DNA. Translation: CAA86859.1 .
    PIRi T23872.
    RefSeqi NP_001254267.1. NM_001267338.1.
    UniGenei Cel.14876.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1ZL9 X-ray 2.01 A/B 1-207 [» ]
    ProteinModelPortali Q09596.
    SMRi Q09596. Positions 1-207.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 52227. 1 interaction.
    DIPi DIP-26899N.
    IntActi Q09596. 27 interactions.
    MINTi MINT-1122168.
    STRINGi 6239.R03D7.6.

    Proteomic databases

    PaxDbi Q09596.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai R03D7.6a ; R03D7.6a ; WBGene00001753 .
    GeneIDi 187537.
    KEGGi cel:CELE_R03D7.6.
    UCSCi R03D7.6. c. elegans.

    Organism-specific databases

    CTDi 187537.
    WormBasei R03D7.6a ; CE01613 ; WBGene00001753 ; gst-5.

    Phylogenomic databases

    eggNOGi NOG271723.
    GeneTreei ENSGT00670000097856.
    HOGENOMi HOG000115733.
    InParanoidi Q09596.
    KOi K00799.
    OMAi DIFLPAF.
    PhylomeDBi Q09596.

    Miscellaneous databases

    EvolutionaryTracei Q09596.
    NextBioi 935622.

    Gene expression databases

    ArrayExpressi Q09596.

    Family and domain databases

    Gene3Di 1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProi IPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF00043. GST_C. 1 hit.
    PF02798. GST_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEi PS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiGST5_CAEEL
    AccessioniPrimary (citable) accession number: Q09596
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3