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Q09596

- GST5_CAEEL

UniProt

Q09596 - GST5_CAEEL

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Protein

Probable glutathione S-transferase 5

Gene

gst-5

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei8 – 81GlutathioneBy similarity
Binding sitei39 – 391GlutathioneBy similarity
Binding sitei43 – 431GlutathioneBy similarity

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB-EC

GO - Biological processi

  1. innate immune response Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Enzyme and pathway databases

ReactomeiREACT_184548. Detoxification of Reactive Oxygen Species.
REACT_263468. Glutathione conjugation.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glutathione S-transferase 5 (EC:2.5.1.18)
Alternative name(s):
GST class-sigma
Gene namesi
Name:gst-5
ORF Names:R03D7.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome II

Organism-specific databases

WormBaseiR03D7.6a; CE01613; WBGene00001753; gst-5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 207207Probable glutathione S-transferase 5PRO_0000185928Add
BLAST

Proteomic databases

PaxDbiQ09596.

Expressioni

Gene expression databases

ExpressionAtlasiQ09596. baseline and differential.

Interactioni

Protein-protein interaction databases

BioGridi52227. 1 interaction.
DIPiDIP-26899N.
IntActiQ09596. 27 interactions.
MINTiMINT-1122168.
STRINGi6239.R03D7.6.

Structurei

Secondary structure

1
207
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 129Combined sources
Helixi13 – 153Combined sources
Helixi16 – 2510Combined sources
Beta strandi30 – 345Combined sources
Turni36 – 383Combined sources
Helixi39 – 446Combined sources
Beta strandi55 – 584Combined sources
Beta strandi61 – 644Combined sources
Helixi66 – 7611Combined sources
Helixi84 – 11128Combined sources
Helixi119 – 1257Combined sources
Helixi127 – 14519Combined sources
Beta strandi147 – 1515Combined sources
Helixi157 – 17115Combined sources
Helixi180 – 19112Combined sources
Helixi193 – 2019Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ZL9X-ray2.01A/B1-207[»]
ProteinModelPortaliQ09596.
SMRiQ09596. Positions 1-207.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ09596.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 8180GST N-terminalAdd
BLAST
Domaini83 – 207125GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni52 – 532Glutathione bindingBy similarity
Regioni65 – 662Glutathione bindingBy similarity

Sequence similaritiesi

Belongs to the GST superfamily. Sigma family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiNOG271723.
GeneTreeiENSGT00670000097856.
HOGENOMiHOG000115733.
InParanoidiQ09596.
KOiK00799.
OMAiDIFLPAF.
PhylomeDBiQ09596.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q09596-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVSYKLTYFN GRGAGEVSRQ IFAYAGQQYE DNRVTQEQWP ALKETCAAPF
60 70 80 90 100
GQLPFLEVDG KKLAQSHAIA RFLAREFKLN GKTAWEEAQV NSLADQYKDY
110 120 130 140 150
SSEARPYFYA VMGFGPGDVE TLKKDIFLPA FEKFYGFLVN FLKASGSGFL
160 170 180 190 200
VGDSLTWIDL AIAQHSADLI AKGGDFSKFP ELKAHAEKIQ AIPQIKKWIE

TRPVTPF
Length:207
Mass (Da):23,252
Last modified:November 1, 1995 - v1
Checksum:i7FDE101B24F7468B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46828 Genomic DNA. Translation: CAA86859.1.
PIRiT23872.
RefSeqiNP_001254267.1. NM_001267338.1.
UniGeneiCel.14876.

Genome annotation databases

EnsemblMetazoaiR03D7.6a; R03D7.6a; WBGene00001753.
GeneIDi187537.
KEGGicel:CELE_R03D7.6.
UCSCiR03D7.6. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46828 Genomic DNA. Translation: CAA86859.1 .
PIRi T23872.
RefSeqi NP_001254267.1. NM_001267338.1.
UniGenei Cel.14876.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1ZL9 X-ray 2.01 A/B 1-207 [» ]
ProteinModelPortali Q09596.
SMRi Q09596. Positions 1-207.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 52227. 1 interaction.
DIPi DIP-26899N.
IntActi Q09596. 27 interactions.
MINTi MINT-1122168.
STRINGi 6239.R03D7.6.

Proteomic databases

PaxDbi Q09596.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai R03D7.6a ; R03D7.6a ; WBGene00001753 .
GeneIDi 187537.
KEGGi cel:CELE_R03D7.6.
UCSCi R03D7.6. c. elegans.

Organism-specific databases

CTDi 187537.
WormBasei R03D7.6a ; CE01613 ; WBGene00001753 ; gst-5.

Phylogenomic databases

eggNOGi NOG271723.
GeneTreei ENSGT00670000097856.
HOGENOMi HOG000115733.
InParanoidi Q09596.
KOi K00799.
OMAi DIFLPAF.
PhylomeDBi Q09596.

Enzyme and pathway databases

Reactomei REACT_184548. Detoxification of Reactive Oxygen Species.
REACT_263468. Glutathione conjugation.

Miscellaneous databases

EvolutionaryTracei Q09596.
NextBioi 935622.

Gene expression databases

ExpressionAtlasi Q09596. baseline and differential.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view ]
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiGST5_CAEEL
AccessioniPrimary (citable) accession number: Q09596
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 26, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3