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Protein

Probable glutathione S-transferase 5

Gene

gst-5

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei8 – 81GlutathioneBy similarity
Binding sitei39 – 391GlutathioneBy similarity
Binding sitei43 – 431GlutathioneBy similarity

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB-EC

GO - Biological processi

  1. innate immune response Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Enzyme and pathway databases

ReactomeiREACT_184548. Detoxification of Reactive Oxygen Species.
REACT_263468. Glutathione conjugation.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glutathione S-transferase 5 (EC:2.5.1.18)
Alternative name(s):
GST class-sigma
Gene namesi
Name:gst-5
ORF Names:R03D7.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome II

Organism-specific databases

WormBaseiR03D7.6a; CE01613; WBGene00001753; gst-5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 207207Probable glutathione S-transferase 5PRO_0000185928Add
BLAST

Proteomic databases

PaxDbiQ09596.

Expressioni

Gene expression databases

ExpressionAtlasiQ09596. baseline and differential.

Interactioni

Protein-protein interaction databases

BioGridi52227. 1 interaction.
DIPiDIP-26899N.
IntActiQ09596. 27 interactions.
MINTiMINT-1122168.
STRINGi6239.R03D7.6.

Structurei

Secondary structure

1
207
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 129Combined sources
Helixi13 – 153Combined sources
Helixi16 – 2510Combined sources
Beta strandi30 – 345Combined sources
Turni36 – 383Combined sources
Helixi39 – 446Combined sources
Beta strandi55 – 584Combined sources
Beta strandi61 – 644Combined sources
Helixi66 – 7611Combined sources
Helixi84 – 11128Combined sources
Helixi119 – 1257Combined sources
Helixi127 – 14519Combined sources
Beta strandi147 – 1515Combined sources
Helixi157 – 17115Combined sources
Helixi180 – 19112Combined sources
Helixi193 – 2019Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ZL9X-ray2.01A/B1-207[»]
ProteinModelPortaliQ09596.
SMRiQ09596. Positions 1-207.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ09596.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 8180GST N-terminalAdd
BLAST
Domaini83 – 207125GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni52 – 532Glutathione bindingBy similarity
Regioni65 – 662Glutathione bindingBy similarity

Sequence similaritiesi

Belongs to the GST superfamily. Sigma family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiNOG271723.
GeneTreeiENSGT00670000097856.
HOGENOMiHOG000115733.
InParanoidiQ09596.
KOiK00799.
OMAiERPETFI.
PhylomeDBiQ09596.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q09596-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVSYKLTYFN GRGAGEVSRQ IFAYAGQQYE DNRVTQEQWP ALKETCAAPF
60 70 80 90 100
GQLPFLEVDG KKLAQSHAIA RFLAREFKLN GKTAWEEAQV NSLADQYKDY
110 120 130 140 150
SSEARPYFYA VMGFGPGDVE TLKKDIFLPA FEKFYGFLVN FLKASGSGFL
160 170 180 190 200
VGDSLTWIDL AIAQHSADLI AKGGDFSKFP ELKAHAEKIQ AIPQIKKWIE

TRPVTPF
Length:207
Mass (Da):23,252
Last modified:November 1, 1995 - v1
Checksum:i7FDE101B24F7468B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46828 Genomic DNA. Translation: CAA86859.1.
PIRiT23872.
RefSeqiNP_001254267.1. NM_001267338.1.
UniGeneiCel.14876.

Genome annotation databases

EnsemblMetazoaiR03D7.6a; R03D7.6a; WBGene00001753.
GeneIDi187537.
KEGGicel:CELE_R03D7.6.
UCSCiR03D7.6. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46828 Genomic DNA. Translation: CAA86859.1.
PIRiT23872.
RefSeqiNP_001254267.1. NM_001267338.1.
UniGeneiCel.14876.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ZL9X-ray2.01A/B1-207[»]
ProteinModelPortaliQ09596.
SMRiQ09596. Positions 1-207.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi52227. 1 interaction.
DIPiDIP-26899N.
IntActiQ09596. 27 interactions.
MINTiMINT-1122168.
STRINGi6239.R03D7.6.

Proteomic databases

PaxDbiQ09596.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiR03D7.6a; R03D7.6a; WBGene00001753.
GeneIDi187537.
KEGGicel:CELE_R03D7.6.
UCSCiR03D7.6. c. elegans.

Organism-specific databases

CTDi187537.
WormBaseiR03D7.6a; CE01613; WBGene00001753; gst-5.

Phylogenomic databases

eggNOGiNOG271723.
GeneTreeiENSGT00670000097856.
HOGENOMiHOG000115733.
InParanoidiQ09596.
KOiK00799.
OMAiERPETFI.
PhylomeDBiQ09596.

Enzyme and pathway databases

ReactomeiREACT_184548. Detoxification of Reactive Oxygen Species.
REACT_263468. Glutathione conjugation.

Miscellaneous databases

EvolutionaryTraceiQ09596.
NextBioi935622.

Gene expression databases

ExpressionAtlasiQ09596. baseline and differential.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiGST5_CAEEL
AccessioniPrimary (citable) accession number: Q09596
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: January 7, 2015
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.