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Reviewed, UniProtKB/Swiss-Prot Q09596 (GST5_CAEEL)

Last modified February 9, 2010. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Probable glutathione S-transferase 5
    EC=2.5.1.18
Alternative name(s):
    GST class-sigma
Gene names
Name: gst-5
ORF Names: R03D7.6
OrganismCaenorhabditis elegans [Complete proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

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Protein attributes

Sequence length207 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles By similarity.

Catalytic activity

RX + glutathione = HX + R-S-glutathione.

Sequence similarities

Belongs to the GST superfamily. Sigma family.

Contains 1 GST C-terminal domain.

Contains 1 GST N-terminal domain.

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Ontologies

Keywords
   Molecular functionTransferase
   Technical term3D-structure
Complete proteome
Gene Ontology (GO)
   Biological processapoptosis

Inferred from mutant phenotype. Source: WormBase

determination of adult lifespan

Inferred from mutant phenotype. Source: WormBase

   Molecular functionglutathione transferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 207207Probable glutathione S-transferase 5
PRO_0000185928

Regions

Domain2 – 8180GST N-terminal
Domain83 – 207125GST C-terminal

Secondary structure

1 .............................. 207
Helix Strand Turn

Details...

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Sequences

Sequence LengthMass (Da)Tools
Q09596-1 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 7FDE101B24F7468B

FASTA20723,252
        10         20         30         40         50         60 
MVSYKLTYFN GRGAGEVSRQ IFAYAGQQYE DNRVTQEQWP ALKETCAAPF GQLPFLEVDG 

        70         80         90        100        110        120 
KKLAQSHAIA RFLAREFKLN GKTAWEEAQV NSLADQYKDY SSEARPYFYA VMGFGPGDVE 

       130        140        150        160        170        180 
TLKKDIFLPA FEKFYGFLVN FLKASGSGFL VGDSLTWIDL AIAQHSADLI AKGGDFSKFP 

       190        200 
ELKAHAEKIQ AIPQIKKWIE TRPVTPF

« Hide

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References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		Z46828 Genomic DNA. Translation: CAA86859.1.
PIRT23872.
RefSeqNP_496357.1.
UniGeneCel.14876

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1ZL9X-ray2.01A/B1-207[»]
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-26899N.
IntActQ09596. 30 interactions.
STRINGQ09596.

Genome annotation databases

EnsemblR03D7.6; R03D7.6; R03D7.6; Caenorhabditis elegans. [Genome view]
GeneID187537.
KEGGcel:R03D7.6.
NMPDRfig|6239.3.peg.7351.
UCSCR03D7.6. c. elegans.

Organism-specific databases

CTD187537.
WormBaseWBGene00001753. gst-5.
WormPepR03D7.6. CE01613. [WorfDB]

Phylogenomic databases

eggNOGmeNOG14525.
HOGENOMHBG563238.
InParanoidQ09596.
OMASHAIARF.
PhylomeDBQ09596.

Enzyme and pathway databases

BRENDA2.5.1.18. 672.

Gene expression databases

ArrayExpressQ09596.

Family and domain databases

InterProIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR017933. Glutathione_S_Trfase/Cl_chnl_C.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
IPR012335. Thioredoxin_fold.
[Graphical view]
Gene3DG3DSA:1.20.1050.10. GST_C_like. 1 hit.
G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
PfamPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PROSITEPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio935622.

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Entry information

Entry nameGST5_CAEEL
AccessionPrimary (citable) accession number: Q09596
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: February 9, 2010
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectCaenorhabditis annotation project

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Relevant documents

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormPep

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents