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Q09596 (GST5_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable glutathione S-transferase 5

EC=2.5.1.18
Alternative name(s):
GST class-sigma
Gene names
Name:gst-5
ORF Names:R03D7.6
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length207 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles By similarity.

Catalytic activity

RX + glutathione = HX + R-S-glutathione.

Sequence similarities

Belongs to the GST superfamily. Sigma family.

Contains 1 GST C-terminal domain.

Contains 1 GST N-terminal domain.

Ontologies

Keywords
   Molecular functionTransferase
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processinnate immune response

Inferred from expression pattern PubMed 16968778. Source: WormBase

   Molecular_functionglutathione transferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 207207Probable glutathione S-transferase 5
PRO_0000185928

Regions

Domain2 – 8180GST N-terminal
Domain83 – 207125GST C-terminal
Region52 – 532Glutathione binding By similarity
Region65 – 662Glutathione binding By similarity

Sites

Binding site81Glutathione By similarity
Binding site391Glutathione By similarity
Binding site431Glutathione By similarity

Secondary structure

.............................. 207
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q09596 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 7FDE101B24F7468B

FASTA20723,252
        10         20         30         40         50         60 
MVSYKLTYFN GRGAGEVSRQ IFAYAGQQYE DNRVTQEQWP ALKETCAAPF GQLPFLEVDG 

        70         80         90        100        110        120 
KKLAQSHAIA RFLAREFKLN GKTAWEEAQV NSLADQYKDY SSEARPYFYA VMGFGPGDVE 

       130        140        150        160        170        180 
TLKKDIFLPA FEKFYGFLVN FLKASGSGFL VGDSLTWIDL AIAQHSADLI AKGGDFSKFP 

       190        200 
ELKAHAEKIQ AIPQIKKWIE TRPVTPF 

« Hide

References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z46828 Genomic DNA. Translation: CAA86859.1.
PIRT23872.
RefSeqNP_001254267.1. NM_001267338.1.
UniGeneCel.14876.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1ZL9X-ray2.01A/B1-207[»]
ProteinModelPortalQ09596.
SMRQ09596. Positions 1-207.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid52227. 1 interaction.
DIPDIP-26899N.
IntActQ09596. 27 interactions.
MINTMINT-1122168.
STRING6239.R03D7.6.

Proteomic databases

PaxDbQ09596.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaR03D7.6a; R03D7.6a; WBGene00001753.
GeneID187537.
KEGGcel:CELE_R03D7.6.
UCSCR03D7.6. c. elegans.

Organism-specific databases

CTD187537.
WormBaseR03D7.6a; CE01613; WBGene00001753; gst-5.

Phylogenomic databases

eggNOGNOG271723.
GeneTreeENSGT00670000097856.
HOGENOMHOG000115733.
InParanoidQ09596.
KOK00799.
OMADIFLPAF.
PhylomeDBQ09596.

Gene expression databases

ArrayExpressQ09596.

Family and domain databases

Gene3D1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ09596.
NextBio935622.

Entry information

Entry nameGST5_CAEEL
AccessionPrimary (citable) accession number: Q09596
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase