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Protein

Probable glutathione S-transferase 5

Gene

gst-5

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (By similarity). May play a role in the detoxification of reactive oxygen species produced during pathogenic bacterial infection (PubMed:22216003).By similarity1 Publication

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei8GlutathioneBy similarity1
Binding sitei39GlutathioneBy similarity1
Binding sitei43GlutathioneBy similarity1

GO - Molecular functioni

GO - Biological processi

  • innate immune response Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Enzyme and pathway databases

ReactomeiR-CEL-156590. Glutathione conjugation.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glutathione S-transferase 5 (EC:2.5.1.18)
Alternative name(s):
GST class-sigma
Gene namesi
Name:gst-5
ORF Names:R03D7.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiR03D7.6a; CE01613; WBGene00001753; gst-5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001859281 – 207Probable glutathione S-transferase 5Add BLAST207

Proteomic databases

EPDiQ09596.
PaxDbiQ09596.
PeptideAtlasiQ09596.
PRIDEiQ09596.

Expressioni

Gene expression databases

BgeeiWBGene00001753.
ExpressionAtlasiQ09596. differential.

Interactioni

Protein-protein interaction databases

BioGridi52227. 1 interactor.
DIPiDIP-26899N.
IntActiQ09596. 26 interactors.
MINTiMINT-1122168.
STRINGi6239.R03D7.6a.

Structurei

Secondary structure

1207
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 12Combined sources9
Helixi13 – 15Combined sources3
Helixi16 – 25Combined sources10
Beta strandi30 – 34Combined sources5
Turni36 – 38Combined sources3
Helixi39 – 44Combined sources6
Beta strandi55 – 58Combined sources4
Beta strandi61 – 64Combined sources4
Helixi66 – 76Combined sources11
Helixi84 – 111Combined sources28
Helixi119 – 125Combined sources7
Helixi127 – 145Combined sources19
Beta strandi147 – 151Combined sources5
Helixi157 – 171Combined sources15
Helixi180 – 191Combined sources12
Helixi193 – 201Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZL9X-ray2.01A/B1-207[»]
ProteinModelPortaliQ09596.
SMRiQ09596.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ09596.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 81GST N-terminalAdd BLAST80
Domaini83 – 207GST C-terminalAdd BLAST125

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni51 – 53Glutathione bindingBy similarity3
Regioni65 – 66Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Sigma family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiENOG410IN5E. Eukaryota.
ENOG4111Q6N. LUCA.
GeneTreeiENSGT00670000097856.
HOGENOMiHOG000115733.
InParanoidiQ09596.
KOiK00799.
OMAiKETCAAP.
OrthoDBiEOG091G0MBB.
PhylomeDBiQ09596.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF14497. GST_C_3. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q09596-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSYKLTYFN GRGAGEVSRQ IFAYAGQQYE DNRVTQEQWP ALKETCAAPF
60 70 80 90 100
GQLPFLEVDG KKLAQSHAIA RFLAREFKLN GKTAWEEAQV NSLADQYKDY
110 120 130 140 150
SSEARPYFYA VMGFGPGDVE TLKKDIFLPA FEKFYGFLVN FLKASGSGFL
160 170 180 190 200
VGDSLTWIDL AIAQHSADLI AKGGDFSKFP ELKAHAEKIQ AIPQIKKWIE

TRPVTPF
Length:207
Mass (Da):23,252
Last modified:November 1, 1995 - v1
Checksum:i7FDE101B24F7468B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46828 Genomic DNA. Translation: CAA86859.1.
PIRiT23872.
RefSeqiNP_001254267.1. NM_001267338.1.
UniGeneiCel.14876.

Genome annotation databases

EnsemblMetazoaiR03D7.6a; R03D7.6a; WBGene00001753.
GeneIDi187537.
KEGGicel:CELE_R03D7.6.
UCSCiR03D7.6. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46828 Genomic DNA. Translation: CAA86859.1.
PIRiT23872.
RefSeqiNP_001254267.1. NM_001267338.1.
UniGeneiCel.14876.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZL9X-ray2.01A/B1-207[»]
ProteinModelPortaliQ09596.
SMRiQ09596.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi52227. 1 interactor.
DIPiDIP-26899N.
IntActiQ09596. 26 interactors.
MINTiMINT-1122168.
STRINGi6239.R03D7.6a.

Proteomic databases

EPDiQ09596.
PaxDbiQ09596.
PeptideAtlasiQ09596.
PRIDEiQ09596.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiR03D7.6a; R03D7.6a; WBGene00001753.
GeneIDi187537.
KEGGicel:CELE_R03D7.6.
UCSCiR03D7.6. c. elegans.

Organism-specific databases

CTDi187537.
WormBaseiR03D7.6a; CE01613; WBGene00001753; gst-5.

Phylogenomic databases

eggNOGiENOG410IN5E. Eukaryota.
ENOG4111Q6N. LUCA.
GeneTreeiENSGT00670000097856.
HOGENOMiHOG000115733.
InParanoidiQ09596.
KOiK00799.
OMAiKETCAAP.
OrthoDBiEOG091G0MBB.
PhylomeDBiQ09596.

Enzyme and pathway databases

ReactomeiR-CEL-156590. Glutathione conjugation.

Miscellaneous databases

EvolutionaryTraceiQ09596.
PROiQ09596.

Gene expression databases

BgeeiWBGene00001753.
ExpressionAtlasiQ09596. differential.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF14497. GST_C_3. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGST5_CAEEL
AccessioniPrimary (citable) accession number: Q09596
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 30, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.