Reviewed, UniProtKB/Swiss-Prot Q09596 (GST5_CAEEL)

Names and origin

Protein names

Recommended name:
    Probable glutathione S-transferase 5
    EC=2.5.1.18
Alternative name(s):
    GST class-sigma

Gene names

Name:	gst-5
ORF Names:	R03D7.6

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	207 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles By similarity.
Catalytic activity	RX + glutathione = HX + R-S-glutathione.
Sequence similarities	Belongs to the GST superfamily. Sigma family. Contains 1 GST C-terminal domain. Contains 1 GST N-terminal domain.

Ontologies

Keywords
Molecular function	Transferase
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Molecular function	glutathione transferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 207

207

Probable glutathione S-transferase 5

PRO_0000185928

Regions

Domain

2 – 81

80

GST N-terminal

Domain

83 – 207

125

GST C-terminal

Secondary structure

1

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207

Helix Strand Turn

Details...

Beta strand

4 – 12

9

Helix

13 – 15

3

Helix

16 – 25

10

Beta strand

30 – 34

5

Turn

36 – 38

3

Helix

39 – 44

6

Beta strand

55 – 58

4

Beta strand

61 – 64

4

Helix

66 – 76

11

Helix

84 – 111

28

Helix

119 – 125

7

Helix

127 – 145

19

Beta strand

147 – 151

5

Helix

157 – 171

15

Helix

180 – 191

12

Helix

193 – 201

9

Sequences

	Sequence		Length	Mass (Da)
	Q09596-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 7FDE101B24F7468B	FASTA	207	23,252
	10 20 30 40 50 60 MVSYKLTYFN GRGAGEVSRQ IFAYAGQQYE DNRVTQEQWP ALKETCAAPF GQLPFLEVDG 70 80 90 100 110 120 KKLAQSHAIA RFLAREFKLN GKTAWEEAQV NSLADQYKDY SSEARPYFYA VMGFGPGDVE 130 140 150 160 170 180 TLKKDIFLPA FEKFYGFLVN FLKASGSGFL VGDSLTWIDL AIAQHSADLI AKGGDFSKFP 190 200 ELKAHAEKIQ AIPQIKKWIE TRPVTPF

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.

Cross-references

Sequence databases

EMBLGenBankDDBJ

Z46828 Genomic DNA. Translation: CAA86859.1.

PIR

T23872.

RefSeq

NP_496357.1.

UniGene

Cel.14876

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1ZL9	X-ray	2.01	A/B	1-207	[»]

ModBase

Search...

Protein-protein interaction databases

DIP

DIP:26899N.

IntAct

Q09596. 30 interactions.

Genome annotation databases

Ensembl

R03D7.6. Caenorhabditis elegans. [Contig view]

GeneID

187537.

KEGG

cel:R03D7.6.

NMPDR

fig|6239.3.peg.7351.

Organism-specific databases

WormBase

WBGene00001753. gst-5.

WormPep

R03D7.6. CE01613. [WorfDB]

Phylogenomic databases

OMA

Q09596. KDYSSEA.

Enzyme and pathway databases

BRENDA

2.5.1.18. 672.

Gene expression databases

ArrayExpress

Q09596.

Family and domain databases

InterPro

IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR017933. Glutathione_S_Trfase/Cl_chnl_C.
IPR004046. GST_C.
IPR012335. Thioredoxin_fold.
[Graphical view]

Gene3D

G3DSA:1.20.1050.10. GST_C_like. 1 hit.
G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.

Pfam

PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]

PROSITE

PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

935622.

Entry information

Entry name

GST5_CAEEL

Accession

Primary (citable) accession number: Q09596

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	May 5, 2009
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project