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Protein

Protein HIRA

Gene

hira-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SignaLinkiQ09589

Names & Taxonomyi

Protein namesi
Recommended name:
Protein HIRACurated
Alternative name(s):
Histone cell cycle regulator 1 homologImported
Gene namesi
Name:hira-1Imported
ORF Names:K10D2.1Imported
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiK10D2.1a ; CE43736 ; WBGene00019627 ; hira-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002864241 – 935Protein HIRAAdd BLAST935

Proteomic databases

EPDiQ09589
PaxDbiQ09589
PeptideAtlasiQ09589
PRIDEiQ09589

Expressioni

Gene expression databases

BgeeiWBGene00019627

Interactioni

Protein-protein interaction databases

BioGridi40940, 1 interactor
DIPiDIP-26906N
STRINGi6239.K10D2.1a

Structurei

3D structure databases

ProteinModelPortaliQ09589
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati14 – 58WD 1Add BLAST45
Repeati72 – 111WD 2Add BLAST40
Repeati131 – 170WD 3Add BLAST40
Repeati174 – 213WD 4Add BLAST40
Repeati222 – 261WD 5Add BLAST40
Repeati277 – 320WD 6Add BLAST44
Repeati325 – 362WD 7Add BLAST38

Sequence similaritiesi

Belongs to the WD repeat HIR1 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0973 Eukaryota
ENOG410XP1H LUCA
GeneTreeiENSGT00550000074919
HOGENOMiHOG000108885
InParanoidiQ09589
KOiK11293
OMAiLLGPVHY
OrthoDBiEOG091G04F0
PhylomeDBiQ09589

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR031120 HIR1
IPR011494 Hira
IPR019015 HIRA_B_motif
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR13831 PTHR13831, 1 hit
PfamiView protein in Pfam
PF07569 Hira, 1 hit
PF09453 HIRA_B, 1 hit
PF00400 WD40, 2 hits
SMARTiView protein in SMART
SM00320 WD40, 6 hits
SUPFAMiSSF50978 SSF50978, 3 hits
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q09589-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDVYVTSPT FVGHDTGSIL AIDCHPSGKK FITCGQKART SNGLVVVWNA
60 70 80 90 100
EPVLDKKKAS NENVPKLLFQ VESQSQSNSC RWSPDGKRFA FGSDDSSVSV
110 120 130 140 150
WEYVGLINSM GSITGGAQNV ERYKECCVLR GHSMEVLTVE WSPNGKYLAS
160 170 180 190 200
GSIDYRIIIY NARKLPDRIT VLNDIQLPVK GLSWDPIGKY LASLEGDKKL
210 220 230 240 250
RFWATDSWQC VKSVTEPFES NIEETMLTRL DWSPDGKYLM TPAAVRSGKP
260 270 280 290 300
LIKLIQRQTW KSDQFLAGHH KGTTCVRAMP RLIEANLKNG KRMQLTCAAV
310 320 330 340 350
GSRDKSISIW VFPGTLKPLF VINNIFNHTV MDFAWCGRNL LACSQDGTVK
360 370 380 390 400
VIHLSESVIG EMISNEAMSD LCYQIYSIRP PRYELTDKEE DESQDSFNLS
410 420 430 440 450
DLSSSANNAS FVTCPEDVLI KRKKLVAAQQ SSDIQLTKSM EDNSKENESK
460 470 480 490 500
NSEKTMMEER NKQIDVRKDG KRRIQPVFCG TTTADPMTSL SSEGKKTVAP
510 520 530 540 550
PPAKRKALAP AVPAKKGEVD LEDSSDSDDD DEEEEEDMEI SDIESVRNKK
560 570 580 590 600
RKVPATTSQP MLALDLKKPA LRPMEPKSLK TQEGTVLMEA PEQQPKLSQH
610 620 630 640 650
VVDRKGMFVE IDNRWKHGGV ETTQIKLIKK KQQTAENEDD MMDGERRVNH
660 670 680 690 700
ECLWMAVLGS PVIIVAANKH NVVLGCGDKC LRVYRTFCGT HIVSLRLDSL
710 720 730 740 750
PVLIGVTEHA AYALTENGRL STWNLKLGKA VVTRQPLFDC VEASTDNSLI
760 770 780 790 800
SADVSETGVP LIVFSNGSIF TFNVSLSCWI QAITTNVLGR LTSPISDAQL
810 820 830 840 850
SCSNGTTNSA GPLVRLLKRM RKQATAPGVA PQVVKAVKES QLEQLLHCAE
860 870 880 890 900
QLGNPQDYQT MLMLYVETLC EGGSEKKLKN ILNDLSRSGA PMQVCGLRRS
910 920 930
ALYDDVTRMI KLKQPAIAAR IVAGVAASTT TKSLF
Length:935
Mass (Da):103,430
Last modified:May 1, 2007 - v2
Checksum:i3EBFCAEB8B02A3B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284603 Genomic DNA Translation: CCD72864.1
PIRiE88451
RefSeqiNP_871692.2, NM_181963.4
UniGeneiCel.38012

Genome annotation databases

GeneIDi175709
KEGGicel:CELE_K10D2.1

Similar proteinsi

Entry informationi

Entry nameiHIRA_CAEEL
AccessioniPrimary (citable) accession number: Q09589
Secondary accession number(s): C4ALD2, Q8IG07
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2007
Last modified: April 25, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health