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Protein

Protein HIRA homolog

Gene

K10D2.1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

SignaLinkiQ09589.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein HIRA homolog
Gene namesi
ORF Names:K10D2.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiK10D2.1a; CE43736; WBGene00019627.
K10D2.1b; CE39597; WBGene00019627.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002864241 – 935Protein HIRA homologAdd BLAST935

Proteomic databases

EPDiQ09589.
PaxDbiQ09589.
PeptideAtlasiQ09589.
PRIDEiQ09589.

Expressioni

Gene expression databases

BgeeiWBGene00019627.

Interactioni

Protein-protein interaction databases

BioGridi40940. 1 interactor.
DIPiDIP-26906N.
MINTiMINT-1124863.
STRINGi6239.K10D2.1a.

Structurei

3D structure databases

ProteinModelPortaliQ09589.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati14 – 58WD 1Add BLAST45
Repeati72 – 111WD 2Add BLAST40
Repeati131 – 170WD 3Add BLAST40
Repeati174 – 213WD 4Add BLAST40
Repeati222 – 261WD 5Add BLAST40
Repeati277 – 320WD 6Add BLAST44
Repeati325 – 362WD 7Add BLAST38

Sequence similaritiesi

Belongs to the WD repeat HIR1 family.Curated
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0973. Eukaryota.
ENOG410XP1H. LUCA.
GeneTreeiENSGT00550000074919.
HOGENOMiHOG000108885.
InParanoidiQ09589.
KOiK11293.
OMAiTQNDAPQ.
OrthoDBiEOG091G04F0.
PhylomeDBiQ09589.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR031120. HIR1.
IPR011494. Hira.
IPR019015. HIRA_B_motif.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR13831. PTHR13831. 2 hits.
PfamiPF07569. Hira. 1 hit.
PF09453. HIRA_B. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 3 hits.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform a (identifier: Q09589-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGDVYVTSPT FVGHDTGSIL AIDCHPSGKK FITCGQKART SNGLVVVWNA
60 70 80 90 100
EPVLDKKKAS NENVPKLLFQ VESQSQSNSC RWSPDGKRFA FGSDDSSVSV
110 120 130 140 150
WEYVGLINSM GSITGGAQNV ERYKECCVLR GHSMEVLTVE WSPNGKYLAS
160 170 180 190 200
GSIDYRIIIY NARKLPDRIT VLNDIQLPVK GLSWDPIGKY LASLEGDKKL
210 220 230 240 250
RFWATDSWQC VKSVTEPFES NIEETMLTRL DWSPDGKYLM TPAAVRSGKP
260 270 280 290 300
LIKLIQRQTW KSDQFLAGHH KGTTCVRAMP RLIEANLKNG KRMQLTCAAV
310 320 330 340 350
GSRDKSISIW VFPGTLKPLF VINNIFNHTV MDFAWCGRNL LACSQDGTVK
360 370 380 390 400
VIHLSESVIG EMISNEAMSD LCYQIYSIRP PRYELTDKEE DESQDSFNLS
410 420 430 440 450
DLSSSANNAS FVTCPEDVLI KRKKLVAAQQ SSDIQLTKSM EDNSKENESK
460 470 480 490 500
NSEKTMMEER NKQIDVRKDG KRRIQPVFCG TTTADPMTSL SSEGKKTVAP
510 520 530 540 550
PPAKRKALAP AVPAKKGEVD LEDSSDSDDD DEEEEEDMEI SDIESVRNKK
560 570 580 590 600
RKVPATTSQP MLALDLKKPA LRPMEPKSLK TQEGTVLMEA PEQQPKLSQH
610 620 630 640 650
VVDRKGMFVE IDNRWKHGGV ETTQIKLIKK KQQTAENEDD MMDGERRVNH
660 670 680 690 700
ECLWMAVLGS PVIIVAANKH NVVLGCGDKC LRVYRTFCGT HIVSLRLDSL
710 720 730 740 750
PVLIGVTEHA AYALTENGRL STWNLKLGKA VVTRQPLFDC VEASTDNSLI
760 770 780 790 800
SADVSETGVP LIVFSNGSIF TFNVSLSCWI QAITTNVLGR LTSPISDAQL
810 820 830 840 850
SCSNGTTNSA GPLVRLLKRM RKQATAPGVA PQVVKAVKES QLEQLLHCAE
860 870 880 890 900
QLGNPQDYQT MLMLYVETLC EGGSEKKLKN ILNDLSRSGA PMQVCGLRRS
910 920 930
ALYDDVTRMI KLKQPAIAAR IVAGVAASTT TKSLF
Note: No experimental confirmation available.
Length:935
Mass (Da):103,430
Last modified:May 1, 2007 - v2
Checksum:i3EBFCAEB8B02A3B1
GO
Isoform b (identifier: Q09589-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     670-935: Missing.

Note: No experimental confirmation available.
Show »
Length:669
Mass (Da):74,752
Checksum:iC8B9A9DE0FC7ABA2
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_025053670 – 935Missing in isoform b. CuratedAdd BLAST266

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081618 Genomic DNA. Translation: CCD72856.1.
FO081618 Genomic DNA. Translation: CCD72864.1.
PIRiE88451.
RefSeqiNP_498101.2. NM_065700.4. [Q09589-1]
NP_871692.2. NM_181963.4. [Q09589-2]
UniGeneiCel.38012.

Genome annotation databases

EnsemblMetazoaiK10D2.1a; K10D2.1a; WBGene00019627. [Q09589-1]
GeneIDi175709.
KEGGicel:CELE_K10D2.1.
UCSCiK10D2.1a. c. elegans. [Q09589-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081618 Genomic DNA. Translation: CCD72856.1.
FO081618 Genomic DNA. Translation: CCD72864.1.
PIRiE88451.
RefSeqiNP_498101.2. NM_065700.4. [Q09589-1]
NP_871692.2. NM_181963.4. [Q09589-2]
UniGeneiCel.38012.

3D structure databases

ProteinModelPortaliQ09589.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi40940. 1 interactor.
DIPiDIP-26906N.
MINTiMINT-1124863.
STRINGi6239.K10D2.1a.

Proteomic databases

EPDiQ09589.
PaxDbiQ09589.
PeptideAtlasiQ09589.
PRIDEiQ09589.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiK10D2.1a; K10D2.1a; WBGene00019627. [Q09589-1]
GeneIDi175709.
KEGGicel:CELE_K10D2.1.
UCSCiK10D2.1a. c. elegans. [Q09589-1]

Organism-specific databases

CTDi175709.
WormBaseiK10D2.1a; CE43736; WBGene00019627.
K10D2.1b; CE39597; WBGene00019627.

Phylogenomic databases

eggNOGiKOG0973. Eukaryota.
ENOG410XP1H. LUCA.
GeneTreeiENSGT00550000074919.
HOGENOMiHOG000108885.
InParanoidiQ09589.
KOiK11293.
OMAiTQNDAPQ.
OrthoDBiEOG091G04F0.
PhylomeDBiQ09589.

Enzyme and pathway databases

SignaLinkiQ09589.

Miscellaneous databases

PROiQ09589.

Gene expression databases

BgeeiWBGene00019627.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR031120. HIR1.
IPR011494. Hira.
IPR019015. HIRA_B_motif.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR13831. PTHR13831. 2 hits.
PfamiPF07569. Hira. 1 hit.
PF09453. HIRA_B. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 3 hits.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHIRA_CAEEL
AccessioniPrimary (citable) accession number: Q09589
Secondary accession number(s): C4ALD2, Q8IG07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2007
Last modified: November 2, 2016
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.