ID   PSA3_CAEEL              Reviewed;         250 AA.
AC   Q09583;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   27-MAR-2024, entry version 175.
DE   RecName: Full=Proteasome subunit alpha type-3;
DE   AltName: Full=Proteasome subunit alpha 7;
GN   Name=pas-7; ORFNames=ZK945.2;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: The proteasome is a multicatalytic proteinase complex which
CC       is characterized by its ability to cleave peptides with Arg, Phe, Tyr,
CC       Leu, and Glu adjacent to the leaving group at neutral or slightly basic
CC       pH. The proteasome has an ATP-dependent proteolytic activity (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: The 26S proteasome consists of a 20S proteasome core and two
CC       19S regulatory subunits. The 20S proteasome core is composed of 28
CC       subunits that are arranged in four stacked rings, resulting in a
CC       barrel-shaped structure. The two end rings are each formed by seven
CC       alpha subunits, and the two central rings are each formed by seven beta
CC       subunits. The catalytic chamber with the active sites is on the inside
CC       of the barrel (By similarity). {ECO:0000250}.
CC   -!- INTERACTION:
CC       Q09583; O17586: pas-1; NbExp=6; IntAct=EBI-315406, EBI-315388;
CC       Q09583; O44156: pas-6; NbExp=5; IntAct=EBI-315406, EBI-318264;
CC       Q09583; Q09583: pas-7; NbExp=5; IntAct=EBI-315406, EBI-315406;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peptidase T1A family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00808}.
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DR   EMBL; Z48544; CAA88436.2; -; Genomic_DNA.
DR   PIR; T28119; T28119.
DR   RefSeq; NP_496177.2; NM_063776.3.
DR   AlphaFoldDB; Q09583; -.
DR   SMR; Q09583; -.
DR   BioGRID; 39890; 59.
DR   IntAct; Q09583; 13.
DR   STRING; 6239.ZK945.2.1; -.
DR   EPD; Q09583; -.
DR   PaxDb; 6239-ZK945-2-1; -.
DR   PeptideAtlas; Q09583; -.
DR   EnsemblMetazoa; ZK945.2.1; ZK945.2.1; WBGene00003928.
DR   GeneID; 174571; -.
DR   KEGG; cel:CELE_ZK945.2; -.
DR   UCSC; ZK945.2.1; c. elegans.
DR   AGR; WB:WBGene00003928; -.
DR   WormBase; ZK945.2; CE36420; WBGene00003928; pas-7.
DR   eggNOG; KOG0184; Eukaryota.
DR   GeneTree; ENSGT00550000074912; -.
DR   HOGENOM; CLU_035750_0_0_1; -.
DR   InParanoid; Q09583; -.
DR   OMA; RVSMYMH; -.
DR   OrthoDB; 166567at2759; -.
DR   PhylomeDB; Q09583; -.
DR   PRO; PR:Q09583; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00003928; Expressed in adult organism and 4 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IDA:WormBase.
DR   GO; GO:0005634; C:nucleus; IDA:WormBase.
DR   GO; GO:0019773; C:proteasome core complex, alpha-subunit complex; ISS:UniProtKB.
DR   GO; GO:0008441; F:3'(2'),5'-bisphosphate nucleotidase activity; IBA:GO_Central.
DR   GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   CDD; cd03751; proteasome_alpha_type_3; 1.
DR   Gene3D; 3.60.20.10; Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1; 1.
DR   InterPro; IPR029055; Ntn_hydrolases_N.
DR   InterPro; IPR023332; Proteasome_alpha-type.
DR   InterPro; IPR000426; Proteasome_asu_N.
DR   InterPro; IPR001353; Proteasome_sua/b.
DR   PANTHER; PTHR11599:SF10; PROTEASOME SUBUNIT ALPHA TYPE-3; 1.
DR   PANTHER; PTHR11599; PROTEASOME SUBUNIT ALPHA/BETA; 1.
DR   Pfam; PF00227; Proteasome; 1.
DR   Pfam; PF10584; Proteasome_A_N; 1.
DR   SMART; SM00948; Proteasome_A_N; 1.
DR   SUPFAM; SSF56235; N-terminal nucleophile aminohydrolases (Ntn hydrolases); 1.
DR   PROSITE; PS00388; PROTEASOME_ALPHA_1; 1.
DR   PROSITE; PS51475; PROTEASOME_ALPHA_2; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Nucleus; Proteasome; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..250
FT                   /note="Proteasome subunit alpha type-3"
FT                   /id="PRO_0000124095"
SQ   SEQUENCE   250 AA;  27752 MW;  FC97B4486B924855 CRC64;
     MSSIGTGYDL AASTFSPDGR IFQVEYAQKA VDNAGTMIAI RGKNGVVVVA DKLISSKLYT
     DNANPRMFNV NDNVGVAVAG NYPDGFALKN YAYGEAMKWL KDYREPMPIQ NIANSVAEYI
     HIHTLGISRP FGAGAFFMSW NKQTGGRLFL VEPSGLNYEY KAWAVGKHRQ AAKAEIEKLK
     IEELDVNQLV KEAARIIMVV RDENKDKNVQ IEMGWVGEQT NGKYEEVPSE VVTAAEEWAI
     AKLDEDDMDD
//