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Q09583

- PSA3_CAEEL

UniProt

Q09583 - PSA3_CAEEL

Protein

Proteasome subunit alpha type-3

Gene

pas-7

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity By similarity.By similarity

    Catalytic activityi

    Cleavage of peptide bonds with very broad specificity.PROSITE-ProRule annotation

    GO - Molecular functioni

    1. identical protein binding Source: IntAct
    2. protein binding Source: IntAct
    3. threonine-type endopeptidase activity Source: UniProtKB-KW

    GO - Biological processi

    1. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Threonine protease

    Enzyme and pathway databases

    ReactomeiREACT_101459. Regulation of activated PAK-2p34 by proteasome mediated degradation.
    REACT_183279. ER-Phagosome pathway.
    REACT_183284. Cross-presentation of soluble exogenous antigens (endosomes).
    REACT_183296. Antigen processing: Ubiquitination & Proteasome degradation.
    REACT_184635. Orc1 removal from chromatin.
    REACT_205379. SCF-beta-TrCP mediated degradation of Emi1.
    REACT_215136. Asymmetric localization of PCP proteins.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proteasome subunit alpha type-3 (EC:3.4.25.1)
    Alternative name(s):
    Proteasome subunit alpha 7
    Gene namesi
    Name:pas-7
    ORF Names:ZK945.2
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome II

    Organism-specific databases

    WormBaseiZK945.2; CE36420; WBGene00003928; pas-7.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: WormBase
    2. nucleus Source: WormBase
    3. proteasome core complex, alpha-subunit complex Source: InterPro

    Keywords - Cellular componenti

    Cytoplasm, Nucleus, Proteasome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 250249Proteasome subunit alpha type-3PRO_0000124095Add
    BLAST

    Proteomic databases

    PaxDbiQ09583.

    Interactioni

    Subunit structurei

    The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    itself5EBI-315406,EBI-315406
    pas-1O175866EBI-315406,EBI-315388
    pas-6O441565EBI-315406,EBI-318264

    Protein-protein interaction databases

    BioGridi39890. 14 interactions.
    IntActiQ09583. 13 interactions.
    MINTiMINT-210959.
    STRINGi6239.ZK945.2.1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ09583.
    SMRiQ09583. Positions 2-245.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase T1A family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0638.
    GeneTreeiENSGT00550000074912.
    HOGENOMiHOG000091086.
    InParanoidiQ09583.
    KOiK02727.
    OMAiVPDGRHF.
    PhylomeDBiQ09583.

    Family and domain databases

    Gene3Di3.60.20.10. 1 hit.
    InterProiIPR029055. Ntn_hydrolases_N.
    IPR000426. Proteasome_asu_N.
    IPR023332. Proteasome_suA-type.
    IPR001353. Proteasome_sua/b.
    [Graphical view]
    PfamiPF00227. Proteasome. 1 hit.
    PF10584. Proteasome_A_N. 1 hit.
    [Graphical view]
    SMARTiSM00948. Proteasome_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF56235. SSF56235. 1 hit.
    PROSITEiPS00388. PROTEASOME_ALPHA_1. 1 hit.
    PS51475. PROTEASOME_ALPHA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q09583-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSIGTGYDL AASTFSPDGR IFQVEYAQKA VDNAGTMIAI RGKNGVVVVA    50
    DKLISSKLYT DNANPRMFNV NDNVGVAVAG NYPDGFALKN YAYGEAMKWL 100
    KDYREPMPIQ NIANSVAEYI HIHTLGISRP FGAGAFFMSW NKQTGGRLFL 150
    VEPSGLNYEY KAWAVGKHRQ AAKAEIEKLK IEELDVNQLV KEAARIIMVV 200
    RDENKDKNVQ IEMGWVGEQT NGKYEEVPSE VVTAAEEWAI AKLDEDDMDD 250
    Length:250
    Mass (Da):27,752
    Last modified:January 23, 2007 - v3
    Checksum:iFC97B4486B924855
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z48544 Genomic DNA. Translation: CAA88436.2.
    PIRiT28119.
    RefSeqiNP_496177.2. NM_063776.3.
    UniGeneiCel.14673.

    Genome annotation databases

    EnsemblMetazoaiZK945.2.1; ZK945.2.1; WBGene00003928.
    ZK945.2.2; ZK945.2.2; WBGene00003928.
    GeneIDi174571.
    KEGGicel:CELE_ZK945.2.
    UCSCiZK945.2.1. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z48544 Genomic DNA. Translation: CAA88436.2 .
    PIRi T28119.
    RefSeqi NP_496177.2. NM_063776.3.
    UniGenei Cel.14673.

    3D structure databases

    ProteinModelPortali Q09583.
    SMRi Q09583. Positions 2-245.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 39890. 14 interactions.
    IntActi Q09583. 13 interactions.
    MINTi MINT-210959.
    STRINGi 6239.ZK945.2.1.

    Proteomic databases

    PaxDbi Q09583.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai ZK945.2.1 ; ZK945.2.1 ; WBGene00003928 .
    ZK945.2.2 ; ZK945.2.2 ; WBGene00003928 .
    GeneIDi 174571.
    KEGGi cel:CELE_ZK945.2.
    UCSCi ZK945.2.1. c. elegans.

    Organism-specific databases

    CTDi 174571.
    WormBasei ZK945.2 ; CE36420 ; WBGene00003928 ; pas-7.

    Phylogenomic databases

    eggNOGi COG0638.
    GeneTreei ENSGT00550000074912.
    HOGENOMi HOG000091086.
    InParanoidi Q09583.
    KOi K02727.
    OMAi VPDGRHF.
    PhylomeDBi Q09583.

    Enzyme and pathway databases

    Reactomei REACT_101459. Regulation of activated PAK-2p34 by proteasome mediated degradation.
    REACT_183279. ER-Phagosome pathway.
    REACT_183284. Cross-presentation of soluble exogenous antigens (endosomes).
    REACT_183296. Antigen processing: Ubiquitination & Proteasome degradation.
    REACT_184635. Orc1 removal from chromatin.
    REACT_205379. SCF-beta-TrCP mediated degradation of Emi1.
    REACT_215136. Asymmetric localization of PCP proteins.

    Miscellaneous databases

    NextBioi 884604.
    PROi Q09583.

    Family and domain databases

    Gene3Di 3.60.20.10. 1 hit.
    InterProi IPR029055. Ntn_hydrolases_N.
    IPR000426. Proteasome_asu_N.
    IPR023332. Proteasome_suA-type.
    IPR001353. Proteasome_sua/b.
    [Graphical view ]
    Pfami PF00227. Proteasome. 1 hit.
    PF10584. Proteasome_A_N. 1 hit.
    [Graphical view ]
    SMARTi SM00948. Proteasome_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56235. SSF56235. 1 hit.
    PROSITEi PS00388. PROTEASOME_ALPHA_1. 1 hit.
    PS51475. PROTEASOME_ALPHA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiPSA3_CAEEL
    AccessioniPrimary (citable) accession number: Q09583
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 117 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3