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Q09583 (PSA3_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Proteasome subunit alpha type-3

EC=3.4.25.1
Alternative name(s):
Proteasome subunit alpha 7
Gene names
Name:pas-7
ORF Names:ZK945.2
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length250 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity By similarity.

Catalytic activity

Cleavage of peptide bonds with very broad specificity.

Subunit structure

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Sequence similarities

Belongs to the peptidase T1A family.

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 250249Proteasome subunit alpha type-3
PRO_0000124095

Sequences

Sequence LengthMass (Da)Tools
Q09583 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: FC97B4486B924855

FASTA25027,752
        10         20         30         40         50         60 
MSSIGTGYDL AASTFSPDGR IFQVEYAQKA VDNAGTMIAI RGKNGVVVVA DKLISSKLYT 

        70         80         90        100        110        120 
DNANPRMFNV NDNVGVAVAG NYPDGFALKN YAYGEAMKWL KDYREPMPIQ NIANSVAEYI 

       130        140        150        160        170        180 
HIHTLGISRP FGAGAFFMSW NKQTGGRLFL VEPSGLNYEY KAWAVGKHRQ AAKAEIEKLK 

       190        200        210        220        230        240 
IEELDVNQLV KEAARIIMVV RDENKDKNVQ IEMGWVGEQT NGKYEEVPSE VVTAAEEWAI 

       250 
AKLDEDDMDD 

« Hide

References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z48544 Genomic DNA. Translation: CAA88436.2.
PIRT28119.
RefSeqNP_496177.2. NM_063776.3.
UniGeneCel.14673.

3D structure databases

ProteinModelPortalQ09583.
SMRQ09583. Positions 2-245.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid39890. 14 interactions.
IntActQ09583. 13 interactions.
MINTMINT-210959.
STRING6239.ZK945.2.1.

Proteomic databases

PaxDbQ09583.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaZK945.2.1; ZK945.2.1; WBGene00003928.
ZK945.2.2; ZK945.2.2; WBGene00003928.
GeneID174571.
KEGGcel:CELE_ZK945.2.
UCSCZK945.2.1. c. elegans.

Organism-specific databases

CTD174571.
WormBaseZK945.2; CE36420; WBGene00003928; pas-7.

Phylogenomic databases

eggNOGCOG0638.
GeneTreeENSGT00550000074912.
HOGENOMHOG000091086.
InParanoidQ09583.
KOK02727.
OMAVPDGRHF.
PhylomeDBQ09583.

Family and domain databases

Gene3D3.60.20.10. 1 hit.
InterProIPR029055. Ntn_hydrolases_N.
IPR000426. Proteasome_asu_N.
IPR023332. Proteasome_suA-type.
IPR001353. Proteasome_sua/b.
[Graphical view]
PfamPF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
[Graphical view]
SMARTSM00948. Proteasome_A_N. 1 hit.
[Graphical view]
SUPFAMSSF56235. SSF56235. 1 hit.
PROSITEPS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio884604.
PROQ09583.

Entry information

Entry namePSA3_CAEEL
AccessionPrimary (citable) accession number: Q09583
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 115 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase