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Protein

Proteasome subunit alpha type-3

Gene

pas-7

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).By similarity

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.PROSITE-ProRule annotation

GO - Molecular functioni

  1. identical protein binding Source: IntAct
  2. threonine-type endopeptidase activity Source: UniProtKB-KW

GO - Biological processi

  1. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Threonine protease

Enzyme and pathway databases

ReactomeiREACT_101459. Regulation of activated PAK-2p34 by proteasome mediated degradation.
REACT_183279. ER-Phagosome pathway.
REACT_183284. Cross-presentation of soluble exogenous antigens (endosomes).
REACT_183296. Antigen processing: Ubiquitination & Proteasome degradation.
REACT_184635. Orc1 removal from chromatin.
REACT_205379. SCF-beta-TrCP mediated degradation of Emi1.
REACT_215136. Asymmetric localization of PCP proteins.
REACT_243979. CDK-mediated phosphorylation and removal of Cdc6.
REACT_249811. Degradation of beta-catenin by the destruction complex.
REACT_254516. SCF(Skp2)-mediated degradation of p27/p21.
REACT_255237. degradation of DVL.
REACT_261912. Ubiquitin-dependent degradation of Cyclin D1.
REACT_263250. AUF1 (hnRNP D0) destabilizes mRNA.
REACT_263687. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit alpha type-3 (EC:3.4.25.1)
Alternative name(s):
Proteasome subunit alpha 7
Gene namesi
Name:pas-7
ORF Names:ZK945.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome II

Organism-specific databases

WormBaseiZK945.2; CE36420; WBGene00003928; pas-7.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: WormBase
  2. nucleus Source: WormBase
  3. proteasome core complex, alpha-subunit complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 250249Proteasome subunit alpha type-3PRO_0000124095Add
BLAST

Proteomic databases

PaxDbiQ09583.

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
itself5EBI-315406,EBI-315406
pas-1O175866EBI-315406,EBI-315388
pas-6O441565EBI-315406,EBI-318264

Protein-protein interaction databases

BioGridi39890. 14 interactions.
IntActiQ09583. 13 interactions.
MINTiMINT-210959.
STRINGi6239.ZK945.2.1.

Structurei

3D structure databases

ProteinModelPortaliQ09583.
SMRiQ09583. Positions 2-245.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1A family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0638.
GeneTreeiENSGT00550000074912.
HOGENOMiHOG000091086.
InParanoidiQ09583.
KOiK02727.
OMAiARIIYLV.
PhylomeDBiQ09583.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiIPR029055. Ntn_hydrolases_N.
IPR000426. Proteasome_asu_N.
IPR023332. Proteasome_suA-type.
IPR001353. Proteasome_sua/b.
[Graphical view]
PfamiPF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
[Graphical view]
SMARTiSM00948. Proteasome_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiPS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q09583-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSIGTGYDL AASTFSPDGR IFQVEYAQKA VDNAGTMIAI RGKNGVVVVA
60 70 80 90 100
DKLISSKLYT DNANPRMFNV NDNVGVAVAG NYPDGFALKN YAYGEAMKWL
110 120 130 140 150
KDYREPMPIQ NIANSVAEYI HIHTLGISRP FGAGAFFMSW NKQTGGRLFL
160 170 180 190 200
VEPSGLNYEY KAWAVGKHRQ AAKAEIEKLK IEELDVNQLV KEAARIIMVV
210 220 230 240 250
RDENKDKNVQ IEMGWVGEQT NGKYEEVPSE VVTAAEEWAI AKLDEDDMDD
Length:250
Mass (Da):27,752
Last modified:January 23, 2007 - v3
Checksum:iFC97B4486B924855
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48544 Genomic DNA. Translation: CAA88436.2.
PIRiT28119.
RefSeqiNP_496177.2. NM_063776.3.
UniGeneiCel.14673.

Genome annotation databases

EnsemblMetazoaiZK945.2.1; ZK945.2.1; WBGene00003928.
ZK945.2.2; ZK945.2.2; WBGene00003928.
GeneIDi174571.
KEGGicel:CELE_ZK945.2.
UCSCiZK945.2.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48544 Genomic DNA. Translation: CAA88436.2.
PIRiT28119.
RefSeqiNP_496177.2. NM_063776.3.
UniGeneiCel.14673.

3D structure databases

ProteinModelPortaliQ09583.
SMRiQ09583. Positions 2-245.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi39890. 14 interactions.
IntActiQ09583. 13 interactions.
MINTiMINT-210959.
STRINGi6239.ZK945.2.1.

Proteomic databases

PaxDbiQ09583.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiZK945.2.1; ZK945.2.1; WBGene00003928.
ZK945.2.2; ZK945.2.2; WBGene00003928.
GeneIDi174571.
KEGGicel:CELE_ZK945.2.
UCSCiZK945.2.1. c. elegans.

Organism-specific databases

CTDi174571.
WormBaseiZK945.2; CE36420; WBGene00003928; pas-7.

Phylogenomic databases

eggNOGiCOG0638.
GeneTreeiENSGT00550000074912.
HOGENOMiHOG000091086.
InParanoidiQ09583.
KOiK02727.
OMAiARIIYLV.
PhylomeDBiQ09583.

Enzyme and pathway databases

ReactomeiREACT_101459. Regulation of activated PAK-2p34 by proteasome mediated degradation.
REACT_183279. ER-Phagosome pathway.
REACT_183284. Cross-presentation of soluble exogenous antigens (endosomes).
REACT_183296. Antigen processing: Ubiquitination & Proteasome degradation.
REACT_184635. Orc1 removal from chromatin.
REACT_205379. SCF-beta-TrCP mediated degradation of Emi1.
REACT_215136. Asymmetric localization of PCP proteins.
REACT_243979. CDK-mediated phosphorylation and removal of Cdc6.
REACT_249811. Degradation of beta-catenin by the destruction complex.
REACT_254516. SCF(Skp2)-mediated degradation of p27/p21.
REACT_255237. degradation of DVL.
REACT_261912. Ubiquitin-dependent degradation of Cyclin D1.
REACT_263250. AUF1 (hnRNP D0) destabilizes mRNA.
REACT_263687. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.

Miscellaneous databases

NextBioi884604.
PROiQ09583.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiIPR029055. Ntn_hydrolases_N.
IPR000426. Proteasome_asu_N.
IPR023332. Proteasome_suA-type.
IPR001353. Proteasome_sua/b.
[Graphical view]
PfamiPF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
[Graphical view]
SMARTiSM00948. Proteasome_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiPS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiPSA3_CAEEL
AccessioniPrimary (citable) accession number: Q09583
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: January 7, 2015
This is version 120 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.