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Protein

Protein phosphatase PHLPP-like protein

Gene

F43C1.1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Probable protein phosphatase.By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

ReactomeiR-CEL-199418. Negative regulation of the PI3K/AKT network.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase PHLPP-like protein (EC:3.1.3.16)
Gene namesi
ORF Names:F43C1.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiF43C1.1; CE34017; WBGene00009647.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000577861 – 1036Protein phosphatase PHLPP-like proteinAdd BLAST1036

Proteomic databases

PaxDbiQ09564.

Expressioni

Gene expression databases

BgeeiWBGene00009647.

Interactioni

Protein-protein interaction databases

STRINGi6239.F43C1.1.

Structurei

3D structure databases

ProteinModelPortaliQ09564.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati198 – 219LRR 1Add BLAST22
Repeati221 – 242LRR 2Add BLAST22
Repeati244 – 265LRR 3Add BLAST22
Repeati267 – 289LRR 4Add BLAST23
Repeati290 – 310LRR 5Add BLAST21
Repeati331 – 352LRR 6Add BLAST22
Repeati363 – 384LRR 7Add BLAST22
Repeati395 – 416LRR 8Add BLAST22
Repeati418 – 439LRR 9Add BLAST22
Repeati441 – 462LRR 10Add BLAST22
Repeati463 – 484LRR 11Add BLAST22
Repeati487 – 508LRR 12Add BLAST22
Repeati511 – 534LRR 13Add BLAST24
Repeati535 – 556LRR 14Add BLAST22
Repeati559 – 580LRR 15Add BLAST22
Repeati582 – 603LRR 16Add BLAST22
Repeati604 – 624LRR 17Add BLAST21
Repeati627 – 647LRR 18Add BLAST21
Domaini671 – 897PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST227

Sequence similaritiesi

Contains 18 LRR (leucine-rich) repeats.Curated
Contains 1 PPM-type phosphatase domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00440000037833.
HOGENOMiHOG000021823.
InParanoidiQ09564.
KOiK16340.
OMAiDDEYSRI.
OrthoDBiEOG091G03A3.
PhylomeDBiQ09564.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
3.80.10.10. 3 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR001932. PPM-type_phosphatase_dom.
[Graphical view]
PfamiPF13855. LRR_8. 2 hits.
PF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 11 hits.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
SSF81606. SSF81606. 1 hit.
PROSITEiPS51450. LRR. 18 hits.
PS51746. PPM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q09564-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDENLETES TSKALEDILS YTDSPAFRHI FSFFLGRPRI RAKSTLNLDI
60 70 80 90 100
LSEEVVIRKG KLIHTWQNAR AVFYNSNIRL QTKNNQDEAL QIRNMKVDVH
110 120 130 140 150
ESKRGRALRL KDDDVCYLII FQRPNILEAW LTRAQQVEKS NHVDASDEQL
160 170 180 190 200
TLIPEQILNN EARVQILNLR RNSLISRPPT EKSMAPLGYI DDLYRVHSLQ
210 220 230 240 250
VIDLSANQIL SFPIQLTLLS HLRQLNLSSN YISSVPSECS NMRRLQYLNL
260 270 280 290 300
SNNQLDTLPD SISELQNLQS LDISFNQFSQ IPPCLFHLTL EMWRLAGNNI
310 320 330 340 350
EKIDRVGEMQ IQKIDLRRNV LDTSFRLDIE NITHLDLRDN SMISTVHLTN
360 370 380 390 400
LRFLKVIHCE RLQLSSLHLS GESLTHVYAD HNLLDSLVVM PLPQNLQTLS
410 420 430 440 450
LSFNHFRNLP DWISDCPNLT FLRANNNSLV ALPERIFYSQ SLRSIFAFIN
460 470 480 490 500
EIEHIPDFGE ENCLETLILY KNKLSSLPKH FFSILPRLRQ LNISSNFIEL
510 520 530 540 550
LPYFDGSSFC RLQILRCANN YLTENSVPVI VNMKHLKIID LSHNRLNSFD
560 570 580 590 600
DSALSSLELL EDLNLSSNRL TRLADCLALL PCLQVLRAHS NQLVHVPEFR
610 620 630 640 650
ASNQLHTIDV SSNNISLGTL QFKAPPNLRH FDVTCNSGDF DTENFPENAK
660 670 680 690 700
MHSKMNTINI SEGSQNLFGF QIGVSGSRGM KNKQCIRQVR VENTFGFIDG
710 720 730 740 750
GSNSYMSSSI CRFMTSYLKE NVSMDIRSIL LRCHCELGEE GERLGASVMI
760 770 780 790 800
IRVHEKRLEI ASTGTMSAAI ARNQKLKMII NGRYEIDDDE YSRIREAHGF
810 820 830 840 850
VDEENRINGV IGSSRQIGHF STFPVVLPTH SYRNIQLNEQ IEGLIVGNNM
860 870 880 890 900
IWNMLSIDDL NSTFHNNRSP IVVAKKIQDQ LQSYDYGGNS NILVLRRIKP
910 920 930 940 950
QMTFNGFSTS STKNQVTPDI AIPKIDEQLV LAVPALILPE YHPSPPVPPP
960 970 980 990 1000
IPAIRHRTPS PPPPPLPSST PPPVSSEHEE INVRQSSTLS GGYTLSIDRF
1010 1020 1030
YSSSSTVSSR KQFNETRDLL SKSLKLSPPN TVTFNI
Length:1,036
Mass (Da):117,827
Last modified:March 1, 2004 - v2
Checksum:iE714095ADA64F598
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46937 Genomic DNA. Translation: CAA87056.2.
PIRiT22117.
RefSeqiNP_497845.2. NM_065444.2.
UniGeneiCel.10485.

Genome annotation databases

EnsemblMetazoaiF43C1.1; F43C1.1; WBGene00009647.
GeneIDi185690.
KEGGicel:CELE_F43C1.1.
UCSCiF43C1.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46937 Genomic DNA. Translation: CAA87056.2.
PIRiT22117.
RefSeqiNP_497845.2. NM_065444.2.
UniGeneiCel.10485.

3D structure databases

ProteinModelPortaliQ09564.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F43C1.1.

Proteomic databases

PaxDbiQ09564.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF43C1.1; F43C1.1; WBGene00009647.
GeneIDi185690.
KEGGicel:CELE_F43C1.1.
UCSCiF43C1.1. c. elegans.

Organism-specific databases

CTDi185690.
WormBaseiF43C1.1; CE34017; WBGene00009647.

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00440000037833.
HOGENOMiHOG000021823.
InParanoidiQ09564.
KOiK16340.
OMAiDDEYSRI.
OrthoDBiEOG091G03A3.
PhylomeDBiQ09564.

Enzyme and pathway databases

ReactomeiR-CEL-199418. Negative regulation of the PI3K/AKT network.

Miscellaneous databases

PROiQ09564.

Gene expression databases

BgeeiWBGene00009647.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
3.80.10.10. 3 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR001932. PPM-type_phosphatase_dom.
[Graphical view]
PfamiPF13855. LRR_8. 2 hits.
PF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 11 hits.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
SSF81606. SSF81606. 1 hit.
PROSITEiPS51450. LRR. 18 hits.
PS51746. PPM_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPHLPP_CAEEL
AccessioniPrimary (citable) accession number: Q09564
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: March 1, 2004
Last modified: October 5, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.