Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q09564 (PHLPP_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein phosphatase PHLPP-like protein

EC=3.1.3.16
Gene names
ORF Names:F43C1.1
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length1036 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Probable protein phosphatase By similarity.

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactor

Manganese By similarity.

Sequence similarities

Contains 18 LRR (leucine-rich) repeats.

Contains 1 PP2C-like domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10361036Protein phosphatase PHLPP-like protein
PRO_0000057786

Regions

Repeat198 – 21922LRR 1
Repeat221 – 24222LRR 2
Repeat244 – 26522LRR 3
Repeat267 – 28923LRR 4
Repeat290 – 31021LRR 5
Repeat331 – 35222LRR 6
Repeat363 – 38422LRR 7
Repeat395 – 41622LRR 8
Repeat418 – 43922LRR 9
Repeat441 – 46222LRR 10
Repeat463 – 48422LRR 11
Repeat487 – 50822LRR 12
Repeat511 – 53424LRR 13
Repeat535 – 55622LRR 14
Repeat559 – 58022LRR 15
Repeat582 – 60322LRR 16
Repeat604 – 62421LRR 17
Repeat627 – 64721LRR 18
Domain666 – 900235PP2C-like

Sequences

Sequence LengthMass (Da)Tools
Q09564 [UniParc].

Last modified March 1, 2004. Version 2.
Checksum: E714095ADA64F598

FASTA1,036117,827
        10         20         30         40         50         60 
MSDENLETES TSKALEDILS YTDSPAFRHI FSFFLGRPRI RAKSTLNLDI LSEEVVIRKG 

        70         80         90        100        110        120 
KLIHTWQNAR AVFYNSNIRL QTKNNQDEAL QIRNMKVDVH ESKRGRALRL KDDDVCYLII 

       130        140        150        160        170        180 
FQRPNILEAW LTRAQQVEKS NHVDASDEQL TLIPEQILNN EARVQILNLR RNSLISRPPT 

       190        200        210        220        230        240 
EKSMAPLGYI DDLYRVHSLQ VIDLSANQIL SFPIQLTLLS HLRQLNLSSN YISSVPSECS 

       250        260        270        280        290        300 
NMRRLQYLNL SNNQLDTLPD SISELQNLQS LDISFNQFSQ IPPCLFHLTL EMWRLAGNNI 

       310        320        330        340        350        360 
EKIDRVGEMQ IQKIDLRRNV LDTSFRLDIE NITHLDLRDN SMISTVHLTN LRFLKVIHCE 

       370        380        390        400        410        420 
RLQLSSLHLS GESLTHVYAD HNLLDSLVVM PLPQNLQTLS LSFNHFRNLP DWISDCPNLT 

       430        440        450        460        470        480 
FLRANNNSLV ALPERIFYSQ SLRSIFAFIN EIEHIPDFGE ENCLETLILY KNKLSSLPKH 

       490        500        510        520        530        540 
FFSILPRLRQ LNISSNFIEL LPYFDGSSFC RLQILRCANN YLTENSVPVI VNMKHLKIID 

       550        560        570        580        590        600 
LSHNRLNSFD DSALSSLELL EDLNLSSNRL TRLADCLALL PCLQVLRAHS NQLVHVPEFR 

       610        620        630        640        650        660 
ASNQLHTIDV SSNNISLGTL QFKAPPNLRH FDVTCNSGDF DTENFPENAK MHSKMNTINI 

       670        680        690        700        710        720 
SEGSQNLFGF QIGVSGSRGM KNKQCIRQVR VENTFGFIDG GSNSYMSSSI CRFMTSYLKE 

       730        740        750        760        770        780 
NVSMDIRSIL LRCHCELGEE GERLGASVMI IRVHEKRLEI ASTGTMSAAI ARNQKLKMII 

       790        800        810        820        830        840 
NGRYEIDDDE YSRIREAHGF VDEENRINGV IGSSRQIGHF STFPVVLPTH SYRNIQLNEQ 

       850        860        870        880        890        900 
IEGLIVGNNM IWNMLSIDDL NSTFHNNRSP IVVAKKIQDQ LQSYDYGGNS NILVLRRIKP 

       910        920        930        940        950        960 
QMTFNGFSTS STKNQVTPDI AIPKIDEQLV LAVPALILPE YHPSPPVPPP IPAIRHRTPS 

       970        980        990       1000       1010       1020 
PPPPPLPSST PPPVSSEHEE INVRQSSTLS GGYTLSIDRF YSSSSTVSSR KQFNETRDLL 

      1030 
SKSLKLSPPN TVTFNI 

« Hide

References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z46937 Genomic DNA. Translation: CAA87056.2.
PIRT22117.
RefSeqNP_497845.2. NM_065444.2.
UniGeneCel.10485.

3D structure databases

ProteinModelPortalQ09564.
SMRQ09564. Positions 138-647, 738-856.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6239.F43C1.1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaF43C1.1; F43C1.1; F43C1.1.
GeneID185690.
KEGGcel:CELE_F43C1.1.
UCSCF43C1.1. c. elegans.

Organism-specific databases

CTD185690.
WormBaseF43C1.1; CE34017; WBGene00009647.

Phylogenomic databases

eggNOGCOG4886.
HOGENOMHOG000021823.
InParanoidQ09564.
KOK16340.
OMARPRIRAK.
OrthoDBEOG7RFTGK.
PhylomeDBQ09564.

Family and domain databases

Gene3D3.60.40.10. 1 hit.
InterProIPR001611. Leu-rich_rpt.
IPR025875. Leu-rich_rpt_4.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR001932. PP2C-like_dom.
[Graphical view]
PfamPF00560. LRR_1. 2 hits.
PF12799. LRR_4. 1 hit.
PF00481. PP2C. 1 hit.
[Graphical view]
SMARTSM00369. LRR_TYP. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMSSF81606. SSF81606. 1 hit.
PROSITEPS51450. LRR. 18 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio929154.

Entry information

Entry namePHLPP_CAEEL
AccessionPrimary (citable) accession number: Q09564
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: March 1, 2004
Last modified: April 16, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase