Q09564 (PHLPP_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein phosphatase PHLPP-like protein
EC=3.1.3.16

Gene names

ORF Names:

F43C1.1

Organism

Caenorhabditis elegans [Reference proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	1036 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Probable protein phosphatase By similarity.
Catalytic activity	A phosphoprotein + H2O = a protein + phosphate.
Cofactor	Manganese By similarity.
Sequence similarities	Contains 18 LRR (leucine-rich) repeats. Contains 1 PP2C-like domain.

Ontologies

Keywords
Domain	Leucine-rich repeat Repeat
Ligand	Manganese Metal-binding
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	metabolic process Inferred from electronic annotation. Source: GOC
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoprotein phosphatase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1036	1036	Protein phosphatase PHLPP-like protein		PRO_0000057786
Regions
	Repeat	198 – 219	22	LRR 1
	Repeat	221 – 242	22	LRR 2
	Repeat	244 – 265	22	LRR 3
	Repeat	267 – 289	23	LRR 4
	Repeat	290 – 310	21	LRR 5
	Repeat	331 – 352	22	LRR 6
	Repeat	363 – 384	22	LRR 7
	Repeat	395 – 416	22	LRR 8
	Repeat	418 – 439	22	LRR 9
	Repeat	441 – 462	22	LRR 10
	Repeat	463 – 484	22	LRR 11
	Repeat	487 – 508	22	LRR 12
	Repeat	511 – 534	24	LRR 13
	Repeat	535 – 556	22	LRR 14
	Repeat	559 – 580	22	LRR 15
	Repeat	582 – 603	22	LRR 16
	Repeat	604 – 624	21	LRR 17
	Repeat	627 – 647	21	LRR 18
	Domain	666 – 900	235	PP2C-like

Sequences

	Sequence		Length	Mass (Da)
	Q09564 [UniParc]. Last modified March 1, 2004. Version 2. Checksum: E714095ADA64F598	FASTA	1,036	117,827
	10 20 30 40 50 60 MSDENLETES TSKALEDILS YTDSPAFRHI FSFFLGRPRI RAKSTLNLDI LSEEVVIRKG 70 80 90 100 110 120 KLIHTWQNAR AVFYNSNIRL QTKNNQDEAL QIRNMKVDVH ESKRGRALRL KDDDVCYLII 130 140 150 160 170 180 FQRPNILEAW LTRAQQVEKS NHVDASDEQL TLIPEQILNN EARVQILNLR RNSLISRPPT 190 200 210 220 230 240 EKSMAPLGYI DDLYRVHSLQ VIDLSANQIL SFPIQLTLLS HLRQLNLSSN YISSVPSECS 250 260 270 280 290 300 NMRRLQYLNL SNNQLDTLPD SISELQNLQS LDISFNQFSQ IPPCLFHLTL EMWRLAGNNI 310 320 330 340 350 360 EKIDRVGEMQ IQKIDLRRNV LDTSFRLDIE NITHLDLRDN SMISTVHLTN LRFLKVIHCE 370 380 390 400 410 420 RLQLSSLHLS GESLTHVYAD HNLLDSLVVM PLPQNLQTLS LSFNHFRNLP DWISDCPNLT 430 440 450 460 470 480 FLRANNNSLV ALPERIFYSQ SLRSIFAFIN EIEHIPDFGE ENCLETLILY KNKLSSLPKH 490 500 510 520 530 540 FFSILPRLRQ LNISSNFIEL LPYFDGSSFC RLQILRCANN YLTENSVPVI VNMKHLKIID 550 560 570 580 590 600 LSHNRLNSFD DSALSSLELL EDLNLSSNRL TRLADCLALL PCLQVLRAHS NQLVHVPEFR 610 620 630 640 650 660 ASNQLHTIDV SSNNISLGTL QFKAPPNLRH FDVTCNSGDF DTENFPENAK MHSKMNTINI 670 680 690 700 710 720 SEGSQNLFGF QIGVSGSRGM KNKQCIRQVR VENTFGFIDG GSNSYMSSSI CRFMTSYLKE 730 740 750 760 770 780 NVSMDIRSIL LRCHCELGEE GERLGASVMI IRVHEKRLEI ASTGTMSAAI ARNQKLKMII 790 800 810 820 830 840 NGRYEIDDDE YSRIREAHGF VDEENRINGV IGSSRQIGHF STFPVVLPTH SYRNIQLNEQ 850 860 870 880 890 900 IEGLIVGNNM IWNMLSIDDL NSTFHNNRSP IVVAKKIQDQ LQSYDYGGNS NILVLRRIKP 910 920 930 940 950 960 QMTFNGFSTS STKNQVTPDI AIPKIDEQLV LAVPALILPE YHPSPPVPPP IPAIRHRTPS 970 980 990 1000 1010 1020 PPPPPLPSST PPPVSSEHEE INVRQSSTLS GGYTLSIDRF YSSSSTVSSR KQFNETRDLL 1030 SKSLKLSPPN TVTFNI

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z46937 Genomic DNA. Translation: CAA87056.2.
PIR	T22117.
RefSeq	NP_497845.2. NM_065444.2.
UniGene	Cel.10485.
3D structure databases
ProteinModelPortal	Q09564.
SMR	Q09564. Positions 163-636, 738-856.
ModBase	Search...
Protein-protein interaction databases
STRING	6239.F43C1.1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	F43C1.1; F43C1.1; F43C1.1.
GeneID	185690.
KEGG	cel:CELE_F43C1.1.
UCSC	F43C1.1. c. elegans.
Organism-specific databases
CTD	185690.
WormBase	F43C1.1; CE34017; WBGene00009647.
Phylogenomic databases
eggNOG	COG4886.
GeneTree	ENSGT00440000037833.
HOGENOM	HOG000021823.
InParanoid	Q09564.
KO	K16340.
OMA	RPRIRAK.
Family and domain databases
Gene3D	3.60.40.10. 1 hit.
InterPro	IPR001611. Leu-rich_rpt. IPR025875. Leu-rich_rpt_4. IPR003591. Leu-rich_rpt_typical-subtyp. IPR001932. PP2C-like. [Graphical view]
Pfam	PF00560. LRR_1. 1 hit. PF12799. LRR_4. 2 hits. PF00481. PP2C. 1 hit. [Graphical view]
SMART	SM00369. LRR_TYP. 1 hit. SM00332. PP2Cc. 1 hit. [Graphical view]
SUPFAM	SSF81606. PP2C-related. 1 hit.
PROSITE	PS51450. LRR. 18 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	929154.

Entry information

Entry name

PHLPP_CAEEL

Accession

Primary (citable) accession number: Q09564

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	March 1, 2004
Last modified:	May 1, 2013
This is version 91 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project