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Protein

Protein phosphatase PHLPP-like protein

Gene

F43C1.1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Probable protein phosphatase.By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_343224. Negative regulation of the PI3K/AKT network.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase PHLPP-like protein (EC:3.1.3.16)
Gene namesi
ORF Names:F43C1.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiF43C1.1; CE34017; WBGene00009647.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10361036Protein phosphatase PHLPP-like proteinPRO_0000057786Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi6239.F43C1.1.

Structurei

3D structure databases

ProteinModelPortaliQ09564.
SMRiQ09564. Positions 142-662.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati198 – 21922LRR 1Add
BLAST
Repeati221 – 24222LRR 2Add
BLAST
Repeati244 – 26522LRR 3Add
BLAST
Repeati267 – 28923LRR 4Add
BLAST
Repeati290 – 31021LRR 5Add
BLAST
Repeati331 – 35222LRR 6Add
BLAST
Repeati363 – 38422LRR 7Add
BLAST
Repeati395 – 41622LRR 8Add
BLAST
Repeati418 – 43922LRR 9Add
BLAST
Repeati441 – 46222LRR 10Add
BLAST
Repeati463 – 48422LRR 11Add
BLAST
Repeati487 – 50822LRR 12Add
BLAST
Repeati511 – 53424LRR 13Add
BLAST
Repeati535 – 55622LRR 14Add
BLAST
Repeati559 – 58022LRR 15Add
BLAST
Repeati582 – 60322LRR 16Add
BLAST
Repeati604 – 62421LRR 17Add
BLAST
Repeati627 – 64721LRR 18Add
BLAST
Domaini671 – 897227PPM-type phosphatasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 18 LRR (leucine-rich) repeats.Curated
Contains 1 PPM-type phosphatase domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiCOG4886.
GeneTreeiENSGT00440000037833.
HOGENOMiHOG000021823.
InParanoidiQ09564.
KOiK16340.
OMAiDDEYSRI.
OrthoDBiEOG7RFTGK.
PhylomeDBiQ09564.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001611. Leu-rich_rpt.
IPR025875. Leu-rich_rpt_4.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR001932. PP2C-like_dom.
[Graphical view]
PfamiPF00560. LRR_1. 2 hits.
PF12799. LRR_4. 1 hit.
PF13504. LRR_7. 1 hit.
PF13855. LRR_8. 1 hit.
PF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS51450. LRR. 18 hits.
PS51746. PPM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q09564-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDENLETES TSKALEDILS YTDSPAFRHI FSFFLGRPRI RAKSTLNLDI
60 70 80 90 100
LSEEVVIRKG KLIHTWQNAR AVFYNSNIRL QTKNNQDEAL QIRNMKVDVH
110 120 130 140 150
ESKRGRALRL KDDDVCYLII FQRPNILEAW LTRAQQVEKS NHVDASDEQL
160 170 180 190 200
TLIPEQILNN EARVQILNLR RNSLISRPPT EKSMAPLGYI DDLYRVHSLQ
210 220 230 240 250
VIDLSANQIL SFPIQLTLLS HLRQLNLSSN YISSVPSECS NMRRLQYLNL
260 270 280 290 300
SNNQLDTLPD SISELQNLQS LDISFNQFSQ IPPCLFHLTL EMWRLAGNNI
310 320 330 340 350
EKIDRVGEMQ IQKIDLRRNV LDTSFRLDIE NITHLDLRDN SMISTVHLTN
360 370 380 390 400
LRFLKVIHCE RLQLSSLHLS GESLTHVYAD HNLLDSLVVM PLPQNLQTLS
410 420 430 440 450
LSFNHFRNLP DWISDCPNLT FLRANNNSLV ALPERIFYSQ SLRSIFAFIN
460 470 480 490 500
EIEHIPDFGE ENCLETLILY KNKLSSLPKH FFSILPRLRQ LNISSNFIEL
510 520 530 540 550
LPYFDGSSFC RLQILRCANN YLTENSVPVI VNMKHLKIID LSHNRLNSFD
560 570 580 590 600
DSALSSLELL EDLNLSSNRL TRLADCLALL PCLQVLRAHS NQLVHVPEFR
610 620 630 640 650
ASNQLHTIDV SSNNISLGTL QFKAPPNLRH FDVTCNSGDF DTENFPENAK
660 670 680 690 700
MHSKMNTINI SEGSQNLFGF QIGVSGSRGM KNKQCIRQVR VENTFGFIDG
710 720 730 740 750
GSNSYMSSSI CRFMTSYLKE NVSMDIRSIL LRCHCELGEE GERLGASVMI
760 770 780 790 800
IRVHEKRLEI ASTGTMSAAI ARNQKLKMII NGRYEIDDDE YSRIREAHGF
810 820 830 840 850
VDEENRINGV IGSSRQIGHF STFPVVLPTH SYRNIQLNEQ IEGLIVGNNM
860 870 880 890 900
IWNMLSIDDL NSTFHNNRSP IVVAKKIQDQ LQSYDYGGNS NILVLRRIKP
910 920 930 940 950
QMTFNGFSTS STKNQVTPDI AIPKIDEQLV LAVPALILPE YHPSPPVPPP
960 970 980 990 1000
IPAIRHRTPS PPPPPLPSST PPPVSSEHEE INVRQSSTLS GGYTLSIDRF
1010 1020 1030
YSSSSTVSSR KQFNETRDLL SKSLKLSPPN TVTFNI
Length:1,036
Mass (Da):117,827
Last modified:March 1, 2004 - v2
Checksum:iE714095ADA64F598
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46937 Genomic DNA. Translation: CAA87056.2.
PIRiT22117.
RefSeqiNP_497845.2. NM_065444.2.
UniGeneiCel.10485.

Genome annotation databases

EnsemblMetazoaiF43C1.1; F43C1.1; WBGene00009647.
GeneIDi185690.
KEGGicel:CELE_F43C1.1.
UCSCiF43C1.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46937 Genomic DNA. Translation: CAA87056.2.
PIRiT22117.
RefSeqiNP_497845.2. NM_065444.2.
UniGeneiCel.10485.

3D structure databases

ProteinModelPortaliQ09564.
SMRiQ09564. Positions 142-662.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F43C1.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF43C1.1; F43C1.1; WBGene00009647.
GeneIDi185690.
KEGGicel:CELE_F43C1.1.
UCSCiF43C1.1. c. elegans.

Organism-specific databases

CTDi185690.
WormBaseiF43C1.1; CE34017; WBGene00009647.

Phylogenomic databases

eggNOGiCOG4886.
GeneTreeiENSGT00440000037833.
HOGENOMiHOG000021823.
InParanoidiQ09564.
KOiK16340.
OMAiDDEYSRI.
OrthoDBiEOG7RFTGK.
PhylomeDBiQ09564.

Enzyme and pathway databases

ReactomeiREACT_343224. Negative regulation of the PI3K/AKT network.

Miscellaneous databases

NextBioi929154.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001611. Leu-rich_rpt.
IPR025875. Leu-rich_rpt_4.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR001932. PP2C-like_dom.
[Graphical view]
PfamiPF00560. LRR_1. 2 hits.
PF12799. LRR_4. 1 hit.
PF13504. LRR_7. 1 hit.
PF13855. LRR_8. 1 hit.
PF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS51450. LRR. 18 hits.
PS51746. PPM_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiPHLPP_CAEEL
AccessioniPrimary (citable) accession number: Q09564
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: March 1, 2004
Last modified: April 1, 2015
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.