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Q09564

- PHLPP_CAEEL

UniProt

Q09564 - PHLPP_CAEEL

Protein

Protein phosphatase PHLPP-like protein

Gene

F43C1.1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 2 (01 Mar 2004)
      Previous versions | rss
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    Functioni

    Probable protein phosphatase.By similarity

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Manganese.By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. phosphoprotein phosphatase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein phosphatase PHLPP-like protein (EC:3.1.3.16)
    Gene namesi
    ORF Names:F43C1.1
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome III

    Organism-specific databases

    WormBaseiF43C1.1; CE34017; WBGene00009647.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10361036Protein phosphatase PHLPP-like proteinPRO_0000057786Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi6239.F43C1.1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ09564.
    SMRiQ09564. Positions 142-662, 738-856.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati198 – 21922LRR 1Add
    BLAST
    Repeati221 – 24222LRR 2Add
    BLAST
    Repeati244 – 26522LRR 3Add
    BLAST
    Repeati267 – 28923LRR 4Add
    BLAST
    Repeati290 – 31021LRR 5Add
    BLAST
    Repeati331 – 35222LRR 6Add
    BLAST
    Repeati363 – 38422LRR 7Add
    BLAST
    Repeati395 – 41622LRR 8Add
    BLAST
    Repeati418 – 43922LRR 9Add
    BLAST
    Repeati441 – 46222LRR 10Add
    BLAST
    Repeati463 – 48422LRR 11Add
    BLAST
    Repeati487 – 50822LRR 12Add
    BLAST
    Repeati511 – 53424LRR 13Add
    BLAST
    Repeati535 – 55622LRR 14Add
    BLAST
    Repeati559 – 58022LRR 15Add
    BLAST
    Repeati582 – 60322LRR 16Add
    BLAST
    Repeati604 – 62421LRR 17Add
    BLAST
    Repeati627 – 64721LRR 18Add
    BLAST
    Domaini666 – 900235PP2C-likeAdd
    BLAST

    Sequence similaritiesi

    Contains 18 LRR (leucine-rich) repeats.Curated
    Contains 1 PP2C-like domain.Curated

    Keywords - Domaini

    Leucine-rich repeat, Repeat

    Phylogenomic databases

    eggNOGiCOG4886.
    GeneTreeiENSGT00440000037833.
    HOGENOMiHOG000021823.
    InParanoidiQ09564.
    KOiK16340.
    OMAiDDEYSRI.
    OrthoDBiEOG7RFTGK.
    PhylomeDBiQ09564.

    Family and domain databases

    Gene3Di3.60.40.10. 1 hit.
    InterProiIPR001611. Leu-rich_rpt.
    IPR025875. Leu-rich_rpt_4.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR001932. PP2C-like_dom.
    [Graphical view]
    PfamiPF00560. LRR_1. 2 hits.
    PF12799. LRR_4. 1 hit.
    PF13504. LRR_7. 1 hit.
    PF13855. LRR_8. 1 hit.
    PF00481. PP2C. 1 hit.
    [Graphical view]
    SMARTiSM00369. LRR_TYP. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view]
    SUPFAMiSSF81606. SSF81606. 1 hit.
    PROSITEiPS51450. LRR. 18 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q09564-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDENLETES TSKALEDILS YTDSPAFRHI FSFFLGRPRI RAKSTLNLDI     50
    LSEEVVIRKG KLIHTWQNAR AVFYNSNIRL QTKNNQDEAL QIRNMKVDVH 100
    ESKRGRALRL KDDDVCYLII FQRPNILEAW LTRAQQVEKS NHVDASDEQL 150
    TLIPEQILNN EARVQILNLR RNSLISRPPT EKSMAPLGYI DDLYRVHSLQ 200
    VIDLSANQIL SFPIQLTLLS HLRQLNLSSN YISSVPSECS NMRRLQYLNL 250
    SNNQLDTLPD SISELQNLQS LDISFNQFSQ IPPCLFHLTL EMWRLAGNNI 300
    EKIDRVGEMQ IQKIDLRRNV LDTSFRLDIE NITHLDLRDN SMISTVHLTN 350
    LRFLKVIHCE RLQLSSLHLS GESLTHVYAD HNLLDSLVVM PLPQNLQTLS 400
    LSFNHFRNLP DWISDCPNLT FLRANNNSLV ALPERIFYSQ SLRSIFAFIN 450
    EIEHIPDFGE ENCLETLILY KNKLSSLPKH FFSILPRLRQ LNISSNFIEL 500
    LPYFDGSSFC RLQILRCANN YLTENSVPVI VNMKHLKIID LSHNRLNSFD 550
    DSALSSLELL EDLNLSSNRL TRLADCLALL PCLQVLRAHS NQLVHVPEFR 600
    ASNQLHTIDV SSNNISLGTL QFKAPPNLRH FDVTCNSGDF DTENFPENAK 650
    MHSKMNTINI SEGSQNLFGF QIGVSGSRGM KNKQCIRQVR VENTFGFIDG 700
    GSNSYMSSSI CRFMTSYLKE NVSMDIRSIL LRCHCELGEE GERLGASVMI 750
    IRVHEKRLEI ASTGTMSAAI ARNQKLKMII NGRYEIDDDE YSRIREAHGF 800
    VDEENRINGV IGSSRQIGHF STFPVVLPTH SYRNIQLNEQ IEGLIVGNNM 850
    IWNMLSIDDL NSTFHNNRSP IVVAKKIQDQ LQSYDYGGNS NILVLRRIKP 900
    QMTFNGFSTS STKNQVTPDI AIPKIDEQLV LAVPALILPE YHPSPPVPPP 950
    IPAIRHRTPS PPPPPLPSST PPPVSSEHEE INVRQSSTLS GGYTLSIDRF 1000
    YSSSSTVSSR KQFNETRDLL SKSLKLSPPN TVTFNI 1036
    Length:1,036
    Mass (Da):117,827
    Last modified:March 1, 2004 - v2
    Checksum:iE714095ADA64F598
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46937 Genomic DNA. Translation: CAA87056.2.
    PIRiT22117.
    RefSeqiNP_497845.2. NM_065444.2.
    UniGeneiCel.10485.

    Genome annotation databases

    EnsemblMetazoaiF43C1.1; F43C1.1; WBGene00009647.
    GeneIDi185690.
    KEGGicel:CELE_F43C1.1.
    UCSCiF43C1.1. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46937 Genomic DNA. Translation: CAA87056.2 .
    PIRi T22117.
    RefSeqi NP_497845.2. NM_065444.2.
    UniGenei Cel.10485.

    3D structure databases

    ProteinModelPortali Q09564.
    SMRi Q09564. Positions 142-662, 738-856.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6239.F43C1.1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai F43C1.1 ; F43C1.1 ; WBGene00009647 .
    GeneIDi 185690.
    KEGGi cel:CELE_F43C1.1.
    UCSCi F43C1.1. c. elegans.

    Organism-specific databases

    CTDi 185690.
    WormBasei F43C1.1 ; CE34017 ; WBGene00009647 .

    Phylogenomic databases

    eggNOGi COG4886.
    GeneTreei ENSGT00440000037833.
    HOGENOMi HOG000021823.
    InParanoidi Q09564.
    KOi K16340.
    OMAi DDEYSRI.
    OrthoDBi EOG7RFTGK.
    PhylomeDBi Q09564.

    Miscellaneous databases

    NextBioi 929154.

    Family and domain databases

    Gene3Di 3.60.40.10. 1 hit.
    InterProi IPR001611. Leu-rich_rpt.
    IPR025875. Leu-rich_rpt_4.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR001932. PP2C-like_dom.
    [Graphical view ]
    Pfami PF00560. LRR_1. 2 hits.
    PF12799. LRR_4. 1 hit.
    PF13504. LRR_7. 1 hit.
    PF13855. LRR_8. 1 hit.
    PF00481. PP2C. 1 hit.
    [Graphical view ]
    SMARTi SM00369. LRR_TYP. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81606. SSF81606. 1 hit.
    PROSITEi PS51450. LRR. 18 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiPHLPP_CAEEL
    AccessioniPrimary (citable) accession number: Q09564
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: March 1, 2004
    Last modified: October 1, 2014
    This is version 101 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3