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Protein

Protein phosphatase PHLPP-like protein

Gene

phlp-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Probable protein phosphatase.By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.By similarity

Cofactori

Mn2+By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandManganese, Metal-binding

Enzyme and pathway databases

ReactomeiR-CEL-199418 Negative regulation of the PI3K/AKT network

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase PHLPP-like protein (EC:3.1.3.16By similarity)
Alternative name(s):
PH domain and leucine-rich repeat-containing protein phosphatase phlp-2Imported
Gene namesi
Name:phlp-2Imported
ORF Names:F43C1.1Imported
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiF43C1.1 ; CE51952 ; WBGene00009647 ; phlp-2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000577861 – 1126Protein phosphatase PHLPP-like proteinCuratedAdd BLAST1126

Proteomic databases

PaxDbiQ09564
PRIDEiQ09564

Expressioni

Gene expression databases

BgeeiWBGene00009647

Interactioni

Protein-protein interaction databases

STRINGi6239.F43C1.1

Structurei

3D structure databases

ProteinModelPortaliQ09564
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati56 – 79LRR 1Sequence analysisAdd BLAST24
Repeati192 – 213LRR 2Sequence analysisAdd BLAST22
Repeati227 – 250LRR 3Sequence analysisAdd BLAST24
Repeati251 – 276LRR 4Sequence analysisAdd BLAST26
Repeati286 – 309LRR 5Sequence analysisAdd BLAST24
Repeati310 – 332LRR 6Sequence analysisAdd BLAST23
Repeati333 – 355LRR 7Sequence analysisAdd BLAST23
Repeati356 – 378LRR 8Sequence analysisAdd BLAST23
Repeati380 – 403LRR 9Sequence analysisAdd BLAST24
Repeati419 – 445LRR 10Sequence analysisAdd BLAST27
Repeati451 – 476LRR 11Sequence analysisAdd BLAST26
Repeati483 – 506LRR 12Sequence analysisAdd BLAST24
Repeati507 – 529LRR 13Sequence analysisAdd BLAST23
Repeati531 – 551LRR 14Sequence analysisAdd BLAST21
Repeati552 – 574LRR 15Sequence analysisAdd BLAST23
Repeati576 – 601LRR 16Sequence analysisAdd BLAST26
Repeati623 – 646LRR 17Sequence analysisAdd BLAST24
Repeati648 – 672LRR 18Sequence analysisAdd BLAST25
Repeati674 – 692LRR 19Sequence analysisAdd BLAST19
Repeati693 – 714LRR 20Sequence analysisAdd BLAST22
Repeati716 – 743LRR 21Sequence analysisAdd BLAST28
Domaini761 – 987PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST227

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1024 – 1063Pro-richPROSITE-ProRule annotationAdd BLAST40

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
HOGENOMiHOG000021823
InParanoidiQ09564
OMAiMSCEEEL
OrthoDBiEOG091G03A3
PhylomeDBiQ09564

Family and domain databases

Gene3Di3.60.40.10, 1 hit
3.80.10.10, 3 hits
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR036457 PPM-type_dom_sf
IPR001932 PPM-type_phosphatase_dom
PfamiView protein in Pfam
PF13855 LRR_8, 2 hits
PF00481 PP2C, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 11 hits
SM00332 PP2Cc, 1 hit
SUPFAMiSSF81606 SSF81606, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 18 hits
PS51746 PPM_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q09564-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNEQLQSTS SSPSTLLKPI EKKSRFLRLY SSDGQRSTRI ECDEHTTCAQ
60 70 80 90 100
ICQQFSCDVI TLQIGNYHFR QLKSDTSPLA ILQDFCRILT MSDENLETES
110 120 130 140 150
TSKALEDILS YTDSPAFRHI FSFFLGRPRI RAKSTLNLDI LSEEVVIRKG
160 170 180 190 200
KLIHTWQNAR AVFYNSNIRL QTKNNQDEAL QIRNMKVDVH ESKRGRALRL
210 220 230 240 250
KDDDVCYLII FQRPNILEAW LTRAQQVEKS NHVDASDEQL TLIPEQILNN
260 270 280 290 300
EARVQILNLR RNSLISRPPT EKSMAPLGYI DDLYRVHSLQ VIDLSANQIL
310 320 330 340 350
SFPIQLTLLS HLRQLNLSSN YISSVPSECS NMRRLQYLNL SNNQLDTLPD
360 370 380 390 400
SISELQNLQS LDISFNQFSQ IPPCLFHLTL EMWRLAGNNI EKIDRVGEMQ
410 420 430 440 450
IQKIDLRRNV LDTSFRLDIE NITHLDLRDN SMISTVHLTN LRFLKVIHCE
460 470 480 490 500
RLQLSSLHLS GESLTHVYAD HNLLDSLVVM PLPQNLQTLS LSFNHFRNLP
510 520 530 540 550
DWISDCPNLT FLRANNNSLV ALPERIFYSQ SLRSIFAFIN EIEHIPDFGE
560 570 580 590 600
ENCLETLILY KNKLSSLPKH FFSILPRLRQ LNISSNFIEL LPYFDGSSFC
610 620 630 640 650
RLQILRCANN YLTENSVPVI VNMKHLKIID LSHNRLNSFD DSALSSLELL
660 670 680 690 700
EDLNLSSNRL TRLADCLALL PCLQVLRAHS NQLVHVPEFR ASNQLHTIDV
710 720 730 740 750
SSNNISLGTL QFKAPPNLRH FDVTCNSGDF DTENFPENAK MHSKMNTINI
760 770 780 790 800
SEGSQNLFGF QIGVSGSRGM KNKQCIRQVR VENTFGFIDG GSNSYMSSSI
810 820 830 840 850
CRFMTSYLKE NVSMDIRSIL LRCHCELGEE GERLGASVMI IRVHEKRLEI
860 870 880 890 900
ASTGTMSAAI ARNQKLKMII NGRYEIDDDE YSRIREAHGF VDEENRINGV
910 920 930 940 950
IGSSRQIGHF STFPVVLPTH SYRNIQLNEQ IEGLIVGNNM IWNMLSIDDL
960 970 980 990 1000
NSTFHNNRSP IVVAKKIQDQ LQSYDYGGNS NILVLRRIKP QMTFNGFSTS
1010 1020 1030 1040 1050
STKNQVTPDI AIPKIDEQLV LAVPALILPE YHPSPPVPPP IPAIRHRTPS
1060 1070 1080 1090 1100
PPPPPLPSST PPPVSSEHEE INVRQSSTLS GGYTLSIDRF YSSSSTVSSR
1110 1120
KQFNETRDLL SKSLKLSPPN TVTFNI
Length:1,126
Mass (Da):128,125
Last modified:April 25, 2018 - v3
Checksum:i76A5EC60808F9672
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284603 Genomic DNA Translation: CAA87056.2
PIRiT22117
RefSeqiNP_497845.2, NM_065444.2

Genome annotation databases

UCSCiF43C1.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiPHLPP_CAEEL
AccessioniPrimary (citable) accession number: Q09564
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: April 25, 2018
Last modified: May 23, 2018
This is version 126 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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