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Q09545

- SDHB_CAEEL

UniProt

Q09545 - SDHB_CAEEL

Protein

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

Gene

sdhb-1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).By similarity

    Catalytic activityi

    Succinate + a quinone = fumarate + a quinol.

    Cofactori

    Binds 1 2Fe-2S cluster.By similarity
    Binds 1 3Fe-4S cluster.By similarity
    Binds 1 4Fe-4S cluster.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi107 – 1071Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi112 – 1121Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi115 – 1151Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi127 – 1271Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi200 – 2001Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi203 – 2031Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi206 – 2061Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi210 – 2101Iron-sulfur 3 (3Fe-4S)By similarity
    Binding sitei215 – 2151Ubiquinone; shared with DHSDBy similarity
    Metal bindingi257 – 2571Iron-sulfur 3 (3Fe-4S)By similarity
    Metal bindingi263 – 2631Iron-sulfur 3 (3Fe-4S)By similarity
    Metal bindingi267 – 2671Iron-sulfur 2 (4Fe-4S)By similarity

    GO - Molecular functioni

    1. 2 iron, 2 sulfur cluster binding Source: UniProtKB
    2. 3 iron, 4 sulfur cluster binding Source: UniProtKB
    3. 4 iron, 4 sulfur cluster binding Source: UniProtKB
    4. electron carrier activity Source: InterPro
    5. metal ion binding Source: UniProtKB-KW
    6. succinate dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
    7. ubiquinone binding Source: UniProtKB

    GO - Biological processi

    1. tricarboxylic acid cycle Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Transport, Tricarboxylic acid cycle

    Keywords - Ligandi

    2Fe-2S, 3Fe-4S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00223; UER01006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (EC:1.3.5.1)
    Alternative name(s):
    Iron-sulfur subunit of complex II
    Short name:
    Ip
    Gene namesi
    Name:sdhb-1
    Synonyms:tag-55
    ORF Names:F42A8.2
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome II

    Organism-specific databases

    WormBaseiF42A8.2; CE01579; WBGene00006433; sdhb-1.

    Subcellular locationi

    Mitochondrion inner membrane By similarity; Peripheral membrane protein By similarity; Matrix side By similarity

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: UniProtKB
    2. mitochondrial respiratory chain complex II Source: UniProtKB
    3. mitochondrion Source: WormBase

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 298Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrialPRO_0000010354
    Transit peptidei1 – ?MitochondrionSequence Analysis

    Proteomic databases

    PaxDbiQ09545.

    Interactioni

    Subunit structurei

    Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.By similarity

    Protein-protein interaction databases

    BioGridi39806. 1 interaction.
    STRINGi6239.F42A8.2.2.

    Structurei

    3D structure databases

    ProteinModelPortaliQ09545.
    SMRiQ09545. Positions 52-296.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini59 – 147892Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd
    BLAST
    Domaini190 – 220314Fe-4S ferredoxin-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 2Fe-2S ferredoxin-type domain.PROSITE-ProRule annotation
    Contains 1 4Fe-4S ferredoxin-type domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0479.
    GeneTreeiENSGT00390000013558.
    HOGENOMiHOG000160590.
    InParanoidiQ09545.
    KOiK00235.
    OMAiHARDPIS.
    PhylomeDBiQ09545.

    Family and domain databases

    Gene3Di3.10.20.30. 1 hit.
    InterProiIPR001041. 2Fe-2S_ferredoxin-type.
    IPR006058. 2Fe2S_fd_BS.
    IPR017896. 4Fe4S_Fe-S-bd.
    IPR017900. 4Fe4S_Fe_S_CS.
    IPR012675. Beta-grasp_dom.
    IPR009051. Helical_ferredxn.
    IPR004489. Succ_DH/fum_Rdtase_Fe-S.
    IPR025192. Succ_DH/fum_Rdtase_N.
    [Graphical view]
    PfamiPF13085. Fer2_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF46548. SSF46548. 1 hit.
    SSF54292. SSF54292. 1 hit.
    TIGRFAMsiTIGR00384. dhsB. 1 hit.
    PROSITEiPS00197. 2FE2S_FER_1. 1 hit.
    PS51085. 2FE2S_FER_2. 1 hit.
    PS00198. 4FE4S_FER_1. 1 hit.
    PS51379. 4FE4S_FER_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q09545-1 [UniParc]FASTAAdd to Basket

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    MLARSARLLH SAELAANAIR AASGAPATAA AAEASFPSTD DVAAKTKKTG    50
    NRIKTFEIYR FNPEAPGAKP TVQKFDVDLD QCGTMILDAL IKIKNEVDPT 100
    LTFRRSCREG ICGSCAMNIG GQNTLACICK IDSDTSKSTK IYPLPHMFVV 150
    KDLVPDMNLF YAQYASIQPW IQKKTPLTLG EKQMHQSVAE RDRLDGLYEC 200
    ILCACCSTSC PSYWWNADKY LGPAVLMQAY RWVIDSRDDY ATERLHRMHD 250
    SFSAFKCHTI MNCTKTCPKH LNPAKAIGEI KSLLTGFTSK PAAEPSAF 298
    Length:298
    Mass (Da):32,891
    Last modified:October 1, 1996 - v1
    Checksum:i0FDD148A6C9AB824
    GO

    Sequence cautioni

    The sequence BAA23717.1 differs from that shown. Reason: Frameshift at positions 4, 15 and 28.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB008569 mRNA. Translation: BAA23717.1. Frameshift.
    Z47809 Genomic DNA. Translation: CAA87780.1.
    PIRiT22083.
    T37260.
    RefSeqiNP_495992.1. NM_063591.6.
    UniGeneiCel.19522.

    Genome annotation databases

    EnsemblMetazoaiF42A8.2.1; F42A8.2.1; WBGene00006433.
    F42A8.2.2; F42A8.2.2; WBGene00006433.
    GeneIDi174482.
    KEGGicel:CELE_F42A8.2.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB008569 mRNA. Translation: BAA23717.1 . Frameshift.
    Z47809 Genomic DNA. Translation: CAA87780.1 .
    PIRi T22083.
    T37260.
    RefSeqi NP_495992.1. NM_063591.6.
    UniGenei Cel.19522.

    3D structure databases

    ProteinModelPortali Q09545.
    SMRi Q09545. Positions 52-296.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 39806. 1 interaction.
    STRINGi 6239.F42A8.2.2.

    Proteomic databases

    PaxDbi Q09545.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai F42A8.2.1 ; F42A8.2.1 ; WBGene00006433 .
    F42A8.2.2 ; F42A8.2.2 ; WBGene00006433 .
    GeneIDi 174482.
    KEGGi cel:CELE_F42A8.2.

    Organism-specific databases

    CTDi 174482.
    WormBasei F42A8.2 ; CE01579 ; WBGene00006433 ; sdhb-1.

    Phylogenomic databases

    eggNOGi COG0479.
    GeneTreei ENSGT00390000013558.
    HOGENOMi HOG000160590.
    InParanoidi Q09545.
    KOi K00235.
    OMAi HARDPIS.
    PhylomeDBi Q09545.

    Enzyme and pathway databases

    UniPathwayi UPA00223 ; UER01006 .

    Miscellaneous databases

    NextBioi 884224.
    PROi Q09545.

    Family and domain databases

    Gene3Di 3.10.20.30. 1 hit.
    InterProi IPR001041. 2Fe-2S_ferredoxin-type.
    IPR006058. 2Fe2S_fd_BS.
    IPR017896. 4Fe4S_Fe-S-bd.
    IPR017900. 4Fe4S_Fe_S_CS.
    IPR012675. Beta-grasp_dom.
    IPR009051. Helical_ferredxn.
    IPR004489. Succ_DH/fum_Rdtase_Fe-S.
    IPR025192. Succ_DH/fum_Rdtase_N.
    [Graphical view ]
    Pfami PF13085. Fer2_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46548. SSF46548. 1 hit.
    SSF54292. SSF54292. 1 hit.
    TIGRFAMsi TIGR00384. dhsB. 1 hit.
    PROSITEi PS00197. 2FE2S_FER_1. 1 hit.
    PS51085. 2FE2S_FER_2. 1 hit.
    PS00198. 4FE4S_FER_1. 1 hit.
    PS51379. 4FE4S_FER_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Stage-specific isoforms of Ascaris suum complex. II: The fumarate reductase of the parasitic adult and the succinate dehydrogenase of free-living larvae share a common iron-sulfur subunit."
      Amino H., Wang H., Hirawake H., Saruta F., Mizuchi D., Mineki R., Shindo N., Murayama K., Takamiya S., Aoki T., Kojima S., Kita K.
      Mol. Biochem. Parasitol. 106:63-76(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiSDHB_CAEEL
    AccessioniPrimary (citable) accession number: Q09545
    Secondary accession number(s): O44075
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3