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Protein

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

Gene

sdhb-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).By similarity

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.

Cofactori

Protein has several cofactor binding sites:

Pathway: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (eukaryal route).
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (sdha-1), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (sdhb-1), Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (sdha-2), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (eukaryal route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi107 – 1071Iron-sulfur 1 (2Fe-2S)By similarity
Metal bindingi112 – 1121Iron-sulfur 1 (2Fe-2S)By similarity
Metal bindingi115 – 1151Iron-sulfur 1 (2Fe-2S)By similarity
Metal bindingi127 – 1271Iron-sulfur 1 (2Fe-2S)By similarity
Metal bindingi200 – 2001Iron-sulfur 2 (4Fe-4S)By similarity
Metal bindingi203 – 2031Iron-sulfur 2 (4Fe-4S)By similarity
Metal bindingi206 – 2061Iron-sulfur 2 (4Fe-4S)By similarity
Metal bindingi210 – 2101Iron-sulfur 3 (3Fe-4S)By similarity
Binding sitei215 – 2151Ubiquinone; shared with DHSDBy similarity
Metal bindingi257 – 2571Iron-sulfur 3 (3Fe-4S)By similarity
Metal bindingi263 – 2631Iron-sulfur 3 (3Fe-4S)By similarity
Metal bindingi267 – 2671Iron-sulfur 2 (4Fe-4S)By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport, Tricarboxylic acid cycle

Keywords - Ligandi

2Fe-2S, 3Fe-4S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BRENDAi1.3.5.1. 1045.
ReactomeiREACT_287541. Citric acid cycle (TCA cycle).
REACT_330425. Respiratory electron transport.
UniPathwayiUPA00223; UER01006.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (EC:1.3.5.1)
Alternative name(s):
Iron-sulfur subunit of complex II
Short name:
Ip
Gene namesi
Name:sdhb-1
Synonyms:tag-55
ORF Names:F42A8.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiF42A8.2; CE01579; WBGene00006433; sdhb-1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 298Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrialPRO_0000010354
Transit peptidei1 – ?MitochondrionSequence Analysis

Proteomic databases

PaxDbiQ09545.

Expressioni

Gene expression databases

ExpressionAtlasiQ09545. baseline.

Interactioni

Subunit structurei

Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.By similarity

Protein-protein interaction databases

BioGridi39806. 1 interaction.
STRINGi6239.F42A8.2.1.

Structurei

3D structure databases

ProteinModelPortaliQ09545.
SMRiQ09545. Positions 52-296.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini59 – 147892Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd
BLAST
Domaini190 – 220314Fe-4S ferredoxin-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 2Fe-2S ferredoxin-type domain.PROSITE-ProRule annotation
Contains 1 4Fe-4S ferredoxin-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0479.
GeneTreeiENSGT00390000013558.
HOGENOMiHOG000160590.
InParanoidiQ09545.
KOiK00235.
OMAiDAAPFMQ.
PhylomeDBiQ09545.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
InterProiIPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view]
PfamiPF13085. Fer2_3. 1 hit.
[Graphical view]
SUPFAMiSSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsiTIGR00384. dhsB. 1 hit.
PROSITEiPS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q09545-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLARSARLLH SAELAANAIR AASGAPATAA AAEASFPSTD DVAAKTKKTG
60 70 80 90 100
NRIKTFEIYR FNPEAPGAKP TVQKFDVDLD QCGTMILDAL IKIKNEVDPT
110 120 130 140 150
LTFRRSCREG ICGSCAMNIG GQNTLACICK IDSDTSKSTK IYPLPHMFVV
160 170 180 190 200
KDLVPDMNLF YAQYASIQPW IQKKTPLTLG EKQMHQSVAE RDRLDGLYEC
210 220 230 240 250
ILCACCSTSC PSYWWNADKY LGPAVLMQAY RWVIDSRDDY ATERLHRMHD
260 270 280 290
SFSAFKCHTI MNCTKTCPKH LNPAKAIGEI KSLLTGFTSK PAAEPSAF
Length:298
Mass (Da):32,891
Last modified:October 1, 1996 - v1
Checksum:i0FDD148A6C9AB824
GO

Sequence cautioni

The sequence BAA23717.1 differs from that shown. Reason: Frameshift at positions 4, 15 and 28. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB008569 mRNA. Translation: BAA23717.1. Frameshift.
Z47809 Genomic DNA. Translation: CAA87780.1.
PIRiT22083.
T37260.
RefSeqiNP_495992.1. NM_063591.6.
UniGeneiCel.19522.

Genome annotation databases

EnsemblMetazoaiF42A8.2.1; F42A8.2.1; WBGene00006433.
F42A8.2.2; F42A8.2.2; WBGene00006433.
GeneIDi174482.
KEGGicel:CELE_F42A8.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB008569 mRNA. Translation: BAA23717.1. Frameshift.
Z47809 Genomic DNA. Translation: CAA87780.1.
PIRiT22083.
T37260.
RefSeqiNP_495992.1. NM_063591.6.
UniGeneiCel.19522.

3D structure databases

ProteinModelPortaliQ09545.
SMRiQ09545. Positions 52-296.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi39806. 1 interaction.
STRINGi6239.F42A8.2.1.

Proteomic databases

PaxDbiQ09545.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF42A8.2.1; F42A8.2.1; WBGene00006433.
F42A8.2.2; F42A8.2.2; WBGene00006433.
GeneIDi174482.
KEGGicel:CELE_F42A8.2.

Organism-specific databases

CTDi174482.
WormBaseiF42A8.2; CE01579; WBGene00006433; sdhb-1.

Phylogenomic databases

eggNOGiCOG0479.
GeneTreeiENSGT00390000013558.
HOGENOMiHOG000160590.
InParanoidiQ09545.
KOiK00235.
OMAiDAAPFMQ.
PhylomeDBiQ09545.

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006.
BRENDAi1.3.5.1. 1045.
ReactomeiREACT_287541. Citric acid cycle (TCA cycle).
REACT_330425. Respiratory electron transport.

Miscellaneous databases

NextBioi884224.
PROiQ09545.

Gene expression databases

ExpressionAtlasiQ09545. baseline.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
InterProiIPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view]
PfamiPF13085. Fer2_3. 1 hit.
[Graphical view]
SUPFAMiSSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsiTIGR00384. dhsB. 1 hit.
PROSITEiPS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Stage-specific isoforms of Ascaris suum complex. II: The fumarate reductase of the parasitic adult and the succinate dehydrogenase of free-living larvae share a common iron-sulfur subunit."
    Amino H., Wang H., Hirawake H., Saruta F., Mizuchi D., Mineki R., Shindo N., Murayama K., Takamiya S., Aoki T., Kojima S., Kita K.
    Mol. Biochem. Parasitol. 106:63-76(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiSDHB_CAEEL
AccessioniPrimary (citable) accession number: Q09545
Secondary accession number(s): O44075
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 24, 2015
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.