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Q09545 (SDHB_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

EC=1.3.5.1
Alternative name(s):
Iron-sulfur subunit of complex II
Short name=Ip
Gene names
Name:sdhb-1
Synonyms:tag-55
ORF Names:F42A8.2
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length298 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) By similarity.

Catalytic activity

Succinate + a quinone = fumarate + a quinol.

Cofactor

Binds 1 2Fe-2S cluster By similarity.

Binds 1 3Fe-4S cluster By similarity.

Binds 1 4Fe-4S cluster By similarity.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.

Subunit structure

Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit By similarity.

Subcellular location

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side By similarity.

Sequence similarities

Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

Contains 1 2Fe-2S ferredoxin-type domain.

Contains 1 4Fe-4S ferredoxin-type domain.

Sequence caution

The sequence BAA23717.1 differs from that shown. Reason: Frameshift at positions 4, 15 and 28.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion Potential
Chain? – 298Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrialPRO_0000010354

Regions

Domain59 – 147892Fe-2S ferredoxin-type
Domain190 – 220314Fe-4S ferredoxin-type

Sites

Metal binding1071Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding1121Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding1151Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding1271Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding2001Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding2031Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding2061Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding2101Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2571Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2631Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2671Iron-sulfur 2 (4Fe-4S) By similarity
Binding site2151Ubiquinone; shared with DHSD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q09545 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 0FDD148A6C9AB824

FASTA29832,891
        10         20         30         40         50         60 
MLARSARLLH SAELAANAIR AASGAPATAA AAEASFPSTD DVAAKTKKTG NRIKTFEIYR 

        70         80         90        100        110        120 
FNPEAPGAKP TVQKFDVDLD QCGTMILDAL IKIKNEVDPT LTFRRSCREG ICGSCAMNIG 

       130        140        150        160        170        180 
GQNTLACICK IDSDTSKSTK IYPLPHMFVV KDLVPDMNLF YAQYASIQPW IQKKTPLTLG 

       190        200        210        220        230        240 
EKQMHQSVAE RDRLDGLYEC ILCACCSTSC PSYWWNADKY LGPAVLMQAY RWVIDSRDDY 

       250        260        270        280        290 
ATERLHRMHD SFSAFKCHTI MNCTKTCPKH LNPAKAIGEI KSLLTGFTSK PAAEPSAF 

« Hide

References

« Hide 'large scale' references
[1]"Stage-specific isoforms of Ascaris suum complex. II: The fumarate reductase of the parasitic adult and the succinate dehydrogenase of free-living larvae share a common iron-sulfur subunit."
Amino H., Wang H., Hirawake H., Saruta F., Mizuchi D., Mineki R., Shindo N., Murayama K., Takamiya S., Aoki T., Kojima S., Kita K.
Mol. Biochem. Parasitol. 106:63-76(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB008569 mRNA. Translation: BAA23717.1. Frameshift.
Z47809 Genomic DNA. Translation: CAA87780.1.
PIRT22083.
T37260.
RefSeqNP_495992.1. NM_063591.6.
UniGeneCel.19522.

3D structure databases

ProteinModelPortalQ09545.
SMRQ09545. Positions 52-296.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid39806. 1 interaction.
STRING6239.F42A8.2.2.

Proteomic databases

PaxDbQ09545.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaF42A8.2.1; F42A8.2.1; WBGene00006433.
F42A8.2.2; F42A8.2.2; WBGene00006433.
GeneID174482.
KEGGcel:CELE_F42A8.2.

Organism-specific databases

CTD174482.
WormBaseF42A8.2; CE01579; WBGene00006433; sdhb-1.

Phylogenomic databases

eggNOGCOG0479.
GeneTreeENSGT00390000013558.
HOGENOMHOG000160590.
InParanoidQ09545.
KOK00235.
OMAHARDPIS.
PhylomeDBQ09545.

Enzyme and pathway databases

UniPathwayUPA00223; UER01006.

Family and domain databases

Gene3D3.10.20.30. 1 hit.
InterProIPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view]
PfamPF13085. Fer2_3. 1 hit.
[Graphical view]
SUPFAMSSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsTIGR00384. dhsB. 1 hit.
PROSITEPS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio884224.
PROQ09545.

Entry information

Entry nameSDHB_CAEEL
AccessionPrimary (citable) accession number: Q09545
Secondary accession number(s): O44075
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 11, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase