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Protein

Tripeptidyl-peptidase 2

Gene

tpp-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter is inhibited (By similarity). Has a role in regulation of fat storage.By similarity1 Publication

Catalytic activityi

Release of an N-terminal tripeptide from a polypeptide.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei93Charge relay systemBy similarity1
Active sitei314Charge relay systemBy similarity1
Active sitei499Charge relay systemBy similarity1

GO - Molecular functioni

GO - Biological processi

  • positive regulation of lipid storage Source: UniProtKB

Keywordsi

Molecular functionAminopeptidase, Hydrolase, Protease, Serine protease

Enzyme and pathway databases

ReactomeiR-CEL-983168 Antigen processing: Ubiquitination & Proteasome degradation
SignaLinkiQ09541

Protein family/group databases

MEROPSiS08.A56

Names & Taxonomyi

Protein namesi
Recommended name:
Tripeptidyl-peptidase 2 (EC:3.4.14.10)
Short name:
TPP2
Alternative name(s):
Tripeptidyl aminopeptidase
Tripeptidyl peptidase II
Short name:
TPPII
Gene namesi
Name:tpp-2
ORF Names:F21H12.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiF21H12.6 ; CE01917 ; WBGene00017686 ; tpp-2

Pathology & Biotechi

Disruption phenotypei

RNAi-mediated knockdown causes reduced fat storage but does not affect feeding behavior.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000764271 – 1374Tripeptidyl-peptidase 2Add BLAST1374

Proteomic databases

EPDiQ09541
PaxDbiQ09541
PeptideAtlasiQ09541
PRIDEiQ09541

Expressioni

Tissue specificityi

Expressed in intestinal fat-storing cells and some head neurons.1 Publication

Gene expression databases

BgeeiWBGene00017686

Interactioni

Protein-protein interaction databases

STRINGi6239.F21H12.6

Structurei

3D structure databases

ProteinModelPortaliQ09541
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini89 – 559Peptidase S8Add BLAST471

Sequence similaritiesi

Belongs to the peptidase S8 family.Curated

Phylogenomic databases

eggNOGiKOG1114 Eukaryota
COG1404 LUCA
GeneTreeiENSGT00390000014623
HOGENOMiHOG000008178
InParanoidiQ09541
KOiK01280
OMAiWRACIDT
OrthoDBiEOG091G00P0
PhylomeDBiQ09541

Family and domain databases

CDDicd04857 Peptidases_S8_Tripeptidyl_Amin, 1 hit
Gene3Di3.40.50.200, 2 hits
InterProiView protein in InterPro
IPR000209 Peptidase_S8/S53_dom
IPR036852 Peptidase_S8/S53_dom_sf
IPR022398 Peptidase_S8_His-AS
IPR023828 Peptidase_S8_Ser-AS
IPR015500 Peptidase_S8_subtilisin-rel
IPR022229 Peptidase_S8A_TPPII
IPR034051 TPP_II_domain
PfamiView protein in Pfam
PF00082 Peptidase_S8, 1 hit
PF12580 TPPII, 1 hit
PRINTSiPR00723 SUBTILISIN
SUPFAMiSSF52743 SSF52743, 2 hits
PROSITEiView protein in PROSITE
PS00137 SUBTILASE_HIS, 1 hit
PS00138 SUBTILASE_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Q09541-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIVIRNWQRI SYLSFCRFST RSLSIQQFQK TPLLLVVRQQ GSARLKMTSS
60 70 80 90 100
PPEIVPQQPL DALLLNKTDT EQEIFLTKYP NYDGRDILIA ILDTGVDPSL
110 120 130 140 150
PGMQVTTTGE RKMFDVIDCS GAGDVDTSIT RTVKDGVIEG ISGRKLAIPE
160 170 180 190 200
KWKCPTGQYH VGLKPIFELY TKGVKSRVIS ERKEDVVGPS HNIAASEALK
210 220 230 240 250
QLTEHEKVVG GTSEKTSDKW AREDFACKVD FLKSMASVAD VGPVADVVTW
260 270 280 290 300
HDGEMWRVCI DTSFRGRLGL GNVLGTFRET GDYAYLTNKD SVVYTVRVSP
310 320 330 340 350
DGNLTEIVVP SGAHGSHVAG IAAANYPDNP QKNGLAPGAK ILSLNIGDHR
360 370 380 390 400
LGAMETGQAM TRAFNMCAEL NVDIINMSFG EGTHLPDVGR VIEEARRLIN
410 420 430 440 450
RRGVIYVCSA GNQGPALSTV GAPGGTTTGV IGIGAYLTSE SADTLYGVYK
460 470 480 490 500
PVESSIYPWS SRGPCQDGKL GVSLVAPAAA FAGVPQYCRQ SMQMMNGTSM
510 520 530 540 550
SSPNAAGNVA CMLSGLKQNN LKWTPYTVRM ALENTAYMLP HIESFSQGQG
560 570 580 590 600
MIKIATAYEK LSEILVNKVF PPRLTHFEIN VSNHCKKSKG VYVREPNWNG
610 620 630 640 650
PQEFTIGVEP IFQNHLSDNN LPAISFEKQI ILQSTAPWVS HPQTMFVVAQ
660 670 680 690 700
ERTMVVTVDA SKAPKGANYT EIVGIDTADP SLGPIFRIPV TVINPEKVAV
710 720 730 740 750
DQYTSRLVGK SGVTERRFVE VPSWATSAKI TLRSTNKDEM DRFTLHTVYI
760 770 780 790 800
EDDKCSRNTE TQKIQGPIGN EWSKSITVQG GKTLEACVVR AWSRGKNPVD
810 820 830 840 850
VDMTIDFFGV KKPTSISLIH GATNTPIRFQ AAPTKSIDVS PSISLKSLVV
860 870 880 890 900
SLKPQSAKVE PLGPRDMFLT SGLQINRLLL TYQLKVQKPS EVQLQLAGLT
910 920 930 940 950
PYLYESPVDC VLFQIFGANK SFVGASSSYP DRWTQKLEKG DYTIQAQIRY
960 970 980 990 1000
PDDQVLQGMK ELPLLVHVKL GNKISVDLAA SASDATLGKE CKFAGKALLP
1010 1020 1030 1040 1050
NQEMTVYAMN IADDKLPKTI VPTSGSFLAG TFSALKDSDL SDVDKSEVIY
1060 1070 1080 1090 1100
FLSEYSTRPT KGLSMVTTKK DTNQNQEMTD AIRDLEVSWV QKLTDEKAAK
1110 1120 1130 1140 1150
EFFEACLQKY PDHLPLLQNR VKQLMQAKLV DQTPENVQKI IELCGQILQI
1160 1170 1180 1190 1200
TKPNETLQFS SVKQEHDDDL LTVDKWLALT GGSEDQRKDV VKLISQFEER
1210 1220 1230 1240 1250
KKSIILALQA LSSLEQDIEV RKSKFDVPAS LRFGGITPLI FGGKQGEVIN
1260 1270 1280 1290 1300
KKSEGYEALK SKSEQIDATV SEELKKLDSN WTGNQFYVKL LVWLSADDTK
1310 1320 1330 1340 1350
TALISAKHAA ALGQFGRCAK LLNKAGDELK SSATDSQAVD TSLAEVCESL
1360 1370
EWNHLATHFK NSALIKNRTS YRLF
Length:1,374
Mass (Da):151,089
Last modified:November 1, 1997 - v1
Checksum:i6937C862AED1E7FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080717 Genomic DNA Translation: CCD66120.1
PIRiT16129
RefSeqiNP_495221.1, NM_062820.3
UniGeneiCel.17531

Genome annotation databases

EnsemblMetazoaiF21H12.6; F21H12.6; WBGene00017686
GeneIDi174018
KEGGicel:CELE_F21H12.6
UCSCiF21H12.6 c. elegans

Similar proteinsi

Entry informationi

Entry nameiTPP2_CAEEL
AccessioniPrimary (citable) accession number: Q09541
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: March 28, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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