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Q09537

- GRK1_CAEEL

UniProt

Q09537 - GRK1_CAEEL

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Protein

G protein-coupled receptor kinase 1

Gene
grk-1, F19C6.1
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Specifically phosphorylates the activated forms of G protein-coupled receptors By similarity.

Catalytic activityi

ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei232 – 2321ATP By similarity
Active sitei328 – 3281Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi209 – 2179ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. G-protein coupled receptor kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. signal transduction Source: InterPro
  2. termination of G-protein coupled receptor signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ09537.

Names & Taxonomyi

Protein namesi
Recommended name:
G protein-coupled receptor kinase 1 (EC:2.7.11.16)
Gene namesi
Name:grk-1
ORF Names:F19C6.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome X

Organism-specific databases

WormBaseiF19C6.1; CE01554; WBGene00001708; grk-1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 642642G protein-coupled receptor kinase 1PRO_0000086840Add
BLAST

Proteomic databases

PaxDbiQ09537.
PRIDEiQ09537.

Interactioni

Protein-protein interaction databases

STRINGi6239.F19C6.1.

Structurei

3D structure databases

ProteinModelPortaliQ09537.
SMRiQ09537. Positions 2-598.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini52 – 188137RGSAdd
BLAST
Domaini203 – 470268Protein kinaseAdd
BLAST
Domaini480 – 54566AGC-kinase C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 202202N-terminalAdd
BLAST

Sequence similaritiesi

Contains 1 RGS domain.

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00730000110512.
HOGENOMiHOG000006742.
InParanoidiQ09537.
KOiK08291.
OMAiEMMETEC.
OrthoDBiEOG7V1FQK.
PhylomeDBiQ09537.

Family and domain databases

InterProiIPR000961. AGC-kinase_C.
IPR000239. GPCR_kinase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR00717. GPCRKINASE.
SMARTiSM00315. RGS. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q09537-1 [UniParc]FASTAAdd to Basket

« Hide

MEIENIVANT VYIKARESGG QKKGKSKKWK NYLQFPHYTE CLPLKTEIEV    50
TYAFVVEKQP IGKLLFHEFC QATNSQYHQC CQFLTKVEEY ETSDDDGQSR 100
RDLASSIVSL LHSKPEDNPS GSQDEQEFWC SFLSDEVIST CITTADSATH 150
DDEPRSDIFT EPYRLTCQYL TDAPFKEFAE SMYFHRFLQW KWLEKRPVDK 200
HTFRLYRVLG KGGFGEVCAC QVRASGKMYA LKKLEKKRVK KRHAETLSLN 250
EKQILQRINS PFVVSLAYAY ETKDALCLVL TLMNGGDLKF HLYNLMPGGF 300
DEKRVQFYAA EITLGLQHLH SERILYRDLK PENILLDDFG HVRISDLGLA 350
VEIKDNEPIK GRVGTVGYMA PEIVKNERYS YGVDWWGVGC LIYEMIEGKA 400
PFRQRKEKVK REEVERRVRE DQEKYSEKFS EAARTLCRGL LHKEPGFRLG 450
CRRVGRPEDG AEEIRAHPFF NTADTVTGRE PVPWKKMEAG KVTPPFCPDP 500
RAVYAKDVLD IEQFSTVKGV RLDATDTQFY GKFNTGCVSI PWQSEMIETE 550
CFAELNTFHD EDGNVMWNLR PDGINMDERR NGTSKPGFFS RLFRKKNIEV 600
TKSLHDLSHL GVEQQQPPKT STQTPAVRSS RAASASGRTL VI 642
Length:642
Mass (Da):73,778
Last modified:February 1, 1996 - v1
Checksum:iD2A72CBB364793EA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z48006 Genomic DNA. Translation: CAA88047.1.
PIRiT21112.
RefSeqiNP_509676.1. NM_077275.4.
UniGeneiCel.1193.

Genome annotation databases

EnsemblMetazoaiF19C6.1; F19C6.1; WBGene00001708.
GeneIDi181212.
KEGGicel:CELE_F19C6.1.
UCSCiF19C6.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z48006 Genomic DNA. Translation: CAA88047.1 .
PIRi T21112.
RefSeqi NP_509676.1. NM_077275.4.
UniGenei Cel.1193.

3D structure databases

ProteinModelPortali Q09537.
SMRi Q09537. Positions 2-598.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6239.F19C6.1.

Proteomic databases

PaxDbi Q09537.
PRIDEi Q09537.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai F19C6.1 ; F19C6.1 ; WBGene00001708 .
GeneIDi 181212.
KEGGi cel:CELE_F19C6.1.
UCSCi F19C6.1. c. elegans.

Organism-specific databases

CTDi 181212.
WormBasei F19C6.1 ; CE01554 ; WBGene00001708 ; grk-1.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00730000110512.
HOGENOMi HOG000006742.
InParanoidi Q09537.
KOi K08291.
OMAi EMMETEC.
OrthoDBi EOG7V1FQK.
PhylomeDBi Q09537.

Enzyme and pathway databases

SignaLinki Q09537.

Miscellaneous databases

NextBioi 912928.

Family and domain databases

InterProi IPR000961. AGC-kinase_C.
IPR000239. GPCR_kinase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view ]
PRINTSi PR00717. GPCRKINASE.
SMARTi SM00315. RGS. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF48097. SSF48097. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiGRK1_CAEEL
AccessioniPrimary (citable) accession number: Q09537
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 11, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi