Q09537 (GRK1_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
G protein-coupled receptor kinase 1
EC=2.7.11.16

Gene names

Name:	grk-1
ORF Names:	F19C6.1

Organism

Caenorhabditis elegans [Reference proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	642 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Specifically phosphorylates the activated forms of G protein-coupled receptors By similarity.
Catalytic activity	ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate.
Sequence similarities	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. Contains 1 AGC-kinase C-terminal domain. Contains 1 protein kinase domain. Contains 1 RGS domain.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	signal transduction Inferred from electronic annotation. Source: InterPro termination of G-protein coupled receptor signaling pathway Inferred from electronic annotation. Source: InterPro
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW G-protein coupled receptor kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 642	642	G protein-coupled receptor kinase 1		PRO_0000086840
Regions
	Domain	52 – 188	137	RGS
	Domain	203 – 470	268	Protein kinase
	Domain	480 – 545	66	AGC-kinase C-terminal
	Nucleotide binding	209 – 217	9	ATP By similarity
	Region	1 – 202	202	N-terminal
Sites
	Active site	328	1	Proton acceptor By similarity
	Binding site	232	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q09537 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: D2A72CBB364793EA	FASTA	642	73,778
	10 20 30 40 50 60 MEIENIVANT VYIKARESGG QKKGKSKKWK NYLQFPHYTE CLPLKTEIEV TYAFVVEKQP 70 80 90 100 110 120 IGKLLFHEFC QATNSQYHQC CQFLTKVEEY ETSDDDGQSR RDLASSIVSL LHSKPEDNPS 130 140 150 160 170 180 GSQDEQEFWC SFLSDEVIST CITTADSATH DDEPRSDIFT EPYRLTCQYL TDAPFKEFAE 190 200 210 220 230 240 SMYFHRFLQW KWLEKRPVDK HTFRLYRVLG KGGFGEVCAC QVRASGKMYA LKKLEKKRVK 250 260 270 280 290 300 KRHAETLSLN EKQILQRINS PFVVSLAYAY ETKDALCLVL TLMNGGDLKF HLYNLMPGGF 310 320 330 340 350 360 DEKRVQFYAA EITLGLQHLH SERILYRDLK PENILLDDFG HVRISDLGLA VEIKDNEPIK 370 380 390 400 410 420 GRVGTVGYMA PEIVKNERYS YGVDWWGVGC LIYEMIEGKA PFRQRKEKVK REEVERRVRE 430 440 450 460 470 480 DQEKYSEKFS EAARTLCRGL LHKEPGFRLG CRRVGRPEDG AEEIRAHPFF NTADTVTGRE 490 500 510 520 530 540 PVPWKKMEAG KVTPPFCPDP RAVYAKDVLD IEQFSTVKGV RLDATDTQFY GKFNTGCVSI 550 560 570 580 590 600 PWQSEMIETE CFAELNTFHD EDGNVMWNLR PDGINMDERR NGTSKPGFFS RLFRKKNIEV 610 620 630 640 TKSLHDLSHL GVEQQQPPKT STQTPAVRSS RAASASGRTL VI

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z48006 Genomic DNA. Translation: CAA88047.1.
PIR	T21112.
RefSeq	NP_509676.1. NM_077275.4.
3D structure databases
ProteinModelPortal	Q09537.
SMR	Q09537. Positions 2-593.
ModBase	Search...
Protein-protein interaction databases
STRING	6239.F19C6.1.
Proteomic databases
PaxDb	Q09537.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	F19C6.1; F19C6.1; F19C6.1.
GeneID	181212.
KEGG	cel:CELE_F19C6.1.
UCSC	F19C6.1. c. elegans.
Organism-specific databases
CTD	181212.
WormBase	F19C6.1; CE01554; WBGene00001708; grk-1.
Phylogenomic databases
eggNOG	COG0515.
GeneTree	ENSGT00550000074318.
HOGENOM	HOG000006742.
InParanoid	Q09537.
KO	K08291.
OMA	EMMETEC.
Family and domain databases
InterPro	IPR000961. AGC-kinase_C. IPR000239. GPCR_kinase. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR000342. Regulat_G_prot_signal. IPR016137. Regulat_G_prot_signal_superfam. IPR002290. Ser/Thr_dual-sp_kinase_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. PF00615. RGS. 1 hit. [Graphical view]
PRINTS	PR00717. GPCRKINASE.
SMART	SM00315. RGS. 1 hit. SM00133. S_TK_X. 1 hit. SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit. SSF48097. Regulat_G_prot_signal_superfam. 1 hit.
PROSITE	PS51285. AGC_KINASE_CTER. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. PS50132. RGS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	912928.

Entry information

Entry name

GRK1_CAEEL

Accession

Primary (citable) accession number: Q09537

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	May 1, 2013
This is version 99 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project