Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

G protein-coupled receptor kinase 1

Gene

grk-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Specifically phosphorylates the activated forms of G protein-coupled receptors.By similarity

Catalytic activityi

ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei232ATPPROSITE-ProRule annotation1
Active sitei328Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi209 – 217ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ09537.

Names & Taxonomyi

Protein namesi
Recommended name:
G protein-coupled receptor kinase 1 (EC:2.7.11.16)
Gene namesi
Name:grk-1
ORF Names:F19C6.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiF19C6.1; CE01554; WBGene00001708; grk-1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000868401 – 642G protein-coupled receptor kinase 1Add BLAST642

Proteomic databases

EPDiQ09537.
PaxDbiQ09537.
PeptideAtlasiQ09537.
PRIDEiQ09537.

PTM databases

iPTMnetiQ09537.

Expressioni

Gene expression databases

BgeeiWBGene00001708.

Interactioni

Protein-protein interaction databases

STRINGi6239.F19C6.1.

Structurei

3D structure databases

ProteinModelPortaliQ09537.
SMRiQ09537.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 188RGSPROSITE-ProRule annotationAdd BLAST137
Domaini203 – 470Protein kinasePROSITE-ProRule annotationAdd BLAST268
Domaini480 – 545AGC-kinase C-terminalAdd BLAST66

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 202N-terminalAdd BLAST202

Sequence similaritiesi

Contains 1 AGC-kinase C-terminal domain.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 RGS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0986. Eukaryota.
ENOG410YRQZ. LUCA.
GeneTreeiENSGT00860000133699.
HOGENOMiHOG000006742.
InParanoidiQ09537.
KOiK08291.
OMAiQHPIFKN.
OrthoDBiEOG091G062G.
PhylomeDBiQ09537.

Family and domain databases

InterProiIPR000961. AGC-kinase_C.
IPR000239. GPCR_kinase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR016137. RGS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR00717. GPCRKINASE.
SMARTiSM00315. RGS. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q09537-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIENIVANT VYIKARESGG QKKGKSKKWK NYLQFPHYTE CLPLKTEIEV
60 70 80 90 100
TYAFVVEKQP IGKLLFHEFC QATNSQYHQC CQFLTKVEEY ETSDDDGQSR
110 120 130 140 150
RDLASSIVSL LHSKPEDNPS GSQDEQEFWC SFLSDEVIST CITTADSATH
160 170 180 190 200
DDEPRSDIFT EPYRLTCQYL TDAPFKEFAE SMYFHRFLQW KWLEKRPVDK
210 220 230 240 250
HTFRLYRVLG KGGFGEVCAC QVRASGKMYA LKKLEKKRVK KRHAETLSLN
260 270 280 290 300
EKQILQRINS PFVVSLAYAY ETKDALCLVL TLMNGGDLKF HLYNLMPGGF
310 320 330 340 350
DEKRVQFYAA EITLGLQHLH SERILYRDLK PENILLDDFG HVRISDLGLA
360 370 380 390 400
VEIKDNEPIK GRVGTVGYMA PEIVKNERYS YGVDWWGVGC LIYEMIEGKA
410 420 430 440 450
PFRQRKEKVK REEVERRVRE DQEKYSEKFS EAARTLCRGL LHKEPGFRLG
460 470 480 490 500
CRRVGRPEDG AEEIRAHPFF NTADTVTGRE PVPWKKMEAG KVTPPFCPDP
510 520 530 540 550
RAVYAKDVLD IEQFSTVKGV RLDATDTQFY GKFNTGCVSI PWQSEMIETE
560 570 580 590 600
CFAELNTFHD EDGNVMWNLR PDGINMDERR NGTSKPGFFS RLFRKKNIEV
610 620 630 640
TKSLHDLSHL GVEQQQPPKT STQTPAVRSS RAASASGRTL VI
Length:642
Mass (Da):73,778
Last modified:February 1, 1996 - v1
Checksum:iD2A72CBB364793EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48006 Genomic DNA. Translation: CAA88047.1.
PIRiT21112.
RefSeqiNP_509676.1. NM_077275.4.
UniGeneiCel.1193.

Genome annotation databases

EnsemblMetazoaiF19C6.1; F19C6.1; WBGene00001708.
GeneIDi181212.
KEGGicel:CELE_F19C6.1.
UCSCiF19C6.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48006 Genomic DNA. Translation: CAA88047.1.
PIRiT21112.
RefSeqiNP_509676.1. NM_077275.4.
UniGeneiCel.1193.

3D structure databases

ProteinModelPortaliQ09537.
SMRiQ09537.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F19C6.1.

PTM databases

iPTMnetiQ09537.

Proteomic databases

EPDiQ09537.
PaxDbiQ09537.
PeptideAtlasiQ09537.
PRIDEiQ09537.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF19C6.1; F19C6.1; WBGene00001708.
GeneIDi181212.
KEGGicel:CELE_F19C6.1.
UCSCiF19C6.1. c. elegans.

Organism-specific databases

CTDi181212.
WormBaseiF19C6.1; CE01554; WBGene00001708; grk-1.

Phylogenomic databases

eggNOGiKOG0986. Eukaryota.
ENOG410YRQZ. LUCA.
GeneTreeiENSGT00860000133699.
HOGENOMiHOG000006742.
InParanoidiQ09537.
KOiK08291.
OMAiQHPIFKN.
OrthoDBiEOG091G062G.
PhylomeDBiQ09537.

Enzyme and pathway databases

SignaLinkiQ09537.

Miscellaneous databases

PROiQ09537.

Gene expression databases

BgeeiWBGene00001708.

Family and domain databases

InterProiIPR000961. AGC-kinase_C.
IPR000239. GPCR_kinase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR016137. RGS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR00717. GPCRKINASE.
SMARTiSM00315. RGS. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGRK1_CAEEL
AccessioniPrimary (citable) accession number: Q09537
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 30, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.