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Protein

G protein-coupled receptor kinase 1

Gene

grk-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Specifically phosphorylates the activated forms of G protein-coupled receptors.By similarity

Catalytic activityi

ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei232ATPPROSITE-ProRule annotation1
Active sitei328Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi209 – 217ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ09537

Names & Taxonomyi

Protein namesi
Recommended name:
G protein-coupled receptor kinase 1 (EC:2.7.11.16)
Gene namesi
Name:grk-1
ORF Names:F19C6.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiF19C6.1 ; CE01554 ; WBGene00001708 ; grk-1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000868401 – 642G protein-coupled receptor kinase 1Add BLAST642

Proteomic databases

EPDiQ09537
PaxDbiQ09537
PeptideAtlasiQ09537
PRIDEiQ09537

PTM databases

iPTMnetiQ09537

Expressioni

Gene expression databases

BgeeiWBGene00001708

Interactioni

Protein-protein interaction databases

STRINGi6239.F19C6.1

Structurei

3D structure databases

ProteinModelPortaliQ09537
SMRiQ09537
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 188RGSPROSITE-ProRule annotationAdd BLAST137
Domaini203 – 470Protein kinasePROSITE-ProRule annotationAdd BLAST268
Domaini480 – 545AGC-kinase C-terminalAdd BLAST66

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 202N-terminalAdd BLAST202

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0986 Eukaryota
ENOG410YRQZ LUCA
GeneTreeiENSGT00860000133699
HOGENOMiHOG000006742
InParanoidiQ09537
KOiK08291
OMAiGCFPFRR
OrthoDBiEOG091G062G
PhylomeDBiQ09537

Family and domain databases

InterProiView protein in InterPro
IPR000961 AGC-kinase_C
IPR000239 GPCR_kinase
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR016137 RGS
IPR036305 RGS_sf
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
PF00615 RGS, 1 hit
PRINTSiPR00717 GPCRKINASE
SMARTiView protein in SMART
SM00315 RGS, 1 hit
SM00133 S_TK_X, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS50132 RGS, 1 hit

Sequencei

Sequence statusi: Complete.

Q09537-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIENIVANT VYIKARESGG QKKGKSKKWK NYLQFPHYTE CLPLKTEIEV
60 70 80 90 100
TYAFVVEKQP IGKLLFHEFC QATNSQYHQC CQFLTKVEEY ETSDDDGQSR
110 120 130 140 150
RDLASSIVSL LHSKPEDNPS GSQDEQEFWC SFLSDEVIST CITTADSATH
160 170 180 190 200
DDEPRSDIFT EPYRLTCQYL TDAPFKEFAE SMYFHRFLQW KWLEKRPVDK
210 220 230 240 250
HTFRLYRVLG KGGFGEVCAC QVRASGKMYA LKKLEKKRVK KRHAETLSLN
260 270 280 290 300
EKQILQRINS PFVVSLAYAY ETKDALCLVL TLMNGGDLKF HLYNLMPGGF
310 320 330 340 350
DEKRVQFYAA EITLGLQHLH SERILYRDLK PENILLDDFG HVRISDLGLA
360 370 380 390 400
VEIKDNEPIK GRVGTVGYMA PEIVKNERYS YGVDWWGVGC LIYEMIEGKA
410 420 430 440 450
PFRQRKEKVK REEVERRVRE DQEKYSEKFS EAARTLCRGL LHKEPGFRLG
460 470 480 490 500
CRRVGRPEDG AEEIRAHPFF NTADTVTGRE PVPWKKMEAG KVTPPFCPDP
510 520 530 540 550
RAVYAKDVLD IEQFSTVKGV RLDATDTQFY GKFNTGCVSI PWQSEMIETE
560 570 580 590 600
CFAELNTFHD EDGNVMWNLR PDGINMDERR NGTSKPGFFS RLFRKKNIEV
610 620 630 640
TKSLHDLSHL GVEQQQPPKT STQTPAVRSS RAASASGRTL VI
Length:642
Mass (Da):73,778
Last modified:February 1, 1996 - v1
Checksum:iD2A72CBB364793EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48006 Genomic DNA Translation: CAA88047.1
PIRiT21112
RefSeqiNP_509676.1, NM_077275.4
UniGeneiCel.1193

Genome annotation databases

EnsemblMetazoaiF19C6.1; F19C6.1; WBGene00001708
GeneIDi181212
KEGGicel:CELE_F19C6.1
UCSCiF19C6.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiGRK1_CAEEL
AccessioniPrimary (citable) accession number: Q09537
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 23, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families
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