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Protein

G protein-coupled receptor kinase 1

Gene

grk-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Specifically phosphorylates the activated forms of G protein-coupled receptors.By similarity

Catalytic activityi

ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei232 – 2321ATPPROSITE-ProRule annotation
Active sitei328 – 3281Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi209 – 2179ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. G-protein coupled receptor kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. signal transduction Source: InterPro
  2. termination of G-protein coupled receptor signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_352961. G alpha (q) signalling events.
SignaLinkiQ09537.

Names & Taxonomyi

Protein namesi
Recommended name:
G protein-coupled receptor kinase 1 (EC:2.7.11.16)
Gene namesi
Name:grk-1
ORF Names:F19C6.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiF19C6.1; CE01554; WBGene00001708; grk-1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 642642G protein-coupled receptor kinase 1PRO_0000086840Add
BLAST

Proteomic databases

PaxDbiQ09537.
PRIDEiQ09537.

Interactioni

Protein-protein interaction databases

STRINGi6239.F19C6.1.

Structurei

3D structure databases

ProteinModelPortaliQ09537.
SMRiQ09537. Positions 2-593.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini52 – 188137RGSPROSITE-ProRule annotationAdd
BLAST
Domaini203 – 470268Protein kinasePROSITE-ProRule annotationAdd
BLAST
Domaini480 – 54566AGC-kinase C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 202202N-terminalAdd
BLAST

Sequence similaritiesi

Contains 1 AGC-kinase C-terminal domain.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 RGS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00770000120493.
HOGENOMiHOG000006742.
InParanoidiQ09537.
KOiK08291.
OMAiESSCEIC.
OrthoDBiEOG7V1FQK.
PhylomeDBiQ09537.

Family and domain databases

InterProiIPR000961. AGC-kinase_C.
IPR000239. GPCR_kinase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR016137. RGS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR00717. GPCRKINASE.
SMARTiSM00315. RGS. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q09537-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIENIVANT VYIKARESGG QKKGKSKKWK NYLQFPHYTE CLPLKTEIEV
60 70 80 90 100
TYAFVVEKQP IGKLLFHEFC QATNSQYHQC CQFLTKVEEY ETSDDDGQSR
110 120 130 140 150
RDLASSIVSL LHSKPEDNPS GSQDEQEFWC SFLSDEVIST CITTADSATH
160 170 180 190 200
DDEPRSDIFT EPYRLTCQYL TDAPFKEFAE SMYFHRFLQW KWLEKRPVDK
210 220 230 240 250
HTFRLYRVLG KGGFGEVCAC QVRASGKMYA LKKLEKKRVK KRHAETLSLN
260 270 280 290 300
EKQILQRINS PFVVSLAYAY ETKDALCLVL TLMNGGDLKF HLYNLMPGGF
310 320 330 340 350
DEKRVQFYAA EITLGLQHLH SERILYRDLK PENILLDDFG HVRISDLGLA
360 370 380 390 400
VEIKDNEPIK GRVGTVGYMA PEIVKNERYS YGVDWWGVGC LIYEMIEGKA
410 420 430 440 450
PFRQRKEKVK REEVERRVRE DQEKYSEKFS EAARTLCRGL LHKEPGFRLG
460 470 480 490 500
CRRVGRPEDG AEEIRAHPFF NTADTVTGRE PVPWKKMEAG KVTPPFCPDP
510 520 530 540 550
RAVYAKDVLD IEQFSTVKGV RLDATDTQFY GKFNTGCVSI PWQSEMIETE
560 570 580 590 600
CFAELNTFHD EDGNVMWNLR PDGINMDERR NGTSKPGFFS RLFRKKNIEV
610 620 630 640
TKSLHDLSHL GVEQQQPPKT STQTPAVRSS RAASASGRTL VI
Length:642
Mass (Da):73,778
Last modified:February 1, 1996 - v1
Checksum:iD2A72CBB364793EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48006 Genomic DNA. Translation: CAA88047.1.
PIRiT21112.
RefSeqiNP_509676.1. NM_077275.4.
UniGeneiCel.1193.

Genome annotation databases

EnsemblMetazoaiF19C6.1; F19C6.1; WBGene00001708.
GeneIDi181212.
KEGGicel:CELE_F19C6.1.
UCSCiF19C6.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48006 Genomic DNA. Translation: CAA88047.1.
PIRiT21112.
RefSeqiNP_509676.1. NM_077275.4.
UniGeneiCel.1193.

3D structure databases

ProteinModelPortaliQ09537.
SMRiQ09537. Positions 2-593.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F19C6.1.

Proteomic databases

PaxDbiQ09537.
PRIDEiQ09537.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF19C6.1; F19C6.1; WBGene00001708.
GeneIDi181212.
KEGGicel:CELE_F19C6.1.
UCSCiF19C6.1. c. elegans.

Organism-specific databases

CTDi181212.
WormBaseiF19C6.1; CE01554; WBGene00001708; grk-1.

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00770000120493.
HOGENOMiHOG000006742.
InParanoidiQ09537.
KOiK08291.
OMAiESSCEIC.
OrthoDBiEOG7V1FQK.
PhylomeDBiQ09537.

Enzyme and pathway databases

ReactomeiREACT_352961. G alpha (q) signalling events.
SignaLinkiQ09537.

Miscellaneous databases

NextBioi912928.

Family and domain databases

InterProiIPR000961. AGC-kinase_C.
IPR000239. GPCR_kinase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR016137. RGS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR00717. GPCRKINASE.
SMARTiSM00315. RGS. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiGRK1_CAEEL
AccessioniPrimary (citable) accession number: Q09537
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: April 1, 2015
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.