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Q09537 (GRK1_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
G protein-coupled receptor kinase 1

EC=2.7.11.16
Gene names
Name:grk-1
ORF Names:F19C6.1
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length642 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Specifically phosphorylates the activated forms of G protein-coupled receptors By similarity.

Catalytic activity

ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate.

Sequence similarities

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

Contains 1 AGC-kinase C-terminal domain.

Contains 1 protein kinase domain.

Contains 1 RGS domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 642642G protein-coupled receptor kinase 1
PRO_0000086840

Regions

Domain52 – 188137RGS
Domain203 – 470268Protein kinase
Domain480 – 54566AGC-kinase C-terminal
Nucleotide binding209 – 2179ATP By similarity
Region1 – 202202N-terminal

Sites

Active site3281Proton acceptor By similarity
Binding site2321ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q09537 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: D2A72CBB364793EA

FASTA64273,778
        10         20         30         40         50         60 
MEIENIVANT VYIKARESGG QKKGKSKKWK NYLQFPHYTE CLPLKTEIEV TYAFVVEKQP 

        70         80         90        100        110        120 
IGKLLFHEFC QATNSQYHQC CQFLTKVEEY ETSDDDGQSR RDLASSIVSL LHSKPEDNPS 

       130        140        150        160        170        180 
GSQDEQEFWC SFLSDEVIST CITTADSATH DDEPRSDIFT EPYRLTCQYL TDAPFKEFAE 

       190        200        210        220        230        240 
SMYFHRFLQW KWLEKRPVDK HTFRLYRVLG KGGFGEVCAC QVRASGKMYA LKKLEKKRVK 

       250        260        270        280        290        300 
KRHAETLSLN EKQILQRINS PFVVSLAYAY ETKDALCLVL TLMNGGDLKF HLYNLMPGGF 

       310        320        330        340        350        360 
DEKRVQFYAA EITLGLQHLH SERILYRDLK PENILLDDFG HVRISDLGLA VEIKDNEPIK 

       370        380        390        400        410        420 
GRVGTVGYMA PEIVKNERYS YGVDWWGVGC LIYEMIEGKA PFRQRKEKVK REEVERRVRE 

       430        440        450        460        470        480 
DQEKYSEKFS EAARTLCRGL LHKEPGFRLG CRRVGRPEDG AEEIRAHPFF NTADTVTGRE 

       490        500        510        520        530        540 
PVPWKKMEAG KVTPPFCPDP RAVYAKDVLD IEQFSTVKGV RLDATDTQFY GKFNTGCVSI 

       550        560        570        580        590        600 
PWQSEMIETE CFAELNTFHD EDGNVMWNLR PDGINMDERR NGTSKPGFFS RLFRKKNIEV 

       610        620        630        640 
TKSLHDLSHL GVEQQQPPKT STQTPAVRSS RAASASGRTL VI 

« Hide

References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z48006 Genomic DNA. Translation: CAA88047.1.
PIRT21112.
RefSeqNP_509676.1. NM_077275.4.
UniGeneCel.1193.

3D structure databases

ProteinModelPortalQ09537.
SMRQ09537. Positions 2-594.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6239.F19C6.1.

Proteomic databases

PaxDbQ09537.
PRIDEQ09537.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaF19C6.1; F19C6.1; F19C6.1.
GeneID181212.
KEGGcel:CELE_F19C6.1.
UCSCF19C6.1. c. elegans.

Organism-specific databases

CTD181212.
WormBaseF19C6.1; CE01554; WBGene00001708; grk-1.

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000006742.
InParanoidQ09537.
KOK08291.
OMAEMMETEC.
OrthoDBEOG7V1FQK.
PhylomeDBQ09537.

Enzyme and pathway databases

SignaLinkQ09537.

Family and domain databases

InterProIPR000961. AGC-kinase_C.
IPR000239. GPCR_kinase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSPR00717. GPCRKINASE.
SMARTSM00315. RGS. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF48097. SSF48097. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEPS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio912928.

Entry information

Entry nameGRK1_CAEEL
AccessionPrimary (citable) accession number: Q09537
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: April 16, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase