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Protein

Probable pre-mRNA-splicing factor ATP-dependent RNA helicase mog-5

Gene

mog-5

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Could act late in the splicing of pre-mRNA and mediate the release of the spliced mRNA from spliceosomes.By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi563 – 570ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

  • developmental growth Source: WormBase
  • embryonic body morphogenesis Source: WormBase
  • feminization of hermaphroditic germ-line Source: WormBase
  • germ cell development Source: WormBase
  • mRNA splicing, via spliceosome Source: GO_Central

Keywordsi

Molecular functionDevelopmental protein, Helicase, Hydrolase
Biological processmRNA processing, mRNA splicing
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable pre-mRNA-splicing factor ATP-dependent RNA helicase mog-5 (EC:3.6.4.13)
Alternative name(s):
Masculinization of germline protein 5
Sex determination protein mog-5
Gene namesi
Name:mog-5
ORF Names:EEED8.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiEEED8.5; CE01889; WBGene00003393; mog-5.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000551331 – 1200Probable pre-mRNA-splicing factor ATP-dependent RNA helicase mog-5Add BLAST1200

Proteomic databases

EPDiQ09530.
PaxDbiQ09530.
PeptideAtlasiQ09530.
PRIDEiQ09530.

PTM databases

iPTMnetiQ09530.

Expressioni

Gene expression databases

BgeeiWBGene00003393.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
mep-1Q215023EBI-329912,EBI-319858

Protein-protein interaction databases

BioGridi39264. 10 interactors.
DIPiDIP-25759N.
IntActiQ09530. 2 interactors.
MINTiMINT-1046882.
STRINGi6239.EEED8.5.

Structurei

3D structure databases

ProteinModelPortaliQ09530.
SMRiQ09530.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini234 – 304S1 motifPROSITE-ProRule annotationAdd BLAST71
Domaini550 – 713Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST164
Domaini738 – 911Helicase C-terminalPROSITE-ProRule annotationAdd BLAST174

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi660 – 663DEAH box4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi176 – 185Poly-Arg10

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0922. Eukaryota.
COG1185. LUCA.
COG1643. LUCA.
GeneTreeiENSGT00880000137867.
HOGENOMiHOG000175261.
InParanoidiQ09530.
KOiK12818.
OMAiIQKAICS.
OrthoDBiEOG091G030Q.
PhylomeDBiQ09530.

Family and domain databases

InterProiView protein in InterPro
IPR002464. DNA/RNA_helicase_DEAH_CS.
IPR011709. DUF1605.
IPR007502. Helicase-assoc_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR012340. NA-bd_OB-fold.
IPR027417. P-loop_NTPase.
IPR022967. S1_dom.
IPR003029. S1_domain.
PfamiView protein in Pfam
PF04408. HA2. 1 hit.
PF00271. Helicase_C. 1 hit.
PF07717. OB_NTP_bind. 1 hit.
PF00575. S1. 1 hit.
SMARTiView protein in SMART
SM00487. DEXDc. 1 hit.
SM00847. HA2. 1 hit.
SM00490. HELICc. 1 hit.
SM00316. S1. 1 hit.
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00690. DEAH_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50126. S1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q09530-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQLEHLSLV SKVLSEVENH FGVVEKDVAE FVIHLAQENP TFDKLKKALD
60 70 80 90 100
SQGLGDQFDD SLTATILRIV QSMTAVKKKN KKGGDSKEDI KDSHKITLIS
110 120 130 140 150
DAKEEIKARL PALAMANTAK EKEDNEDDLM AQLEKMEGRY ESEKRLQKES
160 170 180 190 200
DSKRNRSRSR SRSRDRKRRR SRSGDRDRRR RSRSREDRRD RDRRDRDRDR
210 220 230 240 250
DRGRGDRRGD DRQRDRRDRR DDGGARKSEV AEIGKIYDGR VNSIQSFGAF
260 270 280 290 300
ITLEGFRQKQ EGLVHISQIR NERVQTVADV LKRGENVKVK VNKIENGKIS
310 320 330 340 350
LSMKEVDQNS GEDLNPRETD LNPDAIGVRP RTPPASTSSW MNPEASGVGQ
360 370 380 390 400
GPSTSIGGGK ARVRISTPER WELRQMQGAG VLTATDMPDF DEEMGVLRNY
410 420 430 440 450
DDESDGEDIE IELVEDEPDF LRGYGKGGAE IEPVKVVKNP DGSLAQAALM
460 470 480 490 500
QGALSKERKE TKIQAQRERD MDTQKGFSSN ARILDPMSGN QSTAWSADES
510 520 530 540 550
KDRNNKMKEM PEWLKHVTAG GKATYGRRTN LSMVEQRESL PIFALKKNLM
560 570 580 590 600
EAMIDNQILV VVGETGSGKT TQMTQYAIEA GLGRRGKIGC TQPRRVAAMS
610 620 630 640 650
VAKRVAEEYG CKLGTDVGYT IRFEDCTSQD TIIKYMTDGM LLRECLIDPD
660 670 680 690 700
LSGYSLIMLD EAHERTIHTD VLFGLLKAAA RKRPELKLII TSATLDSVKF
710 720 730 740 750
SEYFLEAPIF TIPGRTFPVE ILYTREPESD YLEAAHITVM QIHLTEPPGD
760 770 780 790 800
VLVFLTGQEE IDTSCEVLYE RMKSMGPDVP ELIILPVYGA LPSEMQTRIF
810 820 830 840 850
DPAPAGKRKV VIATNIAETS LTIDGIFYVV DPGFVKQKIY NPKSGMDSLV
860 870 880 890 900
VTPISQAAAK QRSGRAGRTG PGKCYRLYTE RAFRDEMLPT PVPEIQRTNL
910 920 930 940 950
ASTLLQLKAM GINNLIDFDF MDAPPLDSMI TALNTLHTLS ALDGDGLLTK
960 970 980 990 1000
LGRRMAEFPL EPSLSKLLIM SVDLGCSEEV LTIVAMLNVQ NIFYRPKEKQ
1010 1020 1030 1040 1050
DHADQKKAKF HQPEGDHLTL LAVYNSWKNH HFSQPWCFEN FIQVRSMKRA
1060 1070 1080 1090 1100
QDIRKQLLGI MDRHKLLMVS CGRDVSRVQK AICSGFFRNA AKRDPQEGYR
1110 1120 1130 1140 1150
TLTDGQNVYI HPSSACFQQQ PEWVVYHELV MTTKEYMREV TAIDPKWLVE
1160 1170 1180 1190 1200
FAPSFFKIGD STKLSTFKRN QKIDPLFDKY ADANAWRITR VKKRIYNPNK
Length:1,200
Mass (Da):135,759
Last modified:November 1, 1997 - v1
Checksum:i023C46E494D7F44F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF286899 mRNA. Translation: AAG01332.1.
FO081042 Genomic DNA. Translation: CCD68732.1.
PIRiT15921.
RefSeqiNP_495019.1. NM_062618.6.
UniGeneiCel.7556.

Genome annotation databases

EnsemblMetazoaiEEED8.5; EEED8.5; WBGene00003393.
GeneIDi173920.
KEGGicel:CELE_EEED8.5.
UCSCiEEED8.5. c. elegans.

Similar proteinsi

Entry informationi

Entry nameiMOG5_CAEEL
AccessioniPrimary (citable) accession number: Q09530
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 5, 2017
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families