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Protein

Probable dimethyladenosine transferase

Gene

E02H1.1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle.By similarity

Catalytic activityi

4 S-adenosyl-L-methionine + adenine(1779)/adenine(1780) in 18S rRNA = 4 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(1779)/N(6)-dimethyladenine(1780) in 18S rRNA.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei31 – 311S-adenosyl-L-methionine; via carbonyl oxygenPROSITE-ProRule annotation
Binding sitei33 – 331S-adenosyl-L-methionine; via amide nitrogenPROSITE-ProRule annotation
Binding sitei58 – 581S-adenosyl-L-methionine; via carbonyl oxygenPROSITE-ProRule annotation
Binding sitei79 – 791S-adenosyl-L-methioninePROSITE-ProRule annotation
Binding sitei107 – 1071S-adenosyl-L-methioninePROSITE-ProRule annotation
Binding sitei122 – 1221S-adenosyl-L-methioninePROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

rRNA processing

Keywords - Ligandi

RNA-binding, S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dimethyladenosine transferase (EC:2.1.1.183)
Alternative name(s):
Probable 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase
Probable 18S rRNA dimethylase
Probable S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase
Gene namesi
ORF Names:E02H1.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiE02H1.1; CE30642; WBGene00008455.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 308308Probable dimethyladenosine transferasePRO_0000101468Add
BLAST

Proteomic databases

EPDiQ09522.
PaxDbiQ09522.

Interactioni

Protein-protein interaction databases

BioGridi48796. 1 interaction.
STRINGi6239.E02H1.1.1.

Structurei

3D structure databases

ProteinModelPortaliQ09522.
SMRiQ09522. Positions 30-306.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0820. Eukaryota.
COG0030. LUCA.
GeneTreeiENSGT00530000063389.
HOGENOMiHOG000227963.
InParanoidiQ09522.
KOiK14191.
OMAiDVMKMEW.
OrthoDBiEOG7RZ5QG.
PhylomeDBiQ09522.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR001737. KsgA/Erm.
IPR020596. rRNA_Ade_Mease_Trfase_CS.
IPR020598. rRNA_Ade_methylase_Trfase_N.
IPR011530. rRNA_adenine_dimethylase.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR11727. PTHR11727. 1 hit.
PfamiPF00398. RrnaAD. 1 hit.
[Graphical view]
SMARTiSM00650. rADc. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00755. ksgA. 1 hit.
PROSITEiPS01131. RRNA_A_DIMETH. 1 hit.
PS51689. SAM_RNA_A_N6_MT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q09522-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKTSKVKKT KAGSSTGNVQ SLPFNTDKGQ HILKNPGVVN AIVEKSALKA
60 70 80 90 100
TDTVLEVGPG TGNLTVKMLE VAKTVIACEI DPRMIAEVKK RVMGTPLQNK
110 120 130 140 150
LQVNGGDVMK MEWPFFDVCV ANLPYQISSP FVQKLLLHRP LPRYAVLMFQ
160 170 180 190 200
KEFADRLVAR PGDKDYSRLS VNVQLLAKVE MLMKVKRTEF RPPPKVDSAV
210 220 230 240 250
VRIAPKNPPP PVNFVEWEGL LRLCFMRKNK TLMAIFRLSN VIEVIEDNFR
260 270 280 290 300
KVCSFKNKPI PKDLNMKKVI EETLTASGYG ESRARKMRVE DFLALLLAFN

KADIHFLS
Length:308
Mass (Da):34,610
Last modified:January 17, 2003 - v2
Checksum:i91AAD079D9F1F31C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z47075 Genomic DNA. Translation: CAA87382.2.
PIRiT20417.
RefSeqiNP_496061.2. NM_063660.7.
UniGeneiCel.20277.

Genome annotation databases

EnsemblMetazoaiE02H1.1.1; E02H1.1.1; WBGene00008455.
E02H1.1.2; E02H1.1.2; WBGene00008455.
GeneIDi183993.
KEGGicel:CELE_E02H1.1.
UCSCiE02H1.1.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z47075 Genomic DNA. Translation: CAA87382.2.
PIRiT20417.
RefSeqiNP_496061.2. NM_063660.7.
UniGeneiCel.20277.

3D structure databases

ProteinModelPortaliQ09522.
SMRiQ09522. Positions 30-306.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi48796. 1 interaction.
STRINGi6239.E02H1.1.1.

Proteomic databases

EPDiQ09522.
PaxDbiQ09522.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiE02H1.1.1; E02H1.1.1; WBGene00008455.
E02H1.1.2; E02H1.1.2; WBGene00008455.
GeneIDi183993.
KEGGicel:CELE_E02H1.1.
UCSCiE02H1.1.1. c. elegans.

Organism-specific databases

CTDi183993.
WormBaseiE02H1.1; CE30642; WBGene00008455.

Phylogenomic databases

eggNOGiKOG0820. Eukaryota.
COG0030. LUCA.
GeneTreeiENSGT00530000063389.
HOGENOMiHOG000227963.
InParanoidiQ09522.
KOiK14191.
OMAiDVMKMEW.
OrthoDBiEOG7RZ5QG.
PhylomeDBiQ09522.

Miscellaneous databases

PROiQ09522.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR001737. KsgA/Erm.
IPR020596. rRNA_Ade_Mease_Trfase_CS.
IPR020598. rRNA_Ade_methylase_Trfase_N.
IPR011530. rRNA_adenine_dimethylase.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR11727. PTHR11727. 1 hit.
PfamiPF00398. RrnaAD. 1 hit.
[Graphical view]
SMARTiSM00650. rADc. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00755. ksgA. 1 hit.
PROSITEiPS01131. RRNA_A_DIMETH. 1 hit.
PS51689. SAM_RNA_A_N6_MT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiDIM1_CAEEL
AccessioniPrimary (citable) accession number: Q09522
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 17, 2003
Last modified: July 6, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.