ID   FOLC_CAEEL              Reviewed;         510 AA.
AC   Q09509;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   16-JUN-2009, entry version 55.
DE   RecName: Full=Putative folylpolyglutamate synthase;
DE            EC=6.3.2.17;
DE   AltName: Full=Folylpoly-gamma-glutamate synthetase;
DE            Short=FPGS;
DE   AltName: Full=Tetrahydrofolylpolyglutamate synthase;
DE            Short=Tetrahydrofolate synthase;
GN   ORFNames=F25B5.6;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea;
OC   Rhabditidae; Peloderinae; Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   MEDLINE=99069613; PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for
RT   investigating biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Conversion of folates to polyglutamate derivatives (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + tetrahydropteroyl-(gamma-Glu)(n) + L-
CC       glutamate = ADP + phosphate + tetrahydropteroyl-(gamma-Glu)(n+1).
CC   -!- PATHWAY: Cofactor biosynthesis; tetrahydrofolylpolyglutamate
CC       biosynthesis.
CC   -!- SIMILARITY: Belongs to the folylpolyglutamate synthase family.
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DR   EMBL; U23172; AAC46527.1; -; Genomic_DNA.
DR   PIR; T16146; T16146.
DR   RefSeq; NP_498292.1; -.
DR   UniGene; Cel.8718; -.
DR   HSSP; P15925; 1FGS.
DR   Ensembl; F25B5.6; Caenorhabditis elegans.
DR   GeneID; 175842; -.
DR   WormBase; WBGene00017777; F25B5.6.
DR   WormPep; F25B5.6; CE01923.
DR   BRENDA; 6.3.2.17; 672.
DR   NextBio; 889900; -.
DR   ArrayExpress; Q09509; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004326; F:tetrahydrofolylpolyglutamate synthase activity; IEA:EC.
DR   GO; GO:0009396; P:folic acid and derivative biosynthetic process; IEA:InterPro.
DR   GO; GO:0006730; P:one-carbon compound metabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR018109; Folylpolyglutamate_synth_CS.
DR   InterPro; IPR001645; Fpolygl_synthtse.
DR   InterPro; IPR004101; Mur_ligase_C.
DR   InterPro; IPR013221; Mur_ligase_cen.
DR   Gene3D; G3DSA:3.90.190.20; Mur_ligase_C; 1.
DR   Gene3D; G3DSA:3.40.1190.10; Mur_ligase_cen; 1.
DR   PANTHER; PTHR11136; Fpolygl_synthtse; 1.
DR   Pfam; PF02875; Mur_ligase_C; 1.
DR   TIGRFAMs; TIGR01499; folC; 1.
DR   PROSITE; PS01011; FOLYLPOLYGLU_SYNT_1; 1.
DR   PROSITE; PS01012; FOLYLPOLYGLU_SYNT_2; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Complete proteome; Ligase; Nucleotide-binding;
KW   One-carbon metabolism.
FT   CHAIN         1    510       Putative folylpolyglutamate synthase.
FT                                /FTId=PRO_0000168306.
FT   NP_BIND      95    101       ATP (Potential).
SQ   SEQUENCE   510 AA;  56433 MW;  12A965157DFED84A CRC64;
     MRLLPQTNRI LLPTTSSTAC GANQLRMSSE KAVPCYEESV RLLNGLQSNA ATIKKLRVQR
     ENLQAINLPQ CRKYLESLNI SAEDLNALNI IHVSGTKGKG SACAFVESIL RSQGLRTGFY
     SSPHLVHVRE RIQVDGQPVS EQMFAEEFFH VYDIIKREHS DNMPAYFKFL TLLAFRIFVK
     LNVQVMILEV GIGGEYDCTN VVEKPKVCGV TTLDYDHMSI LGNKLSEIAW HKAGIFKESV
     PAFYSPTTTE AEEVLIARAI SKHVPLFQTP PVSAYQFARD ISPGIRGAHQ FSNVSMALQL
     VRAWAEKCGF PLPGVPLSTD TSGFNVPLWM CDAIESCRWP GRSQIVSTDR NVTYLLDGAH
     TPKSMEACSE WAAEEIVNLK KENVKKILLF QCTADRCPST LIKYLKPLGI SQIVSCPTQL
     HSSIDKSADS ANLNASRDEQ AEKANQCVQA WKESLDQPES VTEDQMKVFD CISSAYKFIE
     SQAASQEILV LVTGSLHLVG GVLNLAGKGK
//