Reviewed, UniProtKB/Swiss-Prot Q09509 (FOLC_CAEEL)

Names and origin

Protein names

Recommended name:
    Putative folylpolyglutamate synthase
    EC=6.3.2.17
Alternative name(s):
    Folylpoly-gamma-glutamate synthetase
      Short name=FPGS
    Tetrahydrofolylpolyglutamate synthase
      Short name=Tetrahydrofolate synthase

Gene names

ORF Names:

F25B5.6

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	510 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Conversion of folates to polyglutamate derivatives By similarity.
Catalytic activity	ATP + tetrahydropteroyl-(gamma-Glu)(n) + L-glutamate = ADP + phosphate + tetrahydropteroyl-(gamma-Glu)(n+1).
Pathway	Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.
Sequence similarities	Belongs to the folylpolyglutamate synthase family.

Ontologies

Keywords
Biological process	One-carbon metabolism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	folic acid and derivative biosynthetic process Inferred from electronic annotation. Source: InterPro one-carbon compound metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW tetrahydrofolylpolyglutamate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 510	510	Putative folylpolyglutamate synthase		PRO_0000168306
Regions
	Nucleotide binding	95 – 101	7	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q09509-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 12A965157DFED84A	FASTA	510	56,433
	10 20 30 40 50 60 MRLLPQTNRI LLPTTSSTAC GANQLRMSSE KAVPCYEESV RLLNGLQSNA ATIKKLRVQR 70 80 90 100 110 120 ENLQAINLPQ CRKYLESLNI SAEDLNALNI IHVSGTKGKG SACAFVESIL RSQGLRTGFY 130 140 150 160 170 180 SSPHLVHVRE RIQVDGQPVS EQMFAEEFFH VYDIIKREHS DNMPAYFKFL TLLAFRIFVK 190 200 210 220 230 240 LNVQVMILEV GIGGEYDCTN VVEKPKVCGV TTLDYDHMSI LGNKLSEIAW HKAGIFKESV 250 260 270 280 290 300 PAFYSPTTTE AEEVLIARAI SKHVPLFQTP PVSAYQFARD ISPGIRGAHQ FSNVSMALQL 310 320 330 340 350 360 VRAWAEKCGF PLPGVPLSTD TSGFNVPLWM CDAIESCRWP GRSQIVSTDR NVTYLLDGAH 370 380 390 400 410 420 TPKSMEACSE WAAEEIVNLK KENVKKILLF QCTADRCPST LIKYLKPLGI SQIVSCPTQL 430 440 450 460 470 480 HSSIDKSADS ANLNASRDEQ AEKANQCVQA WKESLDQPES VTEDQMKVFD CISSAYKFIE 490 500 510 SQAASQEILV LVTGSLHLVG GVLNLAGKGK

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U23172 Genomic DNA. Translation: AAC46527.1.
PIR	T16146.
RefSeq	NP_498292.1.
UniGene	Cel.8718
3D structure databases
HSSP	HSSP built from PDB template 1FGS based on UniProtKB P15925.
ModBase	Search...
Genome annotation databases
Ensembl	F25B5.6. Caenorhabditis elegans. [Contig view]
GeneID	175842.
Organism-specific databases
WormBase	WBGene00017777. F25B5.6.
WormPep	F25B5.6. CE01923. [WorfDB]
Enzyme and pathway databases
BRENDA	6.3.2.17. 672.
Gene expression databases
ArrayExpress	Q09509.
Family and domain databases
InterPro	IPR018109. Folylpolyglutamate_synth_CS. IPR001645. Fpolygl_synthtse. IPR004101. Mur_ligase_C. IPR013221. Mur_ligase_cen. [Graphical view]
Gene3D	G3DSA:3.90.190.20. Mur_ligase_C. 1 hit. G3DSA:3.40.1190.10. Mur_ligase_cen. 1 hit.
PANTHER	PTHR11136. Fpolygl_synthtse. 1 hit.
Pfam	PF02875. Mur_ligase_C. 1 hit. [Graphical view]
TIGRFAMs	TIGR01499. folC. 1 hit.
PROSITE	PS01011. FOLYLPOLYGLU_SYNT_1. 1 hit. PS01012. FOLYLPOLYGLU_SYNT_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	889900.

Entry information

Entry name

FOLC_CAEEL

Accession

Primary (citable) accession number: Q09509

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	June 16, 2009
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project