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Q09508

- SDHA_CAEEL

UniProt

Q09508 - SDHA_CAEEL

Protein

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Gene

sdha-1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 3 (02 Aug 2002)
      Previous versions | rss
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    Functioni

    Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).By similarity

    Catalytic activityi

    Succinate + a quinone = fumarate + a quinol.

    Cofactori

    FAD.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei256 – 2561FADBy similarity
    Binding sitei277 – 2771SubstrateBy similarity
    Binding sitei289 – 2891SubstrateBy similarity
    Active sitei321 – 3211Proton acceptorBy similarity
    Binding sitei388 – 3881SubstrateBy similarity
    Binding sitei422 – 4221FADBy similarity
    Binding sitei433 – 4331SubstrateBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi49 – 546FADBy similarity
    Nucleotide bindingi72 – 8716FADBy similarityAdd
    BLAST
    Nucleotide bindingi438 – 4392FADBy similarity

    GO - Molecular functioni

    1. flavin adenine dinucleotide binding Source: InterPro
    2. succinate dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

    GO - Biological processi

    1. electron transport chain Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Transport, Tricarboxylic acid cycle

    Keywords - Ligandi

    FAD, Flavoprotein

    Enzyme and pathway databases

    UniPathwayiUPA00223; UER01006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (EC:1.3.5.1)
    Alternative name(s):
    Flavoprotein subunit of complex II
    Short name:
    FP
    Gene namesi
    Name:sdha-1
    ORF Names:C03G5.1/D2021.3
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome X

    Organism-specific databases

    WormBaseiC03G5.1; CE03917; WBGene00015391; sdha-1.

    Subcellular locationi

    Mitochondrion inner membrane By similarity; Peripheral membrane protein By similarity; Matrix side By similarity

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: UniProtKB
    2. mitochondrion Source: WormBase

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3131MitochondrionSequence AnalysisAdd
    BLAST
    Chaini32 – 646615Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialPRO_0000010339Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei80 – 801Tele-8alpha-FAD histidineBy similarity

    Proteomic databases

    PaxDbiQ09508.

    2D gel databases

    World-2DPAGE0020:Q09508.

    Interactioni

    Subunit structurei

    Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ09508.
    SMRiQ09508. Positions 34-646.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG1053.
    GeneTreeiENSGT00750000117848.
    HOGENOMiHOG000160475.
    InParanoidiQ09508.
    KOiK00234.
    OMAiYRTCAAA.
    OrthoDBiEOG7MH0XJ.
    PhylomeDBiQ09508.

    Family and domain databases

    Gene3Di1.20.58.100. 1 hit.
    3.90.700.10. 1 hit.
    InterProiIPR003953. FAD_bind_dom.
    IPR003952. FRD_SDH_FAD_BS.
    IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
    IPR027477. Succ_DH/fumarate_Rdtase_cat.
    IPR011281. Succ_DH_flav_su_fwd.
    IPR014006. Succ_Dhase_FrdA_Gneg.
    [Graphical view]
    PfamiPF00890. FAD_binding_2. 1 hit.
    PF02910. Succ_DH_flav_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF46977. SSF46977. 1 hit.
    SSF56425. SSF56425. 1 hit.
    TIGRFAMsiTIGR01816. sdhA_forward. 1 hit.
    TIGR01812. sdhA_frdA_Gneg. 1 hit.
    PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q09508-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLRAASNGLR NTVAARSVSL SAANHSDAKR SDIAQYKVVD HAYDAVVVGA    50
    GGAGLRAAMG LAEGGLKTAV ITKLFPTRSH TVAAQGGINA ALGNMNPDNW 100
    RWHFYDTVKG SDWLGDQDAI HYMTREAERA VIELENYGMP FSRTTDGKIY 150
    QRAFGGQSND FGRGGQAHRT CCVADRTGHS LLHTLYGASL QYNCNYFVEY 200
    FALDLIMENG VCVGVIAMDL EDGTIHRFRS KNTVLATGGY GRAFFSCTSA 250
    HTCTGDGTAL TARAGINNSD MEFVQFHPTG IYGAGCLITE GSRGEGGYLV 300
    NSAGERFMER YAPNAKDLAS RDVVSRSMTV EIMEGRGVGP DKDHIYLQLH 350
    HLPAEQLQQR LPGISETAMI FAGVDVTKEP IPVIPTVHYN MGGVPTNYKG 400
    QVLNYTPKKG DEVVPGLYAA GECGAHSVHG ANRLGANSLL DLVIFGRACA 450
    IDILKNTSAG VGVPELPKNA GEASVANIDK LRHNKGDIST AELRLTMQKS 500
    MQNHAAVFRR GDILKEGVKV LSKLYKDQAH LNVADKGLVW NSDLIETLEL 550
    QNLLINATQT IVAAENREES RGAHARDDFP DRLDELDYSK PLEGQTKKEL 600
    KDHWRKHSII RSNIETGEVS LDYRPVIDTT LDKSETDWVP PKVRSY 646
    Length:646
    Mass (Da):70,398
    Last modified:August 2, 2002 - v3
    Checksum:iCD7CF55A6D26E6D1
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti64 – 641G → E in BAA21637. (PubMed:7739664)Curated
    Sequence conflicti267 – 2671N → S in BAA21637. (PubMed:7739664)Curated
    Sequence conflicti303 – 3031A → S in BAA21637. (PubMed:7739664)Curated
    Sequence conflicti315 – 3151A → S in BAA21637. (PubMed:7739664)Curated
    Sequence conflicti463 – 4631V → G in BAA21637. (PubMed:7739664)Curated
    Sequence conflicti483 – 4864HNKG → TTRE in BAA21637. (PubMed:7739664)Curated
    Sequence conflicti640 – 6401P → A in BAA21637. (PubMed:7739664)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D30651 mRNA. Translation: BAA21637.1.
    FO080313 Genomic DNA. Translation: CCD62793.1.
    PIRiT15398.
    T41753.
    RefSeqiNP_509446.1. NM_077045.5.
    UniGeneiCel.5321.

    Genome annotation databases

    EnsemblMetazoaiC03G5.1; C03G5.1; WBGene00015391.
    GeneIDi181108.
    KEGGicel:CELE_C03G5.1.
    UCSCiC03G5.1.2. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D30651 mRNA. Translation: BAA21637.1 .
    FO080313 Genomic DNA. Translation: CCD62793.1 .
    PIRi T15398.
    T41753.
    RefSeqi NP_509446.1. NM_077045.5.
    UniGenei Cel.5321.

    3D structure databases

    ProteinModelPortali Q09508.
    SMRi Q09508. Positions 34-646.
    ModBasei Search...
    MobiDBi Search...

    2D gel databases

    World-2DPAGE 0020:Q09508.

    Proteomic databases

    PaxDbi Q09508.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai C03G5.1 ; C03G5.1 ; WBGene00015391 .
    GeneIDi 181108.
    KEGGi cel:CELE_C03G5.1.
    UCSCi C03G5.1.2. c. elegans.

    Organism-specific databases

    CTDi 181108.
    WormBasei C03G5.1 ; CE03917 ; WBGene00015391 ; sdha-1.

    Phylogenomic databases

    eggNOGi COG1053.
    GeneTreei ENSGT00750000117848.
    HOGENOMi HOG000160475.
    InParanoidi Q09508.
    KOi K00234.
    OMAi YRTCAAA.
    OrthoDBi EOG7MH0XJ.
    PhylomeDBi Q09508.

    Enzyme and pathway databases

    UniPathwayi UPA00223 ; UER01006 .

    Miscellaneous databases

    NextBioi 912432.
    PROi Q09508.

    Family and domain databases

    Gene3Di 1.20.58.100. 1 hit.
    3.90.700.10. 1 hit.
    InterProi IPR003953. FAD_bind_dom.
    IPR003952. FRD_SDH_FAD_BS.
    IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
    IPR027477. Succ_DH/fumarate_Rdtase_cat.
    IPR011281. Succ_DH_flav_su_fwd.
    IPR014006. Succ_Dhase_FrdA_Gneg.
    [Graphical view ]
    Pfami PF00890. FAD_binding_2. 1 hit.
    PF02910. Succ_DH_flav_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46977. SSF46977. 1 hit.
    SSF56425. SSF56425. 1 hit.
    TIGRFAMsi TIGR01816. sdhA_forward. 1 hit.
    TIGR01812. sdhA_frdA_Gneg. 1 hit.
    PROSITEi PS00504. FRD_SDH_FAD_BINDING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence comparison between the flavoprotein subunit of the fumarate reductase (complex II) of the anaerobic parasitic nematode, Ascaris suum and the succinate dehydrogenase of the aerobic, free-living nematode, Caenorhabditis elegans."
      Kuramochi T., Hirawake H., Kojima S., Takamiya S., Furushima R., Aoki T., Komuniecki R., Kita K.
      Mol. Biochem. Parasitol. 68:177-187(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Bristol N2.
    2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiSDHA_CAEEL
    AccessioniPrimary (citable) accession number: Q09508
    Secondary accession number(s): Q17616, Q34089
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: August 2, 2002
    Last modified: October 1, 2014
    This is version 123 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3