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Protein

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Gene

sdha-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).By similarity

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.By similarity

Cofactori

FADBy similarity

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (eukaryal route).By similarity
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (sdha-1), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (sdhb-1), Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (sdha-2), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (eukaryal route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei256FADBy similarity1
Binding sitei277SubstrateBy similarity1
Binding sitei289SubstrateBy similarity1
Active sitei321Proton acceptorBy similarity1
Binding sitei388SubstrateBy similarity1
Binding sitei422FADBy similarity1
Binding sitei433SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi49 – 54FADBy similarity6
Nucleotide bindingi72 – 87FADBy similarityAdd BLAST16
Nucleotide bindingi438 – 439FADBy similarity2

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport, Tricarboxylic acid cycle

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

ReactomeiR-CEL-71403. Citric acid cycle (TCA cycle).
UniPathwayiUPA00223; UER01006.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (EC:1.3.5.1By similarity)
Alternative name(s):
Flavoprotein subunit of complex II
Short name:
FP
Gene namesi
Name:sdha-1
ORF Names:C03G5.1/D2021.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiC03G5.1; CE03917; WBGene00015391; sdha-1.

Subcellular locationi

  • Mitochondrion inner membrane By similarity; Peripheral membrane protein By similarity; Matrix side By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 31MitochondrionSequence analysisAdd BLAST31
ChainiPRO_000001033932 – 646Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialAdd BLAST615

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei80Tele-8alpha-FAD histidineBy similarity1

Proteomic databases

EPDiQ09508.
PaxDbiQ09508.
PeptideAtlasiQ09508.

2D gel databases

World-2DPAGE0020:Q09508.

Expressioni

Gene expression databases

BgeeiWBGene00015391.

Interactioni

Subunit structurei

Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.By similarity

Protein-protein interaction databases

STRINGi6239.C03G5.1.2.

Structurei

3D structure databases

ProteinModelPortaliQ09508.
SMRiQ09508.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2403. Eukaryota.
COG1053. LUCA.
GeneTreeiENSGT00390000010046.
HOGENOMiHOG000160475.
InParanoidiQ09508.
KOiK00234.
OMAiSMTVEIM.
OrthoDBiEOG091G041Z.
PhylomeDBiQ09508.

Family and domain databases

Gene3Di1.20.58.100. 1 hit.
3.50.50.60. 2 hits.
3.90.700.10. 1 hit.
InterProiIPR003953. FAD-binding_2.
IPR023753. FAD/NAD-binding_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR030664. SdhA/FrdA/AprA.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000171. SDHA_APRA_LASPO. 1 hit.
SUPFAMiSSF46977. SSF46977. 1 hit.
SSF51905. SSF51905. 2 hits.
SSF56425. SSF56425. 1 hit.
TIGRFAMsiTIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q09508-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRAASNGLR NTVAARSVSL SAANHSDAKR SDIAQYKVVD HAYDAVVVGA
60 70 80 90 100
GGAGLRAAMG LAEGGLKTAV ITKLFPTRSH TVAAQGGINA ALGNMNPDNW
110 120 130 140 150
RWHFYDTVKG SDWLGDQDAI HYMTREAERA VIELENYGMP FSRTTDGKIY
160 170 180 190 200
QRAFGGQSND FGRGGQAHRT CCVADRTGHS LLHTLYGASL QYNCNYFVEY
210 220 230 240 250
FALDLIMENG VCVGVIAMDL EDGTIHRFRS KNTVLATGGY GRAFFSCTSA
260 270 280 290 300
HTCTGDGTAL TARAGINNSD MEFVQFHPTG IYGAGCLITE GSRGEGGYLV
310 320 330 340 350
NSAGERFMER YAPNAKDLAS RDVVSRSMTV EIMEGRGVGP DKDHIYLQLH
360 370 380 390 400
HLPAEQLQQR LPGISETAMI FAGVDVTKEP IPVIPTVHYN MGGVPTNYKG
410 420 430 440 450
QVLNYTPKKG DEVVPGLYAA GECGAHSVHG ANRLGANSLL DLVIFGRACA
460 470 480 490 500
IDILKNTSAG VGVPELPKNA GEASVANIDK LRHNKGDIST AELRLTMQKS
510 520 530 540 550
MQNHAAVFRR GDILKEGVKV LSKLYKDQAH LNVADKGLVW NSDLIETLEL
560 570 580 590 600
QNLLINATQT IVAAENREES RGAHARDDFP DRLDELDYSK PLEGQTKKEL
610 620 630 640
KDHWRKHSII RSNIETGEVS LDYRPVIDTT LDKSETDWVP PKVRSY
Length:646
Mass (Da):70,398
Last modified:August 2, 2002 - v3
Checksum:iCD7CF55A6D26E6D1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti64G → E in BAA21637 (PubMed:7739664).Curated1
Sequence conflicti267N → S in BAA21637 (PubMed:7739664).Curated1
Sequence conflicti303A → S in BAA21637 (PubMed:7739664).Curated1
Sequence conflicti315A → S in BAA21637 (PubMed:7739664).Curated1
Sequence conflicti463V → G in BAA21637 (PubMed:7739664).Curated1
Sequence conflicti483 – 486HNKG → TTRE in BAA21637 (PubMed:7739664).Curated4
Sequence conflicti640P → A in BAA21637 (PubMed:7739664).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D30651 mRNA. Translation: BAA21637.1.
FO080313 Genomic DNA. Translation: CCD62793.1.
PIRiT15398.
T41753.
RefSeqiNP_509446.1. NM_077045.5.
UniGeneiCel.5321.

Genome annotation databases

EnsemblMetazoaiC03G5.1; C03G5.1; WBGene00015391.
GeneIDi181108.
KEGGicel:CELE_C03G5.1.
UCSCiC03G5.1.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D30651 mRNA. Translation: BAA21637.1.
FO080313 Genomic DNA. Translation: CCD62793.1.
PIRiT15398.
T41753.
RefSeqiNP_509446.1. NM_077045.5.
UniGeneiCel.5321.

3D structure databases

ProteinModelPortaliQ09508.
SMRiQ09508.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.C03G5.1.2.

2D gel databases

World-2DPAGE0020:Q09508.

Proteomic databases

EPDiQ09508.
PaxDbiQ09508.
PeptideAtlasiQ09508.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC03G5.1; C03G5.1; WBGene00015391.
GeneIDi181108.
KEGGicel:CELE_C03G5.1.
UCSCiC03G5.1.2. c. elegans.

Organism-specific databases

CTDi181108.
WormBaseiC03G5.1; CE03917; WBGene00015391; sdha-1.

Phylogenomic databases

eggNOGiKOG2403. Eukaryota.
COG1053. LUCA.
GeneTreeiENSGT00390000010046.
HOGENOMiHOG000160475.
InParanoidiQ09508.
KOiK00234.
OMAiSMTVEIM.
OrthoDBiEOG091G041Z.
PhylomeDBiQ09508.

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006.
ReactomeiR-CEL-71403. Citric acid cycle (TCA cycle).

Miscellaneous databases

PROiQ09508.

Gene expression databases

BgeeiWBGene00015391.

Family and domain databases

Gene3Di1.20.58.100. 1 hit.
3.50.50.60. 2 hits.
3.90.700.10. 1 hit.
InterProiIPR003953. FAD-binding_2.
IPR023753. FAD/NAD-binding_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR030664. SdhA/FrdA/AprA.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000171. SDHA_APRA_LASPO. 1 hit.
SUPFAMiSSF46977. SSF46977. 1 hit.
SSF51905. SSF51905. 2 hits.
SSF56425. SSF56425. 1 hit.
TIGRFAMsiTIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSDHA_CAEEL
AccessioniPrimary (citable) accession number: Q09508
Secondary accession number(s): Q17616, Q34089
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: August 2, 2002
Last modified: November 30, 2016
This is version 142 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.