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Q09508

- SDHA_CAEEL

UniProt

Q09508 - SDHA_CAEEL

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Protein
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
Gene
sdha-1, C03G5.1/D2021.3
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) By similarity.

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.

Cofactori

FAD By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei256 – 2561FAD By similarity
Binding sitei277 – 2771Substrate By similarity
Binding sitei289 – 2891Substrate By similarity
Active sitei321 – 3211Proton acceptor By similarity
Binding sitei388 – 3881Substrate By similarity
Binding sitei422 – 4221FAD By similarity
Binding sitei433 – 4331Substrate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi49 – 546FAD By similarity
Nucleotide bindingi72 – 8716FAD By similarity
Add
BLAST
Nucleotide bindingi438 – 4392FAD By similarity

GO - Molecular functioni

  1. flavin adenine dinucleotide binding Source: InterPro
  2. succinate dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

GO - Biological processi

  1. electron transport chain Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport, Tricarboxylic acid cycle

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (EC:1.3.5.1)
Alternative name(s):
Flavoprotein subunit of complex II
Short name:
FP
Gene namesi
Name:sdha-1
ORF Names:C03G5.1/D2021.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome X

Organism-specific databases

WormBaseiC03G5.1; CE03917; WBGene00015391; sdha-1.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial inner membrane Source: UniProtKB
  2. mitochondrion Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3131Mitochondrion Reviewed prediction
Add
BLAST
Chaini32 – 646615Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
PRO_0000010339Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei80 – 801Tele-8alpha-FAD histidine By similarity

Proteomic databases

PaxDbiQ09508.

2D gel databases

World-2DPAGE0020:Q09508.

Interactioni

Subunit structurei

Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ09508.
SMRiQ09508. Positions 34-646.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG1053.
GeneTreeiENSGT00750000117848.
HOGENOMiHOG000160475.
InParanoidiQ09508.
KOiK00234.
OMAiYRTCAAA.
OrthoDBiEOG7MH0XJ.
PhylomeDBiQ09508.

Family and domain databases

Gene3Di1.20.58.100. 1 hit.
3.90.700.10. 1 hit.
InterProiIPR003953. FAD_bind_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
SUPFAMiSSF46977. SSF46977. 1 hit.
SSF56425. SSF56425. 1 hit.
TIGRFAMsiTIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q09508-1 [UniParc]FASTAAdd to Basket

« Hide

MLRAASNGLR NTVAARSVSL SAANHSDAKR SDIAQYKVVD HAYDAVVVGA    50
GGAGLRAAMG LAEGGLKTAV ITKLFPTRSH TVAAQGGINA ALGNMNPDNW 100
RWHFYDTVKG SDWLGDQDAI HYMTREAERA VIELENYGMP FSRTTDGKIY 150
QRAFGGQSND FGRGGQAHRT CCVADRTGHS LLHTLYGASL QYNCNYFVEY 200
FALDLIMENG VCVGVIAMDL EDGTIHRFRS KNTVLATGGY GRAFFSCTSA 250
HTCTGDGTAL TARAGINNSD MEFVQFHPTG IYGAGCLITE GSRGEGGYLV 300
NSAGERFMER YAPNAKDLAS RDVVSRSMTV EIMEGRGVGP DKDHIYLQLH 350
HLPAEQLQQR LPGISETAMI FAGVDVTKEP IPVIPTVHYN MGGVPTNYKG 400
QVLNYTPKKG DEVVPGLYAA GECGAHSVHG ANRLGANSLL DLVIFGRACA 450
IDILKNTSAG VGVPELPKNA GEASVANIDK LRHNKGDIST AELRLTMQKS 500
MQNHAAVFRR GDILKEGVKV LSKLYKDQAH LNVADKGLVW NSDLIETLEL 550
QNLLINATQT IVAAENREES RGAHARDDFP DRLDELDYSK PLEGQTKKEL 600
KDHWRKHSII RSNIETGEVS LDYRPVIDTT LDKSETDWVP PKVRSY 646
Length:646
Mass (Da):70,398
Last modified:August 2, 2002 - v3
Checksum:iCD7CF55A6D26E6D1
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti64 – 641G → E in BAA21637. 1 Publication
Sequence conflicti267 – 2671N → S in BAA21637. 1 Publication
Sequence conflicti303 – 3031A → S in BAA21637. 1 Publication
Sequence conflicti315 – 3151A → S in BAA21637. 1 Publication
Sequence conflicti463 – 4631V → G in BAA21637. 1 Publication
Sequence conflicti483 – 4864HNKG → TTRE in BAA21637. 1 Publication
Sequence conflicti640 – 6401P → A in BAA21637. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D30651 mRNA. Translation: BAA21637.1.
FO080313 Genomic DNA. Translation: CCD62793.1.
PIRiT15398.
T41753.
RefSeqiNP_509446.1. NM_077045.5.
UniGeneiCel.5321.

Genome annotation databases

EnsemblMetazoaiC03G5.1; C03G5.1; WBGene00015391.
GeneIDi181108.
KEGGicel:CELE_C03G5.1.
UCSCiC03G5.1.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D30651 mRNA. Translation: BAA21637.1 .
FO080313 Genomic DNA. Translation: CCD62793.1 .
PIRi T15398.
T41753.
RefSeqi NP_509446.1. NM_077045.5.
UniGenei Cel.5321.

3D structure databases

ProteinModelPortali Q09508.
SMRi Q09508. Positions 34-646.
ModBasei Search...
MobiDBi Search...

2D gel databases

World-2DPAGE 0020:Q09508.

Proteomic databases

PaxDbi Q09508.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai C03G5.1 ; C03G5.1 ; WBGene00015391 .
GeneIDi 181108.
KEGGi cel:CELE_C03G5.1.
UCSCi C03G5.1.2. c. elegans.

Organism-specific databases

CTDi 181108.
WormBasei C03G5.1 ; CE03917 ; WBGene00015391 ; sdha-1.

Phylogenomic databases

eggNOGi COG1053.
GeneTreei ENSGT00750000117848.
HOGENOMi HOG000160475.
InParanoidi Q09508.
KOi K00234.
OMAi YRTCAAA.
OrthoDBi EOG7MH0XJ.
PhylomeDBi Q09508.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER01006 .

Miscellaneous databases

NextBioi 912432.
PROi Q09508.

Family and domain databases

Gene3Di 1.20.58.100. 1 hit.
3.90.700.10. 1 hit.
InterProi IPR003953. FAD_bind_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view ]
Pfami PF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view ]
SUPFAMi SSF46977. SSF46977. 1 hit.
SSF56425. SSF56425. 1 hit.
TIGRFAMsi TIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEi PS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence comparison between the flavoprotein subunit of the fumarate reductase (complex II) of the anaerobic parasitic nematode, Ascaris suum and the succinate dehydrogenase of the aerobic, free-living nematode, Caenorhabditis elegans."
    Kuramochi T., Hirawake H., Kojima S., Takamiya S., Furushima R., Aoki T., Komuniecki R., Kita K.
    Mol. Biochem. Parasitol. 68:177-187(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiSDHA_CAEEL
AccessioniPrimary (citable) accession number: Q09508
Secondary accession number(s): Q17616, Q34089
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: August 2, 2002
Last modified: June 11, 2014
This is version 122 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi