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Q09508

- SDHA_CAEEL

UniProt

Q09508 - SDHA_CAEEL

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Protein

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Gene

sdha-1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).By similarity

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.

Cofactori

FAD.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei256 – 2561FADBy similarity
Binding sitei277 – 2771SubstrateBy similarity
Binding sitei289 – 2891SubstrateBy similarity
Active sitei321 – 3211Proton acceptorBy similarity
Binding sitei388 – 3881SubstrateBy similarity
Binding sitei422 – 4221FADBy similarity
Binding sitei433 – 4331SubstrateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi49 – 546FADBy similarity
Nucleotide bindingi72 – 8716FADBy similarityAdd
BLAST
Nucleotide bindingi438 – 4392FADBy similarity

GO - Molecular functioni

  1. flavin adenine dinucleotide binding Source: InterPro
  2. succinate dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

GO - Biological processi

  1. electron transport chain Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport, Tricarboxylic acid cycle

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (EC:1.3.5.1)
Alternative name(s):
Flavoprotein subunit of complex II
Short name:
FP
Gene namesi
Name:sdha-1
ORF Names:C03G5.1/D2021.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome X

Organism-specific databases

WormBaseiC03G5.1; CE03917; WBGene00015391; sdha-1.

Subcellular locationi

Mitochondrion inner membrane By similarity; Peripheral membrane protein By similarity; Matrix side By similarity

GO - Cellular componenti

  1. mitochondrial inner membrane Source: UniProtKB
  2. mitochondrion Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3131MitochondrionSequence AnalysisAdd
BLAST
Chaini32 – 646615Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialPRO_0000010339Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei80 – 801Tele-8alpha-FAD histidineBy similarity

Proteomic databases

PaxDbiQ09508.

2D gel databases

World-2DPAGE0020:Q09508.

Interactioni

Subunit structurei

Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ09508.
SMRiQ09508. Positions 34-646.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG1053.
GeneTreeiENSGT00390000010046.
HOGENOMiHOG000160475.
InParanoidiQ09508.
KOiK00234.
OMAiYRTCAAA.
OrthoDBiEOG7MH0XJ.
PhylomeDBiQ09508.

Family and domain databases

Gene3Di1.20.58.100. 1 hit.
3.90.700.10. 1 hit.
InterProiIPR003953. FAD_bind_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
SUPFAMiSSF46977. SSF46977. 1 hit.
SSF56425. SSF56425. 1 hit.
TIGRFAMsiTIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q09508-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLRAASNGLR NTVAARSVSL SAANHSDAKR SDIAQYKVVD HAYDAVVVGA
60 70 80 90 100
GGAGLRAAMG LAEGGLKTAV ITKLFPTRSH TVAAQGGINA ALGNMNPDNW
110 120 130 140 150
RWHFYDTVKG SDWLGDQDAI HYMTREAERA VIELENYGMP FSRTTDGKIY
160 170 180 190 200
QRAFGGQSND FGRGGQAHRT CCVADRTGHS LLHTLYGASL QYNCNYFVEY
210 220 230 240 250
FALDLIMENG VCVGVIAMDL EDGTIHRFRS KNTVLATGGY GRAFFSCTSA
260 270 280 290 300
HTCTGDGTAL TARAGINNSD MEFVQFHPTG IYGAGCLITE GSRGEGGYLV
310 320 330 340 350
NSAGERFMER YAPNAKDLAS RDVVSRSMTV EIMEGRGVGP DKDHIYLQLH
360 370 380 390 400
HLPAEQLQQR LPGISETAMI FAGVDVTKEP IPVIPTVHYN MGGVPTNYKG
410 420 430 440 450
QVLNYTPKKG DEVVPGLYAA GECGAHSVHG ANRLGANSLL DLVIFGRACA
460 470 480 490 500
IDILKNTSAG VGVPELPKNA GEASVANIDK LRHNKGDIST AELRLTMQKS
510 520 530 540 550
MQNHAAVFRR GDILKEGVKV LSKLYKDQAH LNVADKGLVW NSDLIETLEL
560 570 580 590 600
QNLLINATQT IVAAENREES RGAHARDDFP DRLDELDYSK PLEGQTKKEL
610 620 630 640
KDHWRKHSII RSNIETGEVS LDYRPVIDTT LDKSETDWVP PKVRSY
Length:646
Mass (Da):70,398
Last modified:August 2, 2002 - v3
Checksum:iCD7CF55A6D26E6D1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti64 – 641G → E in BAA21637. (PubMed:7739664)Curated
Sequence conflicti267 – 2671N → S in BAA21637. (PubMed:7739664)Curated
Sequence conflicti303 – 3031A → S in BAA21637. (PubMed:7739664)Curated
Sequence conflicti315 – 3151A → S in BAA21637. (PubMed:7739664)Curated
Sequence conflicti463 – 4631V → G in BAA21637. (PubMed:7739664)Curated
Sequence conflicti483 – 4864HNKG → TTRE in BAA21637. (PubMed:7739664)Curated
Sequence conflicti640 – 6401P → A in BAA21637. (PubMed:7739664)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D30651 mRNA. Translation: BAA21637.1.
FO080313 Genomic DNA. Translation: CCD62793.1.
PIRiT15398.
T41753.
RefSeqiNP_509446.1. NM_077045.5.
UniGeneiCel.5321.

Genome annotation databases

EnsemblMetazoaiC03G5.1; C03G5.1; WBGene00015391.
GeneIDi181108.
KEGGicel:CELE_C03G5.1.
UCSCiC03G5.1.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D30651 mRNA. Translation: BAA21637.1 .
FO080313 Genomic DNA. Translation: CCD62793.1 .
PIRi T15398.
T41753.
RefSeqi NP_509446.1. NM_077045.5.
UniGenei Cel.5321.

3D structure databases

ProteinModelPortali Q09508.
SMRi Q09508. Positions 34-646.
ModBasei Search...
MobiDBi Search...

2D gel databases

World-2DPAGE 0020:Q09508.

Proteomic databases

PaxDbi Q09508.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai C03G5.1 ; C03G5.1 ; WBGene00015391 .
GeneIDi 181108.
KEGGi cel:CELE_C03G5.1.
UCSCi C03G5.1.2. c. elegans.

Organism-specific databases

CTDi 181108.
WormBasei C03G5.1 ; CE03917 ; WBGene00015391 ; sdha-1.

Phylogenomic databases

eggNOGi COG1053.
GeneTreei ENSGT00390000010046.
HOGENOMi HOG000160475.
InParanoidi Q09508.
KOi K00234.
OMAi YRTCAAA.
OrthoDBi EOG7MH0XJ.
PhylomeDBi Q09508.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER01006 .

Miscellaneous databases

NextBioi 912432.
PROi Q09508.

Family and domain databases

Gene3Di 1.20.58.100. 1 hit.
3.90.700.10. 1 hit.
InterProi IPR003953. FAD_bind_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view ]
Pfami PF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view ]
SUPFAMi SSF46977. SSF46977. 1 hit.
SSF56425. SSF56425. 1 hit.
TIGRFAMsi TIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEi PS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence comparison between the flavoprotein subunit of the fumarate reductase (complex II) of the anaerobic parasitic nematode, Ascaris suum and the succinate dehydrogenase of the aerobic, free-living nematode, Caenorhabditis elegans."
    Kuramochi T., Hirawake H., Kojima S., Takamiya S., Furushima R., Aoki T., Komuniecki R., Kita K.
    Mol. Biochem. Parasitol. 68:177-187(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiSDHA_CAEEL
AccessioniPrimary (citable) accession number: Q09508
Secondary accession number(s): Q17616, Q34089
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: August 2, 2002
Last modified: October 29, 2014
This is version 124 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3