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Protein

Putative serine/threonine-protein phosphatase pph-6

Gene

pph-6

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi79 – 791Manganese 1By similarity
Metal bindingi81 – 811Manganese 1By similarity
Metal bindingi107 – 1071Manganese 1By similarity
Metal bindingi107 – 1071Manganese 2By similarity
Metal bindingi139 – 1391Manganese 2By similarity
Active sitei140 – 1401Proton donorBy similarity
Metal bindingi189 – 1891Manganese 2By similarity
Metal bindingi264 – 2641Manganese 2By similarity

GO - Molecular functioni

GO - Biological processi

  • cortical actin cytoskeleton organization Source: WormBase
  • establishment of mitotic spindle localization Source: WormBase
  • first cell cycle pseudocleavage Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative serine/threonine-protein phosphatase pph-6 (EC:3.1.3.16)
Gene namesi
Name:pph-6
ORF Names:C34C12.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiC34C12.3; CE31433; WBGene00007922; pph-6.

Subcellular locationi

GO - Cellular componenti

  • astral microtubule Source: WormBase
  • cell cortex Source: WormBase
  • cytoplasm Source: WormBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 331331Putative serine/threonine-protein phosphatase pph-6PRO_0000058917Add
BLAST

Proteomic databases

PaxDbiQ09496.
PRIDEiQ09496.

Interactioni

Protein-protein interaction databases

BioGridi48030. 4 interactions.
IntActiQ09496. 1 interaction.
STRINGi6239.C34C12.3.

Structurei

3D structure databases

ProteinModelPortaliQ09496.
SMRiQ09496. Positions 20-331.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-X subfamily.Curated

Phylogenomic databases

eggNOGiCOG0639.
GeneTreeiENSGT00550000074961.
HOGENOMiHOG000172696.
InParanoidiQ09496.
KOiK15498.
OMAiWITWASE.
OrthoDBiEOG7B8S44.
PhylomeDBiQ09496.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q09496-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIDTNLLRVT VCDEGELEKS TTHFIGSRKI EPEQWITWAS ECKYLPESDA
60 70 80 90 100
VALCATLIDR LSLEANVVPV SSPVTICGDI HGQFYDLLEL FKTGGTVPNT
110 120 130 140 150
KYVFMGDYVD RGHYSLETVT LLFCLLLKYP NQITLLRGNH ESRRISNVYG
160 170 180 190 200
FYDECQNKYG HGNVHKWFCK VFDVLPIGAL IDESVLCVHG GLSPDIRTID
210 220 230 240 250
SLMLLDRAQE VPNKGPLCDI MWSDPDDDVE DWVISQRGAG FVFGAKVTEE
260 270 280 290 300
FLMNNDLSLL CRSHQLVDEG FKYMFNEKLA TVWSAPNYCY RCGNAAAVFE
310 320 330
IDGNNRSTKY FNAVPDGSRE KPDRVVAPYF L
Length:331
Mass (Da):37,388
Last modified:January 17, 2003 - v2
Checksum:iACE68C04772E9262
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46996 Genomic DNA. Translation: CAA87100.2.
PIRiT19701.
RefSeqiNP_497714.2. NM_065313.5.
UniGeneiCel.19977.

Genome annotation databases

EnsemblMetazoaiC34C12.3; C34C12.3; WBGene00007922.
GeneIDi183199.
KEGGicel:CELE_C34C12.3.
UCSCiC34C12.3. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46996 Genomic DNA. Translation: CAA87100.2.
PIRiT19701.
RefSeqiNP_497714.2. NM_065313.5.
UniGeneiCel.19977.

3D structure databases

ProteinModelPortaliQ09496.
SMRiQ09496. Positions 20-331.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi48030. 4 interactions.
IntActiQ09496. 1 interaction.
STRINGi6239.C34C12.3.

Proteomic databases

PaxDbiQ09496.
PRIDEiQ09496.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC34C12.3; C34C12.3; WBGene00007922.
GeneIDi183199.
KEGGicel:CELE_C34C12.3.
UCSCiC34C12.3. c. elegans.

Organism-specific databases

CTDi183199.
WormBaseiC34C12.3; CE31433; WBGene00007922; pph-6.

Phylogenomic databases

eggNOGiCOG0639.
GeneTreeiENSGT00550000074961.
HOGENOMiHOG000172696.
InParanoidiQ09496.
KOiK15498.
OMAiWITWASE.
OrthoDBiEOG7B8S44.
PhylomeDBiQ09496.

Miscellaneous databases

NextBioi920272.
PROiQ09496.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiPPH6_CAEEL
AccessioniPrimary (citable) accession number: Q09496
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 17, 2003
Last modified: June 24, 2015
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.