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Q09496

- PPH6_CAEEL

UniProt

Q09496 - PPH6_CAEEL

Protein

Putative serine/threonine-protein phosphatase pph-6

Gene

pph-6

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 2 (17 Jan 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi79 – 791Manganese 1By similarity
    Metal bindingi81 – 811Manganese 1By similarity
    Metal bindingi107 – 1071Manganese 1By similarity
    Metal bindingi107 – 1071Manganese 2By similarity
    Metal bindingi139 – 1391Manganese 2By similarity
    Active sitei140 – 1401Proton donorBy similarity
    Metal bindingi189 – 1891Manganese 2By similarity
    Metal bindingi264 – 2641Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. phosphoprotein phosphatase activity Source: UniProtKB-KW

    GO - Biological processi

    1. cortical actin cytoskeleton organization Source: WormBase
    2. establishment of mitotic spindle localization Source: WormBase
    3. first cell cycle pseudocleavage Source: WormBase

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative serine/threonine-protein phosphatase pph-6 (EC:3.1.3.16)
    Gene namesi
    Name:pph-6
    ORF Names:C34C12.3
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome III

    Organism-specific databases

    WormBaseiC34C12.3; CE31433; WBGene00007922; pph-6.

    Subcellular locationi

    GO - Cellular componenti

    1. astral microtubule Source: WormBase
    2. cell cortex Source: WormBase
    3. cytoplasm Source: WormBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 331331Putative serine/threonine-protein phosphatase pph-6PRO_0000058917Add
    BLAST

    Proteomic databases

    PaxDbiQ09496.
    PRIDEiQ09496.

    Interactioni

    Protein-protein interaction databases

    BioGridi48030. 4 interactions.
    IntActiQ09496. 1 interaction.
    STRINGi6239.C34C12.3.

    Structurei

    3D structure databases

    ProteinModelPortaliQ09496.
    SMRiQ09496. Positions 31-302.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PPP phosphatase family. PP-X subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG0639.
    GeneTreeiENSGT00550000074961.
    HOGENOMiHOG000172696.
    InParanoidiQ09496.
    KOiK15498.
    OMAiWITWASE.
    OrthoDBiEOG7B8S44.
    PhylomeDBiQ09496.

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    InterProiIPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    PRINTSiPR00114. STPHPHTASE.
    SMARTiSM00156. PP2Ac. 1 hit.
    [Graphical view]
    SUPFAMiSSF56300. SSF56300. 1 hit.
    PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q09496-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIDTNLLRVT VCDEGELEKS TTHFIGSRKI EPEQWITWAS ECKYLPESDA    50
    VALCATLIDR LSLEANVVPV SSPVTICGDI HGQFYDLLEL FKTGGTVPNT 100
    KYVFMGDYVD RGHYSLETVT LLFCLLLKYP NQITLLRGNH ESRRISNVYG 150
    FYDECQNKYG HGNVHKWFCK VFDVLPIGAL IDESVLCVHG GLSPDIRTID 200
    SLMLLDRAQE VPNKGPLCDI MWSDPDDDVE DWVISQRGAG FVFGAKVTEE 250
    FLMNNDLSLL CRSHQLVDEG FKYMFNEKLA TVWSAPNYCY RCGNAAAVFE 300
    IDGNNRSTKY FNAVPDGSRE KPDRVVAPYF L 331
    Length:331
    Mass (Da):37,388
    Last modified:January 17, 2003 - v2
    Checksum:iACE68C04772E9262
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46996 Genomic DNA. Translation: CAA87100.2.
    PIRiT19701.
    RefSeqiNP_497714.2. NM_065313.5.
    UniGeneiCel.19977.

    Genome annotation databases

    EnsemblMetazoaiC34C12.3; C34C12.3; WBGene00007922.
    GeneIDi183199.
    KEGGicel:CELE_C34C12.3.
    UCSCiC34C12.3. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46996 Genomic DNA. Translation: CAA87100.2 .
    PIRi T19701.
    RefSeqi NP_497714.2. NM_065313.5.
    UniGenei Cel.19977.

    3D structure databases

    ProteinModelPortali Q09496.
    SMRi Q09496. Positions 31-302.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 48030. 4 interactions.
    IntActi Q09496. 1 interaction.
    STRINGi 6239.C34C12.3.

    Proteomic databases

    PaxDbi Q09496.
    PRIDEi Q09496.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai C34C12.3 ; C34C12.3 ; WBGene00007922 .
    GeneIDi 183199.
    KEGGi cel:CELE_C34C12.3.
    UCSCi C34C12.3. c. elegans.

    Organism-specific databases

    CTDi 183199.
    WormBasei C34C12.3 ; CE31433 ; WBGene00007922 ; pph-6.

    Phylogenomic databases

    eggNOGi COG0639.
    GeneTreei ENSGT00550000074961.
    HOGENOMi HOG000172696.
    InParanoidi Q09496.
    KOi K15498.
    OMAi WITWASE.
    OrthoDBi EOG7B8S44.
    PhylomeDBi Q09496.

    Miscellaneous databases

    NextBioi 920272.
    PROi Q09496.

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    InterProi IPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    PRINTSi PR00114. STPHPHTASE.
    SMARTi SM00156. PP2Ac. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56300. SSF56300. 1 hit.
    PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiPPH6_CAEEL
    AccessioniPrimary (citable) accession number: Q09496
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: January 17, 2003
    Last modified: October 1, 2014
    This is version 110 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3