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Protein

Serine/threonine-protein kinase sma-6

Gene

sma-6

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in TGF-beta pathway. May be a receptor for daf-7.

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei292 – 2921ATPPROSITE-ProRule annotation
Active sitei397 – 3971Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi271 – 2799ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. BMP binding Source: WormBase
  3. receptor signaling protein serine/threonine kinase activity Source: InterPro
  4. transforming growth factor beta-activated receptor activity Source: InterPro
  5. transmembrane receptor protein serine/threonine kinase activity Source: WormBase

GO - Biological processi

  1. BMP signaling pathway Source: WormBase
  2. dauer larval development Source: WormBase
  3. defense response to fungus Source: WormBase
  4. innate immune response Source: WormBase
  5. maintenance of protein location in nucleus Source: WormBase
  6. nematode male tail tip morphogenesis Source: WormBase
  7. positive regulation of multicellular organism growth Source: WormBase
  8. positive regulation of protein catabolic process Source: WormBase
  9. positive regulation of transcription from RNA polymerase II promoter Source: WormBase
  10. regulation of cell adhesion Source: WormBase
  11. regulation of cell morphogenesis Source: WormBase
  12. reproduction Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Kinase, Receptor, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 1045.
ReactomeiREACT_107985. Signaling by BMP.
REACT_183486. Signaling by NODAL.
SignaLinkiQ09488.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase sma-6 (EC:2.7.11.30)
Gene namesi
Name:sma-6
ORF Names:C32D5.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome II

Organism-specific databases

WormBaseiC32D5.2; CE01842; WBGene00004860; sma-6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 190170ExtracellularSequence AnalysisAdd
BLAST
Transmembranei191 – 21121HelicalSequence AnalysisAdd
BLAST
Topological domaini212 – 636425CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 636616Serine/threonine-protein kinase sma-6PRO_0000024432Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi80 – 801N-linked (GlcNAc...)Sequence Analysis
Glycosylationi184 – 1841N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ09488.
PRIDEiQ09488.

Interactioni

Protein-protein interaction databases

BioGridi39384. 82 interactions.
STRINGi6239.C32D5.2.2.

Structurei

3D structure databases

ProteinModelPortaliQ09488.
SMRiQ09488. Positions 257-605.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini235 – 26430GSPROSITE-ProRule annotationAdd
BLAST
Domaini265 – 606342Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 GS domain.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000118876.
HOGENOMiHOG000230587.
InParanoidiQ09488.
KOiK13578.
OMAiVWLAKWR.
OrthoDBiEOG7Q8CN3.
PhylomeDBiQ09488.

Family and domain databases

InterProiIPR000472. Activin_rcpt.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view]
PRINTSiPR00653. ACTIVIN2R.
SMARTiSM00467. GS. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q09488-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNITFIFILI FGFFNTQKCS KDYDHFDDED LALSIPKNAI GVPKEFRQQV
60 70 80 90 100
LKEMKLRNRP NDILKNRCYC NYDQSICGNN MTCVKQDGAA CYHAVEEVYN
110 120 130 140 150
KAEKRMETLH KWGCATLERG SGASHLTCNS WRAAHHSPKS IGCCYEGNYC
160 170 180 190 200
NKNLIPPAYV HHHKEKALQE KTDNPEDYDS PLENMTRGGK MFIMVFATVM
210 220 230 240 250
SVFAVIGCIY LCITRAEEKS KARARAKTVS LKTESTYMES KSMLEDSGSG
260 270 280 290 300
SGQAALIQRT VRQDLTIIKT IGQGRYGEVR KALYRGSYVA VKTFYTTDED
310 320 330 340 350
SWKNERDVYQ TNMINHENIL QFVAADIWSE EDSMTKMLLI TDYHELGSLS
360 370 380 390 400
DYLCREETLT TDEALRLIHS CICGIEHLHA AVHGTGSFRK PEIAHRDIKS
410 420 430 440 450
KNIIVKRPNV CCIADLGLAL RYQNDKILPE KFNVQVGTKR YMAPELISNK
460 470 480 490 500
LNPKDFSQFK MADIYSMALV MWEVAIRVEV NTCEEVLTVD ETSPDHSASS
510 520 530 540 550
GIGESVSSSG NISRMHLQKT NVEGHSTSLK AKQHVPPFDG IVHNDPNFDE
560 570 580 590 600
MNDVICVRRI RPPPDLAWKN VPALNELSKL MEDSWHSIPH FRHSALKLKK
610 620 630
EMAELIKNPD RQNQSQRKVE FQQQDSGLVE SATNQS
Length:636
Mass (Da):72,235
Last modified:February 1, 1996 - v1
Checksum:i3349C85944E6AE24
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF104017 mRNA. Translation: AAD12261.1.
FO080708 Genomic DNA. Translation: CCD66028.1.
PIRiT15734.
RefSeqiNP_495271.1. NM_062870.5.
UniGeneiCel.5733.

Genome annotation databases

EnsemblMetazoaiC32D5.2; C32D5.2; WBGene00004860.
GeneIDi174044.
KEGGicel:CELE_C32D5.2.
UCSCiC32D5.2.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF104017 mRNA. Translation: AAD12261.1.
FO080708 Genomic DNA. Translation: CCD66028.1.
PIRiT15734.
RefSeqiNP_495271.1. NM_062870.5.
UniGeneiCel.5733.

3D structure databases

ProteinModelPortaliQ09488.
SMRiQ09488. Positions 257-605.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi39384. 82 interactions.
STRINGi6239.C32D5.2.2.

Proteomic databases

PaxDbiQ09488.
PRIDEiQ09488.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC32D5.2; C32D5.2; WBGene00004860.
GeneIDi174044.
KEGGicel:CELE_C32D5.2.
UCSCiC32D5.2.1. c. elegans.

Organism-specific databases

CTDi174044.
WormBaseiC32D5.2; CE01842; WBGene00004860; sma-6.

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000118876.
HOGENOMiHOG000230587.
InParanoidiQ09488.
KOiK13578.
OMAiVWLAKWR.
OrthoDBiEOG7Q8CN3.
PhylomeDBiQ09488.

Enzyme and pathway databases

BRENDAi2.7.10.2. 1045.
ReactomeiREACT_107985. Signaling by BMP.
REACT_183486. Signaling by NODAL.
SignaLinkiQ09488.

Miscellaneous databases

NextBioi882265.
PROiQ09488.

Family and domain databases

InterProiIPR000472. Activin_rcpt.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view]
PRINTSiPR00653. ACTIVIN2R.
SMARTiSM00467. GS. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans."
    Krishna S., Maduzia L.L., Padgett R.W.
    Development 126:251-260(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiSMA6_CAEEL
AccessioniPrimary (citable) accession number: Q09488
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: January 7, 2015
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.