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Q09488

- SMA6_CAEEL

UniProt

Q09488 - SMA6_CAEEL

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Protein
Serine/threonine-protein kinase sma-6
Gene
sma-6, C32D5.2
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Involved in TGF-beta pathway. May be a receptor for daf-7.

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei292 – 2921ATP By similarity
Active sitei397 – 3971Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi271 – 2799ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. BMP binding Source: WormBase
  3. receptor signaling protein serine/threonine kinase activity Source: InterPro
  4. transforming growth factor beta-activated receptor activity Source: InterPro
  5. transmembrane receptor protein serine/threonine kinase activity Source: WormBase

GO - Biological processi

  1. BMP signaling pathway Source: WormBase
  2. dauer larval development Source: WormBase
  3. defense response to fungus Source: WormBase
  4. innate immune response Source: WormBase
  5. maintenance of protein location in nucleus Source: WormBase
  6. positive regulation of multicellular organism growth Source: WormBase
  7. positive regulation of protein catabolic process Source: WormBase
  8. positive regulation of transcription from RNA polymerase II promoter Source: WormBase
  9. regulation of cell adhesion Source: WormBase
  10. regulation of cell morphogenesis Source: WormBase
  11. reproduction Source: WormBase
  12. tail tip morphogenesis Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Kinase, Receptor, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 1045.
SignaLinkiQ09488.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase sma-6 (EC:2.7.11.30)
Gene namesi
Name:sma-6
ORF Names:C32D5.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome II

Organism-specific databases

WormBaseiC32D5.2; CE01842; WBGene00004860; sma-6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 190170Extracellular Reviewed prediction
Add
BLAST
Transmembranei191 – 21121Helical; Reviewed prediction
Add
BLAST
Topological domaini212 – 636425Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed prediction
Add
BLAST
Chaini21 – 636616Serine/threonine-protein kinase sma-6
PRO_0000024432Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi80 – 801N-linked (GlcNAc...) Reviewed prediction
Glycosylationi184 – 1841N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ09488.
PRIDEiQ09488.

Interactioni

Protein-protein interaction databases

BioGridi39384. 82 interactions.
STRINGi6239.C32D5.2.2.

Structurei

3D structure databases

ProteinModelPortaliQ09488.
SMRiQ09488. Positions 242-605.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini235 – 26430GS
Add
BLAST
Domaini265 – 606342Protein kinase
Add
BLAST

Sequence similaritiesi

Contains 1 GS domain.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00560000076906.
HOGENOMiHOG000230587.
InParanoidiQ09488.
KOiK13578.
OMAiVWLAKWR.
OrthoDBiEOG7Q8CN3.
PhylomeDBiQ09488.

Family and domain databases

InterProiIPR000472. Activin_rcpt.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view]
PRINTSiPR00653. ACTIVIN2R.
SMARTiSM00467. GS. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q09488-1 [UniParc]FASTAAdd to Basket

« Hide

MNITFIFILI FGFFNTQKCS KDYDHFDDED LALSIPKNAI GVPKEFRQQV    50
LKEMKLRNRP NDILKNRCYC NYDQSICGNN MTCVKQDGAA CYHAVEEVYN 100
KAEKRMETLH KWGCATLERG SGASHLTCNS WRAAHHSPKS IGCCYEGNYC 150
NKNLIPPAYV HHHKEKALQE KTDNPEDYDS PLENMTRGGK MFIMVFATVM 200
SVFAVIGCIY LCITRAEEKS KARARAKTVS LKTESTYMES KSMLEDSGSG 250
SGQAALIQRT VRQDLTIIKT IGQGRYGEVR KALYRGSYVA VKTFYTTDED 300
SWKNERDVYQ TNMINHENIL QFVAADIWSE EDSMTKMLLI TDYHELGSLS 350
DYLCREETLT TDEALRLIHS CICGIEHLHA AVHGTGSFRK PEIAHRDIKS 400
KNIIVKRPNV CCIADLGLAL RYQNDKILPE KFNVQVGTKR YMAPELISNK 450
LNPKDFSQFK MADIYSMALV MWEVAIRVEV NTCEEVLTVD ETSPDHSASS 500
GIGESVSSSG NISRMHLQKT NVEGHSTSLK AKQHVPPFDG IVHNDPNFDE 550
MNDVICVRRI RPPPDLAWKN VPALNELSKL MEDSWHSIPH FRHSALKLKK 600
EMAELIKNPD RQNQSQRKVE FQQQDSGLVE SATNQS 636
Length:636
Mass (Da):72,235
Last modified:February 1, 1996 - v1
Checksum:i3349C85944E6AE24
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF104017 mRNA. Translation: AAD12261.1.
FO080708 Genomic DNA. Translation: CCD66028.1.
PIRiT15734.
RefSeqiNP_495271.1. NM_062870.5.
UniGeneiCel.5733.

Genome annotation databases

EnsemblMetazoaiC32D5.2; C32D5.2; WBGene00004860.
GeneIDi174044.
KEGGicel:CELE_C32D5.2.
UCSCiC32D5.2.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF104017 mRNA. Translation: AAD12261.1 .
FO080708 Genomic DNA. Translation: CCD66028.1 .
PIRi T15734.
RefSeqi NP_495271.1. NM_062870.5.
UniGenei Cel.5733.

3D structure databases

ProteinModelPortali Q09488.
SMRi Q09488. Positions 242-605.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 39384. 82 interactions.
STRINGi 6239.C32D5.2.2.

Proteomic databases

PaxDbi Q09488.
PRIDEi Q09488.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai C32D5.2 ; C32D5.2 ; WBGene00004860 .
GeneIDi 174044.
KEGGi cel:CELE_C32D5.2.
UCSCi C32D5.2.1. c. elegans.

Organism-specific databases

CTDi 174044.
WormBasei C32D5.2 ; CE01842 ; WBGene00004860 ; sma-6.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00560000076906.
HOGENOMi HOG000230587.
InParanoidi Q09488.
KOi K13578.
OMAi VWLAKWR.
OrthoDBi EOG7Q8CN3.
PhylomeDBi Q09488.

Enzyme and pathway databases

BRENDAi 2.7.10.2. 1045.
SignaLinki Q09488.

Miscellaneous databases

NextBioi 882265.
PROi Q09488.

Family and domain databases

InterProi IPR000472. Activin_rcpt.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view ]
PANTHERi PTHR23255. PTHR23255. 1 hit.
Pfami PF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view ]
PRINTSi PR00653. ACTIVIN2R.
SMARTi SM00467. GS. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 2 hits.
PROSITEi PS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans."
    Krishna S., Maduzia L.L., Padgett R.W.
    Development 126:251-260(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiSMA6_CAEEL
AccessioniPrimary (citable) accession number: Q09488
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 11, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi