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Q09488 (SMA6_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein kinase sma-6

EC=2.7.11.30
Gene names
Name:sma-6
ORF Names:C32D5.2
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length636 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in TGF-beta pathway. May be a receptor for daf-7.

Catalytic activity

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Subcellular location

Membrane; Single-pass type I membrane protein Potential.

Sequence similarities

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

Contains 1 GS domain.

Contains 1 protein kinase domain.

Ontologies

Keywords
   Cellular componentMembrane
   DomainSignal
Transmembrane
Transmembrane helix
   LigandATP-binding
Nucleotide-binding
   Molecular functionDevelopmental protein
Kinase
Receptor
Serine/threonine-protein kinase
Transferase
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processBMP signaling pathway

Inferred from sequence or structural similarity Ref.1. Source: WormBase

dauer larval development

Inferred from genetic interaction PubMed 15840165Ref.1. Source: WormBase

defense response to fungus

Inferred from mutant phenotype PubMed 19198592. Source: WormBase

innate immune response

Inferred from mutant phenotype PubMed 19198592. Source: WormBase

maintenance of protein location in nucleus

Inferred from mutant phenotype PubMed 12397107. Source: WormBase

positive regulation of multicellular organism growth

Inferred from mutant phenotype PubMed 11784045PubMed 12051826PubMed 12571101PubMed 12717735PubMed 15840165Ref.1. Source: WormBase

positive regulation of protein catabolic process

Inferred from mutant phenotype PubMed 12397107. Source: WormBase

positive regulation of transcription from RNA polymerase II promoter

Inferred from mutant phenotype PubMed 12679110PubMed 19198592. Source: WormBase

regulation of cell adhesion

Inferred from mutant phenotype PubMed 12679110. Source: WormBase

regulation of cell morphogenesis

Inferred from mutant phenotype PubMed 24690231. Source: WormBase

reproduction

Inferred from mutant phenotype PubMed 15840165Ref.1. Source: WormBase

tail tip morphogenesis

Inferred from mutant phenotype PubMed 12679110PubMed 12717735Ref.1. Source: WormBase

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from sequence or structural similarity Ref.1. Source: WormBase

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

BMP binding

Inferred from direct assay PubMed 17240342. Source: WormBase

receptor signaling protein serine/threonine kinase activity

Inferred from electronic annotation. Source: InterPro

transforming growth factor beta-activated receptor activity

Inferred from electronic annotation. Source: InterPro

transmembrane receptor protein serine/threonine kinase activity

Inferred from sequence or structural similarity Ref.1. Source: WormBase

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 636616Serine/threonine-protein kinase sma-6
PRO_0000024432

Regions

Topological domain21 – 190170Extracellular Potential
Transmembrane191 – 21121Helical; Potential
Topological domain212 – 636425Cytoplasmic Potential
Domain235 – 26430GS
Domain265 – 606342Protein kinase
Nucleotide binding271 – 2799ATP By similarity

Sites

Active site3971Proton acceptor By similarity
Binding site2921ATP By similarity

Amino acid modifications

Glycosylation801N-linked (GlcNAc...) Potential
Glycosylation1841N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q09488 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 3349C85944E6AE24

FASTA63672,235
        10         20         30         40         50         60 
MNITFIFILI FGFFNTQKCS KDYDHFDDED LALSIPKNAI GVPKEFRQQV LKEMKLRNRP 

        70         80         90        100        110        120 
NDILKNRCYC NYDQSICGNN MTCVKQDGAA CYHAVEEVYN KAEKRMETLH KWGCATLERG 

       130        140        150        160        170        180 
SGASHLTCNS WRAAHHSPKS IGCCYEGNYC NKNLIPPAYV HHHKEKALQE KTDNPEDYDS 

       190        200        210        220        230        240 
PLENMTRGGK MFIMVFATVM SVFAVIGCIY LCITRAEEKS KARARAKTVS LKTESTYMES 

       250        260        270        280        290        300 
KSMLEDSGSG SGQAALIQRT VRQDLTIIKT IGQGRYGEVR KALYRGSYVA VKTFYTTDED 

       310        320        330        340        350        360 
SWKNERDVYQ TNMINHENIL QFVAADIWSE EDSMTKMLLI TDYHELGSLS DYLCREETLT 

       370        380        390        400        410        420 
TDEALRLIHS CICGIEHLHA AVHGTGSFRK PEIAHRDIKS KNIIVKRPNV CCIADLGLAL 

       430        440        450        460        470        480 
RYQNDKILPE KFNVQVGTKR YMAPELISNK LNPKDFSQFK MADIYSMALV MWEVAIRVEV 

       490        500        510        520        530        540 
NTCEEVLTVD ETSPDHSASS GIGESVSSSG NISRMHLQKT NVEGHSTSLK AKQHVPPFDG 

       550        560        570        580        590        600 
IVHNDPNFDE MNDVICVRRI RPPPDLAWKN VPALNELSKL MEDSWHSIPH FRHSALKLKK 

       610        620        630 
EMAELIKNPD RQNQSQRKVE FQQQDSGLVE SATNQS 

« Hide

References

« Hide 'large scale' references
[1]"Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans."
Krishna S., Maduzia L.L., Padgett R.W.
Development 126:251-260(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Bristol N2.
[2]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF104017 mRNA. Translation: AAD12261.1.
FO080708 Genomic DNA. Translation: CCD66028.1.
PIRT15734.
RefSeqNP_495271.1. NM_062870.5.
UniGeneCel.5733.

3D structure databases

ProteinModelPortalQ09488.
SMRQ09488. Positions 242-605.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid39384. 82 interactions.
STRING6239.C32D5.2.2.

Proteomic databases

PaxDbQ09488.
PRIDEQ09488.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaC32D5.2; C32D5.2; WBGene00004860.
GeneID174044.
KEGGcel:CELE_C32D5.2.
UCSCC32D5.2.1. c. elegans.

Organism-specific databases

CTD174044.
WormBaseC32D5.2; CE01842; WBGene00004860; sma-6.

Phylogenomic databases

eggNOGCOG0515.
GeneTreeENSGT00560000076906.
HOGENOMHOG000230587.
InParanoidQ09488.
KOK13578.
OMAVWLAKWR.
OrthoDBEOG7Q8CN3.
PhylomeDBQ09488.

Enzyme and pathway databases

BRENDA2.7.10.2. 1045.
SignaLinkQ09488.

Family and domain databases

InterProIPR000472. Activin_rcpt.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERPTHR23255. PTHR23255. 1 hit.
PfamPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view]
PRINTSPR00653. ACTIVIN2R.
SMARTSM00467. GS. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 2 hits.
PROSITEPS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio882265.
PROQ09488.

Entry information

Entry nameSMA6_CAEEL
AccessionPrimary (citable) accession number: Q09488
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 11, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase