Q09488 (SMA6_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serine/threonine-protein kinase sma-6
EC=2.7.11.30

Gene names

Name:	sma-6
ORF Names:	C32D5.2

Organism

Caenorhabditis elegans [Reference proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	636 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Involved in TGF-beta pathway. May be a receptor for daf-7.
Catalytic activity	ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
Subcellular location	Membrane; Single-pass type I membrane protein Potential.
Sequence similarities	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Contains 1 GS domain. Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal Transmembrane Transmembrane helix
Ligand	ATP-binding Nucleotide-binding
Molecular function	Developmental protein Kinase Receptor Serine/threonine-protein kinase Transferase
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	BMP signaling pathway Inferred from sequence or structural similarity Ref.1. Source: WormBase dauer larval development Inferred from genetic interaction PubMed 15840165Ref.1. Source: WormBase defense response to fungus Inferred from mutant phenotype PubMed 19198592. Source: WormBase innate immune response Inferred from mutant phenotype PubMed 19198592. Source: WormBase maintenance of protein location in nucleus Inferred from mutant phenotype PubMed 12397107. Source: WormBase positive regulation of multicellular organism growth Inferred from mutant phenotype PubMed 11784045PubMed 12051826PubMed 12571101PubMed 12717735PubMed 15840165Ref.1. Source: WormBase positive regulation of protein catabolic process Inferred from mutant phenotype PubMed 12397107. Source: WormBase positive regulation of transcription from RNA polymerase II promoter Inferred from mutant phenotype PubMed 12679110PubMed 19198592. Source: WormBase regulation of cell adhesion Inferred from mutant phenotype PubMed 12679110. Source: WormBase reproduction Inferred from mutant phenotype PubMed 15840165Ref.1. Source: WormBase signal transduction by phosphorylation Inferred from electronic annotation. Source: GOC tail tip morphogenesis Inferred from mutant phenotype PubMed 12679110PubMed 12717735Ref.1. Source: WormBase
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from sequence or structural similarity Ref.1. Source: WormBase
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW BMP binding Inferred from direct assay PubMed 17240342. Source: WormBase receptor signaling protein serine/threonine kinase activity Inferred from electronic annotation. Source: InterPro transforming growth factor beta-activated receptor activity Inferred from electronic annotation. Source: InterPro transmembrane receptor protein serine/threonine kinase activity Inferred from sequence or structural similarity Ref.1. Source: WormBase
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Chain	21 – 636	616	Serine/threonine-protein kinase sma-6		PRO_0000024432
Regions
	Topological domain	21 – 190	170	Extracellular Potential
	Transmembrane	191 – 211	21	Helical; Potential
	Topological domain	212 – 636	425	Cytoplasmic Potential
	Domain	235 – 264	30	GS
	Domain	265 – 606	342	Protein kinase
	Nucleotide binding	271 – 279	9	ATP By similarity
Sites
	Active site	397	1	Proton acceptor By similarity
	Binding site	292	1	ATP By similarity
Amino acid modifications
	Glycosylation	80	1	N-linked (GlcNAc...) Potential
	Glycosylation	184	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q09488 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 3349C85944E6AE24	FASTA	636	72,235
	10 20 30 40 50 60 MNITFIFILI FGFFNTQKCS KDYDHFDDED LALSIPKNAI GVPKEFRQQV LKEMKLRNRP 70 80 90 100 110 120 NDILKNRCYC NYDQSICGNN MTCVKQDGAA CYHAVEEVYN KAEKRMETLH KWGCATLERG 130 140 150 160 170 180 SGASHLTCNS WRAAHHSPKS IGCCYEGNYC NKNLIPPAYV HHHKEKALQE KTDNPEDYDS 190 200 210 220 230 240 PLENMTRGGK MFIMVFATVM SVFAVIGCIY LCITRAEEKS KARARAKTVS LKTESTYMES 250 260 270 280 290 300 KSMLEDSGSG SGQAALIQRT VRQDLTIIKT IGQGRYGEVR KALYRGSYVA VKTFYTTDED 310 320 330 340 350 360 SWKNERDVYQ TNMINHENIL QFVAADIWSE EDSMTKMLLI TDYHELGSLS DYLCREETLT 370 380 390 400 410 420 TDEALRLIHS CICGIEHLHA AVHGTGSFRK PEIAHRDIKS KNIIVKRPNV CCIADLGLAL 430 440 450 460 470 480 RYQNDKILPE KFNVQVGTKR YMAPELISNK LNPKDFSQFK MADIYSMALV MWEVAIRVEV 490 500 510 520 530 540 NTCEEVLTVD ETSPDHSASS GIGESVSSSG NISRMHLQKT NVEGHSTSLK AKQHVPPFDG 550 560 570 580 590 600 IVHNDPNFDE MNDVICVRRI RPPPDLAWKN VPALNELSKL MEDSWHSIPH FRHSALKLKK 610 620 630 EMAELIKNPD RQNQSQRKVE FQQQDSGLVE SATNQS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans." Krishna S., Maduzia L.L., Padgett R.W. Development 126:251-260(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Bristol N2.
[2]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF104017 mRNA. Translation: AAD12261.1. FO080708 Genomic DNA. Translation: CCD66028.1.
PIR	T15734.
RefSeq	NP_495271.1. NM_062870.5.
UniGene	Cel.5733.
3D structure databases
ProteinModelPortal	Q09488.
SMR	Q09488. Positions 257-605.
ModBase	Search...
Protein-protein interaction databases
STRING	6239.C32D5.2.2.
Proteomic databases
PaxDb	Q09488.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	C32D5.2; C32D5.2; C32D5.2.
GeneID	174044.
KEGG	cel:CELE_C32D5.2.
UCSC	C32D5.2.1. c. elegans.
Organism-specific databases
CTD	174044.
WormBase	C32D5.2; CE01842; WBGene00004860; sma-6.
Phylogenomic databases
eggNOG	COG0515.
GeneTree	ENSGT00560000076906.
HOGENOM	HOG000230587.
InParanoid	Q09488.
KO	K13579.
OMA	WLAKWRD.
Enzyme and pathway databases
BRENDA	2.7.10.2. 1045.
Family and domain databases
InterPro	IPR000333. Activin_II/TGFBeta-II_recpt. IPR000472. Activin_rcpt. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR008271. Ser/Thr_kinase_AS. IPR003605. TGF_beta_rcpt_GS. [Graphical view]
Pfam	PF01064. Activin_recp. 1 hit. PF00069. Pkinase. 1 hit. PF08515. TGF_beta_GS. 1 hit. [Graphical view]
PRINTS	PR00653. ACTIVIN2R.
SMART	SM00467. GS. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS51256. GS. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	882265.

Entry information

Entry name

SMA6_CAEEL

Accession

Primary (citable) accession number: Q09488

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	May 1, 2013
This is version 107 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project