Reviewed,
UniProtKB/Swiss-Prot Q09488 (SMA6_CAEEL)
Last modified
July 22, 2008.
Version 66.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Serine/threonine-protein kinase sma-6 EC=2.7.11.30 | ||||
| Gene names |
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| Organism | Caenorhabditis elegans [Complete proteome] | ||||
| Taxonomic identifier | 6239 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Protein attributes
| Sequence length | 636 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Involved in TGF-beta pathway. May be a receptor for daf-7. |
| Catalytic activity | ATP + [receptor-protein] = ADP + [receptor-protein] phosphate. |
| Subcellular location | Membrane; Single-pass type I membrane proteinPotential. |
| Sequence similarities | Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Contains 1 GS domain. Contains 1 protein kinase domain. |
Ontologies
Keywords | |
|---|---|
| Cellular component | Membrane |
| Domain | Signal Transmembrane |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Developmental protein Kinase Receptor Serine/threonine-protein kinase Transferase |
| PTM | Glycoprotein |
| Technical term | Complete proteome |
Gene Ontology (GO) | |
| Biological process | body morphogenesis Inferred from mutant phenotype. Source: WormBase dauer larval development Ref.1Inferred from genetic interaction. Source: WormBase positive regulation of growth rateInferred from mutant phenotype. Source: WormBase positive regulation of multicellular organism growth Ref.1Inferred from mutant phenotype. Source: WormBase reproduction Ref.1Inferred from mutant phenotype. Source: WormBase tail tip morphogenesis Ref.1Inferred from genetic interaction. Source: WormBase |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | ||||
Molecule processing | ||||||||
|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 20 | 20 | Potential | |||||
| Chain | 21 – 636 | 616 | Serine/threonine-protein kinase sma-6 | |||||
Regions | ||||||||
| Topological domain | 21 – 190 | 170 | Extracellular Potential | |||||
| Transmembrane | 191 – 211 | 21 | Potential | |||||
| Topological domain | 212 – 636 | 425 | Cytoplasmic Potential | |||||
| Domain | 235 – 264 | 30 | GS | |||||
| Domain | 265 – 606 | 342 | Protein kinase | |||||
| Nucleotide binding | 271 – 279 | 9 | ATP By similarity | |||||
Sites | ||||||||
| Active site | 397 | 1 | Proton acceptor By similarity | |||||
| Binding site | 292 | 1 | ATP By similarity | |||||
Amino acid modifications | ||||||||
| Glycosylation | 80 | 1 | N-linked (GlcNAc...) Potential | |||||
| Glycosylation | 184 | 1 | N-linked (GlcNAc...) Potential | |||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans." Krishna S., Maduzia L.L., Padgett R.W. Development 126:251-260(1999) [PubMed: 9847239] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Bristol N2. |
| [2] | "Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2. |
Cross-references
Sequence databases | |
|---|---|
| AF104017 mRNA. Translation: AAD12261.1. U23511 Genomic DNA. Translation: AAC46790.1. | |
| PIR | T15734. |
| RefSeq | NP_495271.1. |
| UniGene | Cel.5733 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1IAS based on UniProtKB P36897. |
| ModBase | Search... |
Genome annotation databases | |
| Ensembl | C32D5.2. Caenorhabditis elegans. [Contig view] |
| GeneID | 174044. |
| KEGG | cel:C32D5.2. |
| NMPDR | fig|6239.3.peg.5860. |
Organism-specific databases | |
| WormBase | WBGene00004860. sma-6. |
| WormPep | C32D5.2. CE01842. [WorfDB] |
Gene expression databases | |
| ArrayExpress | Q09488. |
Family and domain databases | |
| InterPro | IPR000333. Activin_II_recpt. IPR000472. Activin_rcpt. IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_bd_CS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. IPR003605. TGF_beta_rcpt_GS. [Graphical view] |
| Pfam | PF01064. Activin_recp. 1 hit. PF00069. Pkinase. 1 hit. PF08515. TGF_beta_GS. 1 hit. [Graphical view] |
| PRINTS | PR00653. ACTIVIN2R. |
| ProDom | PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| SMART | SM00467. GS. 1 hit. [Graphical view] |
| PROSITE | PS51256. GS. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view] |
| BLOCKS | Search... |
Other Resources | |
| ProtoNet | Search... |
Entry information
| Entry name | SMA6_CAEEL | ||||||||
| Accession | Primary (citable) accession number: Q09488 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Caenorhabditis annotation project | ||||||||
Relevant documents
| Caenorhabditis elegans Caenorhabditis elegans: entries, gene names and cross-references to WormPep |
| SIMILARITY comments Index of protein domains and families |

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