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Reviewed, UniProtKB/Swiss-Prot Q09488 (SMA6_CAEEL)

Last modified June 16, 2009. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Serine/threonine-protein kinase sma-6
    EC=2.7.11.30
Gene names
Name: sma-6
ORF Names: C32D5.2
OrganismCaenorhabditis elegans [Complete proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

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Protein attributes

Sequence length636 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Involved in TGF-beta pathway. May be a receptor for daf-7.

Catalytic activity

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Subcellular location

Membrane; Single-pass type I membrane protein Potential.

Sequence similarities

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

Contains 1 GS domain.

Contains 1 protein kinase domain.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 636616Serine/threonine-protein kinase sma-6
PRO_0000024432

Regions

Topological domain21 – 190170Extracellular Potential
Transmembrane191 – 21121 Potential
Topological domain212 – 636425Cytoplasmic Potential
Domain235 – 26430GS
Domain265 – 606342Protein kinase
Nucleotide binding271 – 2799ATP By similarity

Sites

Active site3971Proton acceptor By similarity
Binding site2921ATP By similarity

Amino acid modifications

Glycosylation801N-linked (GlcNAc...) Potential
Glycosylation1841N-linked (GlcNAc...) Potential

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Sequences

Sequence LengthMass (Da)Tools
Q09488-1 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 3349C85944E6AE24

FASTA63672,235
        10         20         30         40         50         60 
MNITFIFILI FGFFNTQKCS KDYDHFDDED LALSIPKNAI GVPKEFRQQV LKEMKLRNRP 

        70         80         90        100        110        120 
NDILKNRCYC NYDQSICGNN MTCVKQDGAA CYHAVEEVYN KAEKRMETLH KWGCATLERG 

       130        140        150        160        170        180 
SGASHLTCNS WRAAHHSPKS IGCCYEGNYC NKNLIPPAYV HHHKEKALQE KTDNPEDYDS 

       190        200        210        220        230        240 
PLENMTRGGK MFIMVFATVM SVFAVIGCIY LCITRAEEKS KARARAKTVS LKTESTYMES 

       250        260        270        280        290        300 
KSMLEDSGSG SGQAALIQRT VRQDLTIIKT IGQGRYGEVR KALYRGSYVA VKTFYTTDED 

       310        320        330        340        350        360 
SWKNERDVYQ TNMINHENIL QFVAADIWSE EDSMTKMLLI TDYHELGSLS DYLCREETLT 

       370        380        390        400        410        420 
TDEALRLIHS CICGIEHLHA AVHGTGSFRK PEIAHRDIKS KNIIVKRPNV CCIADLGLAL 

       430        440        450        460        470        480 
RYQNDKILPE KFNVQVGTKR YMAPELISNK LNPKDFSQFK MADIYSMALV MWEVAIRVEV 

       490        500        510        520        530        540 
NTCEEVLTVD ETSPDHSASS GIGESVSSSG NISRMHLQKT NVEGHSTSLK AKQHVPPFDG 

       550        560        570        580        590        600 
IVHNDPNFDE MNDVICVRRI RPPPDLAWKN VPALNELSKL MEDSWHSIPH FRHSALKLKK 

       610        620        630 
EMAELIKNPD RQNQSQRKVE FQQQDSGLVE SATNQS

« Hide

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References

« Hide 'large scale' references
[1]"Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans."
Krishna S., Maduzia L.L., Padgett R.W.
Development 126:251-260(1999) [PubMed: 9847239] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Bristol N2.
[2]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.

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Cross-references

Sequence databases

AF104017 mRNA. Translation: AAD12261.1.
U23511 Genomic DNA. Translation: AAC46790.1.
PIRT15734.
RefSeqNP_495271.1.
UniGeneCel.5733

3D structure databases

HSSPHSSP built from PDB template 1IAS based on UniProtKB P36897.
ModBaseSearch...

Genome annotation databases

EnsemblC32D5.2. Caenorhabditis elegans. [Contig view]
GeneID174044.
KEGGcel:C32D5.2.
NMPDRfig|6239.3.peg.5860.

Organism-specific databases

WormBaseWBGene00004860. sma-6.
WormPepC32D5.2. CE01842. [WorfDB]

Phylogenomic databases

OMAQ09488. CATLERG.

Enzyme and pathway databases

BRENDA2.7.10.2. 672.
2.7.11.30. 672.

Gene expression databases

ArrayExpressQ09488.

Family and domain databases

InterProIPR000333. Activin_II_recpt.
IPR000472. Activin_rcpt.
IPR000719. Prot_kinase_core.
IPR017441. Protein_kinase_ATP_BS.
IPR017442. Se/Thr_pkinase-rel.
IPR008271. Ser_thr_pkin_AS.
IPR003605. TGF_beta_rcpt_GS.
[Graphical view]
PfamPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view]
PRINTSPR00653. ACTIVIN2R.
ProDomPD000001. Prot_kinase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00467. GS. 1 hit.
[Graphical view]
PROSITEPS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio882265.

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Entry information

Entry nameSMA6_CAEEL
AccessionPrimary (citable) accession number: Q09488
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 16, 2009
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectCaenorhabditis annotation project

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Relevant documents

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormPep

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents