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Q09488

- SMA6_CAEEL

UniProt

Q09488 - SMA6_CAEEL

Protein

Serine/threonine-protein kinase sma-6

Gene

sma-6

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Involved in TGF-beta pathway. May be a receptor for daf-7.

    Catalytic activityi

    ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei292 – 2921ATPPROSITE-ProRule annotation
    Active sitei397 – 3971Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi271 – 2799ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. BMP binding Source: WormBase
    3. receptor signaling protein serine/threonine kinase activity Source: InterPro
    4. transforming growth factor beta-activated receptor activity Source: InterPro
    5. transmembrane receptor protein serine/threonine kinase activity Source: WormBase

    GO - Biological processi

    1. BMP signaling pathway Source: WormBase
    2. dauer larval development Source: WormBase
    3. defense response to fungus Source: WormBase
    4. innate immune response Source: WormBase
    5. maintenance of protein location in nucleus Source: WormBase
    6. nematode male tail tip morphogenesis Source: WormBase
    7. positive regulation of multicellular organism growth Source: WormBase
    8. positive regulation of protein catabolic process Source: WormBase
    9. positive regulation of transcription from RNA polymerase II promoter Source: WormBase
    10. regulation of cell adhesion Source: WormBase
    11. regulation of cell morphogenesis Source: WormBase
    12. reproduction Source: WormBase

    Keywords - Molecular functioni

    Developmental protein, Kinase, Receptor, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.10.2. 1045.
    SignaLinkiQ09488.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase sma-6 (EC:2.7.11.30)
    Gene namesi
    Name:sma-6
    ORF Names:C32D5.2
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome II

    Organism-specific databases

    WormBaseiC32D5.2; CE01842; WBGene00004860; sma-6.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: WormBase

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 636616Serine/threonine-protein kinase sma-6PRO_0000024432Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi80 – 801N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi184 – 1841N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ09488.
    PRIDEiQ09488.

    Interactioni

    Protein-protein interaction databases

    BioGridi39384. 82 interactions.
    STRINGi6239.C32D5.2.2.

    Structurei

    3D structure databases

    ProteinModelPortaliQ09488.
    SMRiQ09488. Positions 242-605.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini21 – 190170ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini212 – 636425CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei191 – 21121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini235 – 26430GSPROSITE-ProRule annotationAdd
    BLAST
    Domaini265 – 606342Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 GS domain.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00560000076906.
    HOGENOMiHOG000230587.
    InParanoidiQ09488.
    KOiK13578.
    OMAiVWLAKWR.
    OrthoDBiEOG7Q8CN3.
    PhylomeDBiQ09488.

    Family and domain databases

    InterProiIPR000472. Activin_rcpt.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    IPR003605. TGF_beta_rcpt_GS.
    IPR000333. TGFB_receptor.
    [Graphical view]
    PANTHERiPTHR23255. PTHR23255. 1 hit.
    PfamiPF01064. Activin_recp. 1 hit.
    PF00069. Pkinase. 1 hit.
    PF08515. TGF_beta_GS. 1 hit.
    [Graphical view]
    PRINTSiPR00653. ACTIVIN2R.
    SMARTiSM00467. GS. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 2 hits.
    PROSITEiPS51256. GS. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q09488-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNITFIFILI FGFFNTQKCS KDYDHFDDED LALSIPKNAI GVPKEFRQQV    50
    LKEMKLRNRP NDILKNRCYC NYDQSICGNN MTCVKQDGAA CYHAVEEVYN 100
    KAEKRMETLH KWGCATLERG SGASHLTCNS WRAAHHSPKS IGCCYEGNYC 150
    NKNLIPPAYV HHHKEKALQE KTDNPEDYDS PLENMTRGGK MFIMVFATVM 200
    SVFAVIGCIY LCITRAEEKS KARARAKTVS LKTESTYMES KSMLEDSGSG 250
    SGQAALIQRT VRQDLTIIKT IGQGRYGEVR KALYRGSYVA VKTFYTTDED 300
    SWKNERDVYQ TNMINHENIL QFVAADIWSE EDSMTKMLLI TDYHELGSLS 350
    DYLCREETLT TDEALRLIHS CICGIEHLHA AVHGTGSFRK PEIAHRDIKS 400
    KNIIVKRPNV CCIADLGLAL RYQNDKILPE KFNVQVGTKR YMAPELISNK 450
    LNPKDFSQFK MADIYSMALV MWEVAIRVEV NTCEEVLTVD ETSPDHSASS 500
    GIGESVSSSG NISRMHLQKT NVEGHSTSLK AKQHVPPFDG IVHNDPNFDE 550
    MNDVICVRRI RPPPDLAWKN VPALNELSKL MEDSWHSIPH FRHSALKLKK 600
    EMAELIKNPD RQNQSQRKVE FQQQDSGLVE SATNQS 636
    Length:636
    Mass (Da):72,235
    Last modified:February 1, 1996 - v1
    Checksum:i3349C85944E6AE24
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF104017 mRNA. Translation: AAD12261.1.
    FO080708 Genomic DNA. Translation: CCD66028.1.
    PIRiT15734.
    RefSeqiNP_495271.1. NM_062870.5.
    UniGeneiCel.5733.

    Genome annotation databases

    EnsemblMetazoaiC32D5.2; C32D5.2; WBGene00004860.
    GeneIDi174044.
    KEGGicel:CELE_C32D5.2.
    UCSCiC32D5.2.1. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF104017 mRNA. Translation: AAD12261.1 .
    FO080708 Genomic DNA. Translation: CCD66028.1 .
    PIRi T15734.
    RefSeqi NP_495271.1. NM_062870.5.
    UniGenei Cel.5733.

    3D structure databases

    ProteinModelPortali Q09488.
    SMRi Q09488. Positions 242-605.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 39384. 82 interactions.
    STRINGi 6239.C32D5.2.2.

    Proteomic databases

    PaxDbi Q09488.
    PRIDEi Q09488.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai C32D5.2 ; C32D5.2 ; WBGene00004860 .
    GeneIDi 174044.
    KEGGi cel:CELE_C32D5.2.
    UCSCi C32D5.2.1. c. elegans.

    Organism-specific databases

    CTDi 174044.
    WormBasei C32D5.2 ; CE01842 ; WBGene00004860 ; sma-6.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00560000076906.
    HOGENOMi HOG000230587.
    InParanoidi Q09488.
    KOi K13578.
    OMAi VWLAKWR.
    OrthoDBi EOG7Q8CN3.
    PhylomeDBi Q09488.

    Enzyme and pathway databases

    BRENDAi 2.7.10.2. 1045.
    SignaLinki Q09488.

    Miscellaneous databases

    NextBioi 882265.
    PROi Q09488.

    Family and domain databases

    InterProi IPR000472. Activin_rcpt.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    IPR003605. TGF_beta_rcpt_GS.
    IPR000333. TGFB_receptor.
    [Graphical view ]
    PANTHERi PTHR23255. PTHR23255. 1 hit.
    Pfami PF01064. Activin_recp. 1 hit.
    PF00069. Pkinase. 1 hit.
    PF08515. TGF_beta_GS. 1 hit.
    [Graphical view ]
    PRINTSi PR00653. ACTIVIN2R.
    SMARTi SM00467. GS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 2 hits.
    PROSITEi PS51256. GS. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans."
      Krishna S., Maduzia L.L., Padgett R.W.
      Development 126:251-260(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Bristol N2.
    2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiSMA6_CAEEL
    AccessioniPrimary (citable) accession number: Q09488
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3