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Protein

Serine/threonine-protein kinase sma-6

Gene

sma-6

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in TGF-beta pathway. May be a receptor for daf-7.

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei292ATPPROSITE-ProRule annotation1
Active sitei397Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi271 – 279ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

  • BMP signaling pathway Source: WormBase
  • dauer larval development Source: WormBase
  • defense response to fungus Source: WormBase
  • innate immune response Source: WormBase
  • maintenance of protein location in nucleus Source: WormBase
  • nematode male tail tip morphogenesis Source: WormBase
  • positive regulation of multicellular organism growth Source: WormBase
  • positive regulation of protein catabolic process Source: WormBase
  • positive regulation of transcription from RNA polymerase II promoter Source: WormBase
  • regulation of cell adhesion Source: WormBase
  • regulation of cell morphogenesis Source: WormBase
  • reproduction Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Kinase, Receptor, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 1045.
SignaLinkiQ09488.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase sma-6 (EC:2.7.11.30)
Gene namesi
Name:sma-6
ORF Names:C32D5.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiC32D5.2; CE01842; WBGene00004860; sma-6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 190ExtracellularSequence analysisAdd BLAST170
Transmembranei191 – 211HelicalSequence analysisAdd BLAST21
Topological domaini212 – 636CytoplasmicSequence analysisAdd BLAST425

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • nucleus Source: GOC
  • plasma membrane Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000002443221 – 636Serine/threonine-protein kinase sma-6Add BLAST616

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi80N-linked (GlcNAc...)Sequence analysis1
Glycosylationi184N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ09488.

Expressioni

Tissue specificityi

Expressed in pharyngeal, hypodermal and intestinal cells.1 Publication

Gene expression databases

BgeeiWBGene00004860.

Interactioni

Subunit structurei

Interacts with sma-10 (PubMed:20502686). Interacts with drag-1 (PubMed:24004951).2 Publications

GO - Molecular functioni

  • BMP binding Source: WormBase

Protein-protein interaction databases

BioGridi39384. 81 interactors.
STRINGi6239.C32D5.2.

Structurei

3D structure databases

ProteinModelPortaliQ09488.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini235 – 264GSPROSITE-ProRule annotationAdd BLAST30
Domaini265 – 606Protein kinasePROSITE-ProRule annotationAdd BLAST342

Sequence similaritiesi

Contains 1 GS domain.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2052. Eukaryota.
ENOG410XQT0. LUCA.
GeneTreeiENSGT00760000118876.
HOGENOMiHOG000230587.
InParanoidiQ09488.
KOiK13578.
OMAiMCNSQLS.
OrthoDBiEOG091G0BIU.
PhylomeDBiQ09488.

Family and domain databases

InterProiIPR000472. Activin_recp.
IPR003605. GS_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 2 hits.
PfamiPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR00653. ACTIVIN2R.
SMARTiSM00467. GS. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q09488-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNITFIFILI FGFFNTQKCS KDYDHFDDED LALSIPKNAI GVPKEFRQQV
60 70 80 90 100
LKEMKLRNRP NDILKNRCYC NYDQSICGNN MTCVKQDGAA CYHAVEEVYN
110 120 130 140 150
KAEKRMETLH KWGCATLERG SGASHLTCNS WRAAHHSPKS IGCCYEGNYC
160 170 180 190 200
NKNLIPPAYV HHHKEKALQE KTDNPEDYDS PLENMTRGGK MFIMVFATVM
210 220 230 240 250
SVFAVIGCIY LCITRAEEKS KARARAKTVS LKTESTYMES KSMLEDSGSG
260 270 280 290 300
SGQAALIQRT VRQDLTIIKT IGQGRYGEVR KALYRGSYVA VKTFYTTDED
310 320 330 340 350
SWKNERDVYQ TNMINHENIL QFVAADIWSE EDSMTKMLLI TDYHELGSLS
360 370 380 390 400
DYLCREETLT TDEALRLIHS CICGIEHLHA AVHGTGSFRK PEIAHRDIKS
410 420 430 440 450
KNIIVKRPNV CCIADLGLAL RYQNDKILPE KFNVQVGTKR YMAPELISNK
460 470 480 490 500
LNPKDFSQFK MADIYSMALV MWEVAIRVEV NTCEEVLTVD ETSPDHSASS
510 520 530 540 550
GIGESVSSSG NISRMHLQKT NVEGHSTSLK AKQHVPPFDG IVHNDPNFDE
560 570 580 590 600
MNDVICVRRI RPPPDLAWKN VPALNELSKL MEDSWHSIPH FRHSALKLKK
610 620 630
EMAELIKNPD RQNQSQRKVE FQQQDSGLVE SATNQS
Length:636
Mass (Da):72,235
Last modified:February 1, 1996 - v1
Checksum:i3349C85944E6AE24
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF104017 mRNA. Translation: AAD12261.1.
FO080708 Genomic DNA. Translation: CCD66028.1.
PIRiT15734.
RefSeqiNP_495271.1. NM_062870.5.
UniGeneiCel.5733.

Genome annotation databases

EnsemblMetazoaiC32D5.2; C32D5.2; WBGene00004860.
GeneIDi174044.
KEGGicel:CELE_C32D5.2.
UCSCiC32D5.2.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF104017 mRNA. Translation: AAD12261.1.
FO080708 Genomic DNA. Translation: CCD66028.1.
PIRiT15734.
RefSeqiNP_495271.1. NM_062870.5.
UniGeneiCel.5733.

3D structure databases

ProteinModelPortaliQ09488.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi39384. 81 interactors.
STRINGi6239.C32D5.2.

Proteomic databases

PaxDbiQ09488.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC32D5.2; C32D5.2; WBGene00004860.
GeneIDi174044.
KEGGicel:CELE_C32D5.2.
UCSCiC32D5.2.1. c. elegans.

Organism-specific databases

CTDi174044.
WormBaseiC32D5.2; CE01842; WBGene00004860; sma-6.

Phylogenomic databases

eggNOGiKOG2052. Eukaryota.
ENOG410XQT0. LUCA.
GeneTreeiENSGT00760000118876.
HOGENOMiHOG000230587.
InParanoidiQ09488.
KOiK13578.
OMAiMCNSQLS.
OrthoDBiEOG091G0BIU.
PhylomeDBiQ09488.

Enzyme and pathway databases

BRENDAi2.7.10.2. 1045.
SignaLinkiQ09488.

Miscellaneous databases

PROiQ09488.

Gene expression databases

BgeeiWBGene00004860.

Family and domain databases

InterProiIPR000472. Activin_recp.
IPR003605. GS_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 2 hits.
PfamiPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR00653. ACTIVIN2R.
SMARTiSM00467. GS. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSMA6_CAEEL
AccessioniPrimary (citable) accession number: Q09488
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 2, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.