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Q09474 (T23O_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tryptophan 2,3-dioxygenase

Short name=TDO
EC=1.13.11.11
Alternative name(s):
Tryptamin 2,3-dioxygenase
Tryptophan oxygenase
Short name=TO
Short name=TRPO
Tryptophan pyrrolase
Tryptophanase
Gene names
ORF Names:C28H8.11
OrganismCaenorhabditis elegans
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length403 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring By similarity.

Catalytic activity

L-tryptophan + O2 = N-formyl-L-kynurenine.

Cofactor

Binds 2 heme groups per tetramer By similarity.

Pathway

Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2.

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the tryptophan 2,3-dioxygenase family.

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 403403Tryptophan 2,3-dioxygenase
PRO_0000072398

Regions

Region39 – 435Substrate binding By similarity
Region69 – 735Substrate binding By similarity

Sites

Metal binding3271Iron (heme axial ligand) By similarity
Binding site1401Substrate By similarity
Binding site1471Heme By similarity
Binding site3411Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q09474 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 8F1E98075CA86A65

FASTA40346,716
        10         20         30         40         50         60 
MACPYLGSGE LTHRVTFMEG GEECQQGVNK VEMGFGQTYS EYLQLDKILT AQRLKSEADG 

        70         80         90        100        110        120 
QRVDDEHLFI VIHQAHELWF KQIIFDLDNV RKLLNNTIVD ETKTLKIVSG LDRMTKILSL 

       130        140        150        160        170        180 
LTEQITLLDT MSPLDFVDFR KYLTPASGFQ SLQFRVLENK LGVRQERRIK YNAQHYKNVF 

       190        200        210        220        230        240 
NDTDLKTLNV TEEEKSLLTL IESWLERTPG LKSTSEDEGF WIKYEKSVNK YLADLAKQAA 

       250        260        270        280        290        300 
DPSNTEEIAK QLTAEYHKTA DAFQSILDPR QHEQHIRNGN RLLSHDATKG AMMIYFYRDM 

       310        320        330        340        350        360 
PRFSQPYQIL TFLMDIDSLF TKWRYNHVLL VQRMLGAKQG TGGSSGYMYL RSTVSDRYKV 

       370        380        390        400 
FLDLFNLSTW LIPREYIPML SPRMVKTLSE HSNLSHSQSS ESD 

« Hide

References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FO080703 Genomic DNA. Translation: CCD65972.1.
PIRB88470.
RefSeqNP_498284.1. NM_065883.3.
UniGeneCel.10783.

3D structure databases

ProteinModelPortalQ09474.
SMRQ09474. Positions 23-371.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-26438N.
IntActQ09474. 5 interactions.
MINTMINT-1048668.
STRINGQ09474.

Proteomic databases

PRIDEQ09474.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaC28H8.11a; C28H8.11a; C28H8.11.
GeneID175836.
KEGGcel:C28H8.11.
NMPDRfig|6239.3.peg.9980.
UCSCC28H8.11c.3. c. elegans.

Organism-specific databases

CTD175836.
WormBaseC28H8.11a; CE01822; WBGene00016201.

Phylogenomic databases

eggNOGmeNOG04229.
HOGENOMHBG647485.
InParanoidQ09474.
OMAKLLVDQV.
PhylomeDBQ09474.

Gene expression databases

ArrayExpressQ09474.

Family and domain databases

InterProIPR004981. Trp_2_3_dOase.
[Graphical view]
KOK00453.
PANTHERPTHR10138. Trp_2_3_dOase. 1 hit.
PfamPF03301. Trp_dioxygenase. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio889870.

Entry information

Entry nameT23O_CAEEL
AccessionPrimary (citable) accession number: Q09474
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: December 14, 2011
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormPep

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families