Reviewed,
UniProtKB/Swiss-Prot Q09474 (T23O_CAEEL)
Last modified
November 25, 2008.
Version 57.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Putative tryptophan 2,3-dioxygenase Short name=TO EC=1.13.11.11 Alternative name(s): Tryptophan pyrrolase Short name=Tryptophanase Tryptophan oxygenase Tryptamin 2,3-dioxygenase Short name=TRPO | ||
| Gene names |
| ||
| Organism | Caenorhabditis elegans [Complete proteome] | ||
| Taxonomic identifier | 6239 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Protein attributes
| Sequence length | 403 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Catalytic activity | L-tryptophan + O(2) = N-formyl-L-kynurenine. |
| Cofactor | Binds 2 heme groups per tetramer. The hemes are protoheme IV By similarity. |
| Pathway | |
| Sequence similarities | Belongs to the tryptophan 2,3-dioxygenase family. |
Ontologies
Keywords | |
|---|---|
| Ligand | Heme Iron Metal-binding |
| Molecular function | Dioxygenase Oxidoreductase |
| Technical term | Complete proteome |
Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: InterPro positive regulation of growth rateInferred from mutant phenotype. Source: WormBase tryptophan catabolic process to kynurenineInferred from electronic annotation. Source: InterPro |
| Molecular function | identical protein binding Inferred from physical interaction. Source: IntAct iron ion bindingInferred from electronic annotation. Source: InterPro tryptophan 2,3-dioxygenase activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| itself | 1 | EBI-316265,EBI-316265 | ||
| gale-1 | O62107 | 1 | EBI-316265,EBI-316270 | |
| kel-8 | O61899 | 1 | EBI-316265,EBI-312469 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 403 | 403 | Putative tryptophan 2,3-dioxygenase | PRO_0000072398 | |||
Sequences
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References
| [1] | "Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2. |
Cross-references
Sequence databases | |
|---|---|
| U20861 Genomic DNA. Translation: AAA62299.1. | |
| PIR | B88470. |
| RefSeq | NP_498284.1. |
| UniGene | Cel.10783 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP:26438N. |
| IntAct | Q09474. |
Genome annotation databases | |
| Ensembl | C28H8.11. Caenorhabditis elegans. [Contig view] |
| GeneID | 175836. |
| NMPDR | fig|6239.3.peg.9980. |
Organism-specific databases | |
| WormBase | WBGene00016201. C28H8.11. |
| WormPep | C28H8.11. CE01822. [WorfDB] |
Gene expression databases | |
| ArrayExpress | Q09474. |
Family and domain databases | |
| InterPro | IPR004981. Trp_2_3_dOase. [Graphical view] |
| PANTHER | PTHR10138. Trp_2_3_dOase. 1 hit. |
| Pfam | PF03301. Trp_dioxygenase. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 889870. |
Entry information
| Entry name | T23O_CAEEL | ||||||||
| Accession | Primary (citable) accession number: Q09474 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Caenorhabditis annotation project | ||||||||
Relevant documents
| Caenorhabditis elegans Caenorhabditis elegans: entries, gene names and cross-references to WormPep |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


