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Q09444 (UBH4_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable ubiquitin carboxyl-terminal hydrolase ubh-4

EC=3.4.19.12
Alternative name(s):
Ubiquitin C-terminal hydrolase family 1 member 4
Ubiquitin thioesterase 4
Gene names
Name:ubh-4
ORF Names:C08B11.7
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length321 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Ubiquitin-protein hydrolase is involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin By similarity.

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sequence similarities

Belongs to the peptidase C12 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 321321Probable ubiquitin carboxyl-terminal hydrolase ubh-4
PRO_0000211071

Sites

Active site831Nucleophile By similarity
Active site1581Proton donor By similarity
Site1731Important for enzyme activity By similarity

Sequences

Sequence LengthMass (Da)Tools
Q09444 [UniParc].

Last modified December 21, 2004. Version 2.
Checksum: F6A658161FC13AD5

FASTA32137,120
        10         20         30         40         50         60 
MTDAGSWCLI ESDPGVFTEM LRGFGVDGLQ VEELYSLDDD KAMTRPTYGL IFLFKWRQGD 

        70         80         90        100        110        120 
ETTGIPSDKQ NIFFAHQTIQ NACATQALIN LLMNVEDTDV KLGNILNQYK EFAIDLDPNT 

       130        140        150        160        170        180 
RGHCLSNSEE IRTVHNSFSR QTLFELDIKG GESEDNYHFV TYVPIGNKVY ELDGLRELPL 

       190        200        210        220        230        240 
EVAEFQKEQD WIEAIKPVIQ QRMQKYSEGE ITFNLMALVP NRKQKLQEMM ENLIQANENN 

       250        260        270        280        290        300 
ELEEQIADLN KAIADEDYKM EMYRKENNRR RHNYTPFVIE LMKILAKEGK LVGLVDNAYQ 

       310        320 
AAKEKSKLNT DITKLELKRK Q 

« Hide

References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z46676 Genomic DNA. Translation: CAA86665.2.
PIRT19070.
RefSeqNP_495684.2. NM_063283.4.
UniGeneCel.15951.

3D structure databases

ProteinModelPortalQ09444.
SMRQ09444. Positions 5-294.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid39621. 1 interaction.
DIPDIP-26660N.
IntActQ09444. 1 interaction.
MINTMINT-1058911.
STRING6239.C08B11.7.

Protein family/group databases

MEROPSC12.005.

Proteomic databases

PaxDbQ09444.
PRIDEQ09444.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaC08B11.7; C08B11.7; WBGene00006724.
GeneID174289.
KEGGcel:CELE_C08B11.7.
UCSCC08B11.7. c. elegans.

Organism-specific databases

CTD174289.
WormBaseC08B11.7; CE36913; WBGene00006724; ubh-4.

Phylogenomic databases

eggNOGNOG321645.
GeneTreeENSGT00510000046560.
HOGENOMHOG000203918.
InParanoidQ09444.
KOK05610.
OMADEDAFHF.
OrthoDBEOG7M3J11.
PhylomeDBQ09444.

Family and domain databases

Gene3D3.40.532.10. 1 hit.
InterProIPR001578. Peptidase_C12_UCH.
IPR017390. Ubiquitinyl_hydrolase_UCH37.
[Graphical view]
PANTHERPTHR10589. PTHR10589. 1 hit.
PfamPF01088. Peptidase_C12. 1 hit.
[Graphical view]
PIRSFPIRSF038120. Ubiquitinyl_hydrolase_UCH37. 1 hit.
PRINTSPR00707. UBCTHYDRLASE.
ProtoNetSearch...

Other

NextBio883384.
PROQ09444.

Entry information

Entry nameUBH4_CAEEL
AccessionPrimary (citable) accession number: Q09444
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: December 21, 2004
Last modified: June 11, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase