Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q09444

- UBH4_CAEEL

UniProt

Q09444 - UBH4_CAEEL

Protein

Probable ubiquitin carboxyl-terminal hydrolase ubh-4

Gene

ubh-4

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 2 (21 Dec 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Ubiquitin-protein hydrolase is involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei83 – 831NucleophileBy similarity
    Active sitei158 – 1581Proton donorBy similarity
    Sitei173 – 1731Important for enzyme activityBy similarity

    GO - Molecular functioni

    1. omega peptidase activity Source: InterPro
    2. ubiquitin-specific protease activity Source: InterPro

    GO - Biological processi

    1. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Protein family/group databases

    MEROPSiC12.005.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable ubiquitin carboxyl-terminal hydrolase ubh-4 (EC:3.4.19.12)
    Alternative name(s):
    Ubiquitin C-terminal hydrolase family 1 member 4
    Ubiquitin thioesterase 4
    Gene namesi
    Name:ubh-4
    ORF Names:C08B11.7
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome II

    Organism-specific databases

    WormBaseiC08B11.7; CE36913; WBGene00006724; ubh-4.

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 321321Probable ubiquitin carboxyl-terminal hydrolase ubh-4PRO_0000211071Add
    BLAST

    Proteomic databases

    PaxDbiQ09444.
    PRIDEiQ09444.

    Interactioni

    Protein-protein interaction databases

    BioGridi39621. 1 interaction.
    DIPiDIP-26660N.
    IntActiQ09444. 1 interaction.
    MINTiMINT-1058911.
    STRINGi6239.C08B11.7.

    Structurei

    3D structure databases

    ProteinModelPortaliQ09444.
    SMRiQ09444. Positions 5-294.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase C12 family.Curated

    Phylogenomic databases

    eggNOGiNOG321645.
    GeneTreeiENSGT00510000046560.
    HOGENOMiHOG000203918.
    InParanoidiQ09444.
    KOiK05610.
    OMAiDEDAFHF.
    OrthoDBiEOG7M3J11.
    PhylomeDBiQ09444.

    Family and domain databases

    Gene3Di3.40.532.10. 1 hit.
    InterProiIPR001578. Peptidase_C12_UCH.
    IPR017390. Ubiquitinyl_hydrolase_UCH37.
    [Graphical view]
    PANTHERiPTHR10589. PTHR10589. 1 hit.
    PfamiPF01088. Peptidase_C12. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038120. Ubiquitinyl_hydrolase_UCH37. 1 hit.
    PRINTSiPR00707. UBCTHYDRLASE.

    Sequencei

    Sequence statusi: Complete.

    Q09444-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTDAGSWCLI ESDPGVFTEM LRGFGVDGLQ VEELYSLDDD KAMTRPTYGL    50
    IFLFKWRQGD ETTGIPSDKQ NIFFAHQTIQ NACATQALIN LLMNVEDTDV 100
    KLGNILNQYK EFAIDLDPNT RGHCLSNSEE IRTVHNSFSR QTLFELDIKG 150
    GESEDNYHFV TYVPIGNKVY ELDGLRELPL EVAEFQKEQD WIEAIKPVIQ 200
    QRMQKYSEGE ITFNLMALVP NRKQKLQEMM ENLIQANENN ELEEQIADLN 250
    KAIADEDYKM EMYRKENNRR RHNYTPFVIE LMKILAKEGK LVGLVDNAYQ 300
    AAKEKSKLNT DITKLELKRK Q 321
    Length:321
    Mass (Da):37,120
    Last modified:December 21, 2004 - v2
    Checksum:iF6A658161FC13AD5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46676 Genomic DNA. Translation: CAA86665.2.
    PIRiT19070.
    RefSeqiNP_495684.2. NM_063283.4.
    UniGeneiCel.15951.

    Genome annotation databases

    EnsemblMetazoaiC08B11.7; C08B11.7; WBGene00006724.
    GeneIDi174289.
    KEGGicel:CELE_C08B11.7.
    UCSCiC08B11.7. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46676 Genomic DNA. Translation: CAA86665.2 .
    PIRi T19070.
    RefSeqi NP_495684.2. NM_063283.4.
    UniGenei Cel.15951.

    3D structure databases

    ProteinModelPortali Q09444.
    SMRi Q09444. Positions 5-294.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 39621. 1 interaction.
    DIPi DIP-26660N.
    IntActi Q09444. 1 interaction.
    MINTi MINT-1058911.
    STRINGi 6239.C08B11.7.

    Protein family/group databases

    MEROPSi C12.005.

    Proteomic databases

    PaxDbi Q09444.
    PRIDEi Q09444.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai C08B11.7 ; C08B11.7 ; WBGene00006724 .
    GeneIDi 174289.
    KEGGi cel:CELE_C08B11.7.
    UCSCi C08B11.7. c. elegans.

    Organism-specific databases

    CTDi 174289.
    WormBasei C08B11.7 ; CE36913 ; WBGene00006724 ; ubh-4.

    Phylogenomic databases

    eggNOGi NOG321645.
    GeneTreei ENSGT00510000046560.
    HOGENOMi HOG000203918.
    InParanoidi Q09444.
    KOi K05610.
    OMAi DEDAFHF.
    OrthoDBi EOG7M3J11.
    PhylomeDBi Q09444.

    Miscellaneous databases

    NextBioi 883384.
    PROi Q09444.

    Family and domain databases

    Gene3Di 3.40.532.10. 1 hit.
    InterProi IPR001578. Peptidase_C12_UCH.
    IPR017390. Ubiquitinyl_hydrolase_UCH37.
    [Graphical view ]
    PANTHERi PTHR10589. PTHR10589. 1 hit.
    Pfami PF01088. Peptidase_C12. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038120. Ubiquitinyl_hydrolase_UCH37. 1 hit.
    PRINTSi PR00707. UBCTHYDRLASE.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiUBH4_CAEEL
    AccessioniPrimary (citable) accession number: Q09444
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 97 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3