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Q09444

- UBH4_CAEEL

UniProt

Q09444 - UBH4_CAEEL

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Protein
Probable ubiquitin carboxyl-terminal hydrolase ubh-4
Gene
ubh-4, C08B11.7
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Ubiquitin-protein hydrolase is involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin By similarity.

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei83 – 831Nucleophile By similarity
Active sitei158 – 1581Proton donor By similarity
Sitei173 – 1731Important for enzyme activity By similarity

GO - Molecular functioni

  1. omega peptidase activity Source: InterPro
  2. ubiquitin-specific protease activity Source: InterPro

GO - Biological processi

  1. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC12.005.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ubiquitin carboxyl-terminal hydrolase ubh-4 (EC:3.4.19.12)
Alternative name(s):
Ubiquitin C-terminal hydrolase family 1 member 4
Ubiquitin thioesterase 4
Gene namesi
Name:ubh-4
ORF Names:C08B11.7
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome II

Organism-specific databases

WormBaseiC08B11.7; CE36913; WBGene00006724; ubh-4.

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 321321Probable ubiquitin carboxyl-terminal hydrolase ubh-4
PRO_0000211071Add
BLAST

Proteomic databases

PaxDbiQ09444.
PRIDEiQ09444.

Interactioni

Protein-protein interaction databases

BioGridi39621. 1 interaction.
DIPiDIP-26660N.
IntActiQ09444. 1 interaction.
MINTiMINT-1058911.
STRINGi6239.C08B11.7.

Structurei

3D structure databases

ProteinModelPortaliQ09444.
SMRiQ09444. Positions 5-294.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C12 family.

Phylogenomic databases

eggNOGiNOG321645.
GeneTreeiENSGT00510000046560.
HOGENOMiHOG000203918.
InParanoidiQ09444.
KOiK05610.
OMAiDEDAFHF.
OrthoDBiEOG7M3J11.
PhylomeDBiQ09444.

Family and domain databases

Gene3Di3.40.532.10. 1 hit.
InterProiIPR001578. Peptidase_C12_UCH.
IPR017390. Ubiquitinyl_hydrolase_UCH37.
[Graphical view]
PANTHERiPTHR10589. PTHR10589. 1 hit.
PfamiPF01088. Peptidase_C12. 1 hit.
[Graphical view]
PIRSFiPIRSF038120. Ubiquitinyl_hydrolase_UCH37. 1 hit.
PRINTSiPR00707. UBCTHYDRLASE.

Sequencei

Sequence statusi: Complete.

Q09444-1 [UniParc]FASTAAdd to Basket

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MTDAGSWCLI ESDPGVFTEM LRGFGVDGLQ VEELYSLDDD KAMTRPTYGL    50
IFLFKWRQGD ETTGIPSDKQ NIFFAHQTIQ NACATQALIN LLMNVEDTDV 100
KLGNILNQYK EFAIDLDPNT RGHCLSNSEE IRTVHNSFSR QTLFELDIKG 150
GESEDNYHFV TYVPIGNKVY ELDGLRELPL EVAEFQKEQD WIEAIKPVIQ 200
QRMQKYSEGE ITFNLMALVP NRKQKLQEMM ENLIQANENN ELEEQIADLN 250
KAIADEDYKM EMYRKENNRR RHNYTPFVIE LMKILAKEGK LVGLVDNAYQ 300
AAKEKSKLNT DITKLELKRK Q 321
Length:321
Mass (Da):37,120
Last modified:December 21, 2004 - v2
Checksum:iF6A658161FC13AD5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z46676 Genomic DNA. Translation: CAA86665.2.
PIRiT19070.
RefSeqiNP_495684.2. NM_063283.4.
UniGeneiCel.15951.

Genome annotation databases

EnsemblMetazoaiC08B11.7; C08B11.7; WBGene00006724.
GeneIDi174289.
KEGGicel:CELE_C08B11.7.
UCSCiC08B11.7. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z46676 Genomic DNA. Translation: CAA86665.2 .
PIRi T19070.
RefSeqi NP_495684.2. NM_063283.4.
UniGenei Cel.15951.

3D structure databases

ProteinModelPortali Q09444.
SMRi Q09444. Positions 5-294.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 39621. 1 interaction.
DIPi DIP-26660N.
IntActi Q09444. 1 interaction.
MINTi MINT-1058911.
STRINGi 6239.C08B11.7.

Protein family/group databases

MEROPSi C12.005.

Proteomic databases

PaxDbi Q09444.
PRIDEi Q09444.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai C08B11.7 ; C08B11.7 ; WBGene00006724 .
GeneIDi 174289.
KEGGi cel:CELE_C08B11.7.
UCSCi C08B11.7. c. elegans.

Organism-specific databases

CTDi 174289.
WormBasei C08B11.7 ; CE36913 ; WBGene00006724 ; ubh-4.

Phylogenomic databases

eggNOGi NOG321645.
GeneTreei ENSGT00510000046560.
HOGENOMi HOG000203918.
InParanoidi Q09444.
KOi K05610.
OMAi DEDAFHF.
OrthoDBi EOG7M3J11.
PhylomeDBi Q09444.

Miscellaneous databases

NextBioi 883384.
PROi Q09444.

Family and domain databases

Gene3Di 3.40.532.10. 1 hit.
InterProi IPR001578. Peptidase_C12_UCH.
IPR017390. Ubiquitinyl_hydrolase_UCH37.
[Graphical view ]
PANTHERi PTHR10589. PTHR10589. 1 hit.
Pfami PF01088. Peptidase_C12. 1 hit.
[Graphical view ]
PIRSFi PIRSF038120. Ubiquitinyl_hydrolase_UCH37. 1 hit.
PRINTSi PR00707. UBCTHYDRLASE.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiUBH4_CAEEL
AccessioniPrimary (citable) accession number: Q09444
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: December 21, 2004
Last modified: June 11, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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