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Q09440

- HDA2_CAEEL

UniProt

Q09440 - HDA2_CAEEL

Protein

Putative histone deacetylase 2

Gene

hda-2

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Probably responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity.By similarity

    Catalytic activityi

    Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei162 – 1621By similarity

    GO - Molecular functioni

    1. histone deacetylase activity Source: WormBase
    2. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
    3. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
    4. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
    5. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC
    6. transcription corepressor activity Source: WormBase

    GO - Biological processi

    1. chromatin modification Source: WormBase
    2. DNA protection Source: WormBase
    3. histone deacetylation Source: WormBase
    4. negative regulation of transcription from RNA polymerase II promoter Source: WormBase
    5. nematode male tail tip morphogenesis Source: WormBase
    6. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulator, Hydrolase, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative histone deacetylase 2 (EC:3.5.1.98)
    Gene namesi
    Name:hda-2
    ORF Names:C08B11.2
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome II

    Organism-specific databases

    WormBaseiC08B11.2; CE01472; WBGene00001835; hda-2.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. histone deacetylase complex Source: WormBase

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 507507Putative histone deacetylase 2PRO_0000114720Add
    BLAST

    Proteomic databases

    PaxDbiQ09440.
    PRIDEiQ09440.

    Interactioni

    Protein-protein interaction databases

    BioGridi39617. 2 interactions.
    IntActiQ09440. 1 interaction.
    MINTiMINT-226304.
    STRINGi6239.C08B11.2.

    Structurei

    3D structure databases

    ProteinModelPortaliQ09440.
    SMRiQ09440. Positions 29-395.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni29 – 342314Histone deacetylaseAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0123.
    GeneTreeiENSGT00530000062889.
    HOGENOMiHOG000225180.
    InParanoidiQ09440.
    KOiK06067.
    OMAiRMIRGAP.
    OrthoDBiEOG7VTDRR.
    PhylomeDBiQ09440.

    Family and domain databases

    Gene3Di3.40.800.20. 1 hit.
    InterProiIPR000286. His_deacetylse.
    IPR003084. His_deacetylse_1.
    IPR023801. His_deacetylse_dom.
    [Graphical view]
    PANTHERiPTHR10625. PTHR10625. 1 hit.
    PfamiPF00850. Hist_deacetyl. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
    PRINTSiPR01270. HDASUPER.
    PR01271. HISDACETLASE.

    Sequencei

    Sequence statusi: Complete.

    Q09440-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSDKFKLDT LFDDNDEIIE PDGADVKKRN VAYYYHKDVG HFHYGQLHPM    50
    KPQRLVVCND LVVSYEMPKY MTVVESPKLD AADISVFHTE DYVNFLQTVT 100
    PKLGLTMPDD VLRQFNIGED CPIFAGLWDY CTLYAGGSVE GARRLNHKMN 150
    DIVINWPGGL HHAKKSEASG FCYVNDIVLG ILELLKYHKR VLYIDIDIHH 200
    GDGVQEAFNN SDRVMTVSFH RFGQYFPGSG SIMDKGVGPG KYFAINVPLM 250
    AAIRDEPYLK LFESVISGVE ENFNPEAIVL QCGSDSLCED RLGQFALSFN 300
    AHARAVKYVK SLGKPLMVLG GGGYTLRNVA RCWALETGVI LGLRMDDEIP 350
    GTSLYSHYFT PRLLRPNLVP KMNDANSAAY LASIEKETLA CLRMIRGAPS 400
    VQMQNIVGIR LDEIEQIEEN ERLQKSSKSS IEYEVGKVSE KMEEECFVEE 450
    DSKPPSFPPG QDPRRIGQYW GYDRSGLAPP RSHSDVIEEA KYEDRDRRKD 500
    LNIPGIP 507
    Length:507
    Mass (Da):57,138
    Last modified:November 1, 1995 - v1
    Checksum:iF500D405F7595BAF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46676 Genomic DNA. Translation: CAA86662.1.
    PIRiT19067.
    RefSeqiNP_495678.1. NM_063277.5.
    UniGeneiCel.14857.

    Genome annotation databases

    EnsemblMetazoaiC08B11.2; C08B11.2; WBGene00001835.
    GeneIDi174285.
    KEGGicel:CELE_C08B11.2.
    UCSCiC08B11.2. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46676 Genomic DNA. Translation: CAA86662.1 .
    PIRi T19067.
    RefSeqi NP_495678.1. NM_063277.5.
    UniGenei Cel.14857.

    3D structure databases

    ProteinModelPortali Q09440.
    SMRi Q09440. Positions 29-395.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 39617. 2 interactions.
    IntActi Q09440. 1 interaction.
    MINTi MINT-226304.
    STRINGi 6239.C08B11.2.

    Proteomic databases

    PaxDbi Q09440.
    PRIDEi Q09440.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai C08B11.2 ; C08B11.2 ; WBGene00001835 .
    GeneIDi 174285.
    KEGGi cel:CELE_C08B11.2.
    UCSCi C08B11.2. c. elegans.

    Organism-specific databases

    CTDi 174285.
    WormBasei C08B11.2 ; CE01472 ; WBGene00001835 ; hda-2.

    Phylogenomic databases

    eggNOGi COG0123.
    GeneTreei ENSGT00530000062889.
    HOGENOMi HOG000225180.
    InParanoidi Q09440.
    KOi K06067.
    OMAi RMIRGAP.
    OrthoDBi EOG7VTDRR.
    PhylomeDBi Q09440.

    Miscellaneous databases

    NextBioi 883367.

    Family and domain databases

    Gene3Di 3.40.800.20. 1 hit.
    InterProi IPR000286. His_deacetylse.
    IPR003084. His_deacetylse_1.
    IPR023801. His_deacetylse_dom.
    [Graphical view ]
    PANTHERi PTHR10625. PTHR10625. 1 hit.
    Pfami PF00850. Hist_deacetyl. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037913. His_deacetylse_1. 1 hit.
    PRINTSi PR01270. HDASUPER.
    PR01271. HISDACETLASE.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiHDA2_CAEEL
    AccessioniPrimary (citable) accession number: Q09440
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3