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Q09440

- HDA2_CAEEL

UniProt

Q09440 - HDA2_CAEEL

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Protein

Putative histone deacetylase 2

Gene

hda-2

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Probably responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).By similarity

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei162 – 1621By similarity

GO - Molecular functioni

  1. histone deacetylase activity Source: WormBase
  2. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
  3. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
  4. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
  5. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC
  6. transcription corepressor activity Source: WormBase

GO - Biological processi

  1. chromatin modification Source: WormBase
  2. DNA protection Source: WormBase
  3. histone deacetylation Source: WormBase
  4. negative regulation of transcription from RNA polymerase II promoter Source: WormBase
  5. nematode male tail tip morphogenesis Source: WormBase
  6. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Hydrolase, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiREACT_183219. BMAL1:CLOCK,NPAS2 activates circadian gene expression.
REACT_183225. RORA activates circadian gene expression.
REACT_242668. Circadian Clock.
REACT_249347. Transcriptional regulation of white adipocyte differentiation.
REACT_254518. REV-ERBA represses gene expression.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative histone deacetylase 2 (EC:3.5.1.98)
Gene namesi
Name:hda-2
ORF Names:C08B11.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome II

Organism-specific databases

WormBaseiC08B11.2; CE01472; WBGene00001835; hda-2.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. histone deacetylase complex Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 507507Putative histone deacetylase 2PRO_0000114720Add
BLAST

Proteomic databases

PaxDbiQ09440.
PRIDEiQ09440.

Interactioni

Protein-protein interaction databases

BioGridi39617. 2 interactions.
IntActiQ09440. 1 interaction.
MINTiMINT-226304.
STRINGi6239.C08B11.2.

Structurei

3D structure databases

ProteinModelPortaliQ09440.
SMRiQ09440. Positions 29-395.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni29 – 342314Histone deacetylaseAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0123.
GeneTreeiENSGT00530000062889.
HOGENOMiHOG000225180.
InParanoidiQ09440.
KOiK06067.
OMAiRMIRGAP.
OrthoDBiEOG7VTDRR.
PhylomeDBiQ09440.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.

Sequencei

Sequence statusi: Complete.

Q09440-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSDKFKLDT LFDDNDEIIE PDGADVKKRN VAYYYHKDVG HFHYGQLHPM
60 70 80 90 100
KPQRLVVCND LVVSYEMPKY MTVVESPKLD AADISVFHTE DYVNFLQTVT
110 120 130 140 150
PKLGLTMPDD VLRQFNIGED CPIFAGLWDY CTLYAGGSVE GARRLNHKMN
160 170 180 190 200
DIVINWPGGL HHAKKSEASG FCYVNDIVLG ILELLKYHKR VLYIDIDIHH
210 220 230 240 250
GDGVQEAFNN SDRVMTVSFH RFGQYFPGSG SIMDKGVGPG KYFAINVPLM
260 270 280 290 300
AAIRDEPYLK LFESVISGVE ENFNPEAIVL QCGSDSLCED RLGQFALSFN
310 320 330 340 350
AHARAVKYVK SLGKPLMVLG GGGYTLRNVA RCWALETGVI LGLRMDDEIP
360 370 380 390 400
GTSLYSHYFT PRLLRPNLVP KMNDANSAAY LASIEKETLA CLRMIRGAPS
410 420 430 440 450
VQMQNIVGIR LDEIEQIEEN ERLQKSSKSS IEYEVGKVSE KMEEECFVEE
460 470 480 490 500
DSKPPSFPPG QDPRRIGQYW GYDRSGLAPP RSHSDVIEEA KYEDRDRRKD

LNIPGIP
Length:507
Mass (Da):57,138
Last modified:November 1, 1995 - v1
Checksum:iF500D405F7595BAF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46676 Genomic DNA. Translation: CAA86662.1.
PIRiT19067.
RefSeqiNP_495678.1. NM_063277.5.
UniGeneiCel.14857.

Genome annotation databases

EnsemblMetazoaiC08B11.2; C08B11.2; WBGene00001835.
GeneIDi174285.
KEGGicel:CELE_C08B11.2.
UCSCiC08B11.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46676 Genomic DNA. Translation: CAA86662.1 .
PIRi T19067.
RefSeqi NP_495678.1. NM_063277.5.
UniGenei Cel.14857.

3D structure databases

ProteinModelPortali Q09440.
SMRi Q09440. Positions 29-395.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 39617. 2 interactions.
IntActi Q09440. 1 interaction.
MINTi MINT-226304.
STRINGi 6239.C08B11.2.

Proteomic databases

PaxDbi Q09440.
PRIDEi Q09440.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai C08B11.2 ; C08B11.2 ; WBGene00001835 .
GeneIDi 174285.
KEGGi cel:CELE_C08B11.2.
UCSCi C08B11.2. c. elegans.

Organism-specific databases

CTDi 174285.
WormBasei C08B11.2 ; CE01472 ; WBGene00001835 ; hda-2.

Phylogenomic databases

eggNOGi COG0123.
GeneTreei ENSGT00530000062889.
HOGENOMi HOG000225180.
InParanoidi Q09440.
KOi K06067.
OMAi RMIRGAP.
OrthoDBi EOG7VTDRR.
PhylomeDBi Q09440.

Enzyme and pathway databases

Reactomei REACT_183219. BMAL1:CLOCK,NPAS2 activates circadian gene expression.
REACT_183225. RORA activates circadian gene expression.
REACT_242668. Circadian Clock.
REACT_249347. Transcriptional regulation of white adipocyte differentiation.
REACT_254518. REV-ERBA represses gene expression.

Miscellaneous databases

NextBioi 883367.

Family and domain databases

Gene3Di 3.40.800.20. 1 hit.
InterProi IPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view ]
PANTHERi PTHR10625. PTHR10625. 1 hit.
Pfami PF00850. Hist_deacetyl. 1 hit.
[Graphical view ]
PIRSFi PIRSF037913. His_deacetylse_1. 1 hit.
PRINTSi PR01270. HDASUPER.
PR01271. HISDACETLASE.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiHDA2_CAEEL
AccessioniPrimary (citable) accession number: Q09440
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 26, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3