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Protein

Putative histone deacetylase 2

Gene

hda-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probably responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (By similarity). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). As a likely component of a histone deacetylase complex, together with saeg-1 and hda-2, functions downstream of the cAMP-dependent kinase egl-4 to regulate the expression of genes required for egg-laying and forgaging (PubMed:21573134).By similarity1 Publication

Catalytic activityi

Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei162By similarity1

GO - Molecular functioni

  • histone deacetylase activity Source: WormBase
  • NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
  • transcription corepressor activity Source: WormBase

GO - Biological processi

  • chromatin organization Source: WormBase
  • DNA protection Source: WormBase
  • histone deacetylation Source: WormBase
  • negative regulation of transcription from RNA polymerase II promoter Source: WormBase
  • nematode male tail tip morphogenesis Source: WormBase
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionChromatin regulator, Hydrolase, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-CEL-2467813. Separation of Sister Chromatids.
R-CEL-2500257. Resolution of Sister Chromatid Cohesion.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative histone deacetylase 2 (EC:3.5.1.98)
Gene namesi
Name:hda-2
ORF Names:C08B11.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiC08B11.2; CE01472; WBGene00001835; hda-2.

Subcellular locationi

GO - Cellular componenti

  • histone deacetylase complex Source: WormBase

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001147201 – 507Putative histone deacetylase 2Add BLAST507

Proteomic databases

EPDiQ09440.
PaxDbiQ09440.
PeptideAtlasiQ09440.

Expressioni

Gene expression databases

BgeeiWBGene00001835.

Interactioni

Subunit structurei

May be a component of a histone deacetylase complex containing saeg-2, saeg-1 and hda-2.1 Publication

Protein-protein interaction databases

BioGridi39617. 2 interactors.
IntActiQ09440. 1 interactor.
MINTiMINT-226304.
STRINGi6239.C08B11.2.

Structurei

3D structure databases

ProteinModelPortaliQ09440.
SMRiQ09440.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni29 – 342Histone deacetylaseAdd BLAST314

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1342. Eukaryota.
COG0123. LUCA.
GeneTreeiENSGT00530000062889.
HOGENOMiHOG000225180.
InParanoidiQ09440.
KOiK06067.
OMAiRMIRGAP.
OrthoDBiEOG091G067J.
PhylomeDBiQ09440.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiView protein in InterPro
IPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiView protein in Pfam
PF00850. Hist_deacetyl. 1 hit.
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.

Sequencei

Sequence statusi: Complete.

Q09440-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSDKFKLDT LFDDNDEIIE PDGADVKKRN VAYYYHKDVG HFHYGQLHPM
60 70 80 90 100
KPQRLVVCND LVVSYEMPKY MTVVESPKLD AADISVFHTE DYVNFLQTVT
110 120 130 140 150
PKLGLTMPDD VLRQFNIGED CPIFAGLWDY CTLYAGGSVE GARRLNHKMN
160 170 180 190 200
DIVINWPGGL HHAKKSEASG FCYVNDIVLG ILELLKYHKR VLYIDIDIHH
210 220 230 240 250
GDGVQEAFNN SDRVMTVSFH RFGQYFPGSG SIMDKGVGPG KYFAINVPLM
260 270 280 290 300
AAIRDEPYLK LFESVISGVE ENFNPEAIVL QCGSDSLCED RLGQFALSFN
310 320 330 340 350
AHARAVKYVK SLGKPLMVLG GGGYTLRNVA RCWALETGVI LGLRMDDEIP
360 370 380 390 400
GTSLYSHYFT PRLLRPNLVP KMNDANSAAY LASIEKETLA CLRMIRGAPS
410 420 430 440 450
VQMQNIVGIR LDEIEQIEEN ERLQKSSKSS IEYEVGKVSE KMEEECFVEE
460 470 480 490 500
DSKPPSFPPG QDPRRIGQYW GYDRSGLAPP RSHSDVIEEA KYEDRDRRKD

LNIPGIP
Length:507
Mass (Da):57,138
Last modified:November 1, 1995 - v1
Checksum:iF500D405F7595BAF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46676 Genomic DNA. Translation: CAA86662.1.
PIRiT19067.
RefSeqiNP_495678.1. NM_063277.5.
UniGeneiCel.14857.

Genome annotation databases

EnsemblMetazoaiC08B11.2; C08B11.2; WBGene00001835.
GeneIDi174285.
KEGGicel:CELE_C08B11.2.
UCSCiC08B11.2. c. elegans.

Similar proteinsi

Entry informationi

Entry nameiHDA2_CAEEL
AccessioniPrimary (citable) accession number: Q09440
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: August 30, 2017
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families