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Q09440 (HDA2_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative histone deacetylase 2

EC=3.5.1.98
Gene names
Name:hda-2
ORF Names:C08B11.2
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length507 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Probably responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity.

Catalytic activity

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the histone deacetylase family. HD type 1 subfamily.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Molecular functionChromatin regulator
Hydrolase
Repressor
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processDNA protection

Inferred from mutant phenotype PubMed 12600937. Source: WormBase

chromatin modification

Inferred from sequence or structural similarity PubMed 9531533. Source: WormBase

histone deacetylation

Inferred from sequence or structural similarity PubMed 9531533. Source: WormBase

negative regulation of transcription from RNA polymerase II promoter

Inferred from sequence or structural similarity PubMed 9531533. Source: WormBase

tail tip morphogenesis

Inferred from mutant phenotype PubMed 17506990. Source: WormBase

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componenthistone deacetylase complex

Inferred from sequence or structural similarity PubMed 9531533. Source: WormBase

   Molecular_functionNAD-dependent histone deacetylase activity (H3-K14 specific)

Inferred from electronic annotation. Source: UniProtKB-EC

NAD-dependent histone deacetylase activity (H3-K18 specific)

Inferred from electronic annotation. Source: UniProtKB-EC

NAD-dependent histone deacetylase activity (H3-K9 specific)

Inferred from electronic annotation. Source: UniProtKB-EC

NAD-dependent histone deacetylase activity (H4-K16 specific)

Inferred from electronic annotation. Source: UniProtKB-EC

histone deacetylase activity

Inferred from sequence or structural similarity PubMed 9531533. Source: WormBase

transcription corepressor activity

Inferred from sequence or structural similarity PubMed 9531533. Source: WormBase

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 507507Putative histone deacetylase 2
PRO_0000114720

Regions

Region29 – 342314Histone deacetylase

Sites

Active site1621 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q09440 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: F500D405F7595BAF

FASTA50757,138
        10         20         30         40         50         60 
MSSDKFKLDT LFDDNDEIIE PDGADVKKRN VAYYYHKDVG HFHYGQLHPM KPQRLVVCND 

        70         80         90        100        110        120 
LVVSYEMPKY MTVVESPKLD AADISVFHTE DYVNFLQTVT PKLGLTMPDD VLRQFNIGED 

       130        140        150        160        170        180 
CPIFAGLWDY CTLYAGGSVE GARRLNHKMN DIVINWPGGL HHAKKSEASG FCYVNDIVLG 

       190        200        210        220        230        240 
ILELLKYHKR VLYIDIDIHH GDGVQEAFNN SDRVMTVSFH RFGQYFPGSG SIMDKGVGPG 

       250        260        270        280        290        300 
KYFAINVPLM AAIRDEPYLK LFESVISGVE ENFNPEAIVL QCGSDSLCED RLGQFALSFN 

       310        320        330        340        350        360 
AHARAVKYVK SLGKPLMVLG GGGYTLRNVA RCWALETGVI LGLRMDDEIP GTSLYSHYFT 

       370        380        390        400        410        420 
PRLLRPNLVP KMNDANSAAY LASIEKETLA CLRMIRGAPS VQMQNIVGIR LDEIEQIEEN 

       430        440        450        460        470        480 
ERLQKSSKSS IEYEVGKVSE KMEEECFVEE DSKPPSFPPG QDPRRIGQYW GYDRSGLAPP 

       490        500 
RSHSDVIEEA KYEDRDRRKD LNIPGIP 

« Hide

References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z46676 Genomic DNA. Translation: CAA86662.1.
PIRT19067.
RefSeqNP_495678.1. NM_063277.5.
UniGeneCel.14857.

3D structure databases

ProteinModelPortalQ09440.
SMRQ09440. Positions 28-396.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid39617. 2 interactions.
IntActQ09440. 1 interaction.
MINTMINT-226304.
STRING6239.C08B11.2.

Proteomic databases

PaxDbQ09440.
PRIDEQ09440.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaC08B11.2; C08B11.2; C08B11.2.
GeneID174285.
KEGGcel:CELE_C08B11.2.
UCSCC08B11.2. c. elegans.

Organism-specific databases

CTD174285.
WormBaseC08B11.2; CE01472; WBGene00001835; hda-2.

Phylogenomic databases

eggNOGCOG0123.
HOGENOMHOG000225180.
InParanoidQ09440.
KOK06067.
OMACWALETG.
OrthoDBEOG7VTDRR.
PhylomeDBQ09440.

Family and domain databases

Gene3D3.40.800.20. 1 hit.
InterProIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERPTHR10625. PTHR10625. 1 hit.
PfamPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSPR01270. HDASUPER.
PR01271. HISDACETLASE.
ProtoNetSearch...

Other

NextBio883367.

Entry information

Entry nameHDA2_CAEEL
AccessionPrimary (citable) accession number: Q09440
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase