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Q09438

- MTAP_CAEEL

UniProt

Q09438 - MTAP_CAEEL

Protein

S-methyl-5'-thioadenosine phosphorylase

Gene

B0228.7

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 2 (02 Feb 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.UniRule annotation

    Catalytic activityi

    S-methyl-5'-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei10 – 101PhosphateUniRule annotation
    Sitei170 – 1701Important for substrate specificityUniRule annotation
    Binding sitei188 – 1881Substrate; via amide nitrogenUniRule annotation
    Binding sitei189 – 1891PhosphateUniRule annotation
    Sitei224 – 2241Important for substrate specificityUniRule annotation

    GO - Molecular functioni

    1. phosphorylase activity Source: InterPro
    2. S-methyl-5-thioadenosine phosphorylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. L-methionine biosynthetic process from methylthioadenosine Source: UniProtKB-HAMAP
    2. purine ribonucleoside salvage Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Purine salvage

    Enzyme and pathway databases

    ReactomeiREACT_183249. Methionine salvage pathway.
    SignaLinkiQ09438.
    UniPathwayiUPA00904; UER00873.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    S-methyl-5'-thioadenosine phosphorylaseUniRule annotation (EC:2.4.2.28UniRule annotation)
    Alternative name(s):
    5'-methylthioadenosine phosphorylaseUniRule annotation
    Short name:
    MTA phosphorylaseUniRule annotation
    Short name:
    MTAPUniRule annotation
    Short name:
    MTAPaseUniRule annotation
    Gene namesi
    ORF Names:B0228.7
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome II

    Organism-specific databases

    WormBaseiB0228.7; CE34630; WBGene00015064.

    Subcellular locationi

    Cytoplasm UniRule annotation. Nucleus UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 288288S-methyl-5'-thioadenosine phosphorylasePRO_0000184547Add
    BLAST

    Proteomic databases

    PaxDbiQ09438.

    Interactioni

    Subunit structurei

    Homotrimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi6239.B0228.7.2.

    Structurei

    3D structure databases

    ProteinModelPortaliQ09438.
    SMRiQ09438. Positions 2-271.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni52 – 532Phosphate bindingUniRule annotation
    Regioni85 – 862Phosphate bindingUniRule annotation
    Regioni212 – 2143Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0005.
    GeneTreeiENSGT00550000074874.
    HOGENOMiHOG000228987.
    InParanoidiQ09438.
    KOiK00772.
    OMAiNARANIW.
    PhylomeDBiQ09438.

    Family and domain databases

    Gene3Di3.40.50.1580. 1 hit.
    HAMAPiMF_01963. MTAP.
    InterProiIPR010044. MTAP.
    IPR000845. Nucleoside_phosphorylase_d.
    IPR001369. PNP/MTAP.
    IPR018099. Purine_phosphorylase-2_CS.
    [Graphical view]
    PANTHERiPTHR11904. PTHR11904. 1 hit.
    PfamiPF01048. PNP_UDP_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF53167. SSF53167. 1 hit.
    TIGRFAMsiTIGR01694. MTAP. 1 hit.
    PROSITEiPS01240. PNP_MTAP_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q09438-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVKVGIIGGS GLEDPNILLD PVTVAVDTPY GKPSDDVVEG TINGVECVLL    50
    ARHGRKHDIM PGNVNFRANL WALYSRGVDV IIASTACGSL QENVEPGHLL 100
    FPDSVFDRTT GRQSTFFDGS YDQAPGVCHI QAHPTYNEKL RQVLISTAER 150
    CQLVHHRTGF GVCIEGPRFS TKAESMVFKS WGASLVNMTM MPECILAKEL 200
    GIPYATTALV TDYDCWKEED HVTASSVMKV FAANVEKAKT LFVEAVGEIG 250
    KIDWSAEILK LKTEARESVM ISPDVVIPFL TTDNQKKF 288
    Length:288
    Mass (Da):31,564
    Last modified:February 2, 2004 - v2
    Checksum:iA998E73C52DA1D3C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080130 Genomic DNA. Translation: CCD61451.1.
    PIRiT29047.
    RefSeqiNP_495629.2. NM_063228.6.
    UniGeneiCel.16075.

    Genome annotation databases

    EnsemblMetazoaiB0228.7.1; B0228.7.1; WBGene00015064.
    B0228.7.2; B0228.7.2; WBGene00015064.
    GeneIDi174252.
    KEGGicel:CELE_B0228.7.
    UCSCiB0228.7.1. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080130 Genomic DNA. Translation: CCD61451.1 .
    PIRi T29047.
    RefSeqi NP_495629.2. NM_063228.6.
    UniGenei Cel.16075.

    3D structure databases

    ProteinModelPortali Q09438.
    SMRi Q09438. Positions 2-271.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6239.B0228.7.2.

    Proteomic databases

    PaxDbi Q09438.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai B0228.7.1 ; B0228.7.1 ; WBGene00015064 .
    B0228.7.2 ; B0228.7.2 ; WBGene00015064 .
    GeneIDi 174252.
    KEGGi cel:CELE_B0228.7.
    UCSCi B0228.7.1. c. elegans.

    Organism-specific databases

    CTDi 174252.
    WormBasei B0228.7 ; CE34630 ; WBGene00015064 .

    Phylogenomic databases

    eggNOGi COG0005.
    GeneTreei ENSGT00550000074874.
    HOGENOMi HOG000228987.
    InParanoidi Q09438.
    KOi K00772.
    OMAi NARANIW.
    PhylomeDBi Q09438.

    Enzyme and pathway databases

    UniPathwayi UPA00904 ; UER00873 .
    Reactomei REACT_183249. Methionine salvage pathway.
    SignaLinki Q09438.

    Miscellaneous databases

    NextBioi 883235.
    PROi Q09438.

    Family and domain databases

    Gene3Di 3.40.50.1580. 1 hit.
    HAMAPi MF_01963. MTAP.
    InterProi IPR010044. MTAP.
    IPR000845. Nucleoside_phosphorylase_d.
    IPR001369. PNP/MTAP.
    IPR018099. Purine_phosphorylase-2_CS.
    [Graphical view ]
    PANTHERi PTHR11904. PTHR11904. 1 hit.
    Pfami PF01048. PNP_UDP_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53167. SSF53167. 1 hit.
    TIGRFAMsi TIGR01694. MTAP. 1 hit.
    PROSITEi PS01240. PNP_MTAP_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiMTAP_CAEEL
    AccessioniPrimary (citable) accession number: Q09438
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: February 2, 2004
    Last modified: October 1, 2014
    This is version 95 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3