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Q09438

- MTAP_CAEEL

UniProt

Q09438 - MTAP_CAEEL

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Protein
S-methyl-5'-thioadenosine phosphorylase
Gene
B0228.7
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates By similarity.UniRule annotation

Catalytic activityi

S-methyl-5'-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei10 – 101Phosphate By similarity
Sitei170 – 1701Important for substrate specificity By similarity
Binding sitei188 – 1881Substrate; via amide nitrogen By similarity
Binding sitei189 – 1891Phosphate By similarity
Sitei224 – 2241Important for substrate specificity By similarity

GO - Molecular functioni

  1. S-methyl-5-thioadenosine phosphorylase activity Source: UniProtKB-HAMAP
  2. phosphorylase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. L-methionine salvage from methylthioadenosine Source: UniProtKB-HAMAP
  2. purine ribonucleoside salvage Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Purine salvage

Enzyme and pathway databases

ReactomeiREACT_183249. Methionine salvage pathway.
SignaLinkiQ09438.
UniPathwayiUPA00904; UER00873.

Names & Taxonomyi

Protein namesi
Recommended name:
S-methyl-5'-thioadenosine phosphorylase (EC:2.4.2.28)
Alternative name(s):
5'-methylthioadenosine phosphorylase
Short name:
MTA phosphorylase
Short name:
MTAP
Short name:
MTAPase
Gene namesi
ORF Names:B0228.7
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome II

Organism-specific databases

WormBaseiB0228.7; CE34630; WBGene00015064.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 288288S-methyl-5'-thioadenosine phosphorylaseUniRule annotation
PRO_0000184547Add
BLAST

Proteomic databases

PaxDbiQ09438.

Interactioni

Subunit structurei

Homotrimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi6239.B0228.7.2.

Structurei

3D structure databases

ProteinModelPortaliQ09438.
SMRiQ09438. Positions 2-271.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni52 – 532Phosphate binding By similarity
Regioni85 – 862Phosphate binding By similarity
Regioni212 – 2143Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0005.
GeneTreeiENSGT00550000074874.
HOGENOMiHOG000228987.
InParanoidiQ09438.
KOiK00772.
OMAiNARANIW.
PhylomeDBiQ09438.

Family and domain databases

Gene3Di3.40.50.1580. 1 hit.
HAMAPiMF_01963. MTAP.
InterProiIPR010044. MTAP.
IPR000845. Nucleoside_phosphorylase_d.
IPR001369. PNP/MTAP.
IPR018099. Purine_phosphorylase-2_CS.
[Graphical view]
PANTHERiPTHR11904. PTHR11904. 1 hit.
PfamiPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
SUPFAMiSSF53167. SSF53167. 1 hit.
TIGRFAMsiTIGR01694. MTAP. 1 hit.
PROSITEiPS01240. PNP_MTAP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q09438-1 [UniParc]FASTAAdd to Basket

« Hide

MVKVGIIGGS GLEDPNILLD PVTVAVDTPY GKPSDDVVEG TINGVECVLL    50
ARHGRKHDIM PGNVNFRANL WALYSRGVDV IIASTACGSL QENVEPGHLL 100
FPDSVFDRTT GRQSTFFDGS YDQAPGVCHI QAHPTYNEKL RQVLISTAER 150
CQLVHHRTGF GVCIEGPRFS TKAESMVFKS WGASLVNMTM MPECILAKEL 200
GIPYATTALV TDYDCWKEED HVTASSVMKV FAANVEKAKT LFVEAVGEIG 250
KIDWSAEILK LKTEARESVM ISPDVVIPFL TTDNQKKF 288
Length:288
Mass (Da):31,564
Last modified:February 2, 2004 - v2
Checksum:iA998E73C52DA1D3C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO080130 Genomic DNA. Translation: CCD61451.1.
PIRiT29047.
RefSeqiNP_495629.2. NM_063228.6.
UniGeneiCel.16075.

Genome annotation databases

EnsemblMetazoaiB0228.7.1; B0228.7.1; WBGene00015064.
B0228.7.2; B0228.7.2; WBGene00015064.
GeneIDi174252.
KEGGicel:CELE_B0228.7.
UCSCiB0228.7.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO080130 Genomic DNA. Translation: CCD61451.1 .
PIRi T29047.
RefSeqi NP_495629.2. NM_063228.6.
UniGenei Cel.16075.

3D structure databases

ProteinModelPortali Q09438.
SMRi Q09438. Positions 2-271.
ModBasei Search...

Protein-protein interaction databases

STRINGi 6239.B0228.7.2.

Proteomic databases

PaxDbi Q09438.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai B0228.7.1 ; B0228.7.1 ; WBGene00015064 .
B0228.7.2 ; B0228.7.2 ; WBGene00015064 .
GeneIDi 174252.
KEGGi cel:CELE_B0228.7.
UCSCi B0228.7.1. c. elegans.

Organism-specific databases

CTDi 174252.
WormBasei B0228.7 ; CE34630 ; WBGene00015064 .

Phylogenomic databases

eggNOGi COG0005.
GeneTreei ENSGT00550000074874.
HOGENOMi HOG000228987.
InParanoidi Q09438.
KOi K00772.
OMAi NARANIW.
PhylomeDBi Q09438.

Enzyme and pathway databases

UniPathwayi UPA00904 ; UER00873 .
Reactomei REACT_183249. Methionine salvage pathway.
SignaLinki Q09438.

Miscellaneous databases

NextBioi 883235.
PROi Q09438.

Family and domain databases

Gene3Di 3.40.50.1580. 1 hit.
HAMAPi MF_01963. MTAP.
InterProi IPR010044. MTAP.
IPR000845. Nucleoside_phosphorylase_d.
IPR001369. PNP/MTAP.
IPR018099. Purine_phosphorylase-2_CS.
[Graphical view ]
PANTHERi PTHR11904. PTHR11904. 1 hit.
Pfami PF01048. PNP_UDP_1. 1 hit.
[Graphical view ]
SUPFAMi SSF53167. SSF53167. 1 hit.
TIGRFAMsi TIGR01694. MTAP. 1 hit.
PROSITEi PS01240. PNP_MTAP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiMTAP_CAEEL
AccessioniPrimary (citable) accession number: Q09438
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: February 2, 2004
Last modified: September 3, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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