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Q09435 (GCY1_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Guanylate cyclase receptor-type gcy-1
EC=4.6.1.2
Gene names
Name:gcy-1
ORF Names:AH6.1
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length1137 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

GTP = 3',5'-cyclic GMP + diphosphate.

Subcellular location

Membrane; Single-pass type I membrane protein Potential.

Sequence similarities

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

Contains 1 guanylate cyclase domain.

Contains 1 protein kinase domain.

Ontologies

Keywords
   Biological processcGMP biosynthesis
   Cellular componentMembrane
   DomainSignal
Transmembrane
Transmembrane helix
   LigandGTP-binding
Nucleotide-binding
   Molecular functionLyase
Receptor
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processintracellular signal transduction

Inferred from electronic annotation. Source: InterPro

   Cellular_componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionATP binding

Inferred from electronic annotation. Source: InterPro

GTP binding

Inferred from electronic annotation. Source: UniProtKB-KW

guanylate cyclase activity

Inferred from electronic annotation. Source: EC

protein kinase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 11371119Guanylate cyclase receptor-type gcy-1
PRO_0000012388

Regions

Topological domain19 – 494476Extracellular Potential
Transmembrane495 – 51521Helical; Potential
Topological domain516 – 1137622Cytoplasmic Potential
Domain557 – 826270Protein kinase
Domain898 – 1028131Guanylate cyclase

Amino acid modifications

Glycosylation2191N-linked (GlcNAc...) Potential
Glycosylation3481N-linked (GlcNAc...) Potential
Glycosylation3581N-linked (GlcNAc...) Potential
Glycosylation3841N-linked (GlcNAc...) Potential
Glycosylation4171N-linked (GlcNAc...) Potential
Glycosylation4511N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q09435 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 93EC01501F0228F9

FASTA1,137128,104
        10         20         30         40         50         60 
MQIFTILLLF NIFPSIFVQN LPDTTVAPRT KRTIKIGIAA AQRIQTSSIG WSVCGGAVPL 

        70         80         90        100        110        120 
AIERLKEMGF VKDFDFEYIV DYTECDLGSV VRAGMEFIKT HKVDVIIGPP CAQALRLMSF 

       130        140        150        160        170        180 
LAENYKKPVL GWGFVSDTDL SDVIRFPHLT TVIPNSLMLG YAASKMLTTF HWNRVALLYY 

       190        200        210        220        230        240 
FSDVKYCSGV MNDIEATFND PSTPNVNIVI KAEIYLNDNE TTDNVFQTVK SRARIILWCT 

       250        260        270        280        290        300 
QTSVEKRDYL IKIATHDMIG DEYVHIMLSM RNVAFGTQTS LGKPTFSQSG LTPIWESFTE 

       310        320        330        340        350        360 
GTDGFEKMAK QAATRMFVLD VNSEVADKKY LEYMQKNIIK AVQSPPMNCS TVECMTANTT 

       370        380        390        400        410        420 
IMGGYARHLF DVVYLYGIAL THTNSTDPAV YGDVDVLVHQ FVTSFQGMTG HVVISPNLTR 

       430        440        450        460        470        480 
MPIFQLYGLN SDYDQVALVD FTYTNSVMVP NVTLFYKDEG GAVWSYYGHS RPLDIPICGF 

       490        500        510        520        530        540 
LGKSCPVSFW EQYKILIFVA IAVIVLMVLI MIIGCLCVIS GKRAERARIN AEWQVPFAKL 

       550        560        570        580        590        600 
IESEKQVRGK GASRRSLQSA PSISTGHSGV TTVSDFCENY TMMMYEKEMV LTAKYQYTHL 

       610        620        630        640        650        660 
TKADKERFVK MRKLDHENIN RFIGLSIDSA HFISVTKLCS RGSLQDILSR GNFSMDYFFM 

       670        680        690        700        710        720 
FCIIRDVAKG LEYLHKTFLR LHGNLRSATC LVNDSWQVKL AEYGMDNLVE EQTPPKKRLL 

       730        740        750        760        770        780 
WVAPEVLRGS LSVSQMEPSA DIYSFAIIAS EILTKKEAWD ILDRKEDCEE IVYNVKKGGL 

       790        800        810        820        830        840 
FPIRPEIITD IHDVNPALIA LVKDCWAEVP EDRPTAENIC SQMKGLVSKQ KTNLMDHVFN 

       850        860        870        880        890        900 
MLEEYTSTLE EEIEERTKEL TLEKKKADIL LSRMLPKQVA ERLKAGQTVE PEGFDSVTVF 

       910        920        930        940        950        960 
FSDVVKFTIL ASKCSPFQTV NLLNDLYSNF DTIIEQHGVY KVESIGDGYL CVSGLPTRNG 

       970        980        990       1000       1010       1020 
YAHIKQIVDM SLKFMEYCKS FNIPHLPREN VELRIGVNSG PCVAGVVGLS MPRYCLFGDT 

      1030       1040       1050       1060       1070       1080 
VNTASRMESN GKPSLIHLTN DAHSLLTTHY PNQYETSSRG EVIIKGKGVM ETFWVHGRFG 

      1090       1100       1110       1120       1130 
EMEPTELRSI SNRSTPPVTN DRWIPNPSSS HGSRPSSVYD PLQGHQKFKM DTLKVAN

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References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		Z48009 Genomic DNA. Translation: CAA88089.1.
PIRT18625.
RefSeqNP_496039.1. NM_063638.1.
UniGeneCel.28717.

3D structure databases

ProteinModelPortalQ09435.
SMRQ09435. Positions 102-440, 544-828, 887-1046.
ModBaseSearch...

Protein-protein interaction databases

STRING6239.AH6.1.

Proteomic databases

PaxDbQ09435.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaAH6.1; AH6.1; AH6.1.
GeneID191639.
KEGGcel:CELE_AH6.1.
UCSCAH6.1. c. elegans.

Organism-specific databases

CTD191639.
WormBaseAH6.1; CE01450; WBGene00001528; gcy-1.

Phylogenomic databases

eggNOGCOG0515.
GeneTreeENSGT00690000101902.
HOGENOMHOG000016255.
InParanoidQ09435.
KOK01769.
OMAIVEYTEC.

Family and domain databases

Gene3D3.30.70.1230. 1 hit.
InterProIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR001828. ANF_lig-bd_rcpt.
IPR011645. Haem_no_assoc-bd.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_cat_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
[Graphical view]
PfamPF01094. ANF_receptor. 1 hit.
PF00211. Guanylate_cyc. 1 hit.
PF07701. HNOBA. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
SMARTSM00044. CYCc. 1 hit.
[Graphical view]
SUPFAMSSF55073. A/G_cyclase. 1 hit.
SSF56112. Kinase_like. 1 hit.
PROSITEPS00452. GUANYLATE_CYCLASE_1. 1 hit.
PS50125. GUANYLATE_CYCLASE_2. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio949780.

Entry information

Entry nameGCY1_CAEEL
AccessionPrimary (citable) accession number: Q09435
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 1, 2013
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase

SIMILARITY comments

Index of protein domains and families

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