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Protein

ATP-binding cassette sub-family C member 8

Gene

Abcc8

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Subunit of the beta-cell ATP-sensitive potassium channel (KATP). Regulator of ATP-sensitive K+ channels and insulin release.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi713 – 720ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1379 – 1386ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

  • ATPase activity, coupled to transmembrane movement of substances Source: InterPro
  • ATP binding Source: RGD
  • potassium channel activity Source: UniProtKB
  • sulfonylurea receptor activity Source: RGD
  • syntaxin binding Source: RGD

GO - Biological processi

  • cellular response to organic substance Source: RGD
  • negative regulation of insulin secretion Source: RGD
  • positive regulation of potassium ion transport Source: RGD
  • response to drug Source: RGD
  • response to insulin Source: RGD
  • response to lipopolysaccharide Source: RGD
  • response to pH Source: RGD
  • response to zinc ion Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-1296025. ATP sensitive Potassium channels.
R-RNO-382556. ABC-family proteins mediated transport.
R-RNO-422356. Regulation of insulin secretion.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family C member 8
Alternative name(s):
Sulfonylurea receptor 1
Gene namesi
Name:Abcc8
Synonyms:Sur, Sur1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi3786. Abcc8.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 34ExtracellularBy similarityAdd BLAST34
Transmembranei35 – 55Helical; Name=1PROSITE-ProRule annotationAdd BLAST21
Topological domaini56 – 75CytoplasmicBy similarityAdd BLAST20
Transmembranei76 – 96Helical; Name=2PROSITE-ProRule annotationAdd BLAST21
Topological domaini97 – 101ExtracellularBy similarity5
Transmembranei102 – 122Helical; Name=3PROSITE-ProRule annotationAdd BLAST21
Topological domaini123 – 134CytoplasmicBy similarityAdd BLAST12
Transmembranei135 – 154Helical; Name=4PROSITE-ProRule annotationAdd BLAST20
Topological domaini155 – 168ExtracellularBy similarityAdd BLAST14
Transmembranei169 – 194Helical; Name=5PROSITE-ProRule annotationAdd BLAST26
Topological domaini195 – 311CytoplasmicBy similarityAdd BLAST117
Transmembranei312 – 331Helical; Name=6PROSITE-ProRule annotationAdd BLAST20
Topological domaini332 – 355ExtracellularBy similarityAdd BLAST24
Transmembranei356 – 376Helical; Name=7PROSITE-ProRule annotationAdd BLAST21
Topological domaini377 – 434CytoplasmicBy similarityAdd BLAST58
Transmembranei435 – 455Helical; Name=8PROSITE-ProRule annotationAdd BLAST21
Topological domaini456 – 458ExtracellularBy similarity3
Transmembranei459 – 479Helical; Name=9PROSITE-ProRule annotationAdd BLAST21
Topological domaini480 – 541CytoplasmicBy similarityAdd BLAST62
Transmembranei542 – 562Helical; Name=10PROSITE-ProRule annotationAdd BLAST21
Topological domaini563 – 584ExtracellularBy similarityAdd BLAST22
Transmembranei585 – 605Helical; Name=11PROSITE-ProRule annotationAdd BLAST21
Topological domaini606 – 1005CytoplasmicBy similarityAdd BLAST400
Transmembranei1006 – 1026Helical; Name=12PROSITE-ProRule annotationAdd BLAST21
Topological domaini1027 – 1073ExtracellularBy similarityAdd BLAST47
Transmembranei1074 – 1094Helical; Name=13PROSITE-ProRule annotationAdd BLAST21
Topological domaini1095 – 1138CytoplasmicBy similarityAdd BLAST44
Transmembranei1139 – 1159Helical; Name=14PROSITE-ProRule annotationAdd BLAST21
Topological domaini1160ExtracellularBy similarity1
Transmembranei1161 – 1181Helical; Name=15PROSITE-ProRule annotationAdd BLAST21
Topological domaini1182 – 1252CytoplasmicBy similarityAdd BLAST71
Transmembranei1253 – 1273Helical; Name=16PROSITE-ProRule annotationAdd BLAST21
Topological domaini1274 – 1277ExtracellularBy similarity4
Transmembranei1278 – 1298Helical; Name=17PROSITE-ProRule annotationAdd BLAST21
Topological domaini1299 – 1582CytoplasmicBy similarityAdd BLAST284

GO - Cellular componenti

  • ATP-sensitive potassium channel complex Source: RGD
  • sarcolemma Source: RGD
  • synaptic vesicle membrane Source: RGD
  • voltage-gated potassium channel complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1944490.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000934011 – 1582ATP-binding cassette sub-family C member 8Add BLAST1582

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi10N-linked (GlcNAc...)1 Publication1
Glycosylationi1050N-linked (GlcNAc...)By similarity1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ09429.
PRIDEiQ09429.

Expressioni

Gene expression databases

ExpressionAtlasiQ09429. baseline and differential.
GenevisibleiQ09429. RN.

Interactioni

Subunit structurei

Interacts with KCNJ11.By similarity

GO - Molecular functioni

  • syntaxin binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028696.

Chemistry databases

BindingDBiQ09429.

Structurei

3D structure databases

ProteinModelPortaliQ09429.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini299 – 602ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST304
Domaini679 – 930ABC transporter 1PROSITE-ProRule annotationAdd BLAST252
Domaini1013 – 1307ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST295
Domaini1345 – 1579ABC transporter 2PROSITE-ProRule annotationAdd BLAST235

Sequence similaritiesi

Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0054. Eukaryota.
COG1132. LUCA.
GeneTreeiENSGT00860000133722.
HOVERGENiHBG101342.
InParanoidiQ09429.
KOiK05032.
OMAiQGQASKY.
OrthoDBiEOG091G00IN.
PhylomeDBiQ09429.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR000844. ABCC8.
IPR027417. P-loop_NTPase.
IPR000388. Sulphorea_rcpt.
[Graphical view]
PANTHERiPTHR24223:SF187. PTHR24223:SF187. 4 hits.
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
PRINTSiPR01093. SULFNYLUR1.
PR01092. SULFNYLUREAR.
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Experimental confirmation may be lacking for some isoforms.
Isoform A (identifier: Q09429-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPLAFCGTEN HSAAYRVDQG VLNNGCFVDA LNVVPHVFLL FITFPILFIG
60 70 80 90 100
WGSQSSKVHI HHSTWLHFPG HNLRWILTFI LLFVLVCEIA EGILSDGVTE
110 120 130 140 150
SRHLHLYMPA GMAFMAAITS VVYYHNIETS NFPKLLIALL IYWTLAFITK
160 170 180 190 200
TIKFVKFYDH AIGFSQLRFC LTGLLVILYG MLLLVEVNVI RVRRYVFFKT
210 220 230 240 250
PREVKPPEDL QDLGVRFLQP FVNLLSKGTY WWMNAFIKTA HKKPIDLRAI
260 270 280 290 300
GKLPIAMRAL TNYQRLCLAF DAQARKDTQS QQGARAIWRA LCHAFGRRLV
310 320 330 340 350
LSSTFRILAD LLGFAGPLCI FGIVDHLGKE NHVFQPKTQF LGVYFVSSQE
360 370 380 390 400
FLGNAYVLAV LLFLALLLQR TFLQASYYVA IETGINLRGA IQTKIYNKIM
410 420 430 440 450
HLSTSNLSMG EMTAGQICNL VAIDTNQLMW FFFLCPNLWA MPVQIIVGVI
460 470 480 490 500
LLYYILGVSA LIGAAVIILL APVQYFVATK LSQAQRSTLE YSNERLKQTN
510 520 530 540 550
EMLRGIKLLK LYAWENIFCS RVEKTRRKEM TSLRAFAVYT SISIFMNTAI
560 570 580 590 600
PIAAVLITFV GHVSFFKESD FSPSVAFASL SLFHILVTPL FLLSSVVRST
610 620 630 640 650
VKALVSVQKL SEFLSSAEIR EEQCAPREPA PQGQAGKYQA VPLKVVNRKR
660 670 680 690 700
PAREEVRDLL GPLQRLTPST DGDADNFCVQ IIGGFFTWTP DGIPTLSNIT
710 720 730 740 750
IRIPRGQLTM IVGQVGCGKS SLLLATLGEM QKVSGAVFWN SSLPDSEGED
760 770 780 790 800
PSNPERETAA DSDARSRGPV AYASQKPWLL NATVEENITF ESPFNKQRYK
810 820 830 840 850
MVIEACSLQP DIDILPHGDQ TQIGERGINL SGGQRQRISV ARALYQHTNV
860 870 880 890 900
VFLDDPFSAL DVHLSDHLMQ AGILELLRDD KRTVVLVTHK LQYLPHADWI
910 920 930 940 950
IAMKDGTIQR EGTLKDFQRS ECQLFEHWKT LMNRQDQELE KETVMERKAP
960 970 980 990 1000
EPSQGLPRAM SSRDGLLLDE DEEEEEAAES EEDDNLSSVL HQRAKIPWRA
1010 1020 1030 1040 1050
CTKYLSSAGI LLLSLLVFSQ LLKHMVLVAI DYWLAKWTDS ALVLSPAARN
1060 1070 1080 1090 1100
CSLSQECALD QSVYAMVFTV LCSLGIALCL VTSVTVEWTG LKVAKRLHRS
1110 1120 1130 1140 1150
LLNRIILAPM RFFETTPLGS ILNRFSSDCN TIDQHIPSTL ECLSRSTLLC
1160 1170 1180 1190 1200
VSALAVISYV TPVFLVALLP LAVVCYFIQK YFRVASRDLQ QLDDTTQLPL
1210 1220 1230 1240 1250
LSHFAETVEG LTTIRAFRYE ARFQQKLLEY TDSNNIASLF LTAANRWLEV
1260 1270 1280 1290 1300
RMEYIGACVV LIAAATSISN SLHRELSAGL VGLGLTYALM VSNYLNWMVR
1310 1320 1330 1340 1350
NLADMEIQLG AVKRIHTLLK TEAESYEGLL APSLIPKNWP DQGKIQIQNL
1360 1370 1380 1390 1400
SVRYDSSLKP VLKHVNALIS PGQKIGICGR TGSGKSSFSL AFFRMVDMFE
1410 1420 1430 1440 1450
GRIIIDGIDI AKLPLHTLRS RLSIILQDPV LFSGTIRFNL DPEKKCSDST
1460 1470 1480 1490 1500
LWEALEIAQL KLVVKALPGG LDAIITEGGE NFSQGQRQLF CLARAFVRKT
1510 1520 1530 1540 1550
SIFIMDEATA SIDMATENIL QKVVMTAFAD RTVVTIAHRV HTILSADLVM
1560 1570 1580
VLKRGAILEF DKPEKLLSQK DSVFASFVRA DK
Length:1,582
Mass (Da):177,185
Last modified:January 23, 2007 - v4
Checksum:i7C57A1CFC86B9214
GO
Isoform B (identifier: Q09429-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1252-1289: Missing.

Show »
Length:1,544
Mass (Da):173,324
Checksum:i338163E4F264FCFE
GO
Isoform C (identifier: Q09429-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     741-741: Missing.

Show »
Length:1,581
Mass (Da):177,097
Checksum:i722EC6057F4333BC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti487S → T in AAA99237 (PubMed:7716547).Curated1
Sequence conflicti699I → T in BAB19011 (Ref. 4) Curated1
Sequence conflicti836 – 837QR → PG in AAA99237 (PubMed:7716547).Curated2
Sequence conflicti1314R → G in AAA99237 (PubMed:7716547).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_000056741Missing in isoform C. 1 Publication1
Alternative sequenceiVSP_0000571252 – 1289Missing in isoform B. 1 PublicationAdd BLAST38

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L40624 mRNA. Translation: AAA99237.1.
X97279 mRNA. Translation: CAA65934.1.
AF039595 mRNA. Translation: AAB96684.1.
AB052294 mRNA. Translation: BAB19011.1.
RefSeqiNP_037171.2. NM_013039.2. [Q09429-1]
XP_008757542.1. XM_008759320.2. [Q09429-3]
UniGeneiRn.11187.

Genome annotation databases

EnsembliENSRNOT00000028696; ENSRNOP00000028696; ENSRNOG00000021130. [Q09429-1]
ENSRNOT00000038798; ENSRNOP00000035010; ENSRNOG00000021130. [Q09429-2]
GeneIDi25559.
KEGGirno:25559.
UCSCiRGD:3786. rat. [Q09429-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L40624 mRNA. Translation: AAA99237.1.
X97279 mRNA. Translation: CAA65934.1.
AF039595 mRNA. Translation: AAB96684.1.
AB052294 mRNA. Translation: BAB19011.1.
RefSeqiNP_037171.2. NM_013039.2. [Q09429-1]
XP_008757542.1. XM_008759320.2. [Q09429-3]
UniGeneiRn.11187.

3D structure databases

ProteinModelPortaliQ09429.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028696.

Chemistry databases

BindingDBiQ09429.
ChEMBLiCHEMBL1944490.

Proteomic databases

PaxDbiQ09429.
PRIDEiQ09429.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000028696; ENSRNOP00000028696; ENSRNOG00000021130. [Q09429-1]
ENSRNOT00000038798; ENSRNOP00000035010; ENSRNOG00000021130. [Q09429-2]
GeneIDi25559.
KEGGirno:25559.
UCSCiRGD:3786. rat. [Q09429-1]

Organism-specific databases

CTDi6833.
RGDi3786. Abcc8.

Phylogenomic databases

eggNOGiKOG0054. Eukaryota.
COG1132. LUCA.
GeneTreeiENSGT00860000133722.
HOVERGENiHBG101342.
InParanoidiQ09429.
KOiK05032.
OMAiQGQASKY.
OrthoDBiEOG091G00IN.
PhylomeDBiQ09429.

Enzyme and pathway databases

ReactomeiR-RNO-1296025. ATP sensitive Potassium channels.
R-RNO-382556. ABC-family proteins mediated transport.
R-RNO-422356. Regulation of insulin secretion.

Miscellaneous databases

PROiQ09429.

Gene expression databases

ExpressionAtlasiQ09429. baseline and differential.
GenevisibleiQ09429. RN.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR000844. ABCC8.
IPR027417. P-loop_NTPase.
IPR000388. Sulphorea_rcpt.
[Graphical view]
PANTHERiPTHR24223:SF187. PTHR24223:SF187. 4 hits.
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
PRINTSiPR01093. SULFNYLUR1.
PR01092. SULFNYLUREAR.
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiABCC8_RAT
AccessioniPrimary (citable) accession number: Q09429
Secondary accession number(s): O54989, P70532, Q9EQT0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 140 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.