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Protein

ATP-binding cassette sub-family C member 8

Gene

Abcc8

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Subunit of the beta-cell ATP-sensitive potassium channel (KATP). Regulator of ATP-sensitive K+ channels and insulin release.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi713 – 7208ATP 1PROSITE-ProRule annotation
Nucleotide bindingi1379 – 13868ATP 2PROSITE-ProRule annotation

GO - Molecular functioni

  • ATPase activity, coupled to transmembrane movement of substances Source: InterPro
  • ATP binding Source: RGD
  • potassium channel activity Source: UniProtKB
  • sulfonylurea receptor activity Source: RGD
  • syntaxin binding Source: RGD

GO - Biological processi

  • cellular response to organic substance Source: RGD
  • negative regulation of insulin secretion Source: RGD
  • positive regulation of potassium ion transport Source: RGD
  • response to drug Source: RGD
  • response to insulin Source: RGD
  • response to lipopolysaccharide Source: RGD
  • response to pH Source: RGD
  • response to zinc ion Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-1296025. ATP sensitive Potassium channels.
R-RNO-382556. ABC-family proteins mediated transport.
R-RNO-422356. Regulation of insulin secretion.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family C member 8
Alternative name(s):
Sulfonylurea receptor 1
Gene namesi
Name:Abcc8
Synonyms:Sur, Sur1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi3786. Abcc8.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3434ExtracellularBy similarityAdd
BLAST
Transmembranei35 – 5521Helical; Name=1PROSITE-ProRule annotationAdd
BLAST
Topological domaini56 – 7520CytoplasmicBy similarityAdd
BLAST
Transmembranei76 – 9621Helical; Name=2PROSITE-ProRule annotationAdd
BLAST
Topological domaini97 – 1015ExtracellularBy similarity
Transmembranei102 – 12221Helical; Name=3PROSITE-ProRule annotationAdd
BLAST
Topological domaini123 – 13412CytoplasmicBy similarityAdd
BLAST
Transmembranei135 – 15420Helical; Name=4PROSITE-ProRule annotationAdd
BLAST
Topological domaini155 – 16814ExtracellularBy similarityAdd
BLAST
Transmembranei169 – 19426Helical; Name=5PROSITE-ProRule annotationAdd
BLAST
Topological domaini195 – 311117CytoplasmicBy similarityAdd
BLAST
Transmembranei312 – 33120Helical; Name=6PROSITE-ProRule annotationAdd
BLAST
Topological domaini332 – 35524ExtracellularBy similarityAdd
BLAST
Transmembranei356 – 37621Helical; Name=7PROSITE-ProRule annotationAdd
BLAST
Topological domaini377 – 43458CytoplasmicBy similarityAdd
BLAST
Transmembranei435 – 45521Helical; Name=8PROSITE-ProRule annotationAdd
BLAST
Topological domaini456 – 4583ExtracellularBy similarity
Transmembranei459 – 47921Helical; Name=9PROSITE-ProRule annotationAdd
BLAST
Topological domaini480 – 54162CytoplasmicBy similarityAdd
BLAST
Transmembranei542 – 56221Helical; Name=10PROSITE-ProRule annotationAdd
BLAST
Topological domaini563 – 58422ExtracellularBy similarityAdd
BLAST
Transmembranei585 – 60521Helical; Name=11PROSITE-ProRule annotationAdd
BLAST
Topological domaini606 – 1005400CytoplasmicBy similarityAdd
BLAST
Transmembranei1006 – 102621Helical; Name=12PROSITE-ProRule annotationAdd
BLAST
Topological domaini1027 – 107347ExtracellularBy similarityAdd
BLAST
Transmembranei1074 – 109421Helical; Name=13PROSITE-ProRule annotationAdd
BLAST
Topological domaini1095 – 113844CytoplasmicBy similarityAdd
BLAST
Transmembranei1139 – 115921Helical; Name=14PROSITE-ProRule annotationAdd
BLAST
Topological domaini1160 – 11601ExtracellularBy similarity
Transmembranei1161 – 118121Helical; Name=15PROSITE-ProRule annotationAdd
BLAST
Topological domaini1182 – 125271CytoplasmicBy similarityAdd
BLAST
Transmembranei1253 – 127321Helical; Name=16PROSITE-ProRule annotationAdd
BLAST
Topological domaini1274 – 12774ExtracellularBy similarity
Transmembranei1278 – 129821Helical; Name=17PROSITE-ProRule annotationAdd
BLAST
Topological domaini1299 – 1582284CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

  • ATP-sensitive potassium channel complex Source: RGD
  • sarcolemma Source: RGD
  • synaptic vesicle membrane Source: RGD
  • voltage-gated potassium channel complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL3038487.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15821582ATP-binding cassette sub-family C member 8PRO_0000093401Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi10 – 101N-linked (GlcNAc...)1 Publication
Glycosylationi1050 – 10501N-linked (GlcNAc...)By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ09429.
PRIDEiQ09429.

Expressioni

Gene expression databases

ExpressionAtlasiQ09429. baseline and differential.
GenevisibleiQ09429. RN.

Interactioni

Subunit structurei

Interacts with KCNJ11.By similarity

GO - Molecular functioni

  • syntaxin binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028696.

Chemistry

BindingDBiQ09429.

Structurei

3D structure databases

ProteinModelPortaliQ09429.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini299 – 602304ABC transmembrane type-1 1PROSITE-ProRule annotationAdd
BLAST
Domaini679 – 930252ABC transporter 1PROSITE-ProRule annotationAdd
BLAST
Domaini1013 – 1307295ABC transmembrane type-1 2PROSITE-ProRule annotationAdd
BLAST
Domaini1345 – 1579235ABC transporter 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0054. Eukaryota.
COG1132. LUCA.
GeneTreeiENSGT00840000129727.
HOVERGENiHBG101342.
InParanoidiQ09429.
KOiK05032.
OMAiQGQASKY.
OrthoDBiEOG091G00IN.
PhylomeDBiQ09429.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR000844. ABCC8.
IPR027417. P-loop_NTPase.
IPR000388. Sulphorea_rcpt.
[Graphical view]
PANTHERiPTHR24223:SF187. PTHR24223:SF187. 4 hits.
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
PRINTSiPR01093. SULFNYLUR1.
PR01092. SULFNYLUREAR.
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Experimental confirmation may be lacking for some isoforms.
Isoform A (identifier: Q09429-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPLAFCGTEN HSAAYRVDQG VLNNGCFVDA LNVVPHVFLL FITFPILFIG
60 70 80 90 100
WGSQSSKVHI HHSTWLHFPG HNLRWILTFI LLFVLVCEIA EGILSDGVTE
110 120 130 140 150
SRHLHLYMPA GMAFMAAITS VVYYHNIETS NFPKLLIALL IYWTLAFITK
160 170 180 190 200
TIKFVKFYDH AIGFSQLRFC LTGLLVILYG MLLLVEVNVI RVRRYVFFKT
210 220 230 240 250
PREVKPPEDL QDLGVRFLQP FVNLLSKGTY WWMNAFIKTA HKKPIDLRAI
260 270 280 290 300
GKLPIAMRAL TNYQRLCLAF DAQARKDTQS QQGARAIWRA LCHAFGRRLV
310 320 330 340 350
LSSTFRILAD LLGFAGPLCI FGIVDHLGKE NHVFQPKTQF LGVYFVSSQE
360 370 380 390 400
FLGNAYVLAV LLFLALLLQR TFLQASYYVA IETGINLRGA IQTKIYNKIM
410 420 430 440 450
HLSTSNLSMG EMTAGQICNL VAIDTNQLMW FFFLCPNLWA MPVQIIVGVI
460 470 480 490 500
LLYYILGVSA LIGAAVIILL APVQYFVATK LSQAQRSTLE YSNERLKQTN
510 520 530 540 550
EMLRGIKLLK LYAWENIFCS RVEKTRRKEM TSLRAFAVYT SISIFMNTAI
560 570 580 590 600
PIAAVLITFV GHVSFFKESD FSPSVAFASL SLFHILVTPL FLLSSVVRST
610 620 630 640 650
VKALVSVQKL SEFLSSAEIR EEQCAPREPA PQGQAGKYQA VPLKVVNRKR
660 670 680 690 700
PAREEVRDLL GPLQRLTPST DGDADNFCVQ IIGGFFTWTP DGIPTLSNIT
710 720 730 740 750
IRIPRGQLTM IVGQVGCGKS SLLLATLGEM QKVSGAVFWN SSLPDSEGED
760 770 780 790 800
PSNPERETAA DSDARSRGPV AYASQKPWLL NATVEENITF ESPFNKQRYK
810 820 830 840 850
MVIEACSLQP DIDILPHGDQ TQIGERGINL SGGQRQRISV ARALYQHTNV
860 870 880 890 900
VFLDDPFSAL DVHLSDHLMQ AGILELLRDD KRTVVLVTHK LQYLPHADWI
910 920 930 940 950
IAMKDGTIQR EGTLKDFQRS ECQLFEHWKT LMNRQDQELE KETVMERKAP
960 970 980 990 1000
EPSQGLPRAM SSRDGLLLDE DEEEEEAAES EEDDNLSSVL HQRAKIPWRA
1010 1020 1030 1040 1050
CTKYLSSAGI LLLSLLVFSQ LLKHMVLVAI DYWLAKWTDS ALVLSPAARN
1060 1070 1080 1090 1100
CSLSQECALD QSVYAMVFTV LCSLGIALCL VTSVTVEWTG LKVAKRLHRS
1110 1120 1130 1140 1150
LLNRIILAPM RFFETTPLGS ILNRFSSDCN TIDQHIPSTL ECLSRSTLLC
1160 1170 1180 1190 1200
VSALAVISYV TPVFLVALLP LAVVCYFIQK YFRVASRDLQ QLDDTTQLPL
1210 1220 1230 1240 1250
LSHFAETVEG LTTIRAFRYE ARFQQKLLEY TDSNNIASLF LTAANRWLEV
1260 1270 1280 1290 1300
RMEYIGACVV LIAAATSISN SLHRELSAGL VGLGLTYALM VSNYLNWMVR
1310 1320 1330 1340 1350
NLADMEIQLG AVKRIHTLLK TEAESYEGLL APSLIPKNWP DQGKIQIQNL
1360 1370 1380 1390 1400
SVRYDSSLKP VLKHVNALIS PGQKIGICGR TGSGKSSFSL AFFRMVDMFE
1410 1420 1430 1440 1450
GRIIIDGIDI AKLPLHTLRS RLSIILQDPV LFSGTIRFNL DPEKKCSDST
1460 1470 1480 1490 1500
LWEALEIAQL KLVVKALPGG LDAIITEGGE NFSQGQRQLF CLARAFVRKT
1510 1520 1530 1540 1550
SIFIMDEATA SIDMATENIL QKVVMTAFAD RTVVTIAHRV HTILSADLVM
1560 1570 1580
VLKRGAILEF DKPEKLLSQK DSVFASFVRA DK
Length:1,582
Mass (Da):177,185
Last modified:January 23, 2007 - v4
Checksum:i7C57A1CFC86B9214
GO
Isoform B (identifier: Q09429-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1252-1289: Missing.

Show »
Length:1,544
Mass (Da):173,324
Checksum:i338163E4F264FCFE
GO
Isoform C (identifier: Q09429-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     741-741: Missing.

Show »
Length:1,581
Mass (Da):177,097
Checksum:i722EC6057F4333BC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti487 – 4871S → T in AAA99237 (PubMed:7716547).Curated
Sequence conflicti699 – 6991I → T in BAB19011 (Ref. 4) Curated
Sequence conflicti836 – 8372QR → PG in AAA99237 (PubMed:7716547).Curated
Sequence conflicti1314 – 13141R → G in AAA99237 (PubMed:7716547).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei741 – 7411Missing in isoform C. 1 PublicationVSP_000056
Alternative sequencei1252 – 128938Missing in isoform B. 1 PublicationVSP_000057Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L40624 mRNA. Translation: AAA99237.1.
X97279 mRNA. Translation: CAA65934.1.
AF039595 mRNA. Translation: AAB96684.1.
AB052294 mRNA. Translation: BAB19011.1.
RefSeqiNP_037171.2. NM_013039.2. [Q09429-1]
XP_008757542.1. XM_008759320.1. [Q09429-3]
UniGeneiRn.11187.

Genome annotation databases

EnsembliENSRNOT00000028696; ENSRNOP00000028696; ENSRNOG00000021130. [Q09429-1]
ENSRNOT00000038798; ENSRNOP00000035010; ENSRNOG00000021130. [Q09429-2]
GeneIDi25559.
KEGGirno:25559.
UCSCiRGD:3786. rat. [Q09429-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L40624 mRNA. Translation: AAA99237.1.
X97279 mRNA. Translation: CAA65934.1.
AF039595 mRNA. Translation: AAB96684.1.
AB052294 mRNA. Translation: BAB19011.1.
RefSeqiNP_037171.2. NM_013039.2. [Q09429-1]
XP_008757542.1. XM_008759320.1. [Q09429-3]
UniGeneiRn.11187.

3D structure databases

ProteinModelPortaliQ09429.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028696.

Chemistry

BindingDBiQ09429.
ChEMBLiCHEMBL3038487.

Proteomic databases

PaxDbiQ09429.
PRIDEiQ09429.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000028696; ENSRNOP00000028696; ENSRNOG00000021130. [Q09429-1]
ENSRNOT00000038798; ENSRNOP00000035010; ENSRNOG00000021130. [Q09429-2]
GeneIDi25559.
KEGGirno:25559.
UCSCiRGD:3786. rat. [Q09429-1]

Organism-specific databases

CTDi6833.
RGDi3786. Abcc8.

Phylogenomic databases

eggNOGiKOG0054. Eukaryota.
COG1132. LUCA.
GeneTreeiENSGT00840000129727.
HOVERGENiHBG101342.
InParanoidiQ09429.
KOiK05032.
OMAiQGQASKY.
OrthoDBiEOG091G00IN.
PhylomeDBiQ09429.

Enzyme and pathway databases

ReactomeiR-RNO-1296025. ATP sensitive Potassium channels.
R-RNO-382556. ABC-family proteins mediated transport.
R-RNO-422356. Regulation of insulin secretion.

Miscellaneous databases

PROiQ09429.

Gene expression databases

ExpressionAtlasiQ09429. baseline and differential.
GenevisibleiQ09429. RN.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR000844. ABCC8.
IPR027417. P-loop_NTPase.
IPR000388. Sulphorea_rcpt.
[Graphical view]
PANTHERiPTHR24223:SF187. PTHR24223:SF187. 4 hits.
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
PRINTSiPR01093. SULFNYLUR1.
PR01092. SULFNYLUREAR.
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiABCC8_RAT
AccessioniPrimary (citable) accession number: Q09429
Secondary accession number(s): O54989, P70532, Q9EQT0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 137 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.