Q09422 (PGAM5_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serine/threonine-protein phosphatase Pgam5, mitochondrial
EC=3.1.3.16

Alternative name(s):
Phosphoglycerate mutase family member 5 homolog

Gene names

Name:	pgam-5
ORF Names:	R07G3.5

Organism

Caenorhabditis elegans [Reference proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	284 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Displays phosphatase activity for serine/threonine residues. Has apparently no phosphoglycerate mutase activity By similarity.
Catalytic activity	A phosphoprotein + H2O = a protein + phosphate.
Subcellular location	Mitochondrion outer membrane; Single-pass membrane protein By similarity.
Sequence similarities	Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion Mitochondrion outer membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein dephosphorylation Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial outer membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	phosphoprotein phosphatase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 284	284	Serine/threonine-protein phosphatase Pgam5, mitochondrial		PRO_0000065425
Regions
	Transmembrane	8 – 24	17	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q09422 [UniParc]. Last modified April 4, 2003. Version 2. Checksum: 820D56CE79E71F90	FASTA	284	32,490
	10 20 30 40 50 60 MVSKIIKLGV PTATLAVGTL LLGDDEKRSA FFRTASAFTQ NHGHKTFDEH FPRGEWDKNW 70 80 90 100 110 120 DFRDPISLVD KGKWEKADEE GKKKLIEEKK ATATRNIFLI RHGQYHLDHE VKMLTPLGRE 130 140 150 160 170 180 QAELLGKRLA NSDIKFTNMT MSTMVRATET ANIILKHLPD DLTRTSSPFI EEGPPYPPVP 190 200 210 220 230 240 DHKTWRPLDP EFYTEAARIE SAYRKIFHRA SPSQKEDSFE LIVCHANVIR YFICRALQFP 250 260 270 280 PEGWLRMSLG NCSLTWITIR PKGHVSVRSI GDIGHLPPNK ISFT

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FO081291 Genomic DNA. Translation: CCD70516.1.
PIR	T16702.
RefSeq	NP_495593.2. NM_063192.4.
3D structure databases
ProteinModelPortal	Q09422.
SMR	Q09422. Positions 86-282.
ModBase	Search...
Protein-protein interaction databases
STRING	6239.R07G3.5.
Proteomic databases
PaxDb	Q09422.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	R07G3.5.1; R07G3.5.1; R07G3.5. R07G3.5.2; R07G3.5.2; R07G3.5.
GeneID	174231.
KEGG	cel:CELE_R07G3.5.
UCSC	R07G3.5. c. elegans.
Organism-specific databases
CTD	174231.
WormBase	R07G3.5; CE31979; WBGene00019941; pgam-5.
Phylogenomic databases
eggNOG	NOG71348.
GeneTree	ENSGT00390000004796.
HOGENOM	HOG000261217.
InParanoid	Q09422.
KO	K15637.
OMA	WLRMSLN.
Family and domain databases
InterPro	IPR013078. His_Pase_superF_clade-1. [Graphical view]
Pfam	PF00300. His_Phos_1. 1 hit. [Graphical view]
SMART	SM00855. PGAM. 1 hit. [Graphical view]
PROSITE	PS00175. PG_MUTASE. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	883113.

Entry information

Entry name

PGAM5_CAEEL

Accession

Primary (citable) accession number: Q09422

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	April 4, 2003
Last modified:	May 1, 2013
This is version 75 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project