Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

High mobility group protein 1.2

Gene

hmg-1.2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi47 – 11771HMG box 1PROSITE-ProRule annotationAdd
BLAST
DNA bindingi135 – 20369HMG box 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • transcription regulatory region DNA binding Source: WormBase

GO - Biological processi

  • cell fate specification Source: WormBase
  • gonad development Source: WormBase
  • positive regulation of transcription from RNA polymerase II promoter Source: WormBase
  • vulval development Source: WormBase
  • Wnt signaling pathway Source: WormBase
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-CEL-211227. Activation of DNA fragmentation factor.
SignaLinkiQ09390.

Names & Taxonomyi

Protein namesi
Recommended name:
High mobility group protein 1.2
Gene namesi
Name:hmg-1.2
ORF Names:F47D12.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiF47D12.4a; CE26923; WBGene00001972; hmg-1.2.
F47D12.4b; CE28233; WBGene00001972; hmg-1.2.
F47D12.4c; CE28234; WBGene00001972; hmg-1.2.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 235235High mobility group protein 1.2PRO_0000048602Add
BLAST

Proteomic databases

EPDiQ09390.
PaxDbiQ09390.
PRIDEiQ09390.

Expressioni

Gene expression databases

BgeeiWBGene00001972.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
lir-1G5EBR03EBI-2414021,EBI-320910

Protein-protein interaction databases

BioGridi41110. 28 interactions.
IntActiQ09390. 4 interactions.
STRINGi6239.F47D12.4a.2.

Structurei

3D structure databases

ProteinModelPortaliQ09390.
SMRiQ09390. Positions 46-206.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 2 HMG box DNA-binding domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0381. Eukaryota.
COG5648. LUCA.
GeneTreeiENSGT00760000119164.
HOGENOMiHOG000197861.
InParanoidiQ09390.
KOiK11295.
OMAiAFFFYSQ.
OrthoDBiEOG091G0P81.
PhylomeDBiQ09390.

Family and domain databases

Gene3Di1.10.30.10. 2 hits.
InterProiIPR009071. HMG_box_dom.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
PF09011. HMG_box_2. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 2 hits.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 2 hits.
PROSITEiPS50118. HMG_BOX_2. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform a (identifier: Q09390-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNSGYSANIF PSSSSPTLYQ SHQLQPNPSA TMYQATPRDM GKPPVRGKTS
60 70 80 90 100
PYGFFVKMCY EEHKKKYPNE NVQVTEISKK CSEKWKTMVD DEKRRFYELA
110 120 130 140 150
QKDAERYQAE VSVAAYGGED AMRKRKRAKK DPHAPKRALS AFFFYSQDKR
160 170 180 190 200
PEIQAGHPDW KVGQVAQELG KMWKLVPQET KDMYEQKAQA DKDRYADEMR
210 220 230
NYKAEMQKMS GMDHYDDDNI HHVVHVEDIN SQNIS
Length:235
Mass (Da):27,320
Last modified:July 11, 2002 - v2
Checksum:i5C5BA447E4259B67
GO
Isoform b (identifier: Q09390-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     25-25: Missing.

Note: No experimental confirmation available.
Show »
Length:234
Mass (Da):27,192
Checksum:i316BB99A3314C41D
GO
Isoform c (identifier: Q09390-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     111-112: Missing.

Note: No experimental confirmation available.
Show »
Length:233
Mass (Da):27,133
Checksum:i2934AD7FE6B07B70
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei25 – 251Missing in isoform b. CuratedVSP_002189
Alternative sequencei111 – 1122Missing in isoform c. CuratedVSP_002190

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF056577 mRNA. Translation: AAC78599.1.
FO080618 Genomic DNA. Translation: CCD83369.1.
FO080618 Genomic DNA. Translation: CCD83370.1.
FO080618 Genomic DNA. Translation: CCD83371.1.
PIRiT43009.
RefSeqiNP_001022599.1. NM_001027428.3. [Q09390-2]
NP_001022600.1. NM_001027429.4. [Q09390-3]
NP_498375.1. NM_065974.7. [Q09390-1]
UniGeneiCel.10345.

Genome annotation databases

EnsemblMetazoaiF47D12.4a.1; F47D12.4a.1; WBGene00001972. [Q09390-1]
F47D12.4a.2; F47D12.4a.2; WBGene00001972. [Q09390-1]
GeneIDi175890.
KEGGicel:CELE_F47D12.4.
UCSCiF47D12.4a.1. c. elegans. [Q09390-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF056577 mRNA. Translation: AAC78599.1.
FO080618 Genomic DNA. Translation: CCD83369.1.
FO080618 Genomic DNA. Translation: CCD83370.1.
FO080618 Genomic DNA. Translation: CCD83371.1.
PIRiT43009.
RefSeqiNP_001022599.1. NM_001027428.3. [Q09390-2]
NP_001022600.1. NM_001027429.4. [Q09390-3]
NP_498375.1. NM_065974.7. [Q09390-1]
UniGeneiCel.10345.

3D structure databases

ProteinModelPortaliQ09390.
SMRiQ09390. Positions 46-206.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi41110. 28 interactions.
IntActiQ09390. 4 interactions.
STRINGi6239.F47D12.4a.2.

Proteomic databases

EPDiQ09390.
PaxDbiQ09390.
PRIDEiQ09390.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF47D12.4a.1; F47D12.4a.1; WBGene00001972. [Q09390-1]
F47D12.4a.2; F47D12.4a.2; WBGene00001972. [Q09390-1]
GeneIDi175890.
KEGGicel:CELE_F47D12.4.
UCSCiF47D12.4a.1. c. elegans. [Q09390-1]

Organism-specific databases

CTDi175890.
WormBaseiF47D12.4a; CE26923; WBGene00001972; hmg-1.2.
F47D12.4b; CE28233; WBGene00001972; hmg-1.2.
F47D12.4c; CE28234; WBGene00001972; hmg-1.2.

Phylogenomic databases

eggNOGiKOG0381. Eukaryota.
COG5648. LUCA.
GeneTreeiENSGT00760000119164.
HOGENOMiHOG000197861.
InParanoidiQ09390.
KOiK11295.
OMAiAFFFYSQ.
OrthoDBiEOG091G0P81.
PhylomeDBiQ09390.

Enzyme and pathway databases

ReactomeiR-CEL-211227. Activation of DNA fragmentation factor.
SignaLinkiQ09390.

Miscellaneous databases

PROiQ09390.

Gene expression databases

BgeeiWBGene00001972.

Family and domain databases

Gene3Di1.10.30.10. 2 hits.
InterProiIPR009071. HMG_box_dom.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
PF09011. HMG_box_2. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 2 hits.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 2 hits.
PROSITEiPS50118. HMG_BOX_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHMG12_CAEEL
AccessioniPrimary (citable) accession number: Q09390
Secondary accession number(s): O77096
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 11, 2002
Last modified: September 7, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.