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Protein

WD repeat-containing protein fzy-1

Gene

fzy-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in metaphase-anaphase transition during meiosis I (PubMed:12498686). Required for embryonic anterior-posterior axis formation (PubMed:11832245).2 Publications

GO - Molecular functioni

GO - Biological processi

  • asymmetric cell division Source: UniProtKB
  • metaphase/anaphase transition of meiosis I Source: UniProtKB
  • polar body extrusion after meiotic divisions Source: UniProtKB
  • polarity specification of anterior/posterior axis Source: UniProtKB
  • positive regulation of ubiquitin protein ligase activity Source: InterPro

Keywordsi

Biological processCell cycle, Cell division, Meiosis, Mitosis

Enzyme and pathway databases

ReactomeiR-CEL-141405 Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
R-CEL-141430 Inactivation of APC/C via direct inhibition of the APC/C complex
R-CEL-174113 SCF-beta-TrCP mediated degradation of Emi1
SignaLinkiQ09373

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein fzy-1
Alternative name(s):
CDC20 protein family homolog 1Curated
Fizzy protein 1
Gene namesi
Name:fzy-11 Publication
ORF Names:ZK177.6Imported
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiZK177.6 ; CE26338 ; WBGene00001511 ; fzy-1

Subcellular locationi

Keywords - Cellular componenti

Chromosome, Cytoplasm

Pathology & Biotechi

Disruption phenotypei

RNAi-mediated knockdown causes embryonic lethality (PubMed:12498686). Embryos are arrested at the metaphase-anaphase transition of meiosis I and lack formation of polar bodies (PubMed:12498686). In addition, causes a loss of asymmetric cell division and par-2 mislocalization in the one-cell embryo followed by an arrest at the one-cell stage (PubMed:11832245).2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi433D → N in h1983; reduction in the number of eggs laid. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000510031 – 507WD repeat-containing protein fzy-1Add BLAST507

Proteomic databases

EPDiQ09373
PaxDbiQ09373
PeptideAtlasiQ09373

PTM databases

iPTMnetiQ09373

Expressioni

Developmental stagei

Expressed in oocytes at the prometaphase and metaphase of meiosis I (at protein level). Expressed in early embryo at the prometaphase and metaphase of mitosis (at protein level).1 Publication

Gene expression databases

BgeeiWBGene00001511

Interactioni

Protein-protein interaction databases

IntActiQ09373, 2 interactors
STRINGi6239.ZK177.6

Structurei

3D structure databases

ProteinModelPortaliQ09373
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati219 – 258WD 1Add BLAST40
Repeati313 – 352WD 2Add BLAST40
Repeati364 – 406WD 3Add BLAST43
Repeati411 – 450WD 4Add BLAST40

Sequence similaritiesi

Belongs to the WD repeat CDC20/Fizzy family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0305 Eukaryota
ENOG410XQ8I LUCA
GeneTreeiENSGT00870000136444
HOGENOMiHOG000017042
InParanoidiQ09373
OMAiDMDMAYF
OrthoDBiEOG091G0510
PhylomeDBiQ09373

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR033010 Cdc20/Fizzy
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR19918 PTHR19918, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 2 hits
SMARTiView protein in SMART
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q09373-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNKGRTPGS AGRTVRSSAQ QNGLTMRKRD MTPTRNTNLL PNATFVGDRF
60 70 80 90 100
LGVRLDQDEL DHANHLMTSK LYSNKENLNN SMSEPNSPEK KSVEGEALKQ
110 120 130 140 150
MMRHKSTGAL TDADDGDRIL CYKKNLAPPP AIGYINQAKV LYSTNSVINP
160 170 180 190 200
ASSVKKSTRH VKETATKVLD GPGLTKDLYS RHLDWGCHNW VAVALGHELY
210 220 230 240 250
LWNTETCVIK NLFEDNAPTN EGLITSVRWS QEGRYISLGY ASGAVKIYDP
260 270 280 290 300
NRPKTTEYVR ELRTLRVGGA SRCASIAWRK QGVMTCGYKS GDIVNHDVRI
310 320 330 340 350
SQHVVSSWGG DNGHCRDVTA LEWSADENMC VSGSSDRTAK IWDGRHVRGS
360 370 380 390 400
TVIQDPEPMF TIDEHTGQVR TAQFCSFRDG ILATGGGIND GTVKLWDVKR
410 420 430 440 450
QFQKVRELNV CETGGVGGIV FNRPYSEMLT ASDDGFLRIY RFNANYKLSH
460 470 480 490 500
EIQASNEPIM DLVGSPFDEV LIGDMEETLK VFQLFNVDKS TNILDRTAPK

NVGLNVR
Length:507
Mass (Da):56,384
Last modified:August 29, 2003 - v2
Checksum:iC68E9F2899109610
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080583 Genomic DNA Translation: CCD64859.1
PIRiT27761
RefSeqiNP_495051.1, NM_062650.4
UniGeneiCel.17170

Genome annotation databases

EnsemblMetazoaiZK177.6; ZK177.6; WBGene00001511
GeneIDi266859
KEGGicel:CELE_ZK177.6
UCSCiZK177.6 c. elegans

Similar proteinsi

Entry informationi

Entry nameiFZY1_CAEEL
AccessioniPrimary (citable) accession number: Q09373
Secondary accession number(s): Q09661
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: August 29, 2003
Last modified: April 25, 2018
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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