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Protein

WD repeat-containing protein fzy-1

Gene

fzy-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-CEL-141405. Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components.
R-CEL-141430. Inactivation of APC/C via direct inhibition of the APC/C complex.
R-CEL-174113. SCF-beta-TrCP mediated degradation of Emi1.
SignaLinkiQ09373.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein fzy-1
Alternative name(s):
Fizzy protein 1
Gene namesi
Name:fzy-1
ORF Names:ZK177.6/ZK177.7
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiZK177.6; CE26338; WBGene00001511; fzy-1.

Subcellular locationi

GO - Cellular componenti

  • condensed chromosome Source: WormBase
  • cytoplasm Source: WormBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 507507WD repeat-containing protein fzy-1PRO_0000051003Add
BLAST

Proteomic databases

EPDiQ09373.
PaxDbiQ09373.
PRIDEiQ09373.

PTM databases

iPTMnetiQ09373.

Interactioni

Protein-protein interaction databases

IntActiQ09373. 2 interactions.
STRINGi6239.ZK177.6.

Structurei

3D structure databases

ProteinModelPortaliQ09373.
SMRiQ09373. Positions 155-488.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati219 – 25840WD 1Add
BLAST
Repeati313 – 35240WD 2Add
BLAST
Repeati364 – 40643WD 3Add
BLAST
Repeati411 – 45040WD 4Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat CDC20/Fizzy family.Curated
Contains 4 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0305. Eukaryota.
ENOG410XQ8I. LUCA.
GeneTreeiENSGT00840000129804.
HOGENOMiHOG000017042.
InParanoidiQ09373.
OMAiQEGRYIS.
OrthoDBiEOG76X602.
PhylomeDBiQ09373.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR033010. Cdc20/Fizzy.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR19918. PTHR19918. 1 hit.
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q09373-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNKGRTPGS AGRTVRSSAQ QNGLTMRKRD MTPTRNTNLL PNATFVGDRF
60 70 80 90 100
LGVRLDQDEL DHANHLMTSK LYSNKENLNN SMSEPNSPEK KSVEGEALKQ
110 120 130 140 150
MMRHKSTGAL TDADDGDRIL CYKKNLAPPP AIGYINQAKV LYSTNSVINP
160 170 180 190 200
ASSVKKSTRH VKETATKVLD GPGLTKDLYS RHLDWGCHNW VAVALGHELY
210 220 230 240 250
LWNTETCVIK NLFEDNAPTN EGLITSVRWS QEGRYISLGY ASGAVKIYDP
260 270 280 290 300
NRPKTTEYVR ELRTLRVGGA SRCASIAWRK QGVMTCGYKS GDIVNHDVRI
310 320 330 340 350
SQHVVSSWGG DNGHCRDVTA LEWSADENMC VSGSSDRTAK IWDGRHVRGS
360 370 380 390 400
TVIQDPEPMF TIDEHTGQVR TAQFCSFRDG ILATGGGIND GTVKLWDVKR
410 420 430 440 450
QFQKVRELNV CETGGVGGIV FNRPYSEMLT ASDDGFLRIY RFNANYKLSH
460 470 480 490 500
EIQASNEPIM DLVGSPFDEV LIGDMEETLK VFQLFNVDKS TNILDRTAPK

NVGLNVR
Length:507
Mass (Da):56,384
Last modified:August 29, 2003 - v2
Checksum:iC68E9F2899109610
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080583 Genomic DNA. Translation: CCD64859.1.
PIRiT27761.
RefSeqiNP_495051.1. NM_062650.4.
UniGeneiCel.17170.

Genome annotation databases

EnsemblMetazoaiZK177.6; ZK177.6; WBGene00001511.
GeneIDi266859.
KEGGicel:CELE_ZK177.6.
UCSCiZK177.6. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080583 Genomic DNA. Translation: CCD64859.1.
PIRiT27761.
RefSeqiNP_495051.1. NM_062650.4.
UniGeneiCel.17170.

3D structure databases

ProteinModelPortaliQ09373.
SMRiQ09373. Positions 155-488.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ09373. 2 interactions.
STRINGi6239.ZK177.6.

PTM databases

iPTMnetiQ09373.

Proteomic databases

EPDiQ09373.
PaxDbiQ09373.
PRIDEiQ09373.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiZK177.6; ZK177.6; WBGene00001511.
GeneIDi266859.
KEGGicel:CELE_ZK177.6.
UCSCiZK177.6. c. elegans.

Organism-specific databases

CTDi266859.
WormBaseiZK177.6; CE26338; WBGene00001511; fzy-1.

Phylogenomic databases

eggNOGiKOG0305. Eukaryota.
ENOG410XQ8I. LUCA.
GeneTreeiENSGT00840000129804.
HOGENOMiHOG000017042.
InParanoidiQ09373.
OMAiQEGRYIS.
OrthoDBiEOG76X602.
PhylomeDBiQ09373.

Enzyme and pathway databases

ReactomeiR-CEL-141405. Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components.
R-CEL-141430. Inactivation of APC/C via direct inhibition of the APC/C complex.
R-CEL-174113. SCF-beta-TrCP mediated degradation of Emi1.
SignaLinkiQ09373.

Miscellaneous databases

NextBioi953290.
PROiQ09373.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR033010. Cdc20/Fizzy.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR19918. PTHR19918. 1 hit.
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiFZY1_CAEEL
AccessioniPrimary (citable) accession number: Q09373
Secondary accession number(s): Q09661
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: August 29, 2003
Last modified: May 11, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.