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Protein

WD repeat-containing protein fzy-1

Gene

fzy-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in metaphase-anaphase transition during meiosis I (PubMed:12498686). Required for embryonic anterior-posterior axis formation (PubMed:11832245).2 Publications

GO - Molecular functioni

GO - Biological processi

  • asymmetric cell division Source: UniProtKB
  • metaphase/anaphase transition of meiosis I Source: UniProtKB
  • polar body extrusion after meiotic divisions Source: UniProtKB
  • polarity specification of anterior/posterior axis Source: UniProtKB
  • positive regulation of ubiquitin protein ligase activity Source: InterPro

Keywordsi

Biological processCell cycle, Cell division, Meiosis, Mitosis

Enzyme and pathway databases

ReactomeiR-CEL-141405. Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components.
R-CEL-141430. Inactivation of APC/C via direct inhibition of the APC/C complex.
SignaLinkiQ09373.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein fzy-1
Alternative name(s):
CDC20 protein family homolog 1Curated
Fizzy protein 1
Gene namesi
Name:fzy-11 Publication
ORF Names:ZK177.6Imported
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiZK177.6; CE26338; WBGene00001511; fzy-1.

Subcellular locationi

  • Chromosome 1 Publication
  • Cytoplasm 1 Publication

  • Note: At prometaphase, localizes around condensed chromosomes. At metaphase, localizes along chromosomes, dissociates from the sister chromatid after separation and localizes to the cytoplasm at anaphase and interphase.1 Publication

GO - Cellular componenti

  • condensed chromosome Source: WormBase
  • cytoplasm Source: WormBase

Keywords - Cellular componenti

Chromosome, Cytoplasm

Pathology & Biotechi

Disruption phenotypei

RNAi-mediated knockdown causes embryonic lethality (PubMed:12498686). Embryos are arrested at the metaphase-anaphase transition of meiosis I and lack formation of polar bodies (PubMed:12498686). In addition, causes a loss of asymmetric cell division and par-2 mislocalization in the one-cell embryo followed by an arrest at the one-cell stage (PubMed:11832245).2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi433D → N in h1983; reduction in the number of eggs laid. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000510031 – 507WD repeat-containing protein fzy-1Add BLAST507

Proteomic databases

EPDiQ09373.
PaxDbiQ09373.
PeptideAtlasiQ09373.

PTM databases

iPTMnetiQ09373.

Expressioni

Developmental stagei

Expressed in oocytes at the prometaphase and metaphase of meiosis I (at protein level). Expressed in early embryo at the prometaphase and metaphase of mitosis (at protein level).1 Publication

Gene expression databases

BgeeiWBGene00001511.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ09373. 2 interactors.
STRINGi6239.ZK177.6.

Structurei

3D structure databases

ProteinModelPortaliQ09373.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati219 – 258WD 1Add BLAST40
Repeati313 – 352WD 2Add BLAST40
Repeati364 – 406WD 3Add BLAST43
Repeati411 – 450WD 4Add BLAST40

Sequence similaritiesi

Belongs to the WD repeat CDC20/Fizzy family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0305. Eukaryota.
ENOG410XQ8I. LUCA.
GeneTreeiENSGT00870000136444.
HOGENOMiHOG000017042.
InParanoidiQ09373.
OMAiDMDMAYF.
OrthoDBiEOG091G0510.
PhylomeDBiQ09373.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiView protein in InterPro
IPR033010. Cdc20/Fizzy.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
PANTHERiPTHR19918. PTHR19918. 1 hit.
PfamiView protein in Pfam
PF00400. WD40. 2 hits.
SMARTiView protein in SMART
SM00320. WD40. 5 hits.
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiView protein in PROSITE
PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.

Sequencei

Sequence statusi: Complete.

Q09373-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNKGRTPGS AGRTVRSSAQ QNGLTMRKRD MTPTRNTNLL PNATFVGDRF
60 70 80 90 100
LGVRLDQDEL DHANHLMTSK LYSNKENLNN SMSEPNSPEK KSVEGEALKQ
110 120 130 140 150
MMRHKSTGAL TDADDGDRIL CYKKNLAPPP AIGYINQAKV LYSTNSVINP
160 170 180 190 200
ASSVKKSTRH VKETATKVLD GPGLTKDLYS RHLDWGCHNW VAVALGHELY
210 220 230 240 250
LWNTETCVIK NLFEDNAPTN EGLITSVRWS QEGRYISLGY ASGAVKIYDP
260 270 280 290 300
NRPKTTEYVR ELRTLRVGGA SRCASIAWRK QGVMTCGYKS GDIVNHDVRI
310 320 330 340 350
SQHVVSSWGG DNGHCRDVTA LEWSADENMC VSGSSDRTAK IWDGRHVRGS
360 370 380 390 400
TVIQDPEPMF TIDEHTGQVR TAQFCSFRDG ILATGGGIND GTVKLWDVKR
410 420 430 440 450
QFQKVRELNV CETGGVGGIV FNRPYSEMLT ASDDGFLRIY RFNANYKLSH
460 470 480 490 500
EIQASNEPIM DLVGSPFDEV LIGDMEETLK VFQLFNVDKS TNILDRTAPK

NVGLNVR
Length:507
Mass (Da):56,384
Last modified:August 29, 2003 - v2
Checksum:iC68E9F2899109610
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080583 Genomic DNA. Translation: CCD64859.1.
PIRiT27761.
RefSeqiNP_495051.1. NM_062650.4.
UniGeneiCel.17170.

Genome annotation databases

EnsemblMetazoaiZK177.6; ZK177.6; WBGene00001511.
GeneIDi266859.
KEGGicel:CELE_ZK177.6.
UCSCiZK177.6. c. elegans.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiFZY1_CAEEL
AccessioniPrimary (citable) accession number: Q09373
Secondary accession number(s): Q09661
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: August 29, 2003
Last modified: June 7, 2017
This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families