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Q09333 (COX1_ALBTU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 1

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene names
Name:COI
Encoded onMitochondrion
OrganismAlbinaria turrita (Door snail) (Clausilia turrita)
Taxonomic identifier27820 [NCBI]
Taxonomic lineageEukaryotaMetazoaLophotrochozoaMolluscaGastropodaHeterobranchiaEuthyneuraPanpulmonataEupulmonataStylommatophoraSigmurethraClausilioideaClausiliidaeAlopiinaeAlbinaria

Protein attributes

Sequence length195 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathway

Energy metabolism; oxidative phosphorylation.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 195›195Cytochrome c oxidase subunit 1
PRO_0000183278

Regions

Transmembrane12 – 3221Helical; Potential
Transmembrane59 – 7921Helical; Potential
Transmembrane88 – 10821Helical; Potential
Transmembrane131 – 15121Helical; Potential

Sites

Metal binding421Iron (heme A axial ligand) Probable
Metal binding501Copper B Probable

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
Q09333 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 863E2B82623E7060

FASTA19522,648
        10         20         30         40         50         60 
IYGSKVQYTA SMYWVLGFIF LFTLGGLTGI VLSNSSLDIM LHDTYYVVAH FHYVLSMGAV 

        70         80         90        100        110        120 
FAIFAGFNFW FPVMTGLVLH ERLAKAQFIV MFIAVNMTFF PQHFLGLAGM PRRYSDYPDS 

       130        140        150        160        170        180 
YFMWNQLSSY GSLMSVFAVL LFVLIVWEAF LSQRSLLFVD ATLYSREWSD GYFPPDFHSN 

       190 
IYQSYITIYK TYYSK 

« Hide

References

[1]"Novel features of metazoan mtDNA revealed from sequence analysis of three mitochondrial DNA segments of the land snail Albinaria turrita (Gastropoda: Clausiliidae)."
Lecanidou R., Douris V., Rodakis G.C.
J. Mol. Evol. 38:369-382(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X71393 Genomic DNA. Translation: CAA50515.1.

3D structure databases

ProteinModelPortalQ09333.
SMRQ09333. Positions 1-188.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00705.

Family and domain databases

Gene3D1.20.210.10. 1 hit.
InterProIPR000883. Cyt_c_Oxase_su1.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERPTHR10422. PTHR10422. 1 hit.
PfamPF00115. COX1. 1 hit.
[Graphical view]
PRINTSPR01165. CYCOXIDASEI.
SUPFAMSSF81442. SSF81442. 1 hit.
PROSITEPS50855. COX1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX1_ALBTU
AccessionPrimary (citable) accession number: Q09333
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways