Q09333 (COX1_ALBTU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 1
EC=1.9.3.1

Alternative name(s):
Cytochrome c oxidase polypeptide I

Gene names

Name:

COI

Encoded on

Mitochondrion

Organism

Albinaria turrita (Door snail) (Clausilia turrita)

Taxonomic identifier

27820 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Lophotrochozoa › Mollusca › Gastropoda › Heterobranchia › Euthyneura › Panpulmonata › Eupulmonata › Stylommatophora › Sigmurethra › Clausilioidea › Clausiliidae › Alopiinae › Albinaria

Protein attributes

Sequence length	195 AA.
Sequence status	Fragment.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Pathway	Energy metabolism; oxidative phosphorylation.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the heme-copper respiratory oxidase family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transmembrane Transmembrane helix
Ligand	Copper Heme Iron Metal-binding
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological_process	aerobic respiration Inferred from electronic annotation. Source: InterPro electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW oxidative phosphorylation Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 195	›195	Cytochrome c oxidase subunit 1		PRO_0000183278
Regions
	Transmembrane	12 – 32	21	Helical; Potential
	Transmembrane	59 – 79	21	Helical; Potential
	Transmembrane	88 – 108	21	Helical; Potential
	Transmembrane	131 – 151	21	Helical; Potential
Sites
	Metal binding	42	1	Iron (heme A axial ligand) Probable
	Metal binding	50	1	Copper B Probable
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	Q09333 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 863E2B82623E7060	FASTA	195	22,648
	10 20 30 40 50 60 IYGSKVQYTA SMYWVLGFIF LFTLGGLTGI VLSNSSLDIM LHDTYYVVAH FHYVLSMGAV 70 80 90 100 110 120 FAIFAGFNFW FPVMTGLVLH ERLAKAQFIV MFIAVNMTFF PQHFLGLAGM PRRYSDYPDS 130 140 150 160 170 180 YFMWNQLSSY GSLMSVFAVL LFVLIVWEAF LSQRSLLFVD ATLYSREWSD GYFPPDFHSN 190 IYQSYITIYK TYYSK

References

[1]

"Novel features of metazoan mtDNA revealed from sequence analysis of three mitochondrial DNA segments of the land snail Albinaria turrita (Gastropoda: Clausiliidae)." Lecanidou R., Douris V., Rodakis G.C. J. Mol. Evol. 38:369-382(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	X71393 Genomic DNA. Translation: CAA50515.1.
3D structure databases
ProteinModelPortal	Q09333.
SMR	Q09333. Positions 1-188.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Enzyme and pathway databases
UniPathway	UPA00705.
Family and domain databases
Gene3D	1.20.210.10. 1 hit.
InterPro	IPR000883. Cyt_c_Oxase_su1. IPR023616. Cyt_c_Oxase_su1_dom. [Graphical view]
PANTHER	PTHR10422. PTHR10422. 1 hit.
Pfam	PF00115. COX1. 1 hit. [Graphical view]
PRINTS	PR01165. CYCOXIDASEI.
SUPFAM	SSF81442. COX1. 1 hit.
PROSITE	PS50855. COX1. 1 hit. PS00077. COX1_CUB. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COX1_ALBTU

Accession

Primary (citable) accession number: Q09333

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	April 3, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)