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Protein

Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

Gene

Mgat2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes an essential step in the conversion of oligo-mannose and hybrid to complex N-glycans.

Catalytic activityi

UDP-N-acetyl-alpha-D-glucosamine + beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein] = UDP + beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-(beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein].

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

  • alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity Source: RGD
  • carbohydrate binding Source: RGD

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.1.143 5301
ReactomeiR-RNO-975578 Reactions specific to the complex N-glycan synthesis pathway
UniPathwayiUPA00378

Protein family/group databases

CAZyiGT16 Glycosyltransferase Family 16

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (EC:2.4.1.143)
Alternative name(s):
Beta-1,2-N-acetylglucosaminyltransferase II
GlcNAc-T II
Short name:
GNT-II
Mannoside acetylglucosaminyltransferase 2
N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II
Gene namesi
Name:Mgat2
Synonyms:Gnt2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi620098 Mgat2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9CytoplasmicSequence analysis9
Transmembranei10 – 29Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST20
Topological domaini30 – 442LumenalSequence analysisAdd BLAST413

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000805201 – 442Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferaseAdd BLAST442

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi64N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi81N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ09326
PRIDEiQ09326

Expressioni

Gene expression databases

BgeeiENSRNOG00000004234
GenevisibleiQ09326 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005608

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2791 Eukaryota
ENOG410XPYF LUCA
GeneTreeiENSGT00390000007341
HOGENOMiHOG000261661
HOVERGENiHBG052467
InParanoidiQ09326
KOiK00736
OMAiRDHELCK
OrthoDBiEOG091G05U3
PhylomeDBiQ09326
TreeFamiTF314772

Family and domain databases

InterProiView protein in InterPro
IPR007754 GlcNAc_II
IPR029044 Nucleotide-diphossugar_trans
PANTHERiPTHR12871 PTHR12871, 1 hit
PfamiView protein in Pfam
PF05060 MGAT2, 1 hit
SUPFAMiSSF53448 SSF53448, 2 hits

Sequencei

Sequence statusi: Complete.

Q09326-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRFRIYKRKV LILTLVVAAC GFVLWSSNGR QRKNDALAPP LLDSEPLRGA
60 70 80 90 100
GHFAASVGIR RVSNDSAAPL VPAVPRPEVD NLTLRYRSLV YQLNFDQMLR
110 120 130 140 150
NVDKDGTWSP GELVLVVQVH NRPEYLRLLI DSLRKAQGIR EVLVIFSHDF
160 170 180 190 200
WSAEINSLIS SVDFCPVLQV FFPFSIQLYP SEFPGSDPRD CPRDLKKNAA
210 220 230 240 250
LKLGCINAEY PDSFGHYREA KFSQTKHHWW WKLHFVWERV KVLQDYTGLI
260 270 280 290 300
LFLEEDHYLA PDFYHVFKKM WKLKQQECPG CDVLSLGTYT TIRSFYGIAD
310 320 330 340 350
KVDVKTWKST EHNMGLALTR DAYQKLIECT DTFCTYDDYN WDWTLQYLTL
360 370 380 390 400
ACLPKVWKVL VPQAPRIFHA GDCGMHHKKT CRPSTQSAQI ESLLNNNKQY
410 420 430 440
LFPETLVIGE KFPMAAISPP RKNGGWGDIR DHELCKSYRR LQ
Length:442
Mass (Da):51,110
Last modified:November 1, 1995 - v1
Checksum:i86A9C8210AA8B7C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U21662 mRNA Translation: AAA86721.1
BC081754 mRNA Translation: AAH81754.1
PIRiA57044
RefSeqiNP_446056.1, NM_053604.2
UniGeneiRn.2342

Genome annotation databases

EnsembliENSRNOT00000005608; ENSRNOP00000005608; ENSRNOG00000004234
GeneIDi94273
KEGGirno:94273
UCSCiRGD:620098 rat

Similar proteinsi

Entry informationi

Entry nameiMGAT2_RAT
AccessioniPrimary (citable) accession number: Q09326
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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