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Q09265 (SUV42_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histone-lysine N-methyltransferase Suv4-20

EC=2.1.1.43
Alternative name(s):
SET domain-containing protein 4
Suppressor of variegation 4-20 homolog
Short name=Su(var)4-20 homolog
Gene names
Name:set-4
Synonyms:tag-337
ORF Names:C32D5.5
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length288 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression By similarity.

Catalytic activity

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

Subcellular location

Nucleus By similarity. Chromosome By similarity.

Sequence similarities

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar4-20 subfamily.

Contains 1 SET domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 288288Histone-lysine N-methyltransferase Suv4-20
PRO_0000065217

Regions

Domain128 – 238111SET

Sequences

Sequence LengthMass (Da)Tools
Q09265 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: B13A5878E3388EA6

FASTA28833,189
        10         20         30         40         50         60 
MQLHEQIANI SVTFNDIPRS DHSMTPTELC YFDDFATTLV VDSVLNFTTH KMSKKRRYLY 

        70         80         90        100        110        120 
QDEYRTARTV MKTFREQRDW TNAIYGLLTL RSVSHFLSKL PPNKLFEFRD HIVRFLNMFI 

       130        140        150        160        170        180 
LDSGYTIQEC KRYSQEGHQG AKLVSTGVWS RGDKIERLSG VVCLLSSEDE DSILAQEGSD 

       190        200        210        220        230        240 
FSVMYSTRKR CSTLWLGPGA YINHDCRPTC EFVSHGSTAH IRVLRDMVPG DEITCFYGSE 

       250        260        270        280 
FFGPNNIDCE CCTCEKNMNG AFSYLRGNEN AEPIISEKKT KYELRSRS 

« Hide

References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FO080708 Genomic DNA. Translation: CCD66031.1.
PIRT15735.
RefSeqNP_495272.1. NM_062871.4.
UniGeneCel.6996.

3D structure databases

ProteinModelPortalQ09265.
SMRQ09265. Positions 24-262.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6239.C32D5.5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaC32D5.5; C32D5.5; WBGene00016313.
GeneID174045.
KEGGcel:CELE_C32D5.5.

Organism-specific databases

CTD174045.
WormBaseC32D5.5; CE01845; WBGene00016313; set-4.

Phylogenomic databases

eggNOGNOG240704.
GeneTreeENSGT00520000055640.
HOGENOMHOG000007250.
InParanoidQ09265.
KOK11429.
OMADHIVRFL.
OrthoDBEOG7MKW6P.
PhylomeDBQ09265.

Family and domain databases

InterProIPR025790. Hist-Lys_N-MTase_Suvar4-20.
IPR001214. SET_dom.
[Graphical view]
PfamPF00856. SET. 1 hit.
[Graphical view]
SMARTSM00317. SET. 1 hit.
[Graphical view]
PROSITEPS51570. SAM_MT43_SUVAR420_2. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio882269.

Entry information

Entry nameSUV42_CAEEL
AccessionPrimary (citable) accession number: Q09265
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 11, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase