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Protein

Histone-lysine N-methyltransferase Suv4-20

Gene

set-4

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression (By similarity).By similarity

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Methyltransferase, Repressor, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

ReactomeiR-CEL-3214841. PKMTs methylate histone lysines.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase Suv4-20 (EC:2.1.1.43)
Alternative name(s):
SET domain-containing protein 4
Suppressor of variegation 4-20 homolog
Short name:
Su(var)4-20 homolog
Gene namesi
Name:set-4
Synonyms:tag-337
ORF Names:C32D5.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiC32D5.5; CE01845; WBGene00016313; set-4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000652171 – 288Histone-lysine N-methyltransferase Suv4-20Add BLAST288

Proteomic databases

EPDiQ09265.
PaxDbiQ09265.
PeptideAtlasiQ09265.

Expressioni

Gene expression databases

BgeeiWBGene00016313.

Interactioni

Protein-protein interaction databases

STRINGi6239.C32D5.5.

Structurei

3D structure databases

ProteinModelPortaliQ09265.
SMRiQ09265.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini128 – 238SETPROSITE-ProRule annotationAdd BLAST111

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar4-20 subfamily.PROSITE-ProRule annotation
Contains 1 SET domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2589. Eukaryota.
ENOG410XPH8. LUCA.
GeneTreeiENSGT00520000055640.
HOGENOMiHOG000007250.
InParanoidiQ09265.
KOiK11429.
OMAiCTCERNG.
OrthoDBiEOG091G0IUY.
PhylomeDBiQ09265.

Family and domain databases

InterProiIPR025790. Hist-Lys_N-MTase_Suvar4-20.
IPR001214. SET_dom.
[Graphical view]
PfamiPF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS51570. SAM_MT43_SUVAR420_2. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q09265-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLHEQIANI SVTFNDIPRS DHSMTPTELC YFDDFATTLV VDSVLNFTTH
60 70 80 90 100
KMSKKRRYLY QDEYRTARTV MKTFREQRDW TNAIYGLLTL RSVSHFLSKL
110 120 130 140 150
PPNKLFEFRD HIVRFLNMFI LDSGYTIQEC KRYSQEGHQG AKLVSTGVWS
160 170 180 190 200
RGDKIERLSG VVCLLSSEDE DSILAQEGSD FSVMYSTRKR CSTLWLGPGA
210 220 230 240 250
YINHDCRPTC EFVSHGSTAH IRVLRDMVPG DEITCFYGSE FFGPNNIDCE
260 270 280
CCTCEKNMNG AFSYLRGNEN AEPIISEKKT KYELRSRS
Length:288
Mass (Da):33,189
Last modified:November 1, 1997 - v1
Checksum:iB13A5878E3388EA6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080708 Genomic DNA. Translation: CCD66031.1.
PIRiT15735.
RefSeqiNP_495272.1. NM_062871.4.
UniGeneiCel.6996.

Genome annotation databases

EnsemblMetazoaiC32D5.5; C32D5.5; WBGene00016313.
GeneIDi174045.
KEGGicel:CELE_C32D5.5.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080708 Genomic DNA. Translation: CCD66031.1.
PIRiT15735.
RefSeqiNP_495272.1. NM_062871.4.
UniGeneiCel.6996.

3D structure databases

ProteinModelPortaliQ09265.
SMRiQ09265.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.C32D5.5.

Proteomic databases

EPDiQ09265.
PaxDbiQ09265.
PeptideAtlasiQ09265.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC32D5.5; C32D5.5; WBGene00016313.
GeneIDi174045.
KEGGicel:CELE_C32D5.5.

Organism-specific databases

CTDi174045.
WormBaseiC32D5.5; CE01845; WBGene00016313; set-4.

Phylogenomic databases

eggNOGiKOG2589. Eukaryota.
ENOG410XPH8. LUCA.
GeneTreeiENSGT00520000055640.
HOGENOMiHOG000007250.
InParanoidiQ09265.
KOiK11429.
OMAiCTCERNG.
OrthoDBiEOG091G0IUY.
PhylomeDBiQ09265.

Enzyme and pathway databases

ReactomeiR-CEL-3214841. PKMTs methylate histone lysines.

Miscellaneous databases

PROiQ09265.

Gene expression databases

BgeeiWBGene00016313.

Family and domain databases

InterProiIPR025790. Hist-Lys_N-MTase_Suvar4-20.
IPR001214. SET_dom.
[Graphical view]
PfamiPF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS51570. SAM_MT43_SUVAR420_2. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSUV42_CAEEL
AccessioniPrimary (citable) accession number: Q09265
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 30, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.