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Q09265

- SUV42_CAEEL

UniProt

Q09265 - SUV42_CAEEL

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Protein
Histone-lysine N-methyltransferase Suv4-20
Gene
set-4, tag-337, C32D5.5
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression By similarity.

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

GO - Molecular functioni

  1. histone methyltransferase activity (H4-K20 specific) Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. determination of adult lifespan Source: UniProtKB
  2. histone H4-K20 trimethylation Source: InterPro
  3. regulation of transcription, DNA-templated Source: UniProtKB-KW
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Methyltransferase, Repressor, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase Suv4-20 (EC:2.1.1.43)
Alternative name(s):
SET domain-containing protein 4
Suppressor of variegation 4-20 homolog
Short name:
Su(var)4-20 homolog
Gene namesi
Name:set-4
Synonyms:tag-337
ORF Names:C32D5.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome II

Organism-specific databases

WormBaseiC32D5.5; CE01845; WBGene00016313; set-4.

Subcellular locationi

Nucleus By similarity. Chromosome By similarity

GO - Cellular componenti

  1. chromosome Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 288288Histone-lysine N-methyltransferase Suv4-20
PRO_0000065217Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi6239.C32D5.5.

Structurei

3D structure databases

ProteinModelPortaliQ09265.
SMRiQ09265. Positions 24-262.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini128 – 238111SET
Add
BLAST

Sequence similaritiesi

Contains 1 SET domain.

Phylogenomic databases

eggNOGiNOG240704.
GeneTreeiENSGT00520000055640.
HOGENOMiHOG000007250.
InParanoidiQ09265.
KOiK11429.
OMAiDHIVRFL.
OrthoDBiEOG7MKW6P.
PhylomeDBiQ09265.

Family and domain databases

InterProiIPR025790. Hist-Lys_N-MTase_Suvar4-20.
IPR001214. SET_dom.
[Graphical view]
PfamiPF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS51570. SAM_MT43_SUVAR420_2. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q09265-1 [UniParc]FASTAAdd to Basket

« Hide

MQLHEQIANI SVTFNDIPRS DHSMTPTELC YFDDFATTLV VDSVLNFTTH    50
KMSKKRRYLY QDEYRTARTV MKTFREQRDW TNAIYGLLTL RSVSHFLSKL 100
PPNKLFEFRD HIVRFLNMFI LDSGYTIQEC KRYSQEGHQG AKLVSTGVWS 150
RGDKIERLSG VVCLLSSEDE DSILAQEGSD FSVMYSTRKR CSTLWLGPGA 200
YINHDCRPTC EFVSHGSTAH IRVLRDMVPG DEITCFYGSE FFGPNNIDCE 250
CCTCEKNMNG AFSYLRGNEN AEPIISEKKT KYELRSRS 288
Length:288
Mass (Da):33,189
Last modified:November 1, 1997 - v1
Checksum:iB13A5878E3388EA6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO080708 Genomic DNA. Translation: CCD66031.1.
PIRiT15735.
RefSeqiNP_495272.1. NM_062871.4.
UniGeneiCel.6996.

Genome annotation databases

EnsemblMetazoaiC32D5.5; C32D5.5; WBGene00016313.
GeneIDi174045.
KEGGicel:CELE_C32D5.5.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO080708 Genomic DNA. Translation: CCD66031.1 .
PIRi T15735.
RefSeqi NP_495272.1. NM_062871.4.
UniGenei Cel.6996.

3D structure databases

ProteinModelPortali Q09265.
SMRi Q09265. Positions 24-262.
ModBasei Search...

Protein-protein interaction databases

STRINGi 6239.C32D5.5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai C32D5.5 ; C32D5.5 ; WBGene00016313 .
GeneIDi 174045.
KEGGi cel:CELE_C32D5.5.

Organism-specific databases

CTDi 174045.
WormBasei C32D5.5 ; CE01845 ; WBGene00016313 ; set-4.

Phylogenomic databases

eggNOGi NOG240704.
GeneTreei ENSGT00520000055640.
HOGENOMi HOG000007250.
InParanoidi Q09265.
KOi K11429.
OMAi DHIVRFL.
OrthoDBi EOG7MKW6P.
PhylomeDBi Q09265.

Miscellaneous databases

NextBioi 882269.

Family and domain databases

InterProi IPR025790. Hist-Lys_N-MTase_Suvar4-20.
IPR001214. SET_dom.
[Graphical view ]
Pfami PF00856. SET. 1 hit.
[Graphical view ]
SMARTi SM00317. SET. 1 hit.
[Graphical view ]
PROSITEi PS51570. SAM_MT43_SUVAR420_2. 1 hit.
PS50280. SET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiSUV42_CAEEL
AccessioniPrimary (citable) accession number: Q09265
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 11, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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