Q09265 (SUV42_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Histone-lysine N-methyltransferase Suv4-20
EC=2.1.1.43

Alternative name(s):
SET domain-containing protein 4
Suppressor of variegation 4-20 homolog
Short name=Su(var)4-20 homolog

Gene names

Name:	set-4
Synonyms:	tag-337
ORF Names:	C32D5.5

Organism

Caenorhabditis elegans [Reference proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	288 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression By similarity.
Catalytic activity	S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
Subcellular location	Nucleus By similarity. Chromosome By similarity.
Sequence similarities	Belongs to the histone-lysine methyltransferase family. Suvar4-20 subfamily. Contains 1 SET domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Chromosome Nucleus
Ligand	S-adenosyl-L-methionine
Molecular function	Chromatin regulator Methyltransferase Repressor Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	determination of adult lifespan Inferred from mutant phenotype PubMed 20555324. Source: UniProtKB histone H4-K20 trimethylation Inferred from electronic annotation. Source: InterPro regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	chromosome Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	histone methyltransferase activity (H4-K20 specific) Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 288	288	Histone-lysine N-methyltransferase Suv4-20		PRO_0000065217
Regions
	Domain	124 – 242	119	SET

Sequences

	Sequence		Length	Mass (Da)
	Q09265 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: B13A5878E3388EA6	FASTA	288	33,189
	10 20 30 40 50 60 MQLHEQIANI SVTFNDIPRS DHSMTPTELC YFDDFATTLV VDSVLNFTTH KMSKKRRYLY 70 80 90 100 110 120 QDEYRTARTV MKTFREQRDW TNAIYGLLTL RSVSHFLSKL PPNKLFEFRD HIVRFLNMFI 130 140 150 160 170 180 LDSGYTIQEC KRYSQEGHQG AKLVSTGVWS RGDKIERLSG VVCLLSSEDE DSILAQEGSD 190 200 210 220 230 240 FSVMYSTRKR CSTLWLGPGA YINHDCRPTC EFVSHGSTAH IRVLRDMVPG DEITCFYGSE 250 260 270 280 FFGPNNIDCE CCTCEKNMNG AFSYLRGNEN AEPIISEKKT KYELRSRS

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FO080708 Genomic DNA. Translation: CCD66031.1.
PIR	T15735.
RefSeq	NP_495272.1. NM_062871.4.
3D structure databases
ProteinModelPortal	Q09265.
SMR	Q09265. Positions 24-262.
ModBase	Search...
Protein-protein interaction databases
STRING	6239.C32D5.5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	C32D5.5; C32D5.5; C32D5.5.
GeneID	174045.
KEGG	cel:CELE_C32D5.5.
Organism-specific databases
CTD	174045.
WormBase	C32D5.5; CE01845; WBGene00016313; set-4.
Phylogenomic databases
eggNOG	NOG240704.
GeneTree	ENSGT00520000055640.
HOGENOM	HOG000007250.
InParanoid	Q09265.
KO	K11429.
OMA	PGAYINH.
Family and domain databases
InterPro	IPR025790. Hist-Lys_N-MTase_Suvar4-20. IPR001214. SET_dom. [Graphical view]
Pfam	PF00856. SET. 1 hit. [Graphical view]
SMART	SM00317. SET. 1 hit. [Graphical view]
PROSITE	PS50280. SET. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	882269.

Entry information

Entry name

SUV42_CAEEL

Accession

Primary (citable) accession number: Q09265

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	May 1, 2013
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project