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Q09265

- SUV42_CAEEL

UniProt

Q09265 - SUV42_CAEEL

Protein

Histone-lysine N-methyltransferase Suv4-20

Gene

set-4

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression By similarity.By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].PROSITE-ProRule annotation

    GO - Molecular functioni

    1. histone methyltransferase activity (H4-K20 specific) Source: InterPro

    GO - Biological processi

    1. determination of adult lifespan Source: UniProtKB
    2. histone H4-K20 trimethylation Source: InterPro
    3. regulation of transcription, DNA-templated Source: UniProtKB-KW
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulator, Methyltransferase, Repressor, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone-lysine N-methyltransferase Suv4-20 (EC:2.1.1.43)
    Alternative name(s):
    SET domain-containing protein 4
    Suppressor of variegation 4-20 homolog
    Short name:
    Su(var)4-20 homolog
    Gene namesi
    Name:set-4
    Synonyms:tag-337
    ORF Names:C32D5.5
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome II

    Organism-specific databases

    WormBaseiC32D5.5; CE01845; WBGene00016313; set-4.

    Subcellular locationi

    Nucleus By similarity. Chromosome By similarity

    GO - Cellular componenti

    1. chromosome Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Chromosome, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 288288Histone-lysine N-methyltransferase Suv4-20PRO_0000065217Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi6239.C32D5.5.

    Structurei

    3D structure databases

    ProteinModelPortaliQ09265.
    SMRiQ09265. Positions 24-262.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini128 – 238111SETPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar4-20 subfamily.PROSITE-ProRule annotation
    Contains 1 SET domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG240704.
    GeneTreeiENSGT00520000055640.
    HOGENOMiHOG000007250.
    InParanoidiQ09265.
    KOiK11429.
    OMAiDHIVRFL.
    OrthoDBiEOG7MKW6P.
    PhylomeDBiQ09265.

    Family and domain databases

    InterProiIPR025790. Hist-Lys_N-MTase_Suvar4-20.
    IPR001214. SET_dom.
    [Graphical view]
    PfamiPF00856. SET. 1 hit.
    [Graphical view]
    SMARTiSM00317. SET. 1 hit.
    [Graphical view]
    PROSITEiPS51570. SAM_MT43_SUVAR420_2. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q09265-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQLHEQIANI SVTFNDIPRS DHSMTPTELC YFDDFATTLV VDSVLNFTTH    50
    KMSKKRRYLY QDEYRTARTV MKTFREQRDW TNAIYGLLTL RSVSHFLSKL 100
    PPNKLFEFRD HIVRFLNMFI LDSGYTIQEC KRYSQEGHQG AKLVSTGVWS 150
    RGDKIERLSG VVCLLSSEDE DSILAQEGSD FSVMYSTRKR CSTLWLGPGA 200
    YINHDCRPTC EFVSHGSTAH IRVLRDMVPG DEITCFYGSE FFGPNNIDCE 250
    CCTCEKNMNG AFSYLRGNEN AEPIISEKKT KYELRSRS 288
    Length:288
    Mass (Da):33,189
    Last modified:November 1, 1997 - v1
    Checksum:iB13A5878E3388EA6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080708 Genomic DNA. Translation: CCD66031.1.
    PIRiT15735.
    RefSeqiNP_495272.1. NM_062871.4.
    UniGeneiCel.6996.

    Genome annotation databases

    EnsemblMetazoaiC32D5.5; C32D5.5; WBGene00016313.
    GeneIDi174045.
    KEGGicel:CELE_C32D5.5.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080708 Genomic DNA. Translation: CCD66031.1 .
    PIRi T15735.
    RefSeqi NP_495272.1. NM_062871.4.
    UniGenei Cel.6996.

    3D structure databases

    ProteinModelPortali Q09265.
    SMRi Q09265. Positions 24-262.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6239.C32D5.5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai C32D5.5 ; C32D5.5 ; WBGene00016313 .
    GeneIDi 174045.
    KEGGi cel:CELE_C32D5.5.

    Organism-specific databases

    CTDi 174045.
    WormBasei C32D5.5 ; CE01845 ; WBGene00016313 ; set-4.

    Phylogenomic databases

    eggNOGi NOG240704.
    GeneTreei ENSGT00520000055640.
    HOGENOMi HOG000007250.
    InParanoidi Q09265.
    KOi K11429.
    OMAi DHIVRFL.
    OrthoDBi EOG7MKW6P.
    PhylomeDBi Q09265.

    Miscellaneous databases

    NextBioi 882269.

    Family and domain databases

    InterProi IPR025790. Hist-Lys_N-MTase_Suvar4-20.
    IPR001214. SET_dom.
    [Graphical view ]
    Pfami PF00856. SET. 1 hit.
    [Graphical view ]
    SMARTi SM00317. SET. 1 hit.
    [Graphical view ]
    PROSITEi PS51570. SAM_MT43_SUVAR420_2. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiSUV42_CAEEL
    AccessioniPrimary (citable) accession number: Q09265
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3