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Q09260

- LAG3_CAEEL

UniProt

Q09260 - LAG3_CAEEL

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Protein

Protein lag-3

Gene

sel-8

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Glp-1 and lin-12 promote signalling by recruiting lag-3 to target promoters, where it functions as a transcriptional activator.

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

SignaLinkiQ09260.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein lag-3
Alternative name(s):
Abnormal cell lineage protein 3
Abnormal germline proliferation protein 3
Gene namesi
Name:sel-8
Synonyms:lag-3
ORF Names:C32A3.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome III

Organism-specific databases

WormBaseiC32A3.1a; CE27810; WBGene00004765; sel-8.
C32A3.1b; CE01505; WBGene00004765; sel-8.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 490490Protein lag-3PRO_0000084353Add
BLAST

Proteomic databases

PaxDbiQ09260.
PRIDEiQ09260.

Interactioni

Subunit structurei

Associates with lag-1.

Protein-protein interaction databases

BioGridi40704. 11 interactions.
IntActiQ09260. 3 interactions.
MINTiMINT-1076351.
STRINGi6239.C32A3.1a.

Structurei

Secondary structure

1
490
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi60 – 8324
Helixi85 – 9814
Helixi100 – 11213

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2FO1X-ray3.12D49-132[»]
ProteinModelPortaliQ09260.
SMRiQ09260. Positions 52-114.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ09260.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi162 – 467306Gln-richAdd
BLAST
Compositional biasi185 – 1884Poly-Gln
Compositional biasi341 – 3466Poly-Gln
Compositional biasi353 – 3575Poly-Gln
Compositional biasi372 – 3809Poly-Gln
Compositional biasi390 – 40011Poly-GlnAdd
BLAST
Compositional biasi433 – 44210Poly-Gln

Phylogenomic databases

eggNOGiNOG250594.
HOGENOMiHOG000019032.
InParanoidiQ09260.
OMAiGEWFDKL.
OrthoDBiEOG7GTT8G.

Family and domain databases

InterProiIPR021587. Transcription_activator_LAG-3.
[Graphical view]
PfamiPF11498. Activator_LAG-3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform a (identifier: Q09260) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDDLSEFFVI EEMFISEPSV AGMKPSTSKT THSPPPEEPT APFVNDNLPN
60 70 80 90 100
PEDEPTIGDL NAFHSGEELH RQRSELARAN YEKARPEMIA NQRAVTAHLF
110 120 130 140 150
NRYTEDEERK RVEQQKNKEA MNASTSAPTS SRNGGQSVEN RKRRNDVVVA
160 170 180 190 200
PPTSEEEWKR AQQQHWMGQQ QPQMQFQMQQ QYHSQQQQYI MMQQQHHHMT
210 220 230 240 250
GMQQIHHQMP STSSADSIRS VPTPASSMHQ PSPAEMRNGC GMSRNATMDM
260 270 280 290 300
TCSPMSGGQP IVDENNLAVP EGEWFDKLAL AVAEQYNVDT ILGPDTYDTF
310 320 330 340 350
LAELDFSSSE SPTKQSPMEM NGDRMPSTAP PPAQNPQHIA QLQQQQNKMR
360 370 380 390 400
LMQQQQQEMQ RIEQQRRQQI MQQQQQQQQQ EHQRQQMLLQ QQQQQQQMQQ
410 420 430 440 450
HHQMNGGGQF ATQAHQQAAY MQQMQRMEQI RHQQQQAQQH QQAQQQHQQQ
460 470 480 490
AQHHQMGYGI PNGYPQQMHM HPPAYGAHHM PQPTAFANIN
Length:490
Mass (Da):56,482
Last modified:June 6, 2002 - v2
Checksum:i396A6C194C382A07
GO
Isoform b (identifier: Q09260-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: Missing.

Note: No experimental confirmation available.

Show »
Length:468
Mass (Da):54,008
Checksum:iB50E623F5AB4D7DB
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2222Missing in isoform b. 1 PublicationVSP_003908Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF241847 mRNA. Translation: AAF71523.1.
AF241846 mRNA. Translation: AAF71522.1.
Z48241 Genomic DNA. Translation: CAA88284.1.
Z48241 Genomic DNA. Translation: CAC42265.1.
PIRiT19628.
RefSeqiNP_001021194.1. NM_001026023.2. [Q09260-1]
NP_001021195.1. NM_001026024.2. [Q09260-2]
UniGeneiCel.19503.

Genome annotation databases

EnsemblMetazoaiC32A3.1a; C32A3.1a; WBGene00004765. [Q09260-1]
GeneIDi175464.
KEGGicel:CELE_C32A3.1.
UCSCiC32A3.1b.2. c. elegans. [Q09260-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF241847 mRNA. Translation: AAF71523.1 .
AF241846 mRNA. Translation: AAF71522.1 .
Z48241 Genomic DNA. Translation: CAA88284.1 .
Z48241 Genomic DNA. Translation: CAC42265.1 .
PIRi T19628.
RefSeqi NP_001021194.1. NM_001026023.2. [Q09260-1 ]
NP_001021195.1. NM_001026024.2. [Q09260-2 ]
UniGenei Cel.19503.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2FO1 X-ray 3.12 D 49-132 [» ]
ProteinModelPortali Q09260.
SMRi Q09260. Positions 52-114.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 40704. 11 interactions.
IntActi Q09260. 3 interactions.
MINTi MINT-1076351.
STRINGi 6239.C32A3.1a.

Proteomic databases

PaxDbi Q09260.
PRIDEi Q09260.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai C32A3.1a ; C32A3.1a ; WBGene00004765 . [Q09260-1 ]
GeneIDi 175464.
KEGGi cel:CELE_C32A3.1.
UCSCi C32A3.1b.2. c. elegans. [Q09260-1 ]

Organism-specific databases

CTDi 175464.
WormBasei C32A3.1a ; CE27810 ; WBGene00004765 ; sel-8.
C32A3.1b ; CE01505 ; WBGene00004765 ; sel-8.

Phylogenomic databases

eggNOGi NOG250594.
HOGENOMi HOG000019032.
InParanoidi Q09260.
OMAi GEWFDKL.
OrthoDBi EOG7GTT8G.

Enzyme and pathway databases

SignaLinki Q09260.

Miscellaneous databases

EvolutionaryTracei Q09260.
NextBioi 888270.

Family and domain databases

InterProi IPR021587. Transcription_activator_LAG-3.
[Graphical view ]
Pfami PF11498. Activator_LAG-3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "LAG-3 is a putative transcriptional activator in the C. elegans Notch pathway."
    Petcherski A.G., Kimble J.
    Nature 405:364-368(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B).
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiLAG3_CAEEL
AccessioniPrimary (citable) accession number: Q09260
Secondary accession number(s): Q9NGS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 6, 2002
Last modified: October 1, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

External Data

Dasty 3