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Protein

Beta-1,4 N-acetylgalactosaminyltransferase 2

Gene

B4galnt2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Responsible for synthesis of murine T-lymphocyte CT antigen. Can add to the low molecular weight acceptor 3'-sialyl-N-acetyllactosamine, to form a non-reducing terminal tetrasaccharide structure.

Catalytic activityi

UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-R = UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-R.

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

  • acetylgalactosaminyltransferase activity Source: UniProtKB

GO - Biological processi

  • lipid glycosylation Source: InterPro
  • negative regulation of cell-cell adhesion Source: UniProtKB
  • protein glycosylation Source: MGI
  • UDP-N-acetylgalactosamine metabolic process Source: UniProtKB
  • UDP-N-acetylglucosamine metabolic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

ReactomeiR-MMU-446203. Asparagine N-linked glycosylation.
UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT12. Glycosyltransferase Family 12.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-1,4 N-acetylgalactosaminyltransferase 2 (EC:2.4.1.-)
Gene namesi
Name:B4galnt2
Synonyms:Galgt2, Ggm3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1342058. B4galnt2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 15CytoplasmicSequence analysisAdd BLAST15
Transmembranei16 – 32Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST17
Topological domaini33 – 510LumenalSequence analysisAdd BLAST478

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000591041 – 510Beta-1,4 N-acetylgalactosaminyltransferase 2Add BLAST510

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi390N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ09199.
PaxDbiQ09199.
PRIDEiQ09199.

PTM databases

iPTMnetiQ09199.
PhosphoSitePlusiQ09199.

Expressioni

Gene expression databases

BgeeiENSMUSG00000013418.
CleanExiMM_B4GALNT2.
ExpressionAtlasiQ09199. baseline and differential.
GenevisibleiQ09199. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037239.

Structurei

3D structure databases

ProteinModelPortaliQ09199.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 2 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF61. Eukaryota.
ENOG4111N56. LUCA.
GeneTreeiENSGT00390000006679.
HOGENOMiHOG000220853.
HOVERGENiHBG004812.
InParanoidiQ09199.
KOiK09655.
OMAiYYTMPFG.
OrthoDBiEOG091G04CW.
PhylomeDBiQ09199.
TreeFamiTF332297.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR001173. Glyco_trans_2-like.
IPR011143. GM2_synthase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF00535. Glycos_transf_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000474. GM2_GD2_synthase. 1 hit.
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequencei

Sequence statusi: Complete.

Q09199-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSSVSFASF RFPWLLKTFV LMVGLATVAF MVRKVSLTTD FSTFKPKFPE
60 70 80 90 100
PARVDPVLKL LPEEHLRKLF TYSDIWLFPK NQCDCNSGKL RMKYKFQDAY
110 120 130 140 150
NQKDLPAVNA RRQAEFEHFQ RREGLPRPPP LLAPPNLPFG YPVHGVEVMP
160 170 180 190 200
LHTILIPGLQ YEGPDAPVYE VILKASLGTL NTLADVPDDE VQGRGQRQLT
210 220 230 240 250
ISTRHRKVLN FILQHVTYTS TEYYLHKVDT VSMEYESSVA KFPVTIKQQT
260 270 280 290 300
VPKLYDPGPE RKIRNLVTIA TKTFLRPHKL KILLQSIRKY YPDITVIVAD
310 320 330 340 350
DSKEPLEIND DYVEYYTMPF GKGWFAGRNL AISQVTTKYV LWVDDDFLFS
360 370 380 390 400
DKTKIEVLVD VLEKTELDVV GGSVQGNTYQ FRLLYEQTKN GSCLHQRWGS
410 420 430 440 450
FQALDGFPGC TLTSGVVNFF LAHTEQLRRV GFDPILQRVA HGEFFIDGLG
460 470 480 490 500
RLLVGSCPGV IINHQVRTPP KDPKLAALEK TYDKYRANTN SVIQFKVALQ
510
YFKNHLYCST
Length:510
Mass (Da):58,317
Last modified:November 1, 1995 - v1
Checksum:i013783C80ADEC3CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L30104 mRNA. Translation: AAA39802.1.
CCDSiCCDS25285.1.
PIRiA53802.
RefSeqiNP_032107.1. NM_008081.3.
UniGeneiMm.340702.

Genome annotation databases

EnsembliENSMUST00000038343; ENSMUSP00000037239; ENSMUSG00000013418.
GeneIDi14422.
KEGGimmu:14422.
UCSCiuc007lax.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L30104 mRNA. Translation: AAA39802.1.
CCDSiCCDS25285.1.
PIRiA53802.
RefSeqiNP_032107.1. NM_008081.3.
UniGeneiMm.340702.

3D structure databases

ProteinModelPortaliQ09199.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037239.

Protein family/group databases

CAZyiGT12. Glycosyltransferase Family 12.

PTM databases

iPTMnetiQ09199.
PhosphoSitePlusiQ09199.

Proteomic databases

MaxQBiQ09199.
PaxDbiQ09199.
PRIDEiQ09199.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038343; ENSMUSP00000037239; ENSMUSG00000013418.
GeneIDi14422.
KEGGimmu:14422.
UCSCiuc007lax.1. mouse.

Organism-specific databases

CTDi124872.
MGIiMGI:1342058. B4galnt2.

Phylogenomic databases

eggNOGiENOG410IF61. Eukaryota.
ENOG4111N56. LUCA.
GeneTreeiENSGT00390000006679.
HOGENOMiHOG000220853.
HOVERGENiHBG004812.
InParanoidiQ09199.
KOiK09655.
OMAiYYTMPFG.
OrthoDBiEOG091G04CW.
PhylomeDBiQ09199.
TreeFamiTF332297.

Enzyme and pathway databases

UniPathwayiUPA00378.
ReactomeiR-MMU-446203. Asparagine N-linked glycosylation.

Miscellaneous databases

PROiQ09199.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000013418.
CleanExiMM_B4GALNT2.
ExpressionAtlasiQ09199. baseline and differential.
GenevisibleiQ09199. MM.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR001173. Glyco_trans_2-like.
IPR011143. GM2_synthase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF00535. Glycos_transf_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000474. GM2_GD2_synthase. 1 hit.
SUPFAMiSSF53448. SSF53448. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiB4GN2_MOUSE
AccessioniPrimary (citable) accession number: Q09199
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.